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Understanding PDF uncertainty in W boson mass measurements

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Chinese Physics C 2022年第12期46卷 179-193页

作者： Jun Gao Dianyu Liu keping xie NPAC Shanghai Key Laboratory for Particle Physics and CosmologySchool of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Particle Astrophysics and Cosmology(MOE) Shanghai 200240China Pittsburgh Particle Physics Astrophysicsand Cosmology CenterDepartment of Physics and AstronomyUniversity of PittsburghPittsburghPA 15260USA

We study the dependence of the transverse mass distribution of charged leptons and the missing energy on parton distributions(PDFs)adapted to W boson mass measurements at the CDF and ATLAS *** compare the shape variations of the distribution induced by different PDFs and find that the spread of predictions from different PDF sets can be significantly larger than the PDF uncertainty predicted by a specific PDF *** suggest analyzing the experimental data using up-to-date PDFs to gain a better understanding of the PDF uncertainties in W boson mass *** also perform a series of Lagrange multiplier scans to identify the constraints on the transverse mass distribution imposed by individual data sets in the CT18 global *** the case of the CDF measurement,the distribution is mostly sensitive to d-quark PDFs in the intermediate x region,which are largely constrained by DIS and Drell-Yan data on deuteron targets and Tevatron lepton charge asymmetry data.

关键词： W-boson mass PDF uncertainty CT18

Collective rotations of fission isomers in actinide nuclei

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Science China(Physics,Mechanics & Astronomy) 2014年第2期57卷 189-193页

作者： xie keping KE WeiYao LIANG WuYang FU XiMing JIAO ChangFeng PEI JunChen XU FuRong School of Physics Peking University State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking University National Institute for Radiological Protection Chinese Center for Disease Control and Prevention

Using the total-Routhian-surface （TRS） method, the rotational behaviors of fission isomers in the second well of actinide nuclei 234-242U, 236-244pu and 238-246Cm were investigated. The pairing-deformation-frequency self-consistent TRS calculations repro- duced reasonably the experimental moments of inertia extracted from spectroscopic data. It is calculated that, in these largely elongated （β2 ≈0.65 and β4≈ 0.03） fission isomers, the ν1/2-[981] neutron and π1/2＋[651] proton align simultaneously at rotational frequency hω≈0.4 - 0.6 MeV （corresponding to spin I≈80h）, which leads to clear upbending in moments of inertia （MoI＇s）. Our calculations have indicated that the hexadecapole deformation f14 influenced significantly the frequency of the rotational alignment of the proton 1/2＋[651] orbit.

关键词： fission isomers total Routhian surface moments of inertia upbending alignment

Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression

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Genes & Diseases 2024年第2期11卷 921-934页

作者： Hui-Qing Zhang Fanyang Kong Xiangyu Kong Tingting Jiang Muyuan Ma Shaojiang Zheng Junli Guo keping xie The Third Department of Medical Oncology Jiangxi Cancer HospitalNanchangJiangxi 330006China Departments of Gastroenterology Changhai HospitalSecond Military Medical UniversityShanghai 200433China Center for Pancreatic Cancer Research The South China University of Technology School of MedicineGuangzhouGuangdong 510006China Hainan Clinical Medical Research Center of the First Affiliated Hospital Hainan Women and Children's Medical CenterHainan Medical UniversityHaikouHainan 570102China Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province Key Laboratory of Emergency and Trauma of Ministry of EducationHainan Medical UniversityHaikouHainan 571199China

Ubiquitously transcribed tetratricopeptide repeat on chromosome X(UTX),also known as lysine(K)-specific demethylase 6A(KDM6A),functions as a tumor suppressor gene or oncogene depending on the tumor type and ***,its tumor-suppressive mechanisms remain largely ***,we investigated the clinical significance and biological effects of UTX expression in pancreatic ductal adenocarcinoma(PDA)and determined the potential mechanisms of its *** expression and its association with clinicopathologic characteristics of PDA patients were analyzed using *** mRNA and protein expression and their regulation in PDA cell lines were measured using quantitative polymerase chain reaction and Western blot *** biological functions of UTX in PDA cell growth,migration,and invasion were determined using gain-and loss-of-function assays with both in vitro and in vivo animal *** expression was reduced in human PDA cell lines and *** UTX expression was associated with poor differentiation and prognosis in *** UTX expression inhibited PDA proliferation,migration,and invasion in vitro and PDA growth and metastasis in vivo,whereas knockdown of UTX expression did the ***,UTX expression was trans-activated by GATA6 ***6-mediated PDA progression could be blocked,at least partially,by silencing UTX *** conclusion,loss of GATA6-mediated UTX expression was evident in human PDA and restored UTX expression suppressed PDA growth and ***,UTX is a tumor suppressor in PDA and may serve as a prognostic biomarker and therapeutic target.

