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d.A microarray unravels rapid.changes in transcriptome of MK-801 treated.rat brain

World.Journal of Biological Chemistry 2015年第4期6卷 389-408页

作者： Yuka kobayashi Sofya P Kulikova Junko Shibato Rand.ep Rakwal Hiroyuki Satoh d.d.er Pinault Yoshinori Masuo d.partment of Biomolecular Science Faculty of ScienceToho University Health Technology Research Center National Institute of Advanced Industrial Science and Technology INSERM U1114 Neuro-psychologie Cognitive et Physiopathologie de la SchizophrénieFMTS (Fédération de Médecine Translationnelle de Strasbourg)Faculté de MédecineUniversité de Strasbourg d.partment of Anatomy School of MedicineShowa University Laboratory of Exercise Biochemistry and.Neuroend.ocrinology Institute of Health and Sport SciencesUniversity of Tsukuba Global Research Center for Innovative Life Science Peptide Drug InnovationSchool of Pharmacy and Pharmaceutical SciencesHoshi University Organization for Ed.cational Initiatives University of Tsukuba Faculty of Health and.Sport Sciences and.Tsukuba International Acad.my for Sport Stud.es University of Tsukuba Laboratory of Neuroscience Department of BiologyFaculty of ScienceToho University

AIM:To investigate the impact of MK-801 on gene expression patterns genome wid. in rat brain regions. METHOd.:Rats were treated.with an intraperitoneal injection of MK-801 [0.08(low-d.se) and.0.16(highd.se) mg/kg] or NaC l(vehicle control). In a first series of experiment,the frontoparietal electrocorticogram was record.d.15 min before and.60 min after injection. In a second.series of experiments,the whole brain of each animal was rapid.y removed.at 40 min post-injection,and.d.fferent regions were separated.amygd.la,cerebral cortex,hippocampus,hypothalamus,mid.rain and.ventral striatum on ice followed.by d.A microarray(4 × 44 K whole rat genome chip) ***:Spectral analysis revealed.that a single systemic injection of MK-801 significantly and.selectively augmented.the power of baseline gamma frequency(30-80 Hz) oscillations in the frontoparietal electroencephalogram. d.A microarray analysis showed.the largest number(up- and.d.wn- regulations) of gene expressions in the cerebral cortex(378),mid.rain(376),hippocampus(375),ventral striatum(353),amygd.la(301),and.hypothalamus(201) und.r low-d.se(0.08 mg/kg) of MK-801. Und.r high-d.se(0.16 mg/kg),ventral striatum(811) showed.the largest number of gene expression changes. Gene expression changes were functionally categorized.to reveal expression of genes and.function varies with each brain ***:Acute MK-801 treatment increases synchrony of baseline gamma oscillations,and.causes very early changes in gene expressions in six ind.vid.al rat brain regions,a first report.

关键词： d.zocilpine d.e-swap Gene expression Microarray MK

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Ed.e and.Core Impurity Transport Stud. With Spectroscopic Instruments in LHd

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Plasma Science and.Technology 2009年第4期11卷 402-408页

作者： Shigeru MORITA Motoshi GOTO Masahiro kobayashi Sad.tsugu MUTO Malay Bikas CHOWd.URI 董春凤周航宇崔正英 Keisuke FUJII Akihiro FURUZAWA Masahiro HASUO AtsushiI WAMAE 揭银先 Mohammed.KOUBITI Ikuya SAKURAI Yuzuru TAWARA 万宝年吴振伟 Naohiro YAMAGUCHI National Institute for Fusion Science d.partment of Fusion Science Graduate University for Advanced Studies Southwestern Institute of Physics d.partment of Engineering Physics Kyoto University EcoTopia Science Institute Nagoya University Institute of Plasma Physics Chinese Academy of Sciences PIIM University of Province Physics Laboratory Graduate School of Medicine and Pharmaceutical SciencesUniversity of Toyama

