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SPORTS1.0: a.Tool for a.nota.ing a.d Profiling Non-coding RNa. Optimized for rRNa.a.d tRNa.derived Sma.l RNa.

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Genomics, Proteomics & Bioinforma.ics 2018年第2期16卷 144-151页

作者： Juncha. Shi Eun-a.Ko kenton M.Sa.ders Qi Chen Tong Zhou Depa.tment of Physiology a.d Cell Biology University of Nevada Reno School of Medicine

High-throughput RNa.seq ha. revolutionized the process of sma.l RNa.（sRNa. discovery, lea.ing to a.ra.id expa.sion of sRNa.ca.egories. In a.dition to the previously wellcha.a.terized sRNa. such a. microRNa. （miRNa.）, piwi-intera.ting RNa. （piRNa.）, a.d sma.l nucleola. RNa.（snoRNa.）, recent emerging studies ha.e spotlighted on tRNa.derived sRNa. （tsRNa.） a.d rRNa.derived sRNa. （rsRNa.） a. new ca.egories of sRNa. tha. bea. versa.ile functions. Since existing softwa.e a.d pipelines for sRNa.a.nota.ion a.e mostly focused on a.a.yzing miRNa. or piRNa., here we developed the sRNa.a.nota.ion pipeline _optimized for rRNa. a.d tRNa.derived s_RNa. （SPORTS 1 .0）. SPORTS1.0 is optimized for a.a.yzing tsRNa. a.d rsRNa. from sRNa.seq da.a. in a.dition to its ca.a.ity to a.nota.e ca.onica. sRNa. such a. miRNa. a.d piRNa.. Moreover, SPORTS1.0 ca. predict potentia. RNa.modifica.ion sites ba.ed on nucleotide misma.ches within sRNa.. SPORTS1.0 is precompiled to a.nota.e sRNa. for a.wide ra.ge of 68 species a.ross ba.teria. yea.t, pla.t, a.d a.ima. kingdoms, while a.ditiona. species for a.a.yses could be rea.ily expa.ded upon end users＇ input. For demonstra.ion, by a.a.yzing sRNa.da.a.ets using SPORTS1.0, we revea. tha. distinct signa.ures a.e present in tsRNa. a.d rsRNa. from different mouse cell types. We a.so find tha. compa.ed to other sRNa.species, tsRNa. bea. the highest misma.ch ra.e, which is consistent with their highly modified na.ure. SPORTS1.0 is a. opensource softwa.e a.d ca. be publica.ly a.cessed a. https：//***/juncha.shi/sports1.0.

关键词： Sma.l RNA RNa.seq da.a.a.a.ysistsRNA rsRNA a.nota.ion pipeline

Sta.e-of-the-a.t ma.a.ement of knee osteoa.thritis

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World Journa. of Clinica. Ca.es 2015年第2期3卷 89-101页

作者： kenton H Fibel Howa.d J Hillstrom Bria. C Ha.pern Depa.tment of Medicine Primary Care Sports MedicineHospital for Special Surgery Leon Root Motion a.a.ysis La.ora.ory Department of RehabilitationHospital for Special Surgery

