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激光选区熔化AlSi10Mg合金的高周疲劳性能和断裂行为

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Transactions of Nonferrous Metals Society of China 2020年第10期30卷 2577-2589页

作者： S.GLODEŽ j.KLEMENC F.ZUPANiČ M.VESENj.K Faculty of Mechanical Engineering University of MariborSmetanova 172000 MariborSlovenia Faculty of Mechanical Engineering University of LjubljanaAškerčeva 61000 LjubljanaSlovenia

研究激光选区熔化(SLM)AlSi10Mg合金的疲劳性能和断裂行为。在脉动拉伸载荷(R=0,R为动态因数)下,将板状试样直接设计成疲劳试验所需形状。利用Weibull条件概率密度函数对疲劳−寿命(S−N)曲线进行建模,采用实值遗传算法(GA)和差分蚁群算法... 详细信息

研究激光选区熔化(SLM)AlSi10Mg合金的疲劳性能和断裂行为。在脉动拉伸载荷(R=0,R为动态因数)下,将板状试样直接设计成疲劳试验所需形状。利用Weibull条件概率密度函数对疲劳−寿命(S−N)曲线进行建模,采用实值遗传算法(GA)和差分蚁群算法(DASA)估计所需的Weibull参数。疲劳试样的断口形貌表明,疲劳裂纹在SLM样品的表面缺陷周围萌生,并以不稳定的方式扩展。然而,SLM大缺陷的存在主要影响裂纹萌生周期,对裂纹扩展影响不大。所得实验结果能为进一步研究增材制造先进材料和结构(如胞元超材料)的疲劳行为提供基础。特别是在二维胞元结构中,胞元结构体的截面通常为矩形,与本研究中的试样形状相对应。

关键词：激光选区熔化 AlSi10Mg合金高周疲劳断裂行为

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香港大榄郊野公园的植物组成与植被数量分类

植物学通报 2008年第1期25卷 50-58页

作者：曾绮微李海生陈桂珠叶创兴黄颂诗黄超弘中山大学环境科学与工程学院广州510275 广东教育学院生物系广州510303 中山大学生命科学学院广州510275 香港中文大学地球信息科学联合实验室中国香港

通过对香港大榄郊野公园森林群落的样地调查, 利用组平均法和除趋势对应分析两种方法, 对样方进行聚类与排序分析。把35个样地划分为11个植被类型, 森林群落可划分为台湾相思(Acacia confusa Merr.)林、红胶木(Lophostemon con- fertus ... 详细信息

通过对香港大榄郊野公园森林群落的样地调查, 利用组平均法和除趋势对应分析两种方法, 对样方进行聚类与排序分析。把35个样地划分为11个植被类型, 森林群落可划分为台湾相思(Acacia confusa Merr.)林、红胶木(Lophostemon con- fertus (R. Br.) Peter G. Wilson ex j. T. Waterh.)林、木荷(Schima superba Gardner ex Champ.)林、柠檬桉(Eucalyptus citriodora Hook.)林、湿地松+鸭脚木(Pinus elliottii Engelm.+ Schefflera octophylla (Lour.) Harms.)林、土沉香(Aquilaria sinensis (Lour.) Spreng.)林、毛叶桉(Eucalyptus torelliana F. Muell.)林; 灌木群落分为山油柑+越南叶下珠(Acronychia pedunculata (L.) Miq.+ Phyllanthus cochinchinensis (Lour.) Spreng.)矮树灌丛、豺皮樟+桃金娘(Litsea rotoundifolia (Nees) Hemsl. var. oblongifolia (Nees) C. K. Allen+Rhodomyrtus tomentosa (Alton) Hassk.)矮树灌丛、大头茶(Gordonia axillaris (Roxb. ex ker Gawl.) D. Dietr.)矮树灌丛、桃金娘+芒萁(Rhodomyrtus tomentosa (Alton) Hassk.+Dicranopteris dichotoma (Thunb.) Bernh.)灌草丛。DCA排序结果反映海拔高度与各个森林群落的分布格局和物种组成关系不大, 而环境湿度是影响森林群落物种组成的主要因素。多样性分析结果显示, 台湾相思林和土沉香林多样性指数最高, 说明台湾相思林逐渐向次生林演变, 除了红胶木林和少数郁闭度低的台湾相思林中有强阳生性树种外, 大部分人工林下植物以阳生性稍耐阴的树种为主。调查结果显示, 大榄郊野公园植物生长条件东部优于西部, 西部的物种丰富度和多样性指数较低, 主要以人工林和灌丛为主, 加上山火频繁发生, 导致长期处于先锋阶段。

