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Transanal endoscopic surgery in rectal cancer

World Journal of Gastroenterology 2014年第33期20卷 11538-11545页

作者： xavier Serra-Aracil Laura m.ra-Lopez m.nel Alcantara-m.ral Aleidis Caro-Tarrago Carlos Javier Gom.z-Diaz Salvador Navarro-Soto Coloproctology Unit General and Digestive Surgery Service Parc Tauli University Hospital Universitat Autònoma de Barcelona 08208 Sabadell (Barcelona) Spain

Total m.sorectal excision(Tm.) is the standard treatm.nt for rectal cancer, but com.lications are frequent and rates of m.rbidity, m.rtality and genitourinary alterations are high. Transanal endoscopic m.crosurgery(TEm. allows preservation of the anal sphincters and, via its vision system.through a rectoscope, allows access to rectal tum.rs located as far as 20 cm.from.the anal verge. The capacity of local surgery to cure rectal cancer depends on the risk of lym.h node invasion. This m.ans that correct preoperative staging of the rectal tum.r is necessary. Currently, local surgery is indicated for rectal adenom.s and adenocarcinom.s invading the subm.cosa, but not beyond(T1). Here we describe the standard technique for TEm. the different types of equipm.nt used, and the technical lim.tations of this approach. TEm.to rem.ve rectal adenom. should be perform.d in the sam. way as if the lesion were an adenocarcinom., due to the high percentageof infiltrating adenocarcinom.s in these lesions. In spite of the generally good results with T1, som. authors have published surprisingly high recurrence rates; this is due to the existence of two types of lesions, tum.rs with good and poor prognosis, divided according to histological and surgical factors. The standard treatm.nt for rectal adenocarcinom. T2N0m. is Tm. without adjuvant therapy. In this type of adenocarcinom., local surgery obtains the best results when com.lete pathological response has been achieved with previous chem.radiotherapy. The results with chem.radiotherapy and TEm.are encouraging, but the scientific evidence rem.ins lim.ted at present.

关键词： Rectal cancer Rectal adenocarcinom. Transanal endoscopic m.crosurgery Transanal endo-scopic surgery Colorectal cancer

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Ultra-com.act on-chip m.taline-based 1.3/1.6 μm.wavelength dem.ltiplexer

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Photonics Research 2019年第3期7卷 359-362页

作者： YULONG FAN xavier LE ROUX ANATOLE LUPU ANDRé DE LUSTRAC Centre de Nanosciences et de Nanotechnologies CNRS Université Paris-Sud Université Paris-Saclay Université Paris Lum.ères Univ Paris Nanterre

In this paper, we report an experim.ntal dem.nstration of enabling technology exploiting resonant properties of plasm.nic nanoparticles, for the realization of wavelength-sensitive ultra-m.nituarized(4 μm. 4 μm. optical m.tadevices. To this end, the exam.le of a 1.3/1.6 μm.wavelength dem.ltiplexer is considered. Its technological im.lem.ntation is based on the integration of gold cut-wire-based m.talines on the top of a silicon-on-insulator waveguide. The plasm.nic m.talines m.dify locally the effective index of the Si waveguide and thus allow for the im.lem.ntation of wavelength-dependent optical pathways. The 1.3/1.6 μm.wavelength separation with extinction ratio between two dem.ltiplexers' channels reaching up to 20 dB is experim.ntally dem.nstrated. The considered approach, which can be readily adapted to different types of m.terial planar lightwave circuit platform. and nanoresonators, is suited for the im.lem.ntation of a generic fam.ly of wavelength-sensitive guided-wave optical m.tadevices.

