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Effects of sclerostin antibody on bone healing

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World Journal of Orthopedics 2021年第9期12卷 651-659页

作者： Atsushi Mihara Kiminori Yukata Toshihiro Seki Ryuta Iwanaga Norihiro Nishida kenzo Fujii Yuji Nagao Takashi Sakai Department of Orthopedic Surgery Yamaguchi University Graduate School of MedicineUbe 755-8505Japan

Promoting bone healing after a fracture has been a frequent subject of ***,sclerostin antibody(Scl-Ab)has been introduced as a new anabolic agent for the treatment of ***-Ab activates the canonical Wnt(cWnt)-β-catenin pathway,leading to an increase in bone formation and decrease in bone *** of its rich osteogenic effects,preclinically,Scl-Ab has shown positive effects on bone healing in rodent models;researchers have reported an increase in bone mass,mechanical strength,histological bone formation,total mineralized callus volume,bone mineral density,neovascularization,proliferating cell nuclear antigen score,and bone morphogenic protein expression at the fracture site after Scl-Ab *** addition,in a rat critical-size femoral-defect model,the Scl-Ab-treated group demonstrated a higher bone healing *** the other hand,two clinical reports have researched Scl-Ab in bone healing and failed to show positive effects in the femur and *** review discusses why Scl-Ab appears to be effective in animal models of fracture healing and not in clinical cases.

关键词： Canonical Wnt-β-catenin pathway Fracture healing Osteoporosis Romosozumab Sclerostin antibody

A new sodium iron phosphate as a stable high-rate cathode material for sodium ion batteries

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Nano Research 2018年第12期11卷 6197-6205页

作者： Xiaobo Zhu Takashi Mochiku hiroki Fujii Kaibin Tang Yuxiang Hu Zhenguo Huang Bin Luo Kiyoshi Ozawa Lianzhou Wang Nanomatefials Centre School of Chemical Engineering and Australian Institute for Bioengineering and NanotechnologyThe University of QueenslandQLD 4072Australia National lnstitute for Matefials Science 1-2-1SengenTsukuba-cityIbaraki 305-0047Japan Hefei National Laboratory for Physical Science at Microscale and Department of Chemistry University of Science and Technology of ChinaHefei 230026China School of Civil and Environmental Engineering University of Technology SydneyNSW 2007Australia

Low-cost room-temperature sodium-ion batteries (SIBs) are expected to promote the development of stationary energy storage applications. However, due to the large size of Na+, most Na+ host structures resembling their Li+ counterparts show sluggish ion mobility and destructive volume changes during Na ion (de)intercalation, resulting in unsatisfactory rate and cycling performances. Herein, we report a new type of sodium iron phosphate (Na0.71Fe1.07PO4), which exhibits an extremely small volume change (~ 1%) during desodiation. When applied as a cathode material for SIBs, this new phosphate delivers a capacity of 78 mA·h·g−1 even at a high rate of 50 C and maintains its capacity over 5,000 cycles at 20 C. In situ synchrotron characterization disclosed a highly reversible solid-solution mechanism during charging/discharging. The findings are believed to contribute to the development of high-performance batteries based on Earth-abundant elements.

关键词： sodium iron phosphate low volume change cathode material long cycle rate performance sodium ion batteries

Optimum Dark Adaptation Period for Evaluating the Maximum Quantum Efficiency of Photosystem II in Ozone-Exposed Rice Leaves

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American Journal of Plant Sciences 2013年第9期4卷 1750-1757页

作者： hiroki hiroki Kobayakawa Katsu Imai School of Agriculture Meiji University Kawasaki Japan.

