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Britanin–a beacon of hope against gastrointestinal tumors?

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World Journal of Clinical Oncology 2024年第4期15卷 523-530页

作者： Agnieszka kajdanek Damian Kołat Lin-Yong Zhao Mateusz Kciuk Zbigniew Pasieka Żaneta kałuzińska-Kołat Department of Biomedicine and Experimental Surgery Medical University of LodzLodz 90-136LodzkiePoland Department of Functional Genomics Medical University of LodzLodz 90-752LodzkiePoland Department of General Surgery&Laboratory of Gastric Cancer State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Gastric Cancer Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Molecular Biotechnology and Genetics University of LodzLodz 90-237LodzkiePoland

Britanin is a bioactive sesquiterpene lactone known for its potent anti-inflammatory and anti-oxidant *** also exhibits significant anti-tumor activity,suppressing tumor growth in vitro and in *** current body of research on Britanin includes thirty papers predominantly related to neoplasms,the majority of which are gastrointestinal tumors that have not been summarized *** drive academic debate,the present paper reviews the available research on Britanin in gastrointestinal *** also outlines novel research directions using data not directly concerned with the digestive system,but which could be adopted in future gastrointestinal *** was found to counteract liver,colorectal,pancreatic,and gastric tumors,by regulating proliferation,apoptosis,autophagy,immune response,migration,and *** confirmed in pancreatic,gastric,and liver cancer,its most commonly noted molecular effects include nuclear factor kappa B and B-cell lymphoma 2 downregulation,as well as Bcl-2-associated X protein ***,it has been found to induce the Akt kinase and Forkhead box O1 axis,activate the AMP-activated protein kinase pathway,elevate interleukin-2 and peroxisome proliferator-activated receptor-γlevels,reduce interleukin-10,as well as downregulate matrix metalloproteinase-9,Twist family bHLH transcription factor 1,and *** also inhibits Myc–HIF1αinteraction and programmed death ligand 1 transcription by interrupting the Ras/RAF/MEK/ERK pathway and mTOR/P70S6K/4EBP1 *** research should aim to unravel the link between Britanin and acetylcholinesterase,mast cells,osteolysis,and ischemia,as compelling data have been provided by studies outside the gastrointestinal *** the cytotoxicity of Britanin on noncancerous cells is significantly lower than that on tumor cells,while still being effective against the latter,further in-depth studies with the use of animal models are *** compound exhi

关键词： Britanin Sesquiterpene lactones Chemotherapeutics Gastrointestinal tumors In vitro In vivo

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基于“固本清源”分期诊治痛风

中医杂志 2024年第18期65卷 1938-1942页

作者：刘维卡玉秀天津中医药大学第一附属医院/国家中医针灸临床医学研究中心天津市300381

认为痛风以脾肾亏虚为本,湿热浊毒痰瘀为源,治疗应以健脾益肾以固本,利湿化浊、清热解毒、散瘀化痰以清源。并根据正虚邪实关系转化进行分期治疗,急性期以湿热毒蕴为急,治以清热解毒,方用自拟秦皮痛风方加减;痛风间歇期以湿浊内蕴为主,... 详细信息

认为痛风以脾肾亏虚为本,湿热浊毒痰瘀为源,治疗应以健脾益肾以固本,利湿化浊、清热解毒、散瘀化痰以清源。并根据正虚邪实关系转化进行分期治疗,急性期以湿热毒蕴为急,治以清热解毒,方用自拟秦皮痛风方加减;痛风间歇期以湿浊内蕴为主,治以利湿化浊,方用除湿茯苓汤加减;慢性期以脾虚湿热和痰瘀痹阻为要,治以健脾清热利湿和化痰散瘀,分别用清热渗湿汤加减及二陈汤合桃红四物汤加减;痛风肾病期以脾肾亏虚为本,夹痰夹瘀夹毒,治疗以健脾益肾,兼以化痰行瘀解毒,方用补脾益肾汤加减。

