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Assessment of in vitro sensitivity of Plasmodium vivax fresh isolates

Asian Pacific Journal of Tropical Biomedicine 2011年第1期1卷 49-53页

作者： Poonuch Muhamad Wanna Chacharoenkul Kanchana Rungsihirunrat Ronnatrai Ruengweerayut kesara nabangchang Pharmacology and Toxicology Unit Graduate Program in Biomedical SciencesThammasat University College of Public Health Chulalongkorn University Mae-Sot General Hospital

Objective:To compare the applicability of the SYBK Grcen-Ⅰ assay with the standard schizont maturalion assay,for determination of sensitivity of Plasmodium vivax(***) to chloroquine and a new antifolale WR ***:The study was conducted at Mae Tao Clinic for migrant workers,Tak Province during April 2009 to July 2010.A total of 64 blood samples(1 mL blood collected into sodium heparinized plastic tube) were collected from patients with monoinfection with *** malaria prior to treatment with standard regimen of a 3-day chloroquine. In vitro sensitivity of *** isolates was evaluated by schizont maturation inhibition and SYBR Green-Ⅰ ***:A total of 30 out of 64 blood samples collected from patients with *** malaria were successfully analyzed using both the microscopic schizont maturation inhibition and SYBR Green-I *** failure rates of the schizont maturation inhibition assay(50%) and the SYBR Green-I assay(54%) were similar(P=0.51).The median IC_(10)s,IC_(50)s and IC_(90)s of both chloroquine and WR99210 were not significantly different from the clinical isolates of *** *** on the cut-off of 100 nM,the prevalences of chloroquine resistance determined by schizont maturation inhibition and SYBR Green-I assays were 19 and 11 isolates,*** strength of agreement between the two methods was very poor for both chloroquine and ***:On the basis of this condition and its superior sensitivity,the microscopic method appears better than the SYUK Green-I Green assay for assessing in vitro sensitivity of fresh *** isolates to antimalarial drugs.

关键词： Plasmodium vivax Chloroquine In vitro sensitivity Schizont maturation inhibition assay SYBR Green-Ⅰassay Fresh isolate Antifolate Malaria Antimalarial drug Standard regimen

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