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藤黄酸抗肿瘤作用机制及联合用药研究进展

中草药 2024年第7期55卷 2423-2432页

作者：孙强涂柯蓉姜先梅齐瑶杨尚沁吕亮亮丁欢欢刘红梅蔡璐璐四川省医学科学院·四川省人民医院药学部四川成都610072 电子科技大学医学院个体化药物治疗四川省重点实验室四川成都610072 西南交通大学生命科学与工程学院四川成都610031 西南医科大学药学院四川泸州646000

恶性肿瘤是全球面临的共同难题,同时也给世界各国带来了超负荷的经济负担。藤黄酸是藤黄Garcinia hanburyi中一种笼状呫吨酮类活性成分,具有抗炎、改善视网膜病变、脏器保护等多种药理活性。近年来,大量研究证实藤黄酸可作为一种潜力巨... 详细信息

恶性肿瘤是全球面临的共同难题,同时也给世界各国带来了超负荷的经济负担。藤黄酸是藤黄Garcinia hanburyi中一种笼状呫吨酮类活性成分,具有抗炎、改善视网膜病变、脏器保护等多种药理活性。近年来,大量研究证实藤黄酸可作为一种潜力巨大的抗肿瘤化合物用于肝癌、肺癌、乳腺癌、结直肠癌等多种癌症的治疗,其机制涉及抑制细胞增殖、阻碍迁移和侵袭、诱导凋亡和自噬、抑制血管生成、诱导铁死亡和焦亡、靶向肿瘤炎症微环境和免疫调控等。此外,大量研究发现藤黄酸可与多种化疗药物或天然产物联合用于癌症的协同治疗。因此,重点总结了藤黄酸的抗肿瘤作用机制及其协同其他药物抗肿瘤的研究进展,为藤黄酸抗肿瘤研究提供参考依据。

关键词：藤黄酸抗肿瘤凋亡迁移联合用药

Habitat heterogeneity and biotic interactions mediate climate influences on seedling survival in a temperate forest

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Forest Ecosystems 2023年第5期10卷 579-588页

作者： Haikun Liu Hang Shi Quan Zhou Man Hu Xiao Shu kerong Zhang Quanfa Zhang Haishan Dang Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical GardenChinese Academy of SciencesWuhan430074China University of Chinese Academy of Sciences Beijing100049China

Seedling stage has long been recognized as the bottleneck of forest regeneration,and the biotic and abiotic processes that dominate at seedling stage largely affect the dynamics of *** might be particularly vulnerable to climate stress,so elucidating the role of interannual climate variation in fostering community dynamics is crucial to understanding the response of forest to climate *** seedling survival data of 69 woody species collected for five consecutive years from a 25-ha permanent plot in a temperate deciduous forest,we identified the effects of biotic interactions and habitat factors on seedling survival,and examined how those effects changed over *** found that interannual climate variations,followed by biotic interactions and habitat conditions,were the most significant predictors of seedling *** light showed a positive impact on seedling mortality,and seedling survival responded differently to soil and air *** of conspecific neighbor density were significantly strengthened with the increase of maximum air temperature and vapor pressure deficits in the growing season,but were weakened by increased maximum soil temperature and precipitation in the non-growing ***,seedling survival was strongly correlated with interannual climate variability at all life stages,and the strength of the correlation increased with seedling *** addition,the importance of biotic and abiotic factors on seedling survival differed significantly among species-trait ***,the neighborhood-mediated effects on mortality might be significantly contributing or even inverting the direct effects of varying abiotic conditions on seedling survival,and density-dependent effects could not be the only important factor influencing seedling survival at an early stage.

关键词： Seedling survival Extreme interannual climate Negative density-dependence Species coexistence

Fatigue properties of titanium alloy custom short stems fabricated by electron beam melting

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Journal of Materials Science & Technology 2020年第17期52卷 180-188页

作者： Liao Wang Shujun Li Mengning Yan Yubo cheng Wentao Hou Yiping Wang Songtao Ai Rui Yang kerong Dai Shanghai Key Laboratory of Orthopaedic Implants Department of Orthopaedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200030China Titanium Alloy Laboratory Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Image Medraw Technology(Shanghai)Company Limited Shanghai 201100China

The fatigue properties of titanium alloy short-stems with four different lengths,manufactured by electron beam melting(EBM)technology,were investigated by in vitro test and finite element(FE)*** simulation results indicate that the maximum tensile stress concentrates at the lateral side of the stem *** magnitude of the concentrated tensile stress increases and the corresponding area of the axial section decreases with increasing of stem *** from fatigue tests demonstrate that fatigue cracks mainly initiate from the rough surface of the stem where the maximum tensile stress *** fatigue strength decreases with the increase of stem length,which is attributed to the higher stress concentration on the longer stem *** addition,it is found that post EBM treatment via hot isostatic processing(HIP)is able to enhance the fatigue properties of the stems,since the pores generated during EBM are mostly closed during *** work also demonstrates that the stress concentration on the stem surface can be effectively mitigated and the corresponding fatigue properties of the EBM-fabricated titanium alloy short stem can be considerably improved by optimizing the design in the stem length.