关键词：痛风脾肾亏虚湿热浊毒

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京津冀区域日常人口流动网络及其结构特征

城市观察 2024年第1期89卷 86-99,161,162页

作者：杨卡国际关系学院公共管理系

结合地理空间分析和社会网络分析方法,基于2018年腾讯出行大数据,对京津冀区域内城市间及对区外人口流动的热度和网络特征进行分析。结果显示:京津冀区域主要城市的对外迁移热度呈现显著的层级分布特征;城市规模和交通影响力与对京联系... 详细信息

结合地理空间分析和社会网络分析方法,基于2018年腾讯出行大数据,对京津冀区域内城市间及对区外人口流动的热度和网络特征进行分析。结果显示:京津冀区域主要城市的对外迁移热度呈现显著的层级分布特征;城市规模和交通影响力与对京联系强度的关联性较强,距离邻近性对第二层级城市对外联系的影响较大;汽车方式的对外人口流动网络受距离律影响显著,与周边城市联系热度较高;飞机、火车等对外联系方式则更符合经济律特征,区域内城市通过飞机和火车方式与全国性经济中心、交通枢纽联系紧密;区内人口流动网络形成以北京为中心的北部大凝聚子群以及东部、南部的3个小凝聚子群,群内联系紧密;区域人口迁移网络以北京—廊坊—天津为核心,以“京津石三角形”区域为密集区。

关键词：京津冀人口流动区域人口格局

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Enhanced conductivity and weakened magnetism in Pb-doped Sr2IrO4

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Chinese Physics B 2024年第1期33卷 696-701页

作者：岳智来甄伟立牛瑞焦珂珂朱文卡皮雳张昌锦 High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of Sciences Science Island Branch of Graduate School University of Science and Technology of China Collaborative Innovation Center of Advanced Microstructures Nanjing University

Group IV element Pb has been selected as the dopant to dope at the Sr site of Sr2IrO4. It is exciting to find that the single-phase crystal structure could be maintained with a high Pb doping level of up to x=0.3 in Sr2-xPbxIrO4. The mapping data obtained from energy-dispersive x-ray spectroscopy analyses give solid evidence that the Pb ions are uniformly distributed in the Sr2IrO4matrix. The incorporation of Pb leads to a moderate depression of the canted antiferromagnetic ordering state. The electrical conductivity could be greatly enhanced when the Pb doping content is higher than x=*** present results give a fresh material base to explore new physics in doped Sr2IrO4systems.

关键词： iridates doping conductivity magnetism

Research Progress of Volatile Substances Analysis and Sensory Evaluation of Soymilk

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Journal of Northeast Agricultural University(English Edition) 2024年第1期31卷 74-82页

作者： Xu Qiongyuan Li ka Huang Meina Liang Yuxin Tao Bingjie Zhang Tingting Song Nannan Ji Yazhou Zhang Huajiang Xia Ning College of Food Science Northeast Agricultural UniversityHarbin 150030China Key Laboratory of Soybean Biology Northeast Agricultural UniversityHarbin 150030China

Soybean is one of the important crops in China. Soymilk, a traditional neutral plant-based protein drink, is rich in high quality proteins. Although soybean milk is rich in nutrients, its marketing among consumers, especially those in Western countries who are used to peaceful flavor, has been limited due to the adverse flavor impact brought by its special composition. In recent years, with the increasing attention to the nutritional value of soymilk, the flavor of soymilk has become a popular research object for scholars at home and abroad. The flavor components of soymilk are mainly volatile small molecular compounds produced by enzymatic reactions catalyzed by lipoxygenase(LOX). After formation, they interact with protein macromolecules to form the overall flavor of soymilk. At present, there are many methods to control the off-odor of soymilk at home and abroad, including physical heating methods, chemical methods, biological enzymatic digestion methods, mask methods, and a variety of breeding methods. These methods effectively reduce the off-odor of soymilk, but all of them have shortcomings. Currently, the sensory characteristics of the beany odor in soymilk are evaluated mainly by traditional human sensory scoring along with the assistance of modern instrument analysis of volatile flavor substances using headspace solid phase microextraction(SPME) gas chromatography coupled with-mass spectrometry(GC-MS). This paper summarized the research results of volatile flavor substances in soymilk in recent years and the sensory evaluation methods of soymilk at home and abroad, and looked forward to the future development direction, hoping to provide some theoretical bases and reference detection methods for solving the problem of soymilk flavor in the future.

