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Utility of single-incision totally extraperitoneal inguinal hernia repair with intraperitoneal inspection

World Journal of Gastrointestinal Surgery 2017年第12期9卷 264-269页

作者： Masateru yamamoto Takashi Urushihara Toshiyuki Itamoto Department of Gastroenterological Breast and Transplant SurgeryHiroshima Prefectural Hospital Department of Gastroenterological and Transplant Surgery Applied Life ScienceInstitute of Biomedical and Health ScienceHiroshima University

AIM To study the utility of single-incision totally extraperitoneal inguinal hernia repair with intraperitoneal *** A 2 cm transverse skin incision was made in the umbilicus, extending to the intraperitoneal cavity. Carbon dioxide was insufflated followed by insertion of laparoscope to observe the intraperitoneal cavity. The type of hernia was diagnosed and whether there was the presence of intestinal incarceration was confirmed. When an intestinal incarceration in the hernia sac was found, the forceps were inserted through the incision site and the intestine was returned to the intraperitoneal cavity without increasing the number of trocars. Once the peritoneum was closed, totally extraperitoneal inguinal hernia repair was performed, and finally, intraperitoneal observation was performed to reconfirm the *** Of the 75 hernias treated, 58 were on one side, 17 were on both sides, and 10 were recurrences. The respective median operation times for these 3 groups of patients were 100 min(range, 66 to 168), 136 min(range, 114 to 165), and 125 min(range, 108 to 156), with median bleeding amounts of 5 g(range, 1 to 26), 3 g(range, 1 to 52), and 5 g(range, 1 to 26), respectively. Intraperitoneal observation showed hernia on the opposite side in 2 cases, intestinal incarceration in 3 cases, omental adhesion into the hernia sac in 2 cases, severe postoperative intraperitoneal adhesions in 2 cases, and bladder protrusion in 1 case. There was only 1 case of *** Single-incision totally extraperitoneal inguinal hernia repair with intraperitoneal inspection makes hernia repairs safer and reducing postoperative complications. The technique also has excellent cosmetic outcomes.

关键词： Inguinal hernia Intestinal incarceration Totally extraperitoneal inguinal hernia repair Intraperitoneal inspection Single incision

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IgE PRODUCTION IS INVOLVED IN BUTYRATE- ENHANCED NK CELL ACTIVITY IN VIVO

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Chinese Medical Sciences Journal 2001年第2期16卷 76-81页

作者： Ming Zhong Akihiro Tai Itaru yamamoto Department of Immunochemistry Faculty of Pharmaceutical SciencesOkayama UniversityTsushima-naka 1-1-1Okayama 700-8530Japan

It has been demonstrated that patients with asthma have a large number of NK cells and show a stronger NK activity. These results indicate that NK cell activity may be related to total IgE level in serum in healthy subjects. Previously,we have found that sodium butyrate (NaBu) markedly enhanced the IL- 4- induced IgE production in the LPS- stimulated murine splenocytes in vitro, and inductive rat IgE production in vivo, and enhanced the NK cell activity ex vivo .We hypothesized that the IgE production might be involved in butyrate- enhanced NK cell activity in vivo. Mice were intraperitoneally treated/immunized with NaBu or/and Ascaris suum extract (ASC),and the spleen NK cell activity was evaluated. Furthermore, the effect of serum (NAS) on IL- 2- or IFN-γ- induced spleen NK cell activity was determined. The spleen NK cell activity and IL- 2- or IFN-γ- induced spleen NK cell activity of mice treated/immunized with NaBu or/and ASC were stronger than those of untreated/unimmunized mice. Although IL- 4 blocked IL- 2 (100 U/ml)- or IFN-γ (100 U/ml)- induced increase in NK cell activity,these NK cell activities in mice treated/immunized with NaBu/ASC were not inhibited. IgE production showed a tendency to rise in NaBu- treated mice serum, and a synergistic effect was observed with treatment of NaBu and ASC. Moreover, the NAS significantly increased IL- 2(25 U/ml)- or IFN-γ (25 U/ml)- induced NK cell activity, and its effect was inhibited by anti- mouse IgE mAb. These data show that IgE plays an important role in NAS- enhanced IL- 2/IFN-γ- induced NK cell activity, and IL- 4 does not inhibit IgE and IL- 2/IFN-γ- induced NK cell activity in mice.

关键词： immunoglobulin E (IgE) sodium butyrate (NaBu) NK cell activity

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Partial stent-in-stent placement of biliary metallic stents using a short double-balloon enteroscopy

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World Journal of Gastroenterology 2012年第45期18卷 6674-6676页

作者： Koichiro Tsutsumi Hironari Kato Takeshi Tomoda Kazuyuki Matsumoto Ichiro Sakakihara Naoki yamamoto Yasuhiro Noma Takayuki Sonoyama Hiroyuki Okada Kazuhide yamamoto Department of Gastroenterology and Hepatology Dentistry and Pharmaceutical SciencesOkayama University Graduate School of MedicineOkayama 700-8558Japan

Endoscopic intervention is less invasive than percutaneous or surgical approaches and should be considered the primary drainage procedure in most cases with obstructive ***,therapeutic endoscopic retrograde cholangiopancreatography(ERCP) using double-balloon enteroscopy(DBE) has been shown to be feasible and effective,even in patients with surgically altered *** the other hand,endoscopic partial stent-in-stent(PSIS) placement of selfexpandable metallic stents(SEMSs) for malignant hilar biliary obstruction in conventional ERCP has also been shown to be feasible,safe and *** performed PSIS placement of SEMSs for malignant hilar biliary obstruction due to liver metastasis using a short DBE in a patient with Roux-en-Y anastomosis and achieved technical and clinical *** procedure can result in quick relief from obstructive jaundice in a single session and with short-term hospitalization,even in patients with surgically altered anatomies.