关键词： Custom short stem Titanium alloy Electron beam melting Fatigue property

安徽省能源、经济与生态环境三大系统耦合协调发展研究

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西安文理学院学报（自然科学版） 2024年第1期27卷 117-124页

作者：金燕芝张克荣王思元姜亮宇阜阳师范大学商学院安徽阜阳236000

为推进能源、经济与生态环境相互融合、协调发展,采用改进熵值法测算2016—2020年安徽省16个地级市能源、经济与生态环境系统综合发展值,并采用耦合协调度模型评价各系统间协调发展水平.得出结论:2016—2020年间三大系统综合发展水平为... 详细信息

为推进能源、经济与生态环境相互融合、协调发展,采用改进熵值法测算2016—2020年安徽省16个地级市能源、经济与生态环境系统综合发展值,并采用耦合协调度模型评价各系统间协调发展水平.得出结论:2016—2020年间三大系统综合发展水平为生态环境系统>经济系统>能源系统,三大系统耦合协调度呈“上升-下降”状态,其中经济与生态环境协调度最高.从演变格局来看,能源与经济耦合协调发展呈现“皖北>皖南”格局,其中皖南地区呈“U型”发展;经济与生态环境协调发展呈现安徽省中部城市低于其相邻城市的分布特征,并且高耦合协调度城市由皖南地区逐步向北扩散.能源与生态环境耦合协调发展呈现“皖北>皖中>皖南”格局,其中皖北地区呈现波动式上升趋势.

关键词：能源经济生态环境综合发展水平耦合协调度

3D Printing Bioink Preparation and Application in Cartilage Tissue Reconstruction in Vitro

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Journal of Shanghai Jiaotong university(Science) 2021年第3期26卷 267-271页

作者： SUN Binbin HAN Yu JIANG Wenbo DAI kerong Department of Orthopaedic Surgery Shanghai Key Laboratory of Orthopaedic ImplantsClinical and Translational Research Center for 3D Printing TechnologyShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China

Three-dimensional(3D)bioprinting technology has great potential for application in the treatment of cartilage ***,the preparation of biocompatible and stable bioinks is still a major *** this study,decellularized extracellular matrix(dECM)of soft tissue was used as the basic material to prepare the *** results showed that this novel dECM-derived bioink had good printing performance and comprised a large number of fine *** characterization revealed that the bioink was compatible with the growth of chondrocytes and that the nanofibrous structure greatly promoted cell *** and immunohistochemical analyses showed that the in vitro printed cartilage displayed the presence of characteristic cartilage ***,a new preparation method for dECM-derived bioink with potential application in generation of cartilage was developed in this study.

关键词： bioink cartilage 3D printing tissue engineering biomaterials

Enoxacin-loaded Poly(lactic-co-glycolic acid) Coating on Porous Magnesium Scaffold as a Drug Delivery System: Antibacterial Properties and Inhibition of Osteoclastic Bone Resorption

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Journal of Materials Science & Technology 2016年第9期32卷 865-873页

作者： Yang Li Xuqiang Liu Lili Tan Ling Ren Peng Wan Yongqiang Hao Xinhua Qu Ke Yang kerong Dai Shanghai Key Laboratory of Orthopaedic Implants Department of Orthopaedic Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Department of Orthopedics First Affiliated Hospital of Nanchang UniversityArtificial Joint Engineering and Technology Research Center of Jiangxi Province Institute of Metal Research Chinese Academy of Sciences

Implant-associated infection remains a difficult medical problem in orthopedic surgery. Therefore, the development of multifunctional bone implants for treating infection and regenerating lost bone tissue, which may be a result of infection, is important. In the present study, we report the fabrication of enoxacin- loaded poly （lactic-co-glycolic acid）（PLGA） coating on porous magnesium scaffold （Enox-PLGA-Mg） which combine the favorable properties of magnesium, the antibacterial property and the effect of inhibition of osteoclastic bone resorption of enoxacin. The drug loaded PLGA coating of Mg scaffold enables higher drug loading efficiency （52%-56%） than non-coating enoxacin loaded Mg scaffold （Enox-Mg）（4%-5%）. Enox- PLGA-Mg exhibits sustained drug release for more than 14 days, and this controlled release of enoxacin signifcantly inhibits bacterial adhesion and prevented biofilm formation by Staphylococcus epidermidis （ATCC35984） and Staphylococcus aureus （ATCC25923）. Biocompatibility tests with Balb/c mouse embryo fibroblasts （Balb/c 3T3 cells） indicate that PLGA-Mg has better biocompatibility than Mg. Finally, we also demonstrate that Enox-PLCA-Mg extract potently inhibited osteoclast formation in vitro. Therefore, Enox- PLCA-Mg has the potential to be used as a multifunctional controlled drug delivery system bone scaffolds to prevent and/or treat orthopedic peri-implant infections.

