检索结果-南通市图书馆

下肢外骨骼机器人联合传统康复训练对脑卒中患者步行功能恢复的疗效观察

在线全文

学校读者我要写书评

暂无评论

昆明医科大学学报 2024年第7期45卷 92-98页

作者：李豫朱琳陈科容李依余忠祥吴成银施红伶云南省第三人民医院康复医学科云南昆明650011

目的探究下肢外骨骼机器人联合康复训练对卒中后偏瘫患者下肢功能恢复情况的疗效。方法选取云南省第三人民医院康复医学科2023年1月至2024年2月收治的36例卒中后下肢偏瘫患者为研究对象,随机分为对照组(n=18)和观察组(n=18)。对照组予... 详细信息

目的探究下肢外骨骼机器人联合康复训练对卒中后偏瘫患者下肢功能恢复情况的疗效。方法选取云南省第三人民医院康复医学科2023年1月至2024年2月收治的36例卒中后下肢偏瘫患者为研究对象,随机分为对照组(n=18)和观察组(n=18)。对照组予以传统康复治疗,观察组在传统康复治疗的基础上予以下肢外骨骼机器人训练,训练前及训练后2周评估患者下肢肌力(髂腰肌、股四头肌、腘绳肌、小腿三头肌、胫骨前肌);下肢运动能力:功能性步行能力量表(FAC)、10 m步行试验(10MWT)、步态分析(Tinetti评分);日常生活能力:ADL评估量表。用近红外功能成像对2名卒中后下肢偏瘫患者及2名健康志愿者运动状态下脑功能进行监测。结果训练2周后,观察组及对照组所有患者下肢功能均有改善。观察组髂腰肌肌力(P<0.01)、股四头肌(P<0.01)、腘绳肌(P<0.01);小腿三头肌(P<0.005),胫骨前肌(P<0.005)肌力较治疗前改善,差异具有统计学意义。观察组和对照组下肢运动能力均得到改善:功能性步行能力量表(FAC)得分提高(P<0.01)、10 m步行试验(10MWT)时间缩短(P<0.01)、步态分析(Tinetti评分)得分提高(P<0.01)。观察组和对照组日常生活能力(ADL评分)均有提高(P<0.01)。近红外脑功能成像实时监测,在外骨骼机器人步行运动状态下,观察到卒中后偏瘫患者2侧大脑半球脑网络连接强度较健康志愿者降低。结论2组治疗方案均有助于改善患者下肢功能,传统康复联合下肢外骨骼机器人联合康复训练对卒中后偏瘫患者下肢肌力及生活质量的改善更显著;增强2侧大脑半球的脑网络连接可能是促进偏瘫患者肢体功能恢复的潜在靶点。

关键词：脑卒中外骨骼机器人偏瘫近红外功能成像

Tris(trimethylsilyl) borate as an electrolyte additive for high-voltage lithium-ion batteries using LiNi_(1/3)Mn_(1/3)Co_(1/3)O_2 cathode

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2016年第4期25卷 659-666页

作者： Chunfeng Yan Ying Xu Jianrong Xia Cuiran Gong kerong chen Key Laboratory of Coal to Ethylene Glycol and Its Related Technology Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences Fujian Chuangxin Science and Develops Co. Ltd.

The influence of tris(trimethylsilyl) borate (TMSB) as an electrolyte additive on lithium ion cells have been studied using Li/LiCo1/3Ni1/3Mn1/3O2 cells at a higher voltage, 4.7 V versus Li/Li+. 1 wt% TMSB can dramatically reduce the capacity fading that occurs during cycling at room temperature (RT) and elevated temperature (60 degrees C). After 150 cycles at 1 C rate (1 C= 278 mAh/g), the capacity retention of Li/LiCo1/3Ni1/3Mn1/3O2 is up to near 72% in the electrolyte with TMSB added, while it is only about 35% in the baseline electrolyte. The electrochemical behaviors, the surface chemistry and structure of Li/LiCo1/3Ni1/3Mn1/3O2 cathode are characterized with charge/discharge test, linear sweep voltammetry (LSV), X-ray photoelectron spectroscopy (XPS), electrochemical impedance spectroscopy (EIS), thermal gravimetric analyses (TGA), scanning electron microscope (SEM) and transmission electron microscopy (TEM). These analysis results reveal that the addition of TMSB is able to protectively modify the electrode CEI film in a manner that suppresses electrolyte decomposition and degradation of electrode surface structure, even though at both a higher voltage of 4.7 V and an elevated temperature of 60 degrees C. (C) 2016 Science Press and Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. and Science Press. All rights reserved.