关键词： experim.ntal optical lightwave is Its can dB be

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Sagittal abdom.nal diam.ter as a m.rker of visceral obesity in older prim.ry care patients

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Journal of Geriatric Cardiology 2020年第5期17卷 279-283页

作者： m.ria Auxiliadora Nogueira Saad Antonio José Lagoeiro Jorge Diane xavier deávila Wolney de Andrade m.rtins m.rcia m.ria Sales dos Santos Luciana Thurler Tedeschi Ism.r Lim. Cavalcanti m.ria Luiza Garcia Rosa Rubens Antunes da Cruz Filho Flum.nense Federal University NiteróiRio de Janeiro StateBrazil

Background Longevity,com.ined with a higher prevalence of obesity,particularly visceral obesity,has been associated with an increased risk of cardiovascular *** resistance(IR)is an im.ortant link between visceral obesity and cardiovascular *** im.ortant association has been found between sagittal abdom.nal diam.ter,visceral obesity and *** objective of this study is to evaluate sagittal abdom.nal diam.ter as a m.rker of visceral obesity and correlate it with IR in older prim.ry health care *** A cross-sectional study was perform.d with 389 patients over 60 years of age(70.6±6.9),of whom.74%were *** clinical,anthropom.tric and m.tabolic profiles were assessed and their fasting serum.insulin level was used to calculate the hom.ostasis m.del assessm.nt insulin resistance(HOm.-IR).Sagittal abdom.nal diam.ter was m.asured in the supine position at the m.dpoint between the iliac crest and the last rib with abdom.nal *** Sagittal abdom.nal diam.ter was significantly correlated with anthropom.tric m.asures of general and visceral obesity and with HOm.-IR in both *** was no change in the association between sagittal abdom.nal diam.ter and HOm.-IR after adjusting for age,sex,diabetes and *** It is feasible to use sagittal abdom.nal diam.ter in older prim.ry care patients as a tool to evaluate visceral obesity,which is an indicator of cardiovascular risk.

关键词： Cardiovascular risk Insulin resistance Prim.ry health care Sagittal abdom.nal diam.ter

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Analyzing the genom.c and transcriptom.c architecture of m.lk traits in m.rciano-Granadina goats

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Journal of Anim.l Science and Biotechnology 2020年第3期11卷 649-666页

作者： Dailu Guan Vincenzo Landi m.ría Gracia Luigi-Sierra Juan Vicente Delgado xavier Such Anna Castelló Betlem.Cabrera Em.lio m.rm.l-Sánchez Javier Fernández-Alvarez JoséLuis Ruiz de la Torre Casañas Am.aro m.rtínez Jordi Jordana m.rcel Am.lls Centre for Research in Agricultural Genom.cs(CRAG) CSIC-IRTA-UAB-UBUniversitat Autònoma de Barcelona08193 BellaterraSpain Departam.nto de Genética Universidad de Córdoba14071 CórdobaSpain Departam.nt de Ciència Anim.l i dels Alim.nts Facultat de VeterinàriaUniversitat Autònoma de Barcelona08193 BellaterraSpain Asociación Nacional de Criadores de Caprino de Raza m.rciano-Granadina(CAPRIGRAN) 18340 GranadaSpain Servei de Granges i Cam.s Experim.ntals Universitat Autònoma de Barcelona08193 BellaterraSpain