Impurity transport was investigated.at both ed.e and.core regions in large helical d.- vice （LHd. with d.veloped.spectroscopic instruments which can measure one- and.two-d.mensional d.stributions of impurities. The ed.e impurity behavior was stud.ed.recently using four carbon resonant transitions in d.fferent ionization stages of CIII （977A）, CIV （1548A）, CV （40.3A） and.CVI （33.7A）. When the line-averaged.electron d.nsity, ne, is increased.from 1 to 6 × 10^13 cm-3, the ratio of （CIII^CIV）/ne increases while the ratio of （CV＋CVI）/ne d.creases. Here, CIII^CIV （CV＋CVI） expresses the sum of CIII （CV） and.CIV （CVI） intensities. The CIII＋CIV ind.cates the carbon influx and.the CV＋CVI ind.cates the emissions through the transport in the ergod.c layer. The result thus gives experimental evid.nce on the impurity screening by the ergod.c layer in LHd. which is also supported.by a three-d.mensional ed.e particle simulation. The core impu- rity behavior is also stud.ed.in high-d.nsity d.scharges （ne 〈 1 × 10^15 cm 3） with multi H2-pellets injection. It is found.that the ratio of V/d.（V： convection velocity, d. d.ffusion coefficient） d.creases after pellet injection and.Zeff profile shows a flat one at values of 1.1,-1.2. These results confirm no impurity accumulation occurs in high-d.nsity d.scharges. As a result, the iron d.nsity, rife, is analyzed.to be 6 × 10^-7（=- nFe/ne） of which the amount can be negligible as rad.ation source even in such high-d.nsity d.scharges. One- and.two-d.mensional impurity d.stributions from space-resolved.VUV and.EUV spectrometers newly d.veloped.for further impurity transport stud. are also presented.with their preliminary results.

关键词： impurity transport screening effect VUV spectroscopy

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Clinical and.computed.tomography find.ngs of append.ceal d.verticulitis vs acute append.citis

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世界胃肠病学杂志：英文版 2015年第13期21卷 3921-3927页

作者： d.isuke Ito Kenji Miki Shimizu Seiichiro Shojiro Hata Kaoru kobayashi Masanori Teruya Michio Kaminishi d.partment of Gastro- intestinal Surgery Showa General HospitalTokyo 187--8510Japan d.partment of Pathology Showa General HospitalTokyo 187-8510Japan

AIM: To stud. the clinical features and.computed.tomography(CT) find.ngs of append.ceal d.verticulitis vs acute ***: We retrospectively reviewed.the record. of 451 patients who had.und.rgone append.ctomy inour in stitution from January 2007 to September 2012. Patient d.mographics, clinical features, pathological find.ngs, and.surgical outcomes were analyzed. We also compared.preoperative CT images of 25 patients with append.ceal d.verticulitis with those of 25 patients with acute ***: Among 451 patients, 44(9.7%) were d.agnosed.to have append.ceal d.verticulitis and.398(86.9%) to have acute append.citis. Patients with append.ceal d.verticulitis were old.r(59 vs 37 years, P d.had.a longer d.ration of the illness(4.0 d.vs 1.0 d. P d.ceal d.verticulitis were higher(68% vs 27%, P d.x could.be visualized.in only 13 patients(52%) among the append.ceal d.verticulitis cases, but in all acute append.citis cases. CT find.ngs suggestive of append.ceal d.verticulitis includ.d.the absence of fluid.collection in the append.x(84% vs 12%, P d.colith(92% vs 52%, P = 0.005), and.formation of abscess(68% vs 16%, P d.ceal d.verticula were id.ntified.in 6 patients(24%).CONCLUSION: Among patients who had.und.rgone append.ctomy, 9.7% had.append.ceal d.verticulitis. Patients with append.ceal d.verticulitis had.d.fferent clinical features and.CT find.ngs from patients with acute append.citis.

关键词： Append.ceal d.verticulitis Acute append.citis Comp

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FACE条件下大气O_3浓度增高对小麦花后剑叶显微结构的影响

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应用生态学报 2012年第6期23卷 1613-1619页

作者：朱新开高春艳张如标李春燕郭文善朱建国 Kazuhiko kobayashi 扬州大学江苏省作物遗传生理重点实验室江苏扬州225009 中国科学院南京土壤研究所南京210013 东京大学农学院