关键词： Growth Invasion Metastasis Pancreatic cancer UTX

Making incurable pancreatic cancer curable

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Malignancy Spectrum 2024年第1期1卷 46-52页

作者： Jianhong An Dacheng xie keping xie Center for Pancreatic Cancer Research The South China University of Technology School of MedicineGuangzhouGuangdongChina Department of Oncology Shanghai Pulmonary HospitalTongji UniversityShanghaiChina

Pancreatic cancer is one of the deadliest malignancies,with limited effectiveness of standard therapies,resulting in little improvement in the 5-year survival rate over the past few ***,advanced radiotherapy techniques and emerging treatment modalities,such as immunotherapy and targeted therapy,are showing tremendous potential as effective treatment options for pancreatic cancer patients who were previously considered *** review summarizes the current advances and challenges in pancreatic cancer treatment strategies and proposes further optimization directions,aiming to provide insights into the cure of incurable pancreatic cancer.

关键词： pancreatic cancer early screening radiotherapy immunotherapy targeted therapy tumor microenvironment

Down-regulation of microRNA-23a promotes pancreatic ductal adenocarcinoma initiation and progression by up-regulation of FOXM1 expression

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Genes & Diseases 2024年第5期11卷 456-469页

作者： Lixin Liang Tian Cai Xiaojia Li Jianhong An Sen Yu Yang Zhang Fengjie Guo Fang Wei Jie He keping xie Tingting Jiang Center for Pancreatic Cancer Research South China University of Technology School of MedicineGuangzhouGuangdong 510006China Department of Laboratory Medicine The Sixth Affiliated Hospital and Nanhai People’s HospitalSouth China University of Technology School of MedicineFoshanGuangdong 528200China The Second Affiliated Hospital and Guangzhou First People’s Hospital South China University of Technology School of MedicineGuangzhouGuangdong 510006China

Transcriptional factor Forkhead box M1(FOXM1)plays an important role in pancreatic ductal adenocarcinoma(PDAC)development and *** molecular mechanisms underlying its dysregulation remain *** identified and functionally validated the microRNAs(miRNAs)that critically regulate FOXM1 expression in *** expression levels of miRNA-23a(miR-23a-3p and-5p)were altered in PDAC cell lines and their effects on FOXM1 signaling and cell proliferation and migration and tumorigenesis were examined in vitro and in vivo using mouse PDAC *** with non-tumor pancreatic tissues,PDAC tissues and cell lines exhibited significantly reduced levels of miR-23a *** miR-23a expression and concomitant increase in FOXM1 expression were also observed in acinar-toductal metaplasia and pancreatic intraepithelial neoplasia,the major premalignant lesions of *** expression of miR-23a reduced the expression of FOXM1 and suppressed cell proliferation and migration in PDAC cells,whereas the inhibitors of miR-23a did the *** or reduced levels of miR-23a increased the levels of FOXM1 expression,while increased expression of FOXM1 down-regulated miR-23a expression,suggesting that miR-23a and FOXM1 were mutual negative regulators of their expression in PDAC ***,the miR-23a/FOXM1 signaling axis is important in PDAC initiation and progression and could serve as an interventional or therapeutic target for patients with early or late stages of PDAC.

关键词： FOXM1 Gene expression Gene regulation MicroRNA Pancreatic cancer Targeted therapy

Molecular Biomarkers of Pancreatic Intraepithelial Neoplasia and Their Implications in Early Diagnosis of and Therapeutic Intervention for and Treatment of Pancreatic Cancer

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Molecular Biomarkers of Pancreatic Intraepithelial Neoplasia...