关键词：聚类郊野公园香港排序植物群落

intravenous immune globulin suppresses angiogenesis in mice and humans

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Signal Transduction and Targeted Therapy 2016年第1期1卷 141-148页

作者： Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj.kerur Shengj.an Li Tetsuhiro Yasuma Benj.min j.Fowler Charles B Wright ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers ingrid E Lundberg Ondrej.Viklicky j.anette HW Leusen j.Sj.f Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco j.yakrishna Ambati Department of Ophthalmology and Visual Sciences University of KentuckyLexingtonKYUSA Department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-ker MultiMedica GroupNaplesItaly Department of Physiology University of KentuckyLexingtonKYUSA Department of Advanced Biomedical Sciences University of Naples‘Federico II’NaplesItaly CEiNGE—Biotecnologie Avanzate s.c.ar.l.NaplesItaly Department of Ophthalmology and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Rheumatology Unit Department of MedicineKarolinska InstitutetKarolinska University HospitalStockholmSweden Department of Nephrology Institute for Clinical and Experimental MedicinePrague 4Czech Republic immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands Department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands Department of Biomedical Engineering University of KentuckyLexingtonKYUSA Department of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA iRCCS MultiMedica MilanoItaly

Human intravenous immune globulin(iVig),a purified igG fraction composed of~60%igG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of *** biological actions of iVig are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their igG(igG)Fc ***,we demonstrated that multiple therapeutic human igG1 antibodies suppress angiogenesis in a target-independent manner via FcγRi,a high-affinity receptor for *** we show that iVig possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic *** was mediated by the Fc region of iVig,required FcγRi and had similar potency in transgenic mice expressing human Fcγ***,iVig therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel *** data place iVig,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical *** addition,they raise the possibility of an unintended effect of iVig on blood vessels.

关键词： doses inhibited degeneration

卵巢早衰与半乳糖-1-磷酸尿苷转移酶基因突变相关性研究

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世界核心医学期刊文摘（妇产科学分册） 2005年第12期1卷 36-36页

作者： Mlinar B. Gerak K. Karas N. et al. j. Lukac-Baj.lo 李跃萍 Department of Clinical Biochemistry Faculty of sker Pharmacy Akere va 7 SI- 1000 Ljubljana Slovenia Dr

We determined the frequency of galactose- 1- phosphate uridyl transferase gene mutations: Q188R, K285N, and the Duarte allelle in 86 patients with idiopathic premature ovarian failure (POF) and 95 controls. No associa... 详细信息

关键词：卵巢早衰基因突变尿苷突变频率

屈光性角膜切削术后病毒性角膜结膜炎导致上皮下浸润

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世界核心医学期刊文摘（眼科学分册） 2005年第3期1卷 48-49页

作者： Arcieri E.S. Arcieri R.S. Franc.a E.T. RochaF.j. 陈立军 Rua Corcovado no 155 38411-092 Uberlandia Minas Gerais Brazil

Purpose. To report three cases of adenoviral keratoconj.nctivitis in patients who have undergone photorefractive keratectomy and that j.st developed subepithe lial infiltrates. Methods. Description of patients that developed postoperative adenoviral keratoconj.nctivitis after photorefractive keratectomy without influe nce in the final visual outcome. Results. All patients presented adenoviral kera toconj.nctivitis 2-3 months after refractive surgery. They developed multiple p inpoint subepithelial infiltrates in six eyes, without haze development. The final uncorrected visual acuity was better or equal to 20/30. Conclusion. Although patients undergoing photorefractive ker atectomy might develop severe corneal scarring following ocular infections, such events may follow their natural evolution.