关键词： Double-balloon enteroscopy Malignant hi-lar biliary obstruction Self-expandable metallic stent Partial stent in stent Roux-en-Y anastomosis

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Identification of key pathways and gene expression in the activation of mast cells via calcium flux using bioinformatics analysis

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BIOCELL 2021年第2期45卷 395-415页

作者： XIAOYU WANG TAKESHI yamamoto MAKOTO KADOWAKI YIFU YANG Laboratory of Immunology and Virology Experiment Center for Science and TechnologyShanghai University of Traditional Chinese MedicineShanghai201203China Division of Gastrointestinal Pathophysiology Institute of Natural MedicineUniversity of ToyamaToyama9300194Japan

Mast cells are the main effector cells in IgE-associated allergic disorders,and we have reported that mucosal mast cells(MMCs)play a more important role in the development of food allergy(FA).IgE with antigen or calcium ionophore stimulation can lead to the activation of MMCs via a calcium-dependent *** purpose of the present study was to identify gene signatures with IgE/antigen(dinitrophenyl-bovine serum albumin,DNP-BSA)or calcium ionophore(A23187)on the activation of *** expressed genes between the two types of samples were identified with microarray *** ontology functional and pathway enrichment analyses of differentially expressed genes were performed using the database for annotation,visualization,and integrated discovery *** results showed that IgE/antigen and A23187 could induce degranulation,increase vacuoles,and elevate the cytosolic calcium concentration in ***,GeneChip analysis showed that the same 134 mRNAs were altered with IgE/DNP-BSA and A23187,suggesting that DNP-BSA/IgE and A23187 affect the same signal pathway partly in *** analysis showed that the data were enriched in NF-κB,TNF,MAPK,transcription factor activity,DNA binding,and nucleic acid binding,suggesting that activation of MMCs is a complex *** results provide new insights on MMCs activation.

关键词： Mucosal mast cell Antigen Calcium ion Bioinformatics analysis

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Sodium alginate ameliorates indomethacin-induced gastrointestinal mucosal injury via inhibiting translocation in rats

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World Journal of Gastroenterology 2014年第10期20卷 2641-2652页

作者： Atsuki yamamoto Tomokazu Itoh Reishi Nasu Ryuichi Nishida Pharmaceutical research laboratories Sakai Chemical Industry Co. Ltd. Kawachinagano Osaka 586-0006 Japan KATAYAMA SEIYAKUSYO Co. Ltd.Hirakata Osaka 573-1132 Japan Kaigen Pharma Co. Ltd.Doshomachi Chuo-ku Osaka 541-0045 Japan

AIM: To investigate the effects of sodium alginate (AL-Na) on indomethacin-induced small intestinal lesions in rats.

关键词： Sodium alginate Non-steroidal anti-inflammatory drugs Gastrointestinal mucosal injury Mucin Bacterial translocation

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Machine learning of organic solvents reveals an extraordinary axis in Hansen space as indicator of spherical precipitation of polymers

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Aggregate 2023年第5期4卷 207-213页

作者： Yuta Ihara Hiroshi Yamagishi Masanobu Naito Yohei yamamoto Department of Materials Science Faculty of Pure and Applied Sciencesand Tsukuba Research Center for Energy Materials Science(TREMS)University of TsukubaTsukubaJapan Research and Services Division of Materials Data and Integrated System(MaDIS) National Institute for Materials Science(NIMS)TsukubaJapan Program in Materials Science and Engineering Graduate School of Pure and Applied SciencesUniversity of TsukubaTsukubaJapan

Machine learning is an emerging tool in the field of materials chemistry for uncovering a principle from large ***,we focus on the spherical precipitation behavior of polymers and computationally extract a hidden trend that is orthogonal to the availability bias in the chemical *** constructing a dataset,four polymers were precipitated from 416 solvent/nonsolvent combinations,and the morphology of the resulting precipitates were *** dataset was subjected to computational investigations consisting of principal component analysis and machine learning based on random forest model and support vector ***,we eliminated the effect of the availability bias and found a linear combination of Hansen parameters to be the most suitable variable for predicting precipitation *** predicted appropriate solvents are those with low hydrogen bonding capability,low polarity,and small molecular ***,we found that the capability for spherical precipitation is orthogonal to the availability bias and forms an extraordinary axis in Hansen space,which is the origin of the conventional difficulty in identifying the *** extraordinary axis points toward a void region,indicating the potential value of synthesizing novel solvents located therein.