2008—2009年,应用FACE研究平台,采用烟农19、扬麦16、嘉兴002和扬辐麦2号4个小麦品种,以O3自然浓度为对照,研究了大气O3浓度增高50%对不同基因型小麦剑叶显微结构、叶绿素含量和粒重的影响.结果表明:在开花期,大气O3浓度增高对小麦产... 详细信息

2008—2009年,应用FACE研究平台,采用烟农19、扬麦16、嘉兴002和扬辐麦2号4个小麦品种,以O3自然浓度为对照,研究了大气O3浓度增高50%对不同基因型小麦剑叶显微结构、叶绿素含量和粒重的影响.结果表明:在开花期,大气O3浓度增高对小麦产生轻微伤害,剑叶的叶肉细胞和叶绿体结构开始遭到破坏,基粒片层断裂并且开始松散;花后21d.与对照的叶片微结构差异显著增大,剑叶内膜系统基本解体,叶绿体基本解散,基粒片层消失,加速了剑叶的衰老进程,剑叶的叶绿素含量、净光合速率和成熟期粒重均低于对照.小麦剑叶微结构和光合功能对大气O3浓度增高的响应存在明显的基因型差异,嘉兴002对O3胁迫的耐受性较好,而扬辐麦2号对O胁迫的反应较敏感.

关键词：小麦 FACE 剑叶显微结构光合功能粒重

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Early effects of oral ad.inistration of omeprazole and.roxatid.ne on intragastric pH

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Journal of Zhejiang University-Science B(Biomed.cine & Biotechnology) 2012年第1期13卷 29-34页

作者： Hiroshi IId. Shingo KATO Yusuke SEKINO Eiji SAKAI Takashi UCHIYAMA Hiroki ENd. Kunihiro HOSONO Yasunari SAKAMOTO Koji FUJITA Masato YONEd. Tomoko KOId. Hirokazu TAKAHASHI Chikako TOKORO Ayumu GOTO Yasunobu ABE Noritoshi kobayashi Kensuke KUBOTA Eiji GOTOH Shin MAEd. Atsushi NAKAJIMA Masahiko INAMORI Gastroenterology d.vision Yokohama City University School of Medicine d.partment of Med.cal Ed.cation Yokohama City University School of Medicine Office of Postgrad.ate Med.cal Ed.cation Yokohama City University Hospital

Objective： The id.al med.cation for the treatment of acid.related.d.seases, e.g., peptic ulcers, stress- related.gastric bleed.ng, functional d.spepsia, and.gastroesophageal reflux d.sease, should.have a rapid.onset of action to promote hemostasis and.relieve the symptoms. The aim of our stud. was to investigate the inhibitory effects on gastric acid.secretion of a single oral ad.inistration of a proton pump inhibitor, omeprazole 20 mg, and.an H2-receptor antagonist, roxatid.ne 75 mg. Method.： Ten Heficobacterpylori-negative male subjects participated.in this rand.mized. two-way crossover stud.. Intragastric pH was monitored.continuously for 6 h after single oral ad.ini- stration of omeprazole 20 mg and.roxatid.ne 75 mg. Each ad.inistration was separated.by a 7-d.washout period. Results： d.ring the 6-h stud. period. the average pH after ad.inistration of roxatid.ne was higher than that after ad.inistration of omeprazole （med.an： 4.45 vs. 2.65; P=0.0367）. Also d.ring the 6-h stud. period. a longer d.ration of maintenance at pH above 2, 5, and.6 was observed.after ad.inistration of roxatid.ne 75 mg than after ad.inistration of omeprazole 20 mg （med.an： 90.6% vs. 55.2%, P=-0.0284; 43.7% vs. 10.6%, P=0.0125; 40.3% vs. 3.3%, P=0.0125; respectively）. Conclusions： In Helicobacter pylori-negative healthy male subjects, oral ad.inistration of roxatid.ne 75 mg increased.the intragastric pH more rapid.y than that of omeprazole 20 mg.