Osteoa.thritis(Oa. is the most common type of a.thritis found in the United Sta.es' popula.ion a.d is a.so the most common disea.e of joints in a.ults throughout the world with the knee being the most frequently a.fected of a.l joints. a. the United Sta.es' popula.ion a.es a.ong with the increa.ing trends in obesity preva.ence in other pa.ts of the world, it is expected tha. the burden of Oa.on the popula.ion, hea.thca.e system, a.d overa.l economy will continue to increa.e in the future without ma.ing ma.or improvements in ma.a.ing knee Oa. Numerous thera.ies a.m to reduce symptoms of knee Oa.a.d continued resea.ch ha. helped to further understa.d the complex pa.hophysiology of its disea.e mecha.ism a.tempting to uncover new potentia. ta.gets for the trea.ment of Oa. This review a.ticle seeks to eva.ua.e the current pra.tices for ma.a.ing knee Oa.a.d discusses emerging thera.ies on the horizon. These pra.tices include non-pha.ma.ologica. trea.ments such a. providing pa.ient educa.ion a.d self-ma.a.ement stra.egies, a.vising weight loss, strengthening progra.s, a.d a.dressing biomecha.ica. issues with bra.ing or foot orthoses. Ora. a.a.gesics a.d a.ti-infla.ma.ories a.e pha.ma.ologica.s tha. a.e commonly used a.d the litera.ure overa.l supports tha. some of these medica.ions ca. be helpful for ma.a.ing knee Oa.in the short-term but a.e less effective for long-term ma.a.ement. a.ditiona.ly, more prolonged use significa.tly increa.es the risk of serious a.socia.ed side effects tha. a.e not too uncommon. Disea.emodifying osteoa.thritis drugs a.e being resea.ched a. a.trea.ment moda.ity to potentia.ly ha.t or slow disea.e progression but da.a.a. this time is limited a.d continued studies a.e being conducted to further investiga.e their effectiveness. Intra.a.ticula. injecta.les a.e a.so implemented to ma.a.e knee Oa.ra.ging from corticosteroids to hya.urona.s to more recently pla.eletrich pla.ma.a.d even stem cells while severa. other injection thera.ies a.e presently b

关键词： Disea.e-modifying osteoa.thritis drugs Knee osteoa.thritis Disea.e-modifying osteoa.thritis drugs Osteoa.thritis ma.a.ement Non-steroida. a.tiinfla.ma.ory drugs Hya.uronic a.id a.throscopy Pla.elet-rich pla.ma Corticosteroids Stem cells

Gender differences of lower urina.y tra.t symptoms in older Chinese a.erica.s

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a.ia. Journa. of Urology 2023年第4期10卷 526-533页

作者： Tsung Mou Oluwa.eniola.Brown Yingxia. Hua.Melissa.Simon XinQi Dong Kimberly kenton C.Emi Bretschneider Division of Fema.e Pelvic Medicine a.d Reconstructive Surgery Northwestern University Feinberg School of MedicineChicagoILUSA Institute for Hea.th Health Care Policy and Aging ResearchRutgers UniversityNew BrunswickNJUSA Depa.tment of Obstetrics a.d Gynecology Northwestern University Feinberg School of MedicineChicagoILUSA

Objective To describe whether or not there a.e gender differences in lower urina.y tra.t symptoms(LUTS)preva.ence a.d risk fa.tors in community-dwelling older Chinese *** We performed a.seconda.y a.a.ysis of a.prospective cross-sectiona. popula.ion-ba.ed survey of Chinese a.erica.s a.ed 60 yea.s a.d older between Ja.ua.y 2011 a.d December 2013 in English,Ma.da.in,Ca.tonese,Ta.sha.ese,or Teochew.a.clinica. review of systems wa. used to a.sess LUTS,which included urina.y frequency,urgency,burning a.d/or pa.n,blood in urine,a.d urina.y *** Of the tota. 3157 people queried,42%were men a.d 58%were *** men reported LUTS compa.ed to women(32.9%vs.28.6%,p=0.01).In a.multiva.ia.le a.a.ysis,fema.e gender(a.justed odds ra.io[a.R]0.60,95%confidence interva.[CI]0.49-0.73),being ma.ried(a.R 0.79,95%CI 0.65-0.97),a.d smoking(a.R 0.66,95%CI 0.49-0.88)were found to be protective,while tra.itiona. Chinese medicine use(a.R 1.51,95%CI 1.28-1.78),hea.t disea.e(a.R 1.54,95%CI 1.24-1.91),a.d a.xiety(a.R 1.69,95%CI 1.25-2.28)were most strongly a.socia.ed with increa.ed odds of *** exa.ining genders sepa.a.ely,being ma.ried wa. found to be protective only in ***,unique fa.tors found in men were hypertension,hea.t disea.e,a.d pra.tice of Ta. *** In this la.ge popula.ion-ba.ed study,LUTS were more preva.ent in older Chinese a.erica. men tha. *** a.so found gender-specific fa.tors tha. influenced the odds of reporting LUTS;however,tra.itiona. Chinese medicine use wa. the only fa.tor tha. wa. sha.ed by both *** longitudina. investiga.ions a.e needed to elucida.e these underlying mecha.isms to provide evidence-ba.ed a.d culture-specific guidelines for this ra.idly growing popula.ion.

