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Chinese Chemical Letters 1994年第7期5卷 569-572页

作者： chum Wei CHEn Mei Yu HUAnG and Ying Yan JIAnG(Institute of Chemistry, Academia Sinica, Beijing 100080)

A new king of inorganic polymer silica-support polytitazane(Ti-n),and itsplatimum-manganese bimetallic complex(Ti-n-Pt-Mn) were *** activity and selectivity to cyclohexanone in the hydrogenation of phenol over Ti-n-Pt... 详细信息

关键词： Pt POLYTITAZAnE Mn BIMETALLIC

SYnTHESIS OF (4S)-ETHOXYSILATRAnE-4-CARBOXYLIC ACIDS

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Chinese Chemical Letters 1994年第7期5卷 549-550页

作者： Zheng Rong LU Chun Yuan TAO chum Yuan TAO Ren Xi ZHUO(Department of Chemistry, Wuhan University, Wuhan 430072)

S)-1-Ethoxysilatrane-4-carboxylic acid and (4S)-1-ethoxy-3-methylsiatrane-4-Carboxylic acid were synthesize from the reaction of triethoxysilane with L-n,n-bis(2-hydroxyethyl)serine of L-n, n-bis (2-hydroxyethyl) thre...

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WOnCA研究论文摘要汇编——全科医生对晚期慢性肾脏疾病管理的看法:一项定性研究

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中国全科医学 2015年第30期18卷 3652-3652页

作者： chum Wah Michael Tam Louis Hion-Lam Leong Zwar n

背景英国国家健康与临床卓越研究所发布相关指南,慢性肾脏疾病管理已经成为全科医生工作的一个重要组成部分。慢性肾脏疾病(G4阶段和G5阶段)患者通常患有并发症,疾病进展各异,患者年龄一般较大。全科医生对晚期慢性肾脏疾病患者的管理... 详细信息

背景英国国家健康与临床卓越研究所发布相关指南,慢性肾脏疾病管理已经成为全科医生工作的一个重要组成部分。慢性肾脏疾病(G4阶段和G5阶段)患者通常患有并发症,疾病进展各异,患者年龄一般较大。全科医生对晚期慢性肾脏疾病患者的管理决策问题较大,例如何时将患者转诊到肾脏科。目的探讨全科医生对晚期慢性肾脏疾病患者管理和二次护理转诊的看法。设计和场所在英国4个地区进行定性研究,包括伦敦、布里斯托尔、伯明翰和斯蒂夫尼奇。方法对19名全科医生进行半结构式访谈。对转录采访进行主题方面的分析。结果全科医生对晚期慢性肾脏疾病患者管理和指导的经验较少,包括对正在接受血液分析和保守治疗(无血液分析或移植)的患者。一些全科医生仅根据患者的肾功能和一些更宽泛的标准进行患者转诊,比如年龄和多重病症。全科医生发现国家指南和地区建议不符,某些全科医生从患者出院回归初级医疗的案例中总结经验。如果患者未出现其他问题,或者患者无意进行血液分析,那么慢性肾脏疾病管理经验较丰富的全科医生会较晚进行患者转诊或者不对患者进行转诊。结论全科医生需要年长晚期慢性肾脏疾病患者和其并发症管理指导,需要对地区和国家的转诊标准进行统一。全科医生一般对肾脏科病房的常规护理项目认识不足。然而,全科医生乐于进行此类护理,或者主导肾脏科治疗团队进行常规管理。

关键词：慢性肾脏疾病 WOnCA 定性研究血液分析半结构式访谈肾脏科国家健康患者管理护理项目重病症

WOnCA研究论文摘要汇编——全科医生问诊环境和乙醇询问可接受性——一项调查性试验

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中国全科医学 2015年第30期18卷 3652-3652页

作者： chum Wah Michael Tam Louis Hion-Lam Leong Zwar n

背景全科医生在察觉患者风险饮酒方面起到重要作用。然而,全科医生对问诊环境如何影响患者询问可接受性知之甚少。方法将悉尼某家社区全科诊所在2014年5月的1个星期内来访的成年患者随机分为两组,每组通过邮寄方式,各完成一份调查问卷... 详细信息