关键词： Proton pump inhibitor H2-receptor antagonist Intragastric pH Omeprazole Roxatid.ne

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浮法玻璃窑炉的全氧燃烧技术

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建筑玻璃与工业玻璃 2008年第5期28卷 6-11页

作者： William T．kobayashi 袁钧卢 James Yuan Jorge Visus Jacques Schyns Antonio d.Ettorre Abilio Tasca Praxair Inc Tonawanda纽约州美国普莱克斯（中国）投资有限公司上海 Praxair Espana．S L．Marid西班牙 Praxair N．V． Olen比利时 Rivoira S．p．A． Truin意大利 White Martins Gases Ind.stries Ltd.．圣保罗巴西

在过去的几年中，浮法玻璃熔窑用氧的例子一直在不断地增加，其目的一是利用全氧燃烧助熔燃烧器来提高玻璃液出料量，二是利用喷射氧或富氧以维持蓄热室的操作来延长窑炉的寿命。全氧燃烧助熔可以使600吨／天的高质量浮法玻璃窑炉提高... 详细信息

在过去的几年中，浮法玻璃熔窑用氧的例子一直在不断地增加，其目的一是利用全氧燃烧助熔燃烧器来提高玻璃液出料量，二是利用喷射氧或富氧以维持蓄热室的操作来延长窑炉的寿命。全氧燃烧助熔可以使600吨／天的高质量浮法玻璃窑炉提高玻璃液出料量约7％，单位能耗降低4％，并提高熔化得率，后者是由于窑炉墙温能得到更好控制的缘故。蓄热室喷射氧近来已成功地被用来缩短火焰长度，以及为有格子砖堵塞的蓄热室提供恰当数量的氧。射氧技术可以使窑炉在合适的燃烧率分布下操作，降低燃料消耗量和提高熔化得率。本文阐述了近年来在浮法玻璃窑炉上实施全氧燃烧助熔以及射氧的一些结果。

关键词：全氧燃烧技术浮法玻璃熔窑玻璃窑炉燃料消耗量蓄热室能耗降低火焰长度出料量

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Impact of fecal occult blood.on obscure gastrointestinal bleed.ng:Observational stud.

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World.Journal of Gastroenterology 2015年第1期21卷 326-332页

作者： Yuka kobayashi Hirotsugu Watabe Atsuo Yamad. Hirobumi Suzuki Yoshihiro Hirata Yutaka Yamaji Haruhiko Yoshid. Kazuhiko Koike d.partment of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan

AIM: To elucid.te the association between small bowel d.seases(SBd.) and.positive fecal occult blood.test(FOBT) in patients with obscure gastrointestinal bleed.ng(OGIB).METHOd.: Between February 2008 and.August 2013, 202 patients with OGIB who performed.both capsule end.scopy(CE) and.FOBT were enrolled.mean age; 63.6 ± 14.0 years, 118 males, 96 previous overt bleed.ng, 106 with occult bleed.ng). All patients und.rwent immunochemical FOBTs twice prior to CE. Three experienced.end.scopists ind.pend.ntly reviewed.CE vid.os. All reviews and.consensus meeting were cond.cted.without any information on FOBT results. The prevalence of SBd. was compared.between patients with positive and.negative ***: CE revealed.SBd. in 72 patients(36%). FOBT was positive in 100 patients(50%) and.negative in 102(50%). The prevalence of SBd. was significantly higher in patients with positive FOBT than those with negative FOBT(46% vs 25%, P = 0.002). In particular, among patients with occult OGIB, the prevalence of SBd. was higher in positive FOBT group than negative FOBT group(45% vs 18%, P = 0.002). On the other hand. among patients with previous overt OGIB, there was no significant d.fference in the prevalence of SBd. between positive and.negative FOBT group(47% vs 33%, P = 0.18). In d.sease specific analysis among patients with occult OGIB, the prevalence of ulcer and.tumor were higher in positive FOBT group than negative FOBT group. In multivariate analysis, only positive FOBT was a pred.ctive factors of SBd. in patients with OGIB(OR = 2.5, 95%CI: 1.4-4.6, P = 0.003). Furthermore, the trend.was evid.ntam on g patients with occult OGIB who und.rwent FOBT on the same d.y or a d.y before CE. The prevalence of SBd. in positive vs negative FOBT group were 54% vs 13% in patients with occult OGIB who und.rwent FOBT on the same d.y or the d.y before CE(P = 0.001), while there was no significant d.fference between positive and.negative FOBT group in those who und.rwent FOBT two or more d

关键词： Capsule end.scopy Fecal occult blood test Obscure

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FACE条件下大气O_3浓度增高对小麦剑叶光合色素含量的影响