关键词： soymilk off-odor volatile substance flavor sensory evaluation

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Analysing the Potential Impact of Climate Change on the Hydrological Regime of the Upper Benue River Basin (North Cameroon)

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Journal of Water Resource and Protection 2024年第8期16卷 569-583页

作者： Elisabeth Dassou Fita Auguste Ombolo Thierry C. Fotso-Nguemo Daniel Bogno Saïdou Augustin Daïka Steven Chouto Felix Abbo Mbele Department of Meteorology and Hydrology The National Advanced School of Engineering of Maroua The University of Maroua Maroua Cameroon Higher Institute of Agriculture Wood Water and Environment The University of Ebolowa Ebolowa Cameroun Department of Hydraulics and Water Management The National Advanced School of Engineering of Maroua The University of Maroua Maroua Cameroon Climate Change Research Laboratory (CCRL) National Institute of Cartography Yaoundé Cameroon Department of Geography Faculty of Arts Letters and Social Sciences University of Maroua Maroua Cameroon

In this study, we analyse the climate variability in the Upper Benue basin and assess its potential impact on the hydrology regime under two different greenhouse gas emission scenarios. The hydrological regime of the basin is more vulnerable to climate variability, especially precipitation and temperature. Observed hydroclimatic data (1950-2015) was analysed using a statistical approach. The potential impact of future climate change on the hydrological regime is quantified using the GR2M model and two climate models: HadGEM2-ES and MIROC5 from CMIP5 under RCP 4.5 and RCP 8.5 greenhouse gas emission scenarios. The main result shows that precipitation varies significantly according to the geographical location and time in the Upper Benue basin. The trend analysis of climatic parameters shows a decrease in annual average precipitation across the study area at a rate of -0.568 mm/year which represents about 37 mm/year over the time 1950-2015 compared to the 1961-1990 reference period. An increase of 0.7°C in mean temperature and 14% of PET are also observed according to the same reference period. The two climate models predict a warming of the basin of about 2°C for both RCP 4.5 and 8.5 scenarios and an increase in precipitation between 1% and 10% between 2015 and 2100. Similarly, the average annual flow is projected to increase by about +2% to +10% in the future for both RCP 4.5 and 8.5 scenarios between 2015 and 2100. Therefore, it is primordial to develop adaptation and mitigation measures to manage efficiently the availability of water resources.

关键词： Climate Variability Hydrological Modelling Climate Models Upper Benue Basin Northern Cameroon

Effect of Cardiac Rehabilitation on Physical Capacity of Heart Failure Patients in Senegal

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World Journal of Cardiovascular Diseases 2024年第8期14卷 447-458页

作者： Ngoné Diaba Gaye Aliou Alassane Ngaidé Joseph Mingou Fatou Aw Mame Madjiguène ka Aimé Mbaye Sy Zakaria Naji Lamrani Abdoul kane Department of Cardiac Rehabilitation Ibra Mamadou Wane Medical Center Dakar Senegal Department of Cardiology Dalal Jam Hospital Guediawaye Senegal Department of Cardiology Idrissa Pouye General Hospital Dakar Senegal School of Medicine Cheikh Anta Diop University Dakar Senegal Department of Cardiology Principal Hospital of Dakar (HPD) Dakar Senegal.