关键词： Tris(trimethylsilyl) borate (TMSB) Electrolyte additive High voltage RT and 60 degrees C Cyclability

Shengmaisan combined with Liuwei Dihuang Decoction alleviates chronic intermittent hypoxia-induced cognitive impairment by activating the EPO/EPOR/JAK2 signaling pathway

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2024年第5期22卷 426-440页

作者： SI Jianchao chen Xue QI kerong LI Dongli LIU Bingbing ZHENG Yuying JI Ensheng YANG Shengchang Department of Physiology Hebei University of Chinese MedicineShijiazhuang 050000China Hebei Technology Innovation Center of TCM Combined Hydrogen Medicine Shijiazhuang 050000China Department of Geriatrics First People’s Hospital of XiaoganXiaogan 432000China

Chronic intermittent hypoxia(CIH),a principal pathophysiological aspect of obstructive sleep apnea(OSA),is associated with cognitive *** evidence suggests that a combination of Shengmaisan and Liuwei Dihuang Decoctions(SMS-LD)can enhance cognitive function by nourishing yin and strengthening the *** study aimed to assess the efficacy and underlying mechanisms of SMS-LD in addressing cognitive impairments induced by *** exposed C57BL/6N mice to CIH for five weeks(20%-5%O_(2),5 min/cycle,8 h/day)and administered SMS-LD intragastrically(15.0 or 30 g·kg^(-1)·day)30 min before each CIH ***,AG490,a JJanus kinase 2(JAK2)inhibitor,was administered via intracerebroventricular *** function was evaluated using the Morris water maze,while synaptic and mitochondrial structures were examined by transmission electron *** stress levels were determined using DHE staining,and the activation of the erythropoietin(ER)/ER receptor(EPOR)/JAK2 signaling pathway was analyzed through immunohistochemistry and Western *** further investigate molecular mechanisms,HT22 cells were treated in vitro with either SMS-LD medicated serum alone or in combination with AG490 and then exposed to CIH for 48 *** results indicate that SMS-LD significantly mitigated CIH-induced cognitive impairments in ***,SMS-LD treatment enhanced dendritic spine density,ameliorated mitochondrial dysfunction,reduced oxidative stress,and activated the EPO/EPOR/JAK2 signaling ***,AG490 negated SMS-LD’s neuroprotective and cognitive improvement effects under CIH *** findings suggest that SMS-LD’s beneficial impact on cognitive impairment and synaptic and mitochondrial integrity under CIH conditions may predominantly be attributed to the activation of the EPO/EPOR/JAK2 signaling pathway.

关键词： Chronic intermittent hypoxia Cognitive impairment Shengmaisan Liuwei Dihuang Decoction Oxidative stress EPO/EPOR/JAK2 signaling pathway

卒中吞咽功能障碍患者生活状况及不同体位对吞咽功能影响的研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

昆明医科大学学报 2024年第8期45卷 182-187页

作者：刘天云陈科容周文刚计全月许坤王秀芳施红玲周盛云南省第三人民医院护理部云南昆明650011 云南省第三人民医院康复医学科云南昆明650011 云南省第三人民医院医务部云南昆明650011 云南中医药大学护理学院云南昆明650500 云南省第三人民医院病案统计科云南昆明650011

目的了解卒中吞咽障碍患者生活状况,找到合适的吞咽体位。方法 2023年1月至9月到云南省第三人民医院老年病科、康复医学科因卒中导致吞咽障碍的90例患者作为研究对象,经洼田饮水试验分级后,根据不同洼田饮水试验等级,按30°、60°、90... 详细信息