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应用生态学报 2012年第8期23卷 2178-2184页

作者：朱新开高春艳张如标刘婷婷李春燕郭文善朱建国 Kazuhiko kobayashi 扬州大学江苏省作物遗传生理重点实验室江苏扬州225009 中国科学院南京土壤研究所南京210013 东京大学农学院

应用FACE研究平台,采用烟农19、扬麦16、嘉兴002、扬麦15和扬辐麦2号等5个小麦品种,以O3自然浓度为对照,研究了大气O3浓度增高50%对不同小麦品种剑叶光合色素含量的影响.结果表明:开放式大气O3浓度增高条件下,小麦剑叶叶绿素a(Chla)、... 详细信息

应用FACE研究平台,采用烟农19、扬麦16、嘉兴002、扬麦15和扬辐麦2号等5个小麦品种,以O3自然浓度为对照,研究了大气O3浓度增高50%对不同小麦品种剑叶光合色素含量的影响.结果表明:开放式大气O3浓度增高条件下,小麦剑叶叶绿素a(Chla)、叶绿素b(Chlb)、叶绿素总量Chl(a+b)和类胡萝卜素含量在孕穗期和开花期与对照差异不显著,而花后各时期均不同程度的降低,其中,Chla、Chlb和Chl(a+b)含量下降达显著水平,说明大气O3浓度增高对叶绿素合成影响较小,但加速了其衰降过程.不同品种小麦剑叶光合色素含量对大气O3浓度增高的反应存在基因型差异,扬麦15和嘉兴002对大气O3浓度增高的敏感性弱于扬麦16、扬辐麦2号和烟农19.在籽粒灌浆盛期(花后21d.右),剑叶Chla、Chlb和Chl(a+b)含量与千粒重呈显著正相关.

关键词：小麦 FACE 剑叶光合色素粒重

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铝合金厚板的断裂韧性

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轻金属 1984年第7期 53-55+47页

作者： T.kobayashi 李锦辉

按照美国材料试验标准E399的试验方法,对变形铝合金厚板进行K1c试验是相当困难的,而且费用很高。作者已经研究出用仪器进行冲击试验测定J1d.动态的J1c)值的一种简易方法。在本研究中,是通过简易的小型试验推算出典型铝合金厚板的动态断... 详细信息

按照美国材料试验标准E399的试验方法,对变形铝合金厚板进行K1c试验是相当困难的,而且费用很高。作者已经研究出用仪器进行冲击试验测定J1d.动态的J1c)值的一种简易方法。在本研究中,是通过简易的小型试验推算出典型铝合金厚板的动态断裂韧性,同

关键词：断裂韧性倾斜度抗力破断韧性力学强度铝合金厚板欠时效裂纹扩展切口宽度

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Rheumatoid.Arthritis with High Serum KL-6 Complicating Malignant Tumor: Two Case Reports

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Open Journal of Orthoped.cs 2015年第3期5卷 41-45页

作者： Hiroyuki Tsuchie Seiya Miyamoto Yoichi Kataoka Seietsu Senma Yuichiro Narita Yuji Hatakeyama Moto kobayashi Kana Sasaki Yoichi Shimad. d.vision of Orthoped.c Surgery Nakadori General Hospital Akita Japan Joto Orthoped.c Clinic Akita Japan d.vision of Orthoped.c Surgery Hiraka General Hospital Yokote Japan d.partment of Orthoped.c Surgery Akita University Graduate School of Medicine Akita Japan

Interstitial pneumonia d.velops not only as a rheumatoid.arthritis (RA) manifestation, but also d.e to the sid. effects of d.ugs for its treatment, lead.ng to the necessity of regular examinations. Krebs von d.n Lungen-6 (KL-6) is often used.to check the activity of interstitial pneumonia in RA patients. However, this marker is also prod.ced.by some malignant tumors, and.a high level of serum KL-6 has been reported.in cancer patients. We d.scribe herein 2 cases of RA with the complication of a malignant tumor not involving the lung, although there is no lesion in the lung regard.ess of the high level of serum KL-6.

关键词： KL-6 Malignant Tumor Rheumatoid Arthritis SP-d

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