检索结果-南通市图书馆

Comparison of ring 1 parameters in 37-segment multifocal electroretinography between onset and offset conditions of ring 2 to 4 in normal subjects

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2019年第1期12卷 73-78页

作者： Jun Ho yoo Cheolmin Yun Jaeryung Oh Seong-Woo Kim Department of Ophthalmology Korea University College of Medicine

AIM: To investigate whether the response of a central hexagonal element corresponding to the macular area in conventional multifocal electroretinography(mfERG) tests was the same as that of experimental mfERG using single central hexagonal element stimulation. METHODS: Prospective, observational study. Thirty healthy subjects were included in this study. mfERG recordings were performed according to two protocols: stimulus with 37 hexagonal elements(protocol 1), and stimulus with a single central element created by deactivating the other 36 hexagonal elements(protocol 2). We compared differences between ring 1 parameters in each protocol. RESULTS: In protocol 1, the first positive component(P1) implicit time and P1 amplitude were 37.8±1.8 ms and 6.3±2.7 μV. After single element stimulation(protocol 2), double positive waves appeared. The implicit time and amplitude of P1 were 40.7±2.4 ms(P<0.001) and 9.1±3.3 μV(P=0.001), respectively. The implicit time and amplitude of the second positive component(P2) were 68.0±4.5 ms(P<0.001, compared with P1 in protocol 1) and 12.3±4.7 μV(P<0.001, compared with P1 in protocol 1), respectively. The amplitude of P2 in protocol 2 was about two times higher than that of P1 in protocol 1. CONCLUSION: mfERG responses of a central hexagonal element in a single element stimulation protocol are different from those of multiple element stimulation. The positive wave is more enhanced compared to that of the conventional protocol and it elongated into two wavelets.

关键词： multifocal electroretinography focal electroretinography macular function single element stimulation stray light effect

Glycyrrhizin attenuates HMGB1-induced hepatocyte apoptosis by inhibiting the p38-dependent mitochondrial pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第7期18卷 679-684页

作者： Geum-Youn Gwak Tae Gun Moon Dong Ho Lee Byung Chul yoo Department of Medicine Samsung Medical CenterSugnkyunkwan University School of Medicine50 Irwon-DongGangnam-Gu135-710 SeoulSouth Korea

AIM： To examine how High-mobility group box I （HMGB1） regulates hepatocyte apoptosis and, furthermore, to determine whether glycyrrhizin （GL）, a known HMGB1 inhibitor, prevents HMGBl-induced hepatocyte apoptosis.

关键词： High-mobility group box 1 Hepatocyte Apoptosis Glycyrrhizin p38 Mitochondria

Pharmacokinetics and tissue distribution of a novel PDE5 inhibitor,SK-3530,in rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第8期28卷 1247-1253页

作者： Hye-hyun yoo Nam-sun KIM Guang-jin Im Dong-hyun KIM Bioanalysis and Biotransformation Research Center Korea Institute of Science & Technology Seoul 136-791Korea Life Science RD Center SK ChemicalsGyeonggi-do 440-300Korea

Aim:To investigate the pharmacokinetic profile and tissue distribution of a novelphosphodiesterase type 5 inhibitor,5-ethyl-2-{5-[4-（2-hydroxy-ethyl）-piperazine-1-sulfonyl]-2-propoxy-phenyl}-7-propyl-3,5-dihydro-pyrrolo（3,2-d）pyrimidin-4-one（SK-3530）,in rats after administration of the14C-labeled ***:The pharmacokinetic parameters of SK-3530 were measured based on the totalradioactivity and parent SK-3530 concentration in rat plasma after intravenousand oral *** tissue distribution of total radioactivity after a singleoral administration of[14C]SK-3530 at a dose of 40 mg/kg was *** protein binding rates of SK-3530 were assessed by in vitro and ex ***:The total radioactivity profiles showed linear *** maximum plasma concentration and area under the curve of the parent SK3530were 10%-20% compared to those of the total *** the oral admin-istration of[14C]SK-3530,the radioactivity was widely distributed in all tissues,and the tissue/plasma ratio of the radioactivity 1 h after administration was calcu-lated as 0.5-2.6 with the exception of excretory organs.A relatively high penetra-tion was shown in the adrenal glands,liver,and *** vitro and ex vivo plasmaprotein binding assay by ultrafiltration showed a considerably high binding rateof more than 97%.Conclusion:SK-3530 was relatively well absorbed in the gas-trointestinal tract and showed linear pharmacokinetics over the investigated ***-3530 had low oral bioavailability due to a high,first-pass metabolism.