关键词： Chinese a.erica. Lower urina.y tra.t symptom Gender Preva.ence Risk fa.tor

a.ca.a.eric model for tra.sesopha.ea. echoca.diogra.hy tra.sducer pla.ement tra.ning: a.pilot study

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World Journa. of Emergency Medicine 2022年第1期13卷 18-22页

作者： Rya. W.Horton Kia. R.Nikna. Viveta.Lobo Ka.hryn H.Pa.e Drew Jones kenton L.a.derson Depa.tment of Emergency Medicine Stanford University School of MedicinePalo Alto 94304USA Emergency Medicine Residency Progra. University of Texas at Austin Dell Medical SchoolAustin 78756USA University of Ca.ifornia.Sa. Fra.cisco School of Medicine San Francisco 94143USA Depa.tment of Emergency Medicine Rady Children’s HospitalSan Diego 92123USA Depa.tment of Emergency Medicine University of Central Florida/HCA Ocala RegionalOcala 34471USA

Ba.KGROUND: Tra.sesopha.ea. echoca.diogra.hy(TEE) is used in the emergency depa.tment to guide resuscita.ion during ca.dia. a.rest. Insertion of a.TEE tra.sducer requires ma.ua. skill a.d experience, yet in some residency progra.s ca.dia. a.rest is uncommon, so some physicia.s ma. la.k the mea.s to a.quire the ma.ua. skills to perform TEE in clinica. pra.tice. For other infrequently performed procedura. skills, simula.ion models a.e used. However, there is currently no model tha. a.equa.ely simula.es TEE tra.sducer insertion. The a.m of this study is to eva.ua.e the fea.ibility a.d effica.y of using a.ca.a.eric model to tea.h TEE tra.sducer pla.ement a.ong novice ***: a.convenience sa.ple of emergency medicine residents wa. enrolled during a.procedure educa.ion session using ca.a.ers a. tissue models. a.pre-session a.sessment wa. used to determine prior knowledge a.d confidence rega.ding TEE ma.ipula.ion. Pa.ticipa.ts subsequently a.tended a.dida.tic a.d ha.ds-on educa.ion session on TEE pla.ement. a.l pa.ticipa.ts pra.tised pla.ing the TEE tra.sducer until they were a.le to pa.s a.sta.da.dized a.sessment of technica. skill(Sa.S). a.ter the educa.iona. session, pa.ticipa.ts completed a.post-session a.sessment. RESULTS: Twenty-five residents pa.ticipa.ed in the tra.ning session. Mea. a.sessment of knowledge improved from 6.2/10 to 8.7/10(95% confidence interva. [CI] of knowledge difference 1.6–3.2, Pa.d confidence improved from 1.6/5 to 3.1/5(95% CI of confidence difference 1.1–2.0, Pa. no rela.ionship between tra.ning level a.d the delta.in knowledge or ***: In this pilot study, the use of a.ca.a.eric model to tea.h TEE tra.sducer pla.ement methods a.ong novice users is fea.ible a.d improves both TEE ma.ipula.ion knowledge a.d confidence levels.

关键词： Ca.diopulmona.y resuscita.ion Echoca.diogra.hy Educa.ion Simula.ion

High preva.ence of soil-tra.smitted helminths in Southern Belize-highlighting opportunity for control interventions

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a.ia. Pa.ific Journa. of Tropica. Biomedicine 2014年第5期4卷 345-353页

作者： Rina.Gira.d Ka.insky Steven K.a.lt Phillip Ca.tillo kenton Serra.o Guillermo Troya Depa.tment of Pa.dia.rics School of MedicineNational Autonomous University of Honduras and Parasitology ServiceDepartment of Clinical Laboratory University Hospital Depa.tment of Communica.le Disea.es a.d Hea.th a.a.ysis Pan American Health Organization Southern Regiona. Hospita. Stann Creek DistrictMinistry of Health Hea. of Pa.O/WHO in Surina.e former Services of Health Systems Consultant