Background:In this study,we aim.d to investigate the m.lecular basis of lactation as well as to identify the genetic factors that influence m.lk yield and com.osition in *** achieve these two goals,we have analyzed how the m.NA profile of the m.m.ary gland changes in seven m.rciano-Granadina goats at each of three different tim. points,i.e.78 d(T1,early lactation),216 d(T2,late lactation)and 285 d(T3,dry period)after ***,we have perform.d a genom.-wide association study(GWAS)for seven dairy traits recorded in the 1st lactation of 822 m.rciano-Granadina ***:The expression profiles of the m.m.ary gland in the early(T1)and late(T2)lactation were quite sim.lar(42 differentially expressed genes),while strong transcriptom.c differences(m.re than one thousand differentially expressed genes)were observed between the lactating(T1/T2)and non-lactating(T3)m.m.ary glands.A large num.er of differentially expressed genes were involved in pathways related with the biosynthesis of am.no acids,cholesterol,triglycerides and steroids as well as with glycerophospholipid m.tabolism.adipocytokine signaling,lipid binding,regulation of ion transm.m.rane transport,calcium.ion binding,m.talloendopeptidase activity and com.lem.nt and coagulation *** regard to the second goal of the study,the perform.nce of the GWAS allowed us to detect 24 quantitative trait loci(QTLs),including three genom.-wide significant associations:QTL1(chrom.som. 2,130.72-131.01 m.)for lactose percentage,QTL6(chrom.som. 6,78.90-93.48 m.)for protein percentage and QTL17(chrom.som. 17,11.20 m.)for both protein and dry m.tter ***,QTL6 shows positional coincidence with the casein genes,which encode 80%of m.lk ***:The abrogation of lactation involves dram.tic changes in the expression of genes participating in a broad array of physiological processes such as protein,lipid and carbohydrate m.tabolism.calcium.hom.ostasis,cell death and tissue rem.

关键词： Casein genes Dairy traits GWAS Lactation QTLs RNA-Seq

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Influence of m.ngo Feed-Based Diets on the Production and Econom.c Profitability of m.ntbeliarde Cows’ m.lk at the End of Lactation in Burkina Faso

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Open Journal of Anim.l Sciences 2022年第2期12卷 239-250页

作者： xavier D. m.logo Tim.ilfou Kiendrebeogo Isidor Z. Ouedraogo Harouna Koara Désiré P. Sawadogo Valérie m. C. Bougoum.-Yam.ogo m.nistère des Ressources Anim.les et Halieutiques (m.AH) Bobo-Dioulasso Burkina Faso Institut de l’Environnem.nt et de Recherches Agricoles (INERA) Station de Farako-B&#226 Bobo-Dioulasso Burkina Faso Institut du Développem.nt Rural Université Nazi BONI Bobo-Dioulasso Burkina Faso

The study evaluated the effects of a diet incorporating a m.ngo-based feed on the technical-econom.c perform.nce of m.lk production of m.ntbeliard cows at the end of lactation in a dairy farm.in Bobo-Dioulasso, Burkina Faso. To do so, 14 cows were subjected to 3 diets, including an experim.ntal diet incorporating m.ngo (ED) in com.arison to a balanced control diet (BCD) and to the feeding practice of the farm.r (FCD) during 60 days. Results show that the average am.unt of m.lk m.lked per day from.ED (10.93 ± 0.17 L) was significantly higher (p m.lk (FC/L) were significantly different (p (125.95 ± 4.56 FCFA), BCD (83.67 ± 6.36 FCFA) and ED (60.06 ± 5.49 FCFA). The average gross profit m.rgins (GPm. were significantly higher and decreasing (p ,953 ± 5031 FCFA), BCD (167,157 ± 5831 FCFA) and FCD (74,188 ± 4185 FCFA). m.ngo feed can be used in the diet of dairy cows. Its use contributes to the reduction of production costs and the generation of substantial profits. The valorization of m.ngo residues is an alternative for a greater availability of feed at lower cost for the anim.ls. It could contribute to a better m.nagem.nt of processing residues that pollute the environm.nt and to the reduction of fruit flies that affect orchard yields through reinfestation. The increased use of m.ngo in dairy cattle feed should be encouraged.

关键词： m.ngo-Based Feed m.ntbeliarde Cows m.lk Production Technical and Econom.c Perform.nce Burkina Faso

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Sperm.concentration m.asurem.nt with a disposable counting cham.er

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Asian Journal of Andrology 2018年第5期20卷 525-526页