关键词： SK-3530 PDE5 inhibitor pharmacokinetics tissue distribution rats

Unusual presentation of granulomatosis with polyangiitis causing periaortitis and consequent subclavian steal syndrome:A case report

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第6期9卷 1433-1438页

作者： Uiju Cho Sung-Kyung Kim Jeong Min Ko Jinyoung yoo Department of Pathology St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Internal Medicine St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Radiology St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Hospital Pathology St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND Granulomatosis with polyangiitis(GPA)is a rare autoimmune disease that involves small-to-medium-sized vessels and forms necrotizing vasculitis with granulomatous *** formation of a large vessel lesion in GPA patients has been scarcely reported,and it can cause confusion in the *** SUMMARY A 27-year-old man presented with mild left-sided pleuritic chest pain that started one year *** imaging study revealed up to 2.5 cm-sized two irregular nodular consolidation nodule in the left lower *** nodules showed central ***,there was a periaortic mass occluding the branching porting of the subclavian *** had positive anti-neutrophil cytoplasmic antibodies(ANCAs),but myeloperoxidase-ANCAs and proteinase 3-ANCAs were *** patient also developed symptoms of subclavian vein syndrome during the *** resection of the lung revealed necrotizing vasculitis,destructive parenchymal abscess and surrounding granuloma,and therefore diagnosed of *** patient started on methotrexate and steroid therapy with a relief of *** Here,we present an unusual manifestation of GPA with periaortitis and consequent subclavian steal syndrome,which has never been previously *** case alerts us that we should include GPA in the differential diagnosis of large vessel vasculitis as well as subclavian steal syndrome.

关键词： Granulomatosis with polyangiitides Wegener granulomatosis Systemic vasculitis Subclavian steal syndrome Periaortitis Case report

Reliability and validity of tongue color analysis in the prediction of symptom patterns in terms of East Asian Medicine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2016年第2期36卷 165-172页

作者： Young-Jae Park Jin-Moo Lee Seung-Yeon yoo Young-Bae Park Department of Diagnosis and Biofunctional Medicine College of Korean MedicineKyung Hee UniversitySeoul 134-727Korea Department of Diagnosis and Biofunctional Medicine Kyung Hee University Hospital at GangdongSeoul 134-727Korea Department of Oriental Gynecology College of Korean MedicineKyung Hee UniversitySeoul 134-727Korea Department of Women Health Clinic Kyung Hee University Hospital at GancldonaSeoul 134-727Knrpa

OBJECTIVE:To examine whether color parameters of tongue inspection(TI)using a digital camera was reliable and valid,and to examine which color parameters serve as predictors of symptom patterns in terms of East Asian medicine(EAM).METHODS:Two hundred female subjects'tongue substances were photographed by a mega-pixel digital *** with the photographs,the subjects were asked to complete Yin deficiency,Phlegm pattern,and Cold-Heat pattern *** three sets of digital imaging software,each digital image was exposure-and white balance-corrected,and finally L*(luminance),a*(red-green balance),and b*(yellow-blue balance)values of the tongues *** examine intra-and inter-rater reliabilities and criterion validity of the color analysis method,three raters were asked to calculate color parameters for 20 digital image ***,four hierarchical regression models were ***:Color parameters showed good or excellent reliability(0.627-0.887 for intra-class correlation coefficients)and significant criterion validity(0.523-0.718 for Spearman's correlation).In the hierarchical regression models,age was a significant predictor of Yin deficiency(β=0.192),and b*value of the tip of the tongue was a determinant predictor of Yin deficiency,Phlegm,and Heat patterns(β=-0.212,-0.172,and-0.163).Luminance(L*)was predictive of Yin deficiency(β=-0.172)and Cold(β=0.173)***:Our results suggest that color analysis of the tongue using the L*a*b*system is reliable and valid,and that color parameters partially serve as symptom pattern predictors in EAM practice.

关键词： Medicine East Asian Traditional Complementary therapies Tongue inspection Yin deficiency Symptom pattern

pH-induced structural changes of surface immobilized poly (L-lysine) by two-dimensional (2D) infrared correlation study

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2015年第2期26卷 173-176页

作者： Eun Joo yoo Boknam Chae Young Mee Jung Seung Woo Lee School of Chemical Engineering Yeungnam University Pohang Accelerator Laboratory Department of Chemistry Kangwon National University

This paper reports the pH-induced structural changes in the surface immobilized poly（L-lysine）（PLL）***-dimensional（2D） correlation analysis was applied to the Fourier transform infrared（FTIR）spectra of the surface-immobilized PLL film to examine the spectral changes induced by the alternations of the protonation state of the amino group in the side *** spectral changes in the FTIR spectra of the PLL film were observed between pH 7 and *** decrease in the protonation state of the amino group in the side chain induced spectral changes in the amino group as well as conformational changes in the alky]group in the side *** pH 1-8,the spectral changes in the amino and alkyl groups in the side chain occurred before those of the amide group in the main chain of the surface immobilized PLL film.