目的了解卒中吞咽障碍患者生活状况,找到合适的吞咽体位。方法 2023年1月至9月到云南省第三人民医院老年病科、康复医学科因卒中导致吞咽障碍的90例患者作为研究对象,经洼田饮水试验分级后,根据不同洼田饮水试验等级,按30°、60°、90°的检查体位将患者随机分成3组,每组30例,并给患者发放《卒中吞咽功能障碍患者生活状况调查问卷》,分析患者生活状况和不同体位对吞咽功能的影响。结果患者生活自理能力异常比例为91.11%,轻度焦虑率6.67%,轻度抑郁率16.67%,中度营养风险率91.11%,胃食管反流率36.67%;不同等级吞咽功能障碍患者的生活自理能力、胃食管反流存在差异(P <0.05);30°、60°分别与90°检查体位对比吞咽造影检查发生渗漏、误吸发生率有差异(P <0.05)。结论卒中吞咽障碍患者的健康状况不太乐观,可以使用30°、60°体位有效降低患者吞咽的渗漏、误吸,通过加强患者健康教育和管理,积极开展营养指导和心理疏导,以及药物、护理、康复训练等综合措施,进一步改善患者的生活质量。

关键词：卒中吞咽障碍生活状况

Mesozoic Volcanic-Intrusive Complexes in the Coastal Area of Southeastern Zhejiang Province: Their Features, Petrogenesis and Distribution Pattern

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 1991年第1期65卷 37-49页

作者： Du Yangsong Wang Dezi chen kerong Department of Earth Sciences, Nanjing University, Nanjing Department of Earth Sciences Nanjing University Nanjing

On the basis of previous studies and by means of field geological, remote sensing, petrographical,mineralogical, petrochemical and geochemical investigations, the authors studied the temporal-spatial distribu-tion of the regional structures, volcanic structures and products of volcanic activity in the coastal area ofsoutheastern Zhejiang. On the basis and through a systematic comparison of the products of magmatism in thearea, it is considered that there exists a compsite volcanic structural belt composed of linear and circular struc-tures and it has been demonstrated that there exist volcanic intrusive complexes--'trinity' composed of vol-canic, subvolcanic and plutonic rocks. It is suggested that the volcanic intrusive complexes in the area belong tothe typical syntexis series and that its materials were derived from a mixed source of crust and mantle.

关键词： Petrogenesis and Distribution Pattern Their Features Mesozoic Volcanic-Intrusive Complexes in the Coastal Area of Southeastern Zhejiang Province

Stimuli-responsive combination therapy of cisplatin and Nrf2 siRNA for improving antitumor treatment of osteosarcoma

在线全文

学校读者我要写书评

暂无评论

Nano Research 2020年第3期13卷 630-637页

作者： Ting-Ting Gu chengjun Li Yurui Xu Lei Zhang Xue Shan Xinyu Huang Leilei Guo kerong chen Xiaojian Wang Haixiong Ge Xinghai Ning National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesNanjing UniversityNanjing210093China Jinling Hospital Department of OrthopedicsSchool of medicineNanjing UniversityNanjing210002China Institute of advanced synthesis Nanjing Tech UniversityNanjing210093China Chemstry and Biomedicine Innovation Center(ChemBIC) Nanjing UniversityNanjing210093China

Cisplatin is a widely applied therapeutics for the treatment of ***,its clinical applications have been hindered due to low efficacy and bioavailability,and particularly frequent emergence of reactive oxygen species(ROS)-decrease induced drug *** transcription factor NF-E2-related factor 2(Nrf2)is increased in cancer patients and induces poor outcome in osteosarcoma treatment,making it a novel target to improve the efficacy of ***,a hyaluronidase-responsive multi-layer liposome(HLCN)for co-delivery of cisplatin and Nrf2 siRNA(siNrf2)is *** is composed of Vpr52-96 modified liposome covered with hyaluronic acid(HA).HLCN selectively accumulates in osteosarcoma by targeting tumor-specific CD44,and can be degraded by endosomal hyaluronidase to generate cationic liposome,which promotes the endosomal escape of Vpr52-96,cisplatin and *** can effectively decrease Nrf2 level,promote ROS generation,activate itochondrial apoptotic pathway,and consequently enhance anticancer efficacy of ***,HLCN shows high cytotoxicity to osteosarcoma cells with an IC50 value of about 1µM,which is four-fold lower than liposomal cisplatin(IC504µM),indicating that Nrf2 silence can significantly improve cisplatin sensitivity in cancer ***,HLCN can remarkably inhibit tumor growth in the xenograft osteosarcoma mice with minimal systemic adverse ***,this novel stimuli-responsive combination therapy of cisplatin and siNrf2 provides a promising strategy for the treatment of osteosarcoma.