关键词：角膜切削术屈光性角膜屈光手术角膜切除术眼部感染腺病毒角膜结膜炎角膜瘢痕自然演变点样

Human igG1 antibodies suppress angiogenesis in a target-independent manner

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Signal Transduction and Targeted Therapy 2016年第1期1卷 158-171页

作者： Sasha Bogdanovich Younghee Kim Takeshi Mizutani Reo Yasuma Laura Tudisco Valeria Cicatiello Ana Bastos-Carvalho Nagaraj.kerur Yoshio Hirano j.dit Z Baffi Valeria Tarallo Shengj.an Li Tetsuhiro Yasuma Parthasarathy Arpitha Benj.min j.Fowler Charles B Wright ivana Apicella Adelaide Greco Arturo Brunetti Menotti Ruvo Annamaria Sandomenico Miho Nozaki Ryo ij.ma Hiroki Kaneko Yuichiro Ogura Hiroko Terasaki Balamurali K Ambati j.anette HW Leusen Wallace Y Langdon Michael R Clark Kathryn L Armour Pierre Bruhns j.Sj.f Verbeek Bradley D Gelfand Sandro De Falco j.yakrishna Ambati Department of Ophthalmology and Visual Sciences University of KentuckyLexingtonKYUSA Department of Ophthalmology and Visual Science Nagoya City University Graduate School of Medical SciencesNagoyaJapan Department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-ker MultiMedica GroupNaplesItaly Department of Advanced Biomedical Sciences University of Naples‘Federico II’NaplesItaly CEiNGE—Biotecnologie Avanzate s.c.a.r.l.NaplesItaly istituto di Biostrutture e Bioimmagini CNRNaplesItaly Department of Ophthalmology and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands School of Pathology and Laboratory Medicine University of Western AustraliaCrawleyWAAustralia Division of immunology Department of PathologyUniversity of CambridgeCambridgeUK Department of immunology Unit of Antibodies in Therapy and PathologyInstitut PasteurParisFrance institut National de la Santéet de la Recherche Médicale(iNSERM)U1222 ParisFrance Department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands Department of Biomedical Engineering University of KentuckyLexingtonKYUSA Department of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA iRCCS MultiMedica MilanoItaly Department of Physiology University of KentuckyLexingtonKYUSA.

Aberrant angiogenesis is implicated in diseases affecting nearly 10%of the world’s *** most widely used antiangiogenic drug is bevacizumab,a humanized igG1 monoclonal antibody that targets human *** bevacizumab does not recognize mouse Vegfa,it inhibits angiogenesis in *** we show bevacizumab suppressed angiogenesis in three mouse models not via Vegfa blockade but rather Fc-mediated signaling through FcγRi(CD64)and c-Cbl,impairing macrophage *** approved humanized or human igG1 antibodies without mouse targets(adalimumab,alemtuzumab,ofatumumab,omalizumab,palivizumab and tocilizumab),mouse igG2a,and overexpression of human igG1-Fc or mouse igG2a-Fc,also inhibited angiogenesis in wild-type and FcγR humanized *** anti-angiogenic effect was abolished by Fcgr1 ablation or knockdown,Fc cleavage,igG-Fc inhibition,disruption of Fc-FcγR interaction,or elimination of FcRγ-initated ***,bevacizumab’s Fc region potentiated its anti-angiogenic activity in humanized VEGFA ***,mice deficient in FcγRi exhibited increased developmental and pathological *** findings reveal an unexpected anti-angiogenic function for FcγRi and a potentially concerning off-target effect of higG1 therapies.

关键词： CD64 angiogenesis antibodies

钠-葡萄糖共转运蛋白-2抑制剂或胰高血糖素样肽-1受体激动剂治疗成人2型糖尿病:临床实践指南

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英国医学杂志中文版 2021年第9期24卷 523-531页