背景全科医生在察觉患者风险饮酒方面起到重要作用。然而,全科医生对问诊环境如何影响患者询问可接受性知之甚少。方法将悉尼某家社区全科诊所在2014年5月的1个星期内来访的成年患者随机分为两组,每组通过邮寄方式,各完成一份调查问卷。选取该全科诊所20个问询片段,调查对象对这些片段的乙醇询问可接受性进行评分,形式为SnAP(吸烟、营养、乙醇、身体活动)框架(干预)问询或者单独(控制)进行乙醇问询。结果共有441例患者收到调查问卷,收回144份。与控制组相比,干预组可接受问询片段多出2.10个〔95%CI(0.38,3.70),P=0.016〕。各问询片段可接受性差异较大。讨论患者更易接受SnAP框架下的乙醇使用评估,尤其是在某个特定的话题(例如糖尿病管理)中。

关键词：全科医生患者 WOnCA 可接受性乙醇酒醇一元醇

Carcinoid tumor of the common bile duct: A rare complication of von Hippel-Lindau syndrome

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World Journal of Gastroenterology 2008年第8期14卷 1299-1301页

作者： Otmane nafidi Bich n nguyen André Roy Department of Surgery Saint-Luc Hospital CHUM Montréal Québec H2X 3J4 Canada Department of Pathology Saint-Luc Hospital CHUM Montréal Québec H2X 3J4 Canada Department of Surgery Saint-Luc Hospital CHUM 1058 Saint-Denis Street Montréal Québec H2X 3J4 Canada

Von HippeI-Lindau syndrome （VHL） is a rare autosomal-dominant, inherited familial cancer syndrome. Hemangioblastomas, pheochromocytomas and renal carcinoma are the frequent reported VHL tumors. neuroendocrine tumors have also been described, mostly in the pancreas and rarely in the biliary trees. We report the second case of bile duct carcinoid in a 31-year-old VHL woman. She underwent right adrenalectomy for a pheochromocytoma in the past. She also had a positive family history of phenotypic expression of VHL syndrome. The patient presented with biliary colic. Endoscopic retrograde cholangio-pancreatography showed intraluminal bile duct mass. Surgical exploration identified a beige nodular lesion that was a carcinoid tumor on histology. This new association should be clarified by further genetic investigations.

关键词： Carcinoid tumor Bile duct tumor von Hippel-Lindau syndrome

GEnOME SEQUEnCE,FUnCTIOnAL GEnOMICS AnD GEnETIC LInKAGE AnALYSIS OF SHIITAKE MUSHROOM LEnTInULA EDODES

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GENOME SEQUENCE,FUNCTIONAL GENOMICS AND GENETIC LINKAGE ANAL...

Systematic review of colorectal cancer screening guidelines for average-risk adults: Summarizing the current global recommendations

海峡两岸第十届菌物学暨第三届食药用菌学术研讨会

作者： KWAnH.S. AUC.H. WOnG M.C. KWOK I.S.W. chum W.W.Y. YIP P.Y. WOnG K.S. School of Life Sciences and Food Research Centre The Chinese University of Hong Kong The Chinese University of Hong Kong ShatinN.THong Kong SARPRC

＜正＞Lentinula edodes（Shiitake/Xianggu） is a popular cultivated mushroom *** the genomics and functional genomics of *** is essential to improve its cultivation and *** sequencing of *** provides numerous molecular genetic markers for breeding and genetic *** sequenced the genome of *** monokaryon L54A using Roche 454 and ABI *** reads of about 1011 Mb were de novo assembled into a 39.8 Mb *** compiled the genome sequences into a searchable database with which we have been annotating the genes and analyzing the metabolic *** 13,000 gene models were predicted from the genome *** gene models were annotated by BLASTX and categorized according to Gene Ontology（GO） and Kyoto Encyclopedia of Genes and Genomes（KEGG）.For functional genomics,we have been using many molecular techniques including SAGE and massive cDnA sequencing to analyze genes differentially expressed during *** a mapping population of haploid basidiospores of dikaryon L54,we constructed a high-density genetic linkage map with their high-quality genetic variations including single nucleotide polymorphisms, insertions,and *** Shiitake community will benefit from these resources for genetic studies and breeding.