Because the transient O3 injury of leaves is lost with time, the evaluation of O3 effect on the maximum quantum efficiency of PSII (Fv/Fm) is difficult. Thus, the authors examined Fv/Fm in rice leaves exposed to different O3 concentrations (0, 0.1, and 0.3 cm3·m-3, expressed as O0, O0.1, and O0.3) under different dark adaptation periods (0, 1, 5, 10, 20, and 30 min, expressed as D0, D1, D5, D10, D20, and D30) to ascertain its optimum time span. Fv/Fm was inhibited by O3;however in the O0 and O0.1 plants, it recovered during dark adaptation. In the O0.3 plants, Fv/Fm decreased gradually with time. F0 was found to be increased by O3, and it increased further in the O0.3 plants during dark adaptation. Under a high light intensity, Fm was decreased by O3, and the O3-induced damage to Fv/Fm was therefore more pronounced. However, the sensitivity of

关键词： Dark-Adapted State Oryza sativa Ozone Stress Photosystem II Quantum Efficiency

Influence of cognitive impairment on cardiac mortality after percutaneous coronary intervention in very elderly patients: a retrospective observational study

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Journal of Geriatric Cardiology 2019年第10期16卷 733-740页

作者： Tomoko Tomioka Ryokichi Takahashi Yosuke Ikumi Shuhei Tanaka Yoshitaka Ito hiroki Shioiri Jiro Koyama Kanichi Inoue Department of Cardiology South-Miyagi Medical Center

Background Cognitive impairment (CI) increases cardiac mortality among very elderly patients. Percutaneous coronary intervention (PCI) for ischemic heart disease (IHD) patients is considered a favorable strategy for decreasing cardiac mortality. Here, we investigated the influence of CI on cardiac mortality after PCI in very elderly patients. Methods We performed a retrospective observational analysis of patients who received PCI between 2012 and 2014 at the South Miyagi Medical Center, Japan. IHD patients over 80 years old who underwent the Mini-Mental State Examination for CI screening during hospitalization and/or who had been diagnosed with CI were included. Participants were divided into CI and non-CI groups, and cardiac mortality and incidence of adverse cardiac events in a 3-year follow-up period were compared between groups. Statistical analyses were performed using the t-test,χ^2 test, and multivariable Cox regression analysis, with major comorbid illness and conventional cardiac risk factors as confounders. Results Of 565 patients, 95 were included (41 CI, 54 non-CI). Cardiac mortality during the follow-up period was significantly higher in the CI group (36%) compared with the non-CI group (13%)(OR = 4.3, 95% CI: 1.56–11.82, P < 0.05). CI was an independent cardiac prognostic factor after PCI and, for CI patients, living only with a CI partner was an independent predictor of cardiac death within three years. Conclusions CI significantly affected cardiac prognosis after PCI in very elderly patients, particularly those living with a CI partner. To improve patients’ prognoses, social background should be considered alongside conventional medical measures.

关键词： Cognitive impairments Family background Mortality Octogenarians Percutaneous coronary intervention

Real-time energy optimization of HEVs under-connected environment: a benchmark problem and receding horizon-based solution

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Control Theory and Technology 2022年第2期20卷 145-160页

作者： Fuguo Xu hiroki Tsunogawa Junichi Kako Xiaosong Hu Shengbo Eben Li Tielong Shen Lars Eriksson Carlos Guardiola Department of Engineering and Applied Sciences Sophia UniversityTokyo 102-8554Japan Higashi-Fuji Research Center Toyota Motor Corporation.Shizuoka 410-1107Japan The State Key Laboratory of Mechanical Transmissions Chongqing UniversityChongqing 400044China The State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China Vehicular Systems Department Electrical EngineeringLinkoping UniversitySE 58183Linkoping.Sweden Departamento de Maquinas y Motores Termicos Universitat Politecnica de Valencia.Camino de Vera s/n46022 ValenciaSpain

In this paper,we propose a benchmark problem for the challengers aiming to energy efficiency control of hybrid electric vehicles(HEVs)on a road with ***,it is assumed that the targeted HEVs are in the connected environment with the obtainment of real-time information of vehicle-to-everything(V2X),including geographic information,vehicle-to-infrastructure(V2I)information and vehicle-to-vehicle(V2V)*** provided simulator consists of an industrial-level HEV model and a traffic scenario database obtained through a commercial traffic simulator,where the running route is generated based on real-world data with slope and intersection *** benchmark problem to be solved is the HEVs powertrain control using traffic information to fulfill fuel economy improvement while satisfying the constraints of driving safety and travel *** show the HEV powertrain characteristics,a case study is given with the speed planning and energy management strategy.