作者： Sheyu Li Per Olav Vandvik Lyubov Lytvyn Gordon H Guyatt Suetonia C Palmer Rene Rodriguez-Gutierrez Farid Foroutan Thomas Agoritsas Reed A C Siemieniuk Michael Walsh Lawrie Frere David j.Tunnicliffe Evi V Nagler Veena Manj. Bj.rn Olav Asvold Vivekanand j.a Mieke Vermandere Karim Gariani Qian Zhao Yan Ren Emma j.ne Cartwright Patrick Gee Alan Wickes Linda Fems Robin Wright Ling Li Qiukui Hao Reem A Mustafa 无郭鹤鸣(译) Chengdu China Chinese Evidencebased Medicine Center Cochrane China Center and MAGIC China CenterWest China HospitalSichuan UniversityChengduChina University of Oslo OsloNorway MAGiC Evidence Ecosystem Foundation Department of Health Research Methods Evidence and ImpactMcMaster UniversityHamiltonONCanada Department of Medicine McMaster UniversityHamiltonONCanada Department of Medicine University of OtagoChristchurchNew Zealand Plataforma iNVEST Medicina UANL-ker Unit(ker Unit Mexico) Subdireccion de InvestigacionUniversidad Autonoma de Nuevo LeonMonterrey64460Mexico Knowledge and Evaluation Research Endocrinology Mayo ClinicRochesterMN55905USA Endocrinology Division Department of Internal MedicineUniversity Hospital"Dr.Jose E.Gonzalez"Universidad Autonoma de Nuevo LeonMonterrey64460Mexico Ted Rogers Center for Heart Research Canada Service of Endocrinology DiabetesNutrition and Patient Therapeutic EducationGeneva University HospitalsGenevaSwitzerland Newbridge Surgery BathUK Sydney School of Public Health The University of SydneySydneyAustralia Centre for Kidney Research The Children's Hospital at WestmeadSydneyAustralia Renal Division Ghent University HospitalBelgium University of California Davis USA Department of Endocrinology Clinic of MedicineSt Olavs HospitalTrondheim University HospitalTrondheimNorway K.G.j.bsen Center for Genetic Epidemiology Department of Public Health and NursingNTNUNorwegian University of Science and TechnologyTrondheimNorway The George institute for Global Health UNSWIndia School of Public Health Imperial CollegeLondonUK Prasanna School of Public Health Manipal Academy of Higher EducationManipalIndia Department of Public Health and Primary Care KU LeuvenLeuvenBelgium international Medical Center/Ward of General Practice West China HospitalSichuan UniversityChengduChina London UK Founder&CEHD iAdvorateInc.VirginiaPatient partner Patient partner The Center of Gerontology and Geriatrics/National Clinical Research Center for Geriatr

临床问题对于存在不同心血管风险及肾脏结局的2型糖尿病患者,在原有生活方式干预和/或其他降糖药物的基础上加用钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂的获益及风险是什么?现行做法几十年来,2型糖尿病... 详细信息