Background: Heart failure is a chronic and severe condition that often results from various heart diseases. Cardiac rehabilitation (CR) is currently a crucial component in managing this condition. The aim was to assess the effects of cardiac rehabilitation on physical capacity of heart failure patients. Methods: This was a cross-sectional study conducted from February 1, 2021, to June 30, 2023. We included all patients with heart failure who underwent cardiac rehabilitation. Data analysis was performed using SPSS software version 24.0, with a significance level set at p Results: The study included 87 heart failure patients, with a male-to-female ratio of 1.8. Mean age was 57.10 years (±11.75). Coronary artery disease was the primary cause of heart failure, accounting for 75.9% of cases. Atrial fibrillation was present in 4.7% of cases. Following cardiac rehabilitation, Left Ventricular Ejection Fraction increased from 40.15% to 49.48% (p = 0.001). Resting heart rate decreased significantly from 81.4 bpm to 68.3 bpm (p = 0.000), and the number of METS increased from 4.3 to 6.57 (+56.8%;p = 0.000). The mean distance covered in the 6-minute walk test significantly increased from 337.8 meters to 522.7 meters (p = 0.000), reflecting a gain of 183.5 meters. Moreover, the increase in the number of METS was more pronounced in females (p = 0.001), non-obese individuals (p = 0.000), non-diabetics (p = 0.001), non-sedentary individuals (p = 0.000), and non-smokers (p = 0.000). The study reported a low readmissions rate of 2.2% and a mortality rate of 1.1%. Conclusion: Our study demonstrates that cardiac rehabilitation is beneficial for black African heart failure patients, resulting in significant improvements in symptoms, physical and capacity.

关键词： Cardiac Rehabilitation Chronic Heart Failure Physical Capacity Senegal

基于KMeans-EDA算法的非均衡评论情感分类研究

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山东理工大学学报（自然科学版） 2024年第4期38卷 45-52页

作者：郭卡安徽外国语学院信息与数学学院安徽合肥231200

学习者真实的评价是反映在线课程优缺点的重要指标,快速准确地获得其反馈,对于在线课程的优化极为重要。为深入挖掘学习者的在线学习行为,继而为在线教学提供有效的数据基础,爬取了中国大学MOOC平台的课程评论文本,基于Bert模型的结构,... 详细信息

学习者真实的评价是反映在线课程优缺点的重要指标,快速准确地获得其反馈,对于在线课程的优化极为重要。为深入挖掘学习者的在线学习行为,继而为在线教学提供有效的数据基础,爬取了中国大学MOOC平台的课程评论文本,基于Bert模型的结构,建立了基于自注意力文本表征的机器学习模型,能够实现对评论文本的精确情感分类,从而获得学习者内隐的情感状态。由于爬取数据中负面评论较少,故设计了KMeans-EDA自适应均衡采样训练策略,解决了训练过程中模型偏向多数类的问题,提升了模型对负面评论的识别能力。实验结果表明,该策略可以将模型对评论文本的F1-score值从0.6902提升到0.7399。

关键词：在线课程评论文本文本情感分类预训练特征表示非均衡训练

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音樂放鬆療法對改善結腸鏡檢查者疼痛的效果研究

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镜湖医学 2024年第1期24卷 75-77页

作者：黃家駒澳門鏡湖醫院護理部中国

目的用音樂療法作為放鬆的介入方式,以減輕結腸鏡檢查者術中的不適,促進結腸鏡檢查的進程及改善舒適度。方法2021年4月12日~5月18日,於澳門某醫院對104位結腸鏡檢查者進行研究,分為研究組及對照組(每組各52人)。研究組結腸鏡檢查者介入... 详细信息

目的用音樂療法作為放鬆的介入方式,以減輕結腸鏡檢查者術中的不適,促進結腸鏡檢查的進程及改善舒適度。方法2021年4月12日~5月18日,於澳門某醫院對104位結腸鏡檢查者進行研究,分為研究組及對照組(每組各52人)。研究組結腸鏡檢查者介入音樂療法,對照組予常規照護,比較兩組疼痛評分(numerical rating scale,NRS)、收縮壓、舒張壓、心率及結腸鏡檢查進鏡時間的差異。結果兩組研究參與者在NRS疼痛評分、術中及術後血壓及心率無差異;兩組結腸鏡檢查的進鏡時間均數沒有顯著差異;但進鏡時間≦10分鐘組(非困難腸鏡組)與>10分鐘組(困難腸鏡組)則存在組間差異,在非困難腸鏡組中,研究組進鏡時間為6.2±1.6分鐘,對照組進鏡時間為7.2±1.6分鐘(T=-2.075,P<0.05);困難腸鏡組則沒有顯著差異。結論音樂放鬆療法對結腸鏡檢查者的疼痛緩解、血壓及心率穩定沒有顯著作用,但仍可縮短“非困難腸鏡”的進鏡時間。

关键词：音樂療法結腸鏡檢查疼痛進鏡時間