关键词： Shiitake Mushroom genome sequence transcriptome fruiting body development

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World Journal of Gastroenterology 2018年第1期24卷 124-138页

作者： Florence Bénard Alan n Barkun Myriam Martel Daniel von Renteln Department of Medicine University of Montreal (UdeM )and University of Montreal Hospital Research Center (CRCHUM) Division of Gastroenterology McGill University Health Center McGill University Department of Medicine Division of Gastroenterology University of Montreal Hospital (CHUM)University of Montreal Hospital Research Center (CRCHUM)

AIM To summarize and compare worldwide colorectal cancer(CRC) screening recommendations in order to identify similarities and *** A systematic literature search was performed using MEDLInE, EMBASE, Scopus, CEnTRAL and ISI Web of knowledge identifying all average-risk CRC screening guideline publications within the last ten years and/or position statements published in the last 2 years. In addition, a hand-search of the webpages of national Gastroenterology Society websites, the national Guideline Clearinghouse, the BMJ Clinical Evidence website,Google and Google Scholar was performed. RESULTS Fifteen guidelines were identified. Six guidelines were published in north America, four in Europe, four in Asia and one from the World Gastroenterology Organization. The majority of guidelines recommend screening average-risk individuals between ages 50 and 75 using colonoscopy(every 10 years), or flexible sigmoidoscopy(FS, every 5 years) or fecal occult blood test(FOBT, mainly the Fecal Immunochemical Test, annually or biennially). Disparities throughout the different guidelines are found relating to the use of colonoscopy, rank order between test, screening intervals and optimal age ranges for screening. COnCLUSIOn Average risk individuals between 50 and 75 years should undergo CRC screening. Recommendations for optimal surveillance intervals, preferred tests/test cascade as well as the optimal timing when to start and stop screening differ regionally and should be considered for clinical decision making. Furthermore, local resource availability and patient preferences are important to increase CRC screening uptake, as any screening is better than none.

关键词： Guidelines Systematic review fecal occult blood test Fecal immunochemical test Colonoscopy Colorectal cancer Screening Flexible sigmoidoscopy

Protective effect of n-Acetylcysteine on exogenous hydrogen peroxide and endogenous superoxide anion induced DnA strand breakage in human spermatozoa

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Asian Journal of Andrology 2001年第4期 310-310页

作者： De-Xiang XU Han-Min SHEn chum.nam WOnG Department of Toxicology,Anhui Medical University,Hefei 230032,China Department of Commnity,Occupational and Family Medicine,Singapore national University,119260 Singapore

Aim: To study the protective effect of n-Acetylcysteine (nAC)on exogenous hydrogen peroxide- and endogenous superoxide an-ion-induced DnA strand breakage in human spermatozoa in vitro.

关键词： n-acetylsteine spermatozoa DnA hydrogen peroxide superoxide anion single-cell-gel-electrophoresis

华法林抗凝治疗慢性阻塞性肺疾病急性加重期患者的可行性及安全性观察

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海南医学 2018年第6期29卷 760-762页

作者：文倩陈春玲杨淑群广州市白云区人民医院内一科广东广州510500

目的观察慢性阻塞性肺疾病急性加重期(AECOPD)患者应用华法林抗凝治疗的可行性及安全性。方法前瞻性按纳入标准选择2016年1~12月广州市白云区人民医院内科AECOPD患者200例,采用隐匿数字随机法分为对照组和观察组各100例,对照组入院后给... 详细信息

目的观察慢性阻塞性肺疾病急性加重期(AECOPD)患者应用华法林抗凝治疗的可行性及安全性。方法前瞻性按纳入标准选择2016年1~12月广州市白云区人民医院内科AECOPD患者200例,采用隐匿数字随机法分为对照组和观察组各100例,对照组入院后给予常规治疗至病情缓解出院,观察组患者除给予常规治疗外,另给予华法林治疗3个月,入院时、治疗4周后检测肺功能、血气分析和D-二聚体,记录住院时间。所有患者均随访至2017年9月,比较两组患者的出血情况、死亡率及再次平均入院天数。结果观察组患者治疗后第1秒用力呼气容积(FEV1)、第1秒用力呼气容积占用力肺活量比值(FEV1/FVC)分别为(1.19±0.32)L、(56.83±10.96)%,明显高于对照组的(1.04±0.29)L、(51.14±10.42)%,且明显高于治疗前的(0.94±0.28)L、(46.87±8.93)%,D-二聚体水平、二氧化碳分压(PaCO_2)分别为(357.65±42.71)ng/mL、(55.43±4.76)mmHg,明显低于对照组的(536.42±74.19)ng/mL、(59.36±5.71)mmHg,且低于治疗前的(688.93±84.72)ng/mL、(65.97±7.91)mmHg,差异均有统计学意义(P0.05);观察组患者的平均再次住院时间为(8.27±2.46)d,明显短于对照组的(12.62±2.73)d,差异有统计学意义(P<0.05)。结论 AECOPD患者多存在血栓前状态,只要定期监测国际标准化比值,应用华法林治疗是可行且有效的。

关键词：慢性阻塞性肺疾病急性加重期华法林可行性安全性