临床问题对于存在不同心血管风险及肾脏结局的2型糖尿病患者,在原有生活方式干预和/或其他降糖药物的基础上加用钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂的获益及风险是什么?现行做法几十年来,2型糖尿病的治疗决策都以控制血糖为主导。SGLT-2抑制剂和GLP-1受体激动剂在传统观念中常被用于二甲双胍治疗后血糖仍控制不佳的患者。目前这一现状已经发生了改变,这得益于多项临床研究结果。研究显示SGLT-2抑制剂和GLP-1受体激动剂拥有独立于药物降糖作用之外的对于动脉粥样硬化性心血管病(CVD)和慢性肾脏病(CKD)的获益。建议本指南阐述了针对不同风险分层的成人2型糖尿病患者使用SGLT-2抑制剂或GLP-1受体激动剂的建议。•伴有3种或更少的心血管风险因素且不存在CVD或CKD:不建议启动SGLT-2抑制剂或GLP-1受体激动剂治疗。(推荐等级:弱)•伴有3种以上心血管风险因素且不存在CVD或CKD:建议启动SGLT-2抑制剂治疗,不建议启动GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD或CKD:建议启动SGLT-2抑制剂治疗和GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD和CKD:建议启动SGLT-2抑制剂治疗(推荐等级:强)和GLP-1受体激动剂治疗。(推荐等级:弱)•对于那些想要进一步降低CVD和CKD结局风险的患者:推荐优先启用SGLT-2抑制剂治疗而非GLP-1受体激动剂治疗。(推荐等级:弱)这项指南是如何制订的一个由患者、临床医生和方法学家共同组成的国际小组提出了这些推荐意见。这些推荐意见基于可信度较高的指南的标准,并使用GRADE分级方法进行评估。该小组采用了息者个体化的观点。证据一项关于获益与风险的系统综述和网络meta分析(764项随机对照研究,包括421346例参与者)发现SGLT-2抑制剂和GLP-1受体激动剂可以降低总体死亡率、心肌梗死发生率、终末期肾病或肾衰竭的发生率(中等至高等质量的证据)。在不同的亚组中这些药物对卒中、因心力衰竭所致住院和其他主要不良事件有不同的影响。药物绝对获益的程度因患者个体风险的不同有很大的差异。(例如,对于接受了超过5年药物治疗的1000例患者,在最低风险人群中死亡人数减少了5人,在最高风险人群中死亡人数减少了48人)。一项关于预后的综述确认了14种风险预测模型,其中一种(RECODe)在证据总结中报告了大部分基线风险评估数据,小组利用该模型以支持风险分层的建议。考虑到患者的价值观及个体差异,指南推荐的支撑证据包括一项对已发表论文的系统综述、一项患者焦点小组研究、一项临床问题总结,以及一项指南调查。指南解读我们依据不同的CVD和CKD风险水平,综合考虑获益、风险和其他因素的平衡,以及每一个风险组别的实际问题,来对推荐意见进行分层。本指南强烈建议CVD和CKD患者使用SGLT-2抑制剂治疗,这说明专家组认为其具有显著的获益。而对于其他成人2型糖尿病患者,推荐等级较弱,这说明专家组想要在获益、风险及治疗花费上取得一个更好的平衡。临床医生通过该指南可以使用可靠的风险计算模型,如RECODe,来明确其患者的个体心血管和肾脏疾病风险。医患交互式总结临床证据和制订决策有助于患者知晓治疗选择,包括进行共同决策。2型糖尿病人群(全球患病率不断增长1-2)正面临着不断增加的心血管疾病、肾脏病和其他并发症的风险3。数十年来,2型糖尿病的管理始终以控制血糖及糖化血红蛋白(HbA1c)为治疗目标4-5,但是,最近的高质量随机对照研究已经对这种以血糖为中心的治疗模式发起了挑战。研究结果显示,强化血糖控制未必会降低大血管不良事件,它还可能带来不利影响监管机构现在要求新型糖尿病药物必须证明其具有心血管和肾脏获益才能获得批准。对两类新药--钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂(见框图1)的临床试验结果显示,在现有治疗方案(常规治疗)之上加用这些药物,对死亡、心肌梗死、卒中、心力衰竭和肾脏的结局(如进展为终末期肾病)都有获益8-12。

关键词：胰高血糖素样肽1 终末期肾病临床研究结果心血管风险 meta分析临床试验结果临床证据控制血糖

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2例青少年的阴茎皮下环形肉芽肿

世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 44-44页

作者： Sidwell R.U. Green j.S.A. Agnew K. 郭战宏 Department of Dermato logy Chelsea and Westminster Hospital SW10 9NH LondonUnited Kingdom

Granuloma annulare (GA) is a benign inflammatory disorder of unknown etiology characterized histologically by dermal palisading granulomas with central degene ration of collagen (necrobiosis). There is a rare subcutaneous clinical variant, this occurring more frequently in children than in adults and very rarely invol ves the penis. We describe 2 cases of penile subcutaneous GA developing in adole scent boys who to our knowledge has not previously been described in literature. Both were initially treated with surgical excision. Circumcision was performed on one of the boys, with subsequent improvement with the resolution of most of t he nodules. Granuloma annulare of the penis is very rare, with only 7 cases repo rted to date [Narouz N, Allan PS, Wade AH. Penile granuloma annulare. Sex Transm infect 1999;75(3):186-7; Trap R,Wiebe B. Granuloma annulare localised to the s haft of the penis. Scand j.Urol Nephrol 1993;27(4):549-51; Laird SM. Granuloma annulare of the penis. Genitourin Med 1992;68(4):277; Hillman Rj. Waldron S, Wal ker MM, et al. Granuloma annulare of the penis. Genitourin Med 1992;68(1):47-9; Kossard S, Collins AG,Wegman A, et al. Necrobiotic granulomas localised to the penis: a possible variant of subcutaneous granuloma annulare. j.Cutan Pathol 199 0;17(2):101-4] and no previous reports in children or adolescents to our knowle dge. All except one of the cases reported so far were of the subcutaneous (nodul ar) form of GA.

关键词：环形肉芽肿包皮环切术手术切除治疗炎症性病变渐进性坏死蛋白变性组织学特点