关键词： Porous magnesium scaffold Poly (lactic-co-glycolic acid) (PLGA)Drug delivery system Bactericidal activity Enoxacin Osteolysis

Hierarchical Co3O4 Microstructures Decorated with Ag and Cu Oxides： Study of Photocatalytic and Electrochemical Properties

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Journal of Wuhan University of Technology(Materials Science) 2017年第6期32卷 1336-1343页

作者：晏涛涛 WU Wenjian LIU Tao 吴明在 BAI Zhiman Lü Qingrong ZHU kerong School of Physics and Materials Science Anhui University Hefei 230039 China

Three-dimensional hierarchical Co3O4 microstructures decorated with Ag and Cu oxides were prepared via displacement reaction and subsequent annealing *** properties measurements revealed that the photocatalystic activities of Cu O/Co3O4 composites（Co3O4 microstructures decorated with Cu O）were enhanced while those of Ag2O/Co3O4 composites（Co3O4 microstructures decorated with Ag2O）were reduced,when compared with those of pure hierarchical Co3O4 microstructures toward the degradation of methyl *** addition,Cu O/Co3O4 composites exhibited an excellent recyclability ability of *** electrochemical properties test indicated that both of the composite oxide electrodes exhibited excellent pseudocapacitive performance with relatively high specific capacitance and good long-term cycling *** the increase of the loaded Ag2O and Cu O dosages deposited on the Co3O4 microstructures surface,the specific capacitance values of the composites were ***2O/Co3O4 composite electrodes showed higher specific capacitance values and better cycling stability than Cu O/Co3O4 composite ones.

关键词： composites chemical synthesis electrochemical measurements electrochemical

Patterns of species diversity and its determinants in a temperate deciduous broad-leaved forest

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Forest Ecosystems 2022年第5期9卷 647-656页

作者： Rui He Man Hu Hang Shi Quan Zhou Xiao Shu kerong Zhang Quanfa Zhang Haishan Dang Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical GardenChinese Academy of SciencesWuhan430074China University of Chinese Academy of Sciences Beijing100049China

Biodiversity conservation has long been a subject of extreme interest to community ecologists,with a particular focus on exploring the underlying causes of species diversity based on niche and neutral *** study aims to identify the potential determinants of species diversity in a deciduous broad-leaved forest in the transitional region from subtropical to temperate climate in *** collected woody plant data and environmental variables in a fully mapped 25-ha permanent forest plot,partitioned the beta-diversity into local contributions(LCBD)and species contributions(SCBD),and then applied multivariate linear regression analysis to test the effects of biotic and abiotic factors on alpha-diversity,LCBD,and *** used variation partitioning in combination with environmental variables and spatial distance to determine the contribution of environment-related variations versus spatial *** results showed that the indices of alpha-diversity(i.e.,species abundance and richness)were positively correlated with soil available phosphorus(P)and negatively with *** the betadiversity,environment and space together explained nearly half of the variations in community *** 60%of the variation of LCBD in the understory layer,40%in the substory layer,and 29%in the canopy layer were jointly explained by topographic,soil and biological variables,with biotic factors playing a dominant role in determining the *** abundance accounted for a large proportion of the variations in SCBD in each vertical stratum,and niche position(NP)was the ecological trait that significantly affected the variations in SCBD in the substory and canopy *** findings help to gain better understanding on how species diversity in forest ecosystem responds to environmental conditions and how it is influenced by biotic factors and ecological traits of species.

关键词： Alpha-diversity Beta-diversity Vertical strata Multivariate linear regression

3D Printing Hip Prostheses Offer Accurate Reconstruction,Stable Fixation,and Functional Recovery for Revision Total Hip Arthroplasty with Complex Acetabular Bone Defect

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Engineering 2020年第11期6卷 1285-1290页

作者： Yongqiang Hao Lei Wang Wenbo Jiang Wen Wu Songtao Ai Lu Shen Shuang Zhao kerong Dai Department of Orthopedics Shanghai Ninth People's HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200011China Medical 3D Printing Innovation Research Center Shanghai Ninth People's HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200011China Department of Radiology Shanghai Ninth People's HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200011China

Complicated and large acetabular bone defects present the main challenges and difficulty in the revision of total hip arthroplasty(THA).This study aimed to explore the advantages of three-dimensional(3D)printing technology in the reconstruction of such acetabular bone *** retrospectively analyzed the prognosis of four severe bone defects around the acetabulum in three patients who were treated using 3D printing *** of bone defect by conventional methods was difficult in these *** this endeavor,we used radiographic methods,related computer software such as Materialise's interactive medical image control system and Siemens NX software,and actual surgical experience to estimate defect volume,prosthesis stability,and installation accuracy,***,a Harris hip score was obtained to evaluate limb *** was found that bone defects could be adequately reconstructed using a 3D printing prosthesis,and its stability was *** Harris hip score indicated a very good functional recovery in all three *** conclusion,3D printing technology had a good therapeutic effect on both complex and large bone defects in the revision of *** was able to achieve good curative effects in patients with large bone defects.

关键词： 3D printing Hip revision Complex and large acetabular bone defect Accurate reconstruction