关键词： stimuli-responsive liposome NF-E2-related factor 2(Nrf2)siRNA(siNrf2) reactive oxygen species(ROS) osteosarcoma combination therapy

Characteristics of Volcanic Rocks in the Shoshonite Province, Eastern China, and Their Metallogenesis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 1996年第3期70卷 246-259页

作者： Wang Dezi, Ren Qijiang, Qiu Jiansheng, chen kerong,Xu Zhaowen and Zeng Jiahu Department of Earth Sciences, Nanjing University, Nanjing, Jiangsu Department of Earth Sciences Nanjing University Nanjing Jiangsu

The shoshonite province in eastern China is characterized by extensive distribution (ca. 80000 km2) of Late Jurassic-Early Cretaceous (165-100 Ma) shoshonite series with subordinate high-K calc-alkali series. It was formed in a dominantly tensile stress field. In comparison with their analogues in island arcs and active continental margins in other countries, the volcanic rocks in the shoshonite province have their specific characteristics in petrology, mineralogy and geochemistry as well as related mineralization association, which are the comprehensive reflection of the special composition and structure of the mantle and crust of the province and the special Mesozoic regional tectonic setting.

关键词： shoshonite province regional tectonic setting isotopic composition mineralogical-petrological-geochemical characteristics eastern China

在线全文

学校读者我要写书评

暂无评论

特殊建筑地面工程若干技术问题与改进措施

工业建筑 2000年第8期30卷 81-81,12页

作者：陈科荣厦门市建设工程质量安全监督站厦门361003

厦门地区近几年来建成或在建的大中型工业厂房、仓库甚至大型公共建筑(展览馆等)工程,有相当数量坐落在滨海岸边、滩地、新填土区或软土层区,已投入使用的一些建筑较大面积地面(坪)出现不均匀下沉、严重开裂.如本市滨南长途汽车站投入... 详细信息

厦门地区近几年来建成或在建的大中型工业厂房、仓库甚至大型公共建筑(展览馆等)工程,有相当数量坐落在滨海岸边、滩地、新填土区或软土层区,已投入使用的一些建筑较大面积地面(坪)出现不均匀下沉、严重开裂.如本市滨南长途汽车站投入使用不到3年,即发生室内地面高低起伏,高差达300～700mm,只得返工和维修处理;某电气开关厂房地面工程尚未竣工验收即出现裂缝.

关键词：特殊建筑地面工程设计施工填土层软土层

中国城市技术转移网络演化的内生机制及空间差异研究

在线全文

学校读者我要写书评

暂无评论

地球信息科学学报 2024年第7期26卷 1672-1687页

作者：李晓瑞盛科荣王传阳山东理工大学经济学院淄博255012

技术知识成为新时期区域创新发展的关键要素,探究技术转移网络生长发育内在机制对于提高区域创新活力具有重要意义。本文基于2001—2020年中国专利权转移数据构建了4个时段的城市技术转移网络,并采用社会网络分析法和随机行动者模型,研... 详细信息

技术知识成为新时期区域创新发展的关键要素,探究技术转移网络生长发育内在机制对于提高区域创新活力具有重要意义。本文基于2001—2020年中国专利权转移数据构建了4个时段的城市技术转移网络,并采用社会网络分析法和随机行动者模型,研究了中国城市技术转移网络演化的内生机制及空间差异。研究发现:①中国城市技术转移网络的演化格局具有明显的“核心—边缘”结构特征。网络整体表现出较强的极化特征,但这种极化性有逐渐下降的态势。同时围绕着核心城市,大量涌现的三方关系在影响链接关系形成的同时,也进一步促成了网络局部等级的分化;②内生结构动力是中国城市技术转移网络生长发育的关键因素。互惠链接和网络闭合构成了城市技术转移网络演化的微观基础;偏好依附是强化城市技术转移网络链接关系的关键力量;③中国城市技术转移网络演化的内生机制具有明显的空间异质性特征。东部南方区城市技术转移网络具有较强的动态性,互惠链接、网络闭合和偏好依附成为技术转移网络生长发育的内生结构动力;东部北方区网络演化速率呈现出下降的趋势,互惠链接和偏好依附促成了网络链接格局的形成;西北内陆和青藏高原区网络演化速率趋于上升,但网络密度小,仅有互惠效应显著。

关键词：技术转移网络社会网络分析随机行动者模型网络演化内生机制空间差异流动空间