第十届全国免疫学学术大会

作者： Junli GUO keping xie Shaojiang Zheng Department of Pathology Affiliated Hospital of Hainan Medical College Hainan Cancer HospitalHainan Provincial Key Laboratory of Carcinogenesis and Intervention Department of Gastroenterology Hepatology and Nutrition The University of Texas MD Anderson Cancer Center

Lack of early detection and effective interventions is a major reason for the poor prognosis and dismal survival rates for pancreatic *** intraepithelial neoplasia(Pan IN)is the most common precursor of invasive pancreatic ductal adenocarcinoma(PDAC).Each stage in the progression from Pan IN to PDAC is well characterized by multiple significant genetic alterations affecting signaling *** the biological behavior and molecular alterations in the progression from Pan IN to PDAC is crucial to the identification of noninvasive biomarkers for early detection and diagnosis and the development of preventive and therapeutic strategies for control of pancreatic cancer *** review focuses on molecular biomarkers of Pan IN and their important roles in early detection and treatment of pancreatic cancer.

关键词： Pan INs Biomarker Early Diagnosis Therapeutic Intervention

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肿瘤药物靶向治疗的最新进展

肿瘤 2006年第4期26卷 389-392页

作者：王理伟周翡李琦 keping xie 同济大学附属东方医院肿瘤中心上海200120 Department of Gastrointestinal Medical Oncology and Cell Biology University of Texas M. D. Anderson Cancer Center Houston Texas 77030 USA

肿瘤药物的靶向治疗是以已知肿瘤发生中涉及的异常分子和基因为靶点而设计和研制的药物。实践证明,肿瘤靶向药物治疗为乳腺癌、肠癌、肺癌等多种恶性肿瘤的治疗提供了新的有效方法。肿瘤靶向药物分为肿瘤细胞单克隆抗体和抑制肿瘤细胞... 详细信息

肿瘤药物的靶向治疗是以已知肿瘤发生中涉及的异常分子和基因为靶点而设计和研制的药物。实践证明,肿瘤靶向药物治疗为乳腺癌、肠癌、肺癌等多种恶性肿瘤的治疗提供了新的有效方法。肿瘤靶向药物分为肿瘤细胞单克隆抗体和抑制肿瘤细胞增殖的靶向药物,其中前者又包括抗肿瘤单抗药物和抗肿瘤单抗偶联物。本文对肿瘤抗体介导的靶向治疗药物的应用现状作一阐述。

关键词：抗肿瘤药靶向治疗分子生物学

转录因子Sp1在胃癌组织中的表达及其与胃癌预后的关系

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中华肿瘤杂志 2007年第2期29卷 107-111页

作者：王理伟李琦华召来周翡 keping xie Daoyan Wei James Yao Jaffer Ajani 南京医科大学卫生部抗体技术重点实验室 210029 同济大学附属东方医院肿瘤医学部上海200120 同济大学附属东方医院肿瘤医学部江苏省扬中市肿瘤防治研究所美国MD Anderson癌症中心

目的探讨转录因子Sp1在胃癌组织中的表达情况及与胃癌患者预后的关系。方法采用免疫组化方法，检测Sp1在86例胃癌组织、53例淋巴结转移灶和57例正常胃黏膜组织中的表达情况，利用凝胶电泳迁移率分析（EMSA）检测正常胃黏膜组织和胃癌组... 详细信息

目的探讨转录因子Sp1在胃癌组织中的表达情况及与胃癌患者预后的关系。方法采用免疫组化方法，检测Sp1在86例胃癌组织、53例淋巴结转移灶和57例正常胃黏膜组织中的表达情况，利用凝胶电泳迁移率分析（EMSA）检测正常胃黏膜组织和胃癌组织中的Sp1活性。应用Cox比例风险回归模型进行多因素分析，确立影响预后的独立因素。结果Sp1蛋白主要在黏液颈细胞胞核内表达，在胃小凹和腺上皮细胞中未见表达。同时，SP1在胃癌组织中高表达，而在胃癌邻近组织、胃癌间质细胞和腺体细胞中呈弱表达或无表达。在胃癌组织中，Sp1阴性表达、弱表达和高表达患者的中位生存时间分别为43个月、47个月和8个月，生存率差异有统计学意义（P＜0．01）。多因素分析显示，Sp1表达、肿瘤分期是影响患者预后的独立因素。结论Sp1在胃癌组织中高表达，可作为预测胃癌患者预后的重要指标。

关键词：转录因子Sp1 胃肿瘤预后组织

Molecular Biomarkers of Pancreatic Intraepithelial Neoplasias and Implications in Early Diagnosis and Therapeutic Intervention

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Molecular Biomarkers of Pancreatic Intraepithelial Neoplasia...