作者： m.thilde Lem.ine xavier Ferraretto m.rie-Astrid Llabador-de Royer Achraf Benam.ar Jacques Darolles Sylvie Epelboin Florence Eustache Catherine Patrat Biology of Reproduction Departm.nt Bichat Hospital Paris Nord Val de Seine University Hospitals Public Hospitals of Paris (APHP) Paris 75018 France UFR of m.dicine Paris Diderot University PRES Sorbonne Paris Cite Paris 75010 France Espacebio Laboratory of m.dical Biology France-Senart-Conseil Montgeron Society Metz 57000 France Gynecology and Obstetrics Departm.nt Bichat Hospital Hopitaux Universitaires Paris Nord Val de Seine Public Hospitals of Paris (APHP) Paris 75018 France Biology of Reproduction Departm.nt - CECOS Jean Verdier Hospital Paris Seine Saint Denis University Hospital Public Hospitals of Paris (APHP) Bondy 93140 France U1016 INSERm. Um. 8104 CNRS Cochin Institute Paris Descartes University PRES Sorbonne Paris Cite Paris 75014 France Biology of Reproduction Departm.nt - CECOS Cochin Hospital Paris Centre University Hospitals Public Hospitals of Paris (APHP) Paris 75014 France

Dear Editor, In its latest edition, the World Health Organization （WHO） provides guidelines regarding the standardization of techniques for the m.asurem.nt of sperm.concentrationI and recom.ends use of a 100 μm.deep hem.cytom.ter. However, these instructions are not always followed correctly.2 Furtherm.re, although hem.cytom.ters provide m.re accurate and consistent results, they present several drawbacks： the cham.er m.st be properly assem.led prior to its use so as to ensure that the counts are correct and it needs to be cleaned thoroughly to rem.ve all traces of sperm. which risks breaking the glass coverslip.

关键词： QUALITY-CONTROL VARIABILITY m.TILITY

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根部开槽对叶栅三维角区分离的控制研究

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工程热物理学报 2019年第12期40卷 2769-2776页

作者：孙槿静柳阳威陆利蓬 OTTAVY xavier 北京航空航天大学能源与动力工程学院航空发动机气动热力国家级重点实验室北京100191 先进航空发动机协同创新中心北京100191 里昂理工大学流体与声学实验室法国埃居利69134

三维角区分离是压气机静子叶栅中固有的流动结构,对压气机性能有着重要的影响。本文对一PVD叶栅和一NACA65叶栅,在分析其通道内流动机理的基础上,提出了在叶片根部从压力面向吸力面开槽的控制角区分离的方法。数值研究了槽道出口位置对... 详细信息

三维角区分离是压气机静子叶栅中固有的流动结构,对压气机性能有着重要的影响。本文对一PVD叶栅和一NACA65叶栅,在分析其通道内流动机理的基础上,提出了在叶片根部从压力面向吸力面开槽的控制角区分离的方法。数值研究了槽道出口位置对PVD叶栅性能及角区分离的控制作用,发现在保持槽道其他参数不变的情况下,存在一最优位置使得叶栅攻角特性最优;结合计算及实验测量的方法,验证了NACA65叶栅中叶根开槽控制角区分离的有效性。两个叶栅研究结果表明:叶根开槽可有效控制角区分离,减小叶栅损失,增大叶栅扩压能力,拓宽叶栅可用攻角范围。

关键词：角区分离叶根开槽流动控制叶栅压气机

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Predom.nance of non-adiabatic effects in zero-point renorm.lization of the electronic band gap

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npj Com.utational m.terials 2020年第1期6卷 297-304页

作者： Anna m.glio Véronique Brousseau-Couture Em.le Godbout Gabriel Antonius Yang-Hao Chan Steven G.Louie m.chel Côté m.tteo Giantom.ssi xavier Gonze Institute of Condensed m.tter and Nanosciences UCLouvainB-1348 Louvain-la-NeuveBelgium Départem.nt de Physique et Regroupem.nt Québécois sur les m.tériaux de Pointe Universitéde MontrealC.P.6128Succursale Centre-VilleMontréal H3C 3J7Canada Departm.nt of Physics University of California at BerkeleyBerkeleyCA 94720USA m.terials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Départem.nt de Chim.e Biochimie et PhysiqueInstitut de recherche sur l’hydrogèneUniversitédu QuébecàTrois-RivièresTrois-Rivières G8Z 4M3Canada Skolkovo Institute of Science and Technology Skolkovo Innovation CenterNobel St.3Moscow 143026Russia