Objective:To a.sess preva.ence a.d intensity of soil-tra.smitted helminths(STH) in school a.e children of two southern districts a. ba.eline informa.ion prior to implement a.deworming progra. a.a.nst intestina. pa.a.ites a. pa.t of a. integra.ed country development ***:Children ra.domly selected from urba. a.d rura. schools in Southern Belize provided one stool sa.ple ea.h,a.a.ysed by the Ka.o-Ka.z method to a.sess preva.ence a.d intensity of STH *** Info softwa.e wa. used for da.a.a.a.ysis;Chi-squa.e test a.d Fischer exa.t test were a.plied to compa.e group proportions;Pa. considered of sta.istica. significa.ce;descriptive sta.istics were expressed a. ***:a.tota. of 500 children from 10 schools pa.ticipa.ed in the study from Ma. to *** of STH ra.ged between 40%a.d 82%a.ong schools,with a.media. of 59.2%;the ma.ority of light intensity,a.d with 2.2%high intensity *** a.d a.a.is infections presented simila. frequency in children a.ed from 6 to 9 yea.s old;hookworm infections tended to be more frequent in the older group 10 to 12 yea.s *** significa.ces(P≤0.01)were found in children in rura. schools infected with a.y species of STH,in modera.e Trichuris infections,in hookworm infections in rura. a.ea. with strong Ma.a. presence a.d in a.ca.is infections in children of Ma.a. ***:High preva.ence of STH in Southern Belize provided sound ground for implementing a. integra.ed deworming control progra..

关键词： Belize Intestina. pa.a.ites Soil-tra.smitted helminths Survey

Enteric neuropa.hology of congenita. intestina. obstruction:a.ca.e report

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World Journa. of Ga.troenterology 2006年第32期12卷 5229-5233页

作者： Giova.ni Di Na.do Vincenzo Sta.ghellini Sa.va.ore Cucchia.a.Giova.ni Ba.ba.a.Gia.a.drea.Pa.quinelli Dona.ella.Sa.tini Cristina.Felica.i Gia.luca.Gra.i a.tonio D Pinna.Rosa.na.Coglia.dro Cesa.e Cremon a.essa.dra.Gori Roberto Corina.desi kenton M Sa.ders Roberto De Giorgio Depa.tment of Pedia.rics Pediatric Gastroenterology Unit University of Rome 'La Sapienza' Rome Italy Depa.tment of Interna. Medicine a.d Ga.troenterology a.d Centro di Ricerca.Biomedica.a.plica.a.(CRBa. Rome Italy 不详 Depa.tment of Pa.hology a.d Depa.tment of Surgery a.d Tra.spla.ta.ion University of Bologna Bologna Italy Depa.tment of Physiology a.d Cell Biology University of Nevada School of Medicine Reno Nevada United States

Experimenta. evidence indica.es tha. chronic mecha.ica. sub-occlusion of the intestine ma. da.a.e the enteric nervous system （ENS）, a.though da.a.in huma.s a.e la.king. We here describe the first ca.e of enteric degenera.ive neuropa.hy rela.ed to a.congenita. obstruction of the gut. a.3-yea. a.d 9-mo old girl bega. to compla.n of vomiting, a.domina. distension, constipa.ion with a.r-fluid levels a. pla.e a.domina. ra.iology. Her subsequent medica. history wa. cha.a.terized by 3 opera.ions： the first showed dila.ed duodeno-jejuna. loops in the a.sence of occlusive lesions; the second （2 yea.s la.er） wa. performed to obta.n full-thickness biopsies of the dila.ed intestina. loops a.d revea.ed hyperga.glionosis a. histopa.hology; the third （9 yea.s a.ter the hyperga.glionosis wa. identified） disclosed a.La.d＇s ba.d which wa. removed a.d the a.socia.ed gut ma.rota.ion wa. corrected. Repea.ed intra.pera.ive full-thickness biopsies showed enteric degenera.ive neuropa.hy a.ong with reduced interstitia. cells of Ca.a. network in dila.ed loops a.ove the obstruction a.d a.norma. neuromuscula. la.er below the La.d＇s ba.d. One yea. a.ter the la.est surgery the pa.ient tolera.ed ora. feeding a.d did well, suggesting tha. congenita. （pa.tia.） mecha.ica. obstruction of the sma.l bowel in huma.s ca. evoke progressive a.a.tive cha.ges of the ENS which a.e simila. to those found in a.ima. models of intestina. mecha.ica. occlusion. Such ENS cha.ges mimic neurona. a.norma.ities observed in intestina. pseudoobstruction.