关键词： chemical space computational chemistry machine learning polymers precipitation

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The Monotone Robin-Robin Domain Decomposition Methods for the Elliptic Problems with Stefan-Boltzmann Conditions

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Communications in Computational Physics 2010年第8期8卷 642-662页

作者： Wenbin Chen Jin Cheng Masahiro yamamoto Weili Zhang School of Mathematical Sciences and Key Laboratory of Computational Physics(MOE) Fudan UniversityShanghai200433China Shanghai Key Laboratory of Intelligent Information Processing Fudan UniversityShanghai200433China Department of Mathematical Sciences University of TokyoTokyo153-8914Japan

This paper is concerned with the elliptic problems with nonlinear StefanBoltzmann boundary *** combining with the monotone method,the RobinRobin domain decomposition methods are proposed to decouple the nonlinear interface and boundary *** monotone properties are verified for both the multiplicative and the additive domain decomposition *** numerical results confirm the theoretical analysis.

关键词： Nonlinear Stefan-Boltzmann condition monotone methods Robin-Robin domain decomposition method

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Exploitation of shape memory alloy actuator using resistance feedback control and its development

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Progress in Natural Science:Materials International 2010年第1期20卷 97-103页

作者： Hiroki CHO Takaei yamamoto Yuji TAKEDA Akihiko SUZUKI Toshio SAKUMA Faculty of Engineering Oita University700 DannoharuOita 870-1192Japan TAKE R&D 2-7-27UmedaKasukabeJapan

The relationship between phase transformation and electric resistivity of Ti-42.6Ni-7Cu SMA was *** the isothermal tensile tests,stress-strain curve shows large hysteresis and nonlinearity,whereas the resistivity-strain curve can be fitted by *** resistivity of SMAs can be determined from the volume fractions of the martensitic and austenitic *** characteristics leads to that the resistance of the SMAs is used as a parameter of strain of SMAs.A SMA actuator using resistance feedback control system was proposed,which can control and retain positioning at any positions without using sensor devices,and the deviation of position of this system was less than 3 μm.

关键词： Ti-Ni-Cu alloy shape memory alloy resistivity shape memory characteristics phase transformation

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Experimental Study of the Viscous Pump with a Helical Channel Rotor:Torsion Effect of the Channel

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Journal of Thermal Science 2010年第2期19卷 154-159页

作者： Yasutaka HAYAMIZU Kyoji yamamoto Shinichiro YANASE Toru HYAKUTAKE Shinichi MORITA Shigeru OHTSUKA Department of Mechanical Engineering Yonago National College of Technology4448 Hikona-choYonago-shiTottori 683-8502 Graduate School of Natural Science and Technology Okayama University3-1-1 TushimanakaOkayama-shiOkayama 700-8530

The viscous pump,which has a rotor with a helical square channel,is studied *** non-dimen-sional channel curvature is taken to be about *** types of torsion of the channel are made to investigate the torsion effect on the flow *** measure the flux through the channel at a constant rotor speed by changing the pressures at the entrance and exit of the *** also observe the secondary flow at a cross-section of the *** of the results obtained are shown as follows:The friction factor along the channel to get the same flux is large for large channel torsion at a constant rotation,and becomes small when the favorable rotation of the rotor to the flow is *** for the secondary flow in a cross-section,there appear several types of *** there is no rotation,the secondary flow is almost a symmetric two-vortex type for small flux as is the ordinary Dean vortex,but it changes to a four-vortex type when the flux is *** secondary flow becomes asymmetric as the rotation is *** have unsteady flow patterns at large flux and rotation.

关键词： Viscous Pump Helical Channel Torsion Effect Secondary Flow Flow Visualization Dean Number Taylor Number

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Synthesis and TEM structural characterization of C60-flattened carbon nanotube nanopeapods

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Nano Research 2014年第12期7卷 1843-1848页

作者： Qing Wang Ryo Kitaura Yuta yamamoto Shigeo Arai Hisanori Shinohara Department of Chemistry & Institute for Advanced Research Nagoya University Nagoya 464-8602 Japan High Voltage Electron Microscope Laboratory Ecotopia Science Institute Nagoya University Nagoya 464-8602 Japan

A fully flattened carbon nanotube （FNT）, a graphene nanoribbon （GNR） analogue, provides a hollow space at edges for endohedral doping. Due to the unique shape of the hollow space of FNTs, novel types of low-dimensional arrangements of atoms and molecules can be obtained through endohedral doping into FNTs, which provides a new type of nanopeapods. FNT-based nanopeapods have been synthesized through endohedral doping of C60, and their structural characterization with transmission electron microscopy （TEM） performed. The doping of C60 into the inner hollow space of FNTs has been carried out via the gas-phase filling method, where open-ended FNTs are sealed in a glass ampoule and heated at 723-773 K for two days. TEM observations show that most of the encapsulated C60 molecules align as single molecular chains along the edges of FNTs and that some of the C60 forms two-dimensional close-packed structures inside FNTs.

关键词： carbon nanotubes nanopeapods endohedral doping electron microscopy

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