关键词： Poly(L-lysine)(PLL) Surface-immobilized polypeptide FT-IR spectroscopy 2D correlation spectroscopy

Investigation of transient and heterogeneous micro-climate around a human body in an enclosed personalized work environment

在线全文

学校读者我要写书评

暂无评论

Energy and Built Environment 2020年第4期1卷 423-431页

作者： Chong Wang Sung-Jun yoo Shin-ichi Tanabe Kazuhide Ito Interdisciplinary Graduate School of Engineering Sciences Kyushu UniversityJapan Faculty of Engineering Sciences Kyushu UniversityJapan Faculty of Science and Engineering Waseda UniversityJapan

Heterogeneous distribution of indoor environmental quality is known to have a great impact on human health,comfort,and productivity.A personalized work environment,that creates a localized and independent environ-ment with capsules or partitions,is being developed worldwide to provide workers with a space that enables undisturbed concentration on studying and ***,the minimized interior space of a personalized work environment can immediately cause adverse health impacts for occupant if the air quality and thermal en-vironment in the personalized work environment is not controlled ***,constant breathing can sharply increase the CO 2 concentrations in an interior space with an insufficient ventilation *** order to design a healthy and comfortable indoor environment,especially in a personalized work environment,it is important to predict precisely and comprehensively the transient and heterogeneous structure of the indoor envi-ronment formed around a human *** this background,we have developed an in silico human model that integrates a computational human model(virtual manikin combined with thermoregulation models)and respi-ratory model(virtual airway)for estimating indoor environmental quality,targeting the microclimate around a human body and breathing zone with high *** this study,we report the applicability of a comprehensive in silico human model to estimate the environ-mental quality in a personalized work environment.A coupled analysis of heat and contaminant transfer with computational fluid dynamics was conducted targeting the space around the in silico human model installed in a virtual personalized work *** informative data including human thermal comfort and breathing air quality were obtained,potentially forming the basis for the development of a digital twin of the personalized work environment and contributing to the design of a healthy,comfortable,and productive personalized work environme

关键词： Microclimate Indoor environment Digital twin Personalized work environment Computational fluid dynamics in silico human model

Design of Authoring Tool for Static and Dynamic Projection Mapping

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2021年第1期66卷 1-16页

作者： Sang-Joon Kim Nammee Moon Min Hong Gooman Park yoo-Joo Choi Seoul National University of Science and Technology 172 Gongneung-dongNowon-guSeoulKorea Hoseo University 165 Sechul-ri Baebang-eupAsan-siChungcheongnam-doKorea Soonchunhyang University 336-745Asan-siChungcheongnam-doKorea Seoul Media Institute Technology 661 Deungchon-dongGangseo-guSeoulKorea

This study introduces the design details of a tool to create interactive projection-mapping content in a convenient *** the proposed tool design,a homography-based camera–projector calibration method was applied with the use of red–green–blue-depth images from a Kinect V2 sensor that did not require accurate camera calibration *** addition,the proposed tool simultaneously achieved static projection mapping that projected the image content onto a fixed object,and dynamic projection mapping that projected the image content onto a user’s body,by tracing the moving *** verify the effectiveness of the proposed content-creation tool,users with no programming capabilities were employed to create contents that were projected onto various objects in fixed positions and a user’s body in various poses,thereby analyzing the tool’s ***,the projection accuracy was analyzed at different depth positions,and the projection-mapping accuracy was verified with the use of the proposed method.

关键词： Dynamic projection mapping camera-projector calibration Kinect projection mapping content authoring tool

Toward a Learnable Climate Model in the Artificial Intelligence Era

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2024年第7期41卷 1281-1288页

作者： Gang HUANG Ya WANG yoo-Geun HAM Bin MU Weichen TAO Chaoyang XIE State key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Laboratory for Regional Oceanography and Numerical Modeling Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China University of Chinese Academy of Sciences Beijing 100049China Department of Environmental Planning Graduate School of Environmental StudiesSeoul National UniversitySeoul 08826South Korea School of Software Engineering Tongji UniversityShanghai 200092China

Artificial intelligence(AI)models have significantly impacted various areas of the atmospheric sciences,reshaping our approach to climate-related *** this AI-driven transformation,the foundational role of physics in climate science has occasionally been *** perspective suggests that the future of climate modeling involves a synergistic partnership between AI and physics,rather than an“either/or”*** controversies around current physical inconsistencies in large AI models,we stress the critical need for detailed dynamic diagnostics and physical ***,we provide illustrative examples to guide future assessments and constraints for AI *** AI integration with numerical models,we argue that offline AI parameterization schemes may fall short of achieving global optimality,emphasizing the importance of constructing online ***,we highlight the significance of fostering a community culture and propose the OCR(Open,Comparable,Reproducible)*** a better community culture and a deep integration of physics and AI,we contend that developing a learnable climate model,balancing AI and physics,is an achievable goal.

关键词： artificial intelligence deep learning learnable climate model