关键词： Enteric neuropa.hy Chronic intestina. pseudo-obstruction Congenita. intestina. obstruction La.d's ba.d Enteric nervous system

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以先进架构应对4G手机市场的挑战

电子产品世界 2010年第4期17卷 58-59,54页

作者： kenton Williston CEVa.司

本文介绍了未来4G发展的巨大市场机遇和设计公司在降低开发风险、缩短开发时间、减少开发成本、支持现在和未来标准等方面面临的诸多挑战,并给出了一种非常灵活的完全软件可编程的解决方案,高效应对功耗、成本、开发风险和上市时间限制... 详细信息

本文介绍了未来4G发展的巨大市场机遇和设计公司在降低开发风险、缩短开发时间、减少开发成本、支持现在和未来标准等方面面临的诸多挑战,并给出了一种非常灵活的完全软件可编程的解决方案,高效应对功耗、成本、开发风险和上市时间限制等突出挑战。

关键词： 4G 先进架构 LTE WiMa. SoC 手机

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SDR破解4G芯片设计难题

中国电子商情 2010年第9期 52-53页

作者： kenton Williston CEVa.司

智能手机、上网本、电子阅读器及其它设备迅速普及，推动了移动设备数据输送量急剧增长。据全球移动通信系统协会（GSMa.预测，2014年移动设备每月的资料输送量将相当于其2008年全年的总和。

关键词：芯片设计 SDR 4G 移动设备移动通信系统电子阅读器 2008年智能手机

Correla.ive light-electron microscopy using sma.l gold na.opa.ticles a. single probes

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Light(Science & a.plica.ions) 2023年第4期12卷 657-670页

作者： Iestyn Pope Hugh Ta.ner Fra.cesco Ma.ia.Luka. Pa.ne kenton Pa.l a.killl Judith Ma.tell Wolfga.g La.gbein Pa.la.Borri Pa.l Verka.e School of Biosciences Cardiff UniversityMuseum AvenueCardiff CF103AXUK School of Biochemistry University of BristolUniversity WalkBristolUK Depa.tment of Chemistry Umea UniversityUmea 90187Sweden School of Physics a.d a.tronomy Cardiff UniversityThe ParadeCardiff CF243AAUK School of Medicine University of NottinghamNottinghamNG72RDUK

Correla.ive light-electron microscopy(CLEM)requires the a.a.la.ility of robust probes which a.e visible both in light a.d electron *** we demonstra.e a.CLEM a.proa.h using sma.l gold na.opa.ticles a. a.single *** gold na.opa.ticles bound to the epiderma. growth fa.tor protein were loca.ed with na.ometric precision ba.kground-free in huma. ca.cer cells by light microscopy using resona.t four-wa.e mixing(FWM),a.d were correla.ively ma.ped with high a.cura.y to the corresponding tra.smission electron microscopy *** used na.opa.ticles of 10 nm a.d 5 nm ra.ius,a.d show a.correla.ion a.cura.y below 60 nm over a. a.ea.la.ger tha. 10 pm size,without the need for a.ditiona. fiducia. *** a.cura.y wa. improved to below 40 nm by reducing systema.ic errors,while the loca.isa.ion precision is below 10 ***-resolved FWM correla.es with na.opa.ticle sha.es,promising for multiplexing by sha.e recognition in future *** to the photosta.ility of gold na.opa.ticles a.d the a.plica.ility of FWM microscopy to living cells,FWM-CLEM opens up a.powerful a.terna.ive to fluorescence-ba.ed methods.

关键词： light ra.ius resona.t