关键词： Powertrain control Connected and automated vehicles Hybrid electric vehicles Vehicle-to-everything

Effects of substrate and transfer on CVD-grown graphene over sapphire-induced Cu films

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Science China Chemistry 2014年第6期57卷 895-901页

作者： HU BaoShan WEI ZiDong AGO hiroki JIN Yan XIA MeiRong LUO ZhengTang PAN QingJiang LIU YunLing School of Chemistry and Chemical Engineering Chongqing University Institute for Materials Chemistry and Engineering Kyushu University Department of Chemical and Biomolecular Engineering Hongkong University of Science and Technology Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationHeilongjiang University State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin University

We differentiated the effects of Cu films deposited on single crystalline a-,r-,and c-plane sapphire substrates upon graphene films synthesized with atmospheric pressure chemical vapor deposition(CVD).The data illustrate that the realization of high-crystalline Cu film is dependent not only on the crystallinity of underlying substrate,but also on the symmetric match of crystallographic geometry between metal film and *** also systematically investigated the effects of PMMA removal on the Raman ID/IG and IG/I2D values of transferred *** results reveal that different PMMA removal methods do not alter the ID/IG values;instead,the residue of PMMA increases the IG/I2D values and the thermal decomposition of PMMA leads to higher IG/I2D values than the removal of PMMA with *** effects of PMMA removal on variations of the Raman spectra are also discussed.

关键词： graphene CVD growth sapphire substrate crystallographic match transfer Raman spectrum

VISUALIZATION OF TURBULENT REACTIVE JET BY USING DIRECT NUMERICAL SIMULATION

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International Journal of Modeling, Simulation, and Scientific Computing 2013年第S1期4卷 70-85页

作者： TOMOAKI WATANABE YASUHIKO SAKAI KOUJI NAGATA OSAMU TERASHIMA hiroki SUZUKI TOSHIYUKI HAYASE YASUMASA ITO Department of Mechanical Science and Engineering Nagoya University Nagoya Aichi464-8603Japan Department of Engineering Physics Nagoya Institute of Technology Nagoya Aichi466-8555Japan Institute of Fluid Science Tohoku University SendaiMiyagi980-8577Japan

Direct numerical simulation(DNS)of turbulent planar jet with a second-order chemical reaction(A+B→R)is performed to investigate the processes of mixing and chemical reactions in spatially developing turbulent free shear *** A is premixed into the jet flow,and reactant B is premixed into the ambient *** is performed at three different Damk¨ohler numbers(Da=0.1,1,and 10).Damk¨ohler number is a ratio of a time scale of a flow to that of chemical reactions,and in this study,the large Da means a fast chemical reaction,and the small Da means a slow chemical *** visualization of velocity field shows that the jet flow is developed by entraining the ambient *** visualization of concentration of reactant A shows that concentration of reactant A for Da=1 and 10 becomes very small in the downstream region because the chemical reaction consumes the reactants and reactant A is diffused with the jet *** comparison of the profiles of chemical reaction rate and concentration of product R,it is found that product R for Da=10 is produced by the chemical reaction at the interface between the jet and the ambient fluids and is diffused into the jet flow,whereas product R for Da=0.1 is produced in the jet flow after reactants A and B are well mixed.

关键词： Turbulent flow direct numerical simulation jet.