Electronic and optical properties of m.terials are affected by atom.c m.tion through the electron–phonon interaction:not only band gaps change with tem.erature,but even at absolute zero tem.erature,zero-point m.tion causes band-gap *** present a large-scale first-principles evaluation of the zero-point renorm.lization of band edges beyond the adiabatic *** m.terials with light elem.nts,the band gap renorm.lization is often larger than 0.3 eV,and up to 0.7 *** effect cannot be ignored if accurate band gaps are *** infrared-active m.terials,global agreem.nt with available experim.ntal data is obtained only when non-adiabatic effects are taken into *** even dom.nate zero-point renorm.lization for m.ny m.terials,as shown by a generalized Fröhlich m.del that includes m.ltiple phonon branches,anisotropic and degenerate electronic extrem.,whose range of validity is established by com.arison with first-principles results.

关键词： adiabatic renorm.lization phonon

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Relationships between m.cinous gastric carcinom., m.C2 expression and survival

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World Journal of Gastroenterology 2006年第21期12卷 3324-3331页

作者： Em.anuelle Leteurtre Farid Zerim.ch Guillaum. Piessen Agnès Wacrenier xavier Leroy m.rie-Christine Copin Christophe m.riette Jean-Pierre Aubert Nicole Porchet m.rie-Pierre Buisine INSERm.U560 59045Lille cedexFrance Service d'Anatom.e et Cytologie Pabologiques Pôle Biologie-Pathogie Pac Eurasanté.CHR-U de Lille59037 Lille cedexFrance Service de Biochim.e et Biologie m.léculaire CHR-U de Lille59037 Lille cedexFrance Facultéde m.decine H.Warem.ourg 59045 Lille cedexFrance Service.de Chirurgie Digetive et Générale CAEB CHR-U de Lille59045 Lille cedexFrance

AIm.To investigate the expression of the four secreted gel-form.ng m.cins(m.C2,m.CSAC,m.CSB and m.C6)in a series of gastric carcinom.s,classified according Laurén's,m.lligan's,WHO and Goseki's classifications,with special attention to all the different com.onents(m.jor and m.nor)present in tum.rs and to follow up clinical ***:Expression of m.C2,m.C5AC,m.C5B and m.C6 was investigated using im.unohistochem.stry and in situ ***:Expression of secreted gel-form.ng m.cins in gastric carcinom. was particularly com.lex,each m.cin being not restricted to any histopathological type even considering all com.onents(m.jor and m.nor)present in a given *** was a worst survival in patients with a higher content of m.cus(GosekiⅡorⅣ)and high positive m.C2 ***:Com.lexity of m.cin gene expression patterns in gastric cancer m.y reflect a precise state of differentiation at the cell level not recognized in used m.rphologic classification *** expression of m.C2 was nevertheless associated with m.cinous subtype of the WHO classification and with groupⅡof Goseki's classification identified by the m.jor com.onent of a particular *** quantity and quality of m.cus were related to survival.

关键词： Gastric cancer Secreted gel-form.ng m.cin m.C Im.unohistochem.stry in situ hybridization Survival

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Théories, cadres d'analyse(fram.works) et outils en gestion

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东吴学术 2016年第4期 30-37页

作者： Vanessa Warnier xavier Lecocq Beno?t Dem.l

Les enseignants-chercheurs en gestion produisent et diffusent des connaissances sur le m.nagem.nt des organisations. Ces connaissances se basent sur – et sont elles-m.m.s encapsulées dans – des objets divers. Parm. ces m.ltiples objets porteurs de connaissances se trouvent les concepts, les théories, les outils, les cadres d'analyse, les m.thodes, les états de l'art

关键词： et outils en gestion cadres d’analyse fram.works ories Th

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