Increased tumor necrosis factor receptor 1 expression in human colorectal adenomas

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World Journal of Gastroenterology 2012年第38期18卷 5360-5368页

作者： Kunihiro Hosono Eiji Yamada hiroki Endo Hirokazu Takahashi Masahiko Inamori Yoshitaka Hippo Hitoshi Nakagama Atsushi Nakajima Division of Gas-troenterology Yokohama City University School of Medicine Yokohama 2360004 Japan Division of Cancer Development System National Cancer Center Research Institute Tokyo 1040045 Japan

AIM: To determine the expression statuses of tumor necrosis factor (TNF)-α, its receptors (TNF-R) and downstream effector molecules in human colorectal adenomas. METHODS: We measured the serum concentrations of TNF-α and its receptors in 62 colorectal adenoma patients and 34 healthy controls. The protein expression of TNF-α, TNF-R1, TNF-R2 and downstream signals of the TNF receptors, such as c-Jun N-terminal kinase (JNK), nuclear factor-κ B and caspase-3, were also investigated in human colorectal adenomas and in normal colorectal mucosal tissues by immunohistochemistry. Immunofluorescence confocal microscopy was used to investigate the consistency of expression of TNF-R1 and phospho-JNK (p-JNK). RESULTS: The serum levels of soluble TNF-R1 (sTNF-R1) in adenoma patients were significantly higher than in the control group (3.67 ± 0.86 ng/mL vs 1.57 ± 0.72 ng/mL, P < 0.001). Receiver operating characteristic analysis revealed the high diagnostic sensitivity of TNF-R1 measurements (AUC was 0.928) for the diagnosis of adenoma, and the best cut-off level of TNF-R1 was 2.08 ng/mL, with a sensitivity of 93.4% and a specificity of 82.4%. There were no significant differences in the serum levels of TNF-α or sTNF-R2 between the two groups. Immunohistochemistry showed high levels of TNF-R1 and p-JNK expression in the epithelial cells of adenomas. Furthermore, a high incidence of co-localization of TNF-R1 and p-JNK was identified in adenoma tissue. CONCLUSION: TNF-R1 may be a promising biomarker of colorectal adenoma, and it may also play an important role in the very early stages of colorectal carcinogenesis.

关键词： Tumor necrosis factor-α Tumor necrosis factor receptor 1 c-Jun N-terminal kinase Colorectal adenoma Biomarker

Rare case of fecal impaction caused by a fecalith originating in a large colonic diverticulum: A case report

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World Journal of Clinical Cases 2021年第2期9卷 416-421页

作者： hiroki Tanabe Kazuyuki Tanaka Mitsuru Goto Tomonobu Sato Keisuke Sato Mikihiro Fujiya Toshikatsu Okumura Division of Gastroenterology and Hematology/Oncology Department of MedicineAsahikawa Medical UniversityAsahikawa 078-8510HokkaidoJapan Department of Gastroenterology Asahikawa Kousei HospitalAsahikawa 078-8211HokkaidoJapan Department of Pathology Asahikawa Kousei HospitalAsahikawa 078-8211HokkaidoJapan

BACKGROUND Fecal impaction is defined as a large mass of compacted feces in the colon and has the potential to induce a serious medical condition in elderly *** impaction is generally preventable,and early recognition of the typical radiological findings is important for making an early *** factors that lead to fecal impaction are usually similar to those causing *** cases with fecal impaction associated with a diverticulum have been *** SUMMARY We present the case of a 62-year-old woman who suffered from abdominal pain and vomiting,had a medical history of repeated acute abdomen and was diagnosed with fecal impaction in the descending colon based on X-ray and computed tomography(CT)*** examination by gastrografinenhanced colonography following colonoscopy and CT colonography,the fecalith was suspected to have been produced at the site of a large diverticulum in the transverse *** fecalith was surgically resected,and a histological diagnosis of pseudodiverticulum was *** was no recurrence during 33 mo of *** This case highlights the importance of accurate identification and treatment of a fecal *** case indicated that the endoscopic evacuation and subsequent colonography were effective for identifying a diverticulum that might have caused fecal impaction.A fecal impaction was associated with the ***,the planned diverticulectomy was *** emergency medical treatment and maintenance treatments should be selected in such cases to prevent recurrence.

关键词： Colonic ileus Constipation Acute abdomen Computed tomography colonography Case report Colonoscopy