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β-1,4甘露二糖对肉仔鸡生长的影响

饲料博览 2013年第10期23卷 36-36页

作者： Masahisa I Yu Y Hiroki Y Kazuhisa H kensuke F Hiroko Y Shin H Hiroshi K

试验研究β-1,4-甘露二糖(MNB)对肉仔鸡体重、胸肌、腿肌、肝脏和腹脂重量的影响,评价MNB能否作为肉仔鸡的饲料添加剂。选择8日龄的肉仔鸡(雄性)24只随机分到两个笼中,分别饲喂基础饲粮或含有0.01%MNB的饲粮,试验共进行14 d。MNB饲粮显... 详细信息

试验研究β-1,4-甘露二糖(MNB)对肉仔鸡体重、胸肌、腿肌、肝脏和腹脂重量的影响,评价MNB能否作为肉仔鸡的饲料添加剂。选择8日龄的肉仔鸡(雄性)24只随机分到两个笼中,分别饲喂基础饲粮或含有0.01%MNB的饲粮,试验共进行14 d。MNB饲粮显著增加了胸肌相对重(P<0.05),但对体重、腿肌、肝脏、腹脂的重量没有影响。MNB显著抑制胸肌肌肉生长抑制素mRNA的表达(P<0.05)。肌肉生长抑制素对成肌细胞的增殖和分化具有负反馈作用,MNB可能减少胸肌肌肉生长抑制素基因的表达。血浆中3-甲基组氨酸的水平是公认的一个肌原纤维蛋白质分解代谢的氨基酸指标,并且MNB饲料对参与蛋白质分解代谢的肌萎缩蛋白质mRNA的表达无影响。此外,MNB对胸肌中蛋白酶mRNA的表达无影响。研究结果表明,MNB对蛋白质水解无影响。因此,MNB是一种可提高肉鸡产肉量的饲料添加剂。

关键词：肉仔鸡二糖生长基础饲粮饲料添加剂 β-1 试验体重

Age is an independent adverse prognostic factor for overall survival in acute myeloid leukemia in Japan

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World Journal of Hematology 2014年第3期3卷 105-114页

作者： Hiroaki Ohnishi Osamu Imataki Yasunori Kawachi Makoto Ide Kimihiro Kawakami Masato Waki Hidetaka Takimoto Yasuo Hoshijima Tetsuya Fukumoto kensuke Matsumoto Fusako Waki Akihito Matsuoka Takamichi Shintani Makiko Uemura Shigeyuki Yokokura Teruhisa Taoka Takuya Matsunaga Department of Internal Medicine Division of En-docrinology and MetabolismHematologyRheumatology and Respiratory MedicineFaculty of MedicineKagawa University Department of Internal Medicine Division of HematologyTakamatsu Red Cross Hospital Department of Internal Medicine Division of HematologyKagawa Prefectural Central Hospital Department of Internal Medicine Division of HematologyKagawa Rosai Hospital Department of Internal Medicine Division of HematologyTakamatsu Municipal Hospital Department of Internal Medicine Division of HematologySakaide City Hospital

AIM: To elucidate risk factors for survival of elderly acute myeloid leukemia(AML) patients in a real-world practice by observational study. METHODS: We conducted a population-based study in 213 adult and elderly AML patients(127 males and 86 females) in Kagawa Prefecture, Japan. To construct this cohort, we gathered all data for patients diagnosed with AML at 7 hospitals in Kagawa between 2006 and 2010. The primary end point was overall survival(OS) after AML diagnosis. Unadjusted Kaplan-Meier survival plots were used to determine OS in the overall cohort. Multivariate analysis was used to determine the independent adverse prognostic factors for OS, with the covariates of interest including age, gender, race/ethnicity, CCI, education, median income, metropolitan statistical area size and history of myelodysplastic ***: The average population of Kagawa during the study period was 992489, and the incidence of AML was 4.26 per 100000 person-years. A total of 197 patients with non-acute promyelocytic leukemia(non-APL)(119 males and 78 females) were also included. The median age of non-APL patients was 70 years(average 67, range 24-95). The 5-year OS rate was 21.1%. Subsequent analysis by age group showed that the survival rate declined with age; the 5-year OS rates of non-APL patients younger than 64 years, 65-74 years, and older than 75 years were 41.5%, 14.1%, and 8.9%, respectively. Multivariate analysis revealed that unfavorable risk karyotype, older age, poor performance status(PS)(3-4), lack of induction chemotherapy, and antecedent haematological disease were independent prognostic predictors. In the subgroup analysis, we also found that older patients with non-APL had lower complete remission rates and higher early death rates than younger patients, irrespective of PS. However, intensive chemotherapy was a significant predictor for longer survival not only in the patients < 75 years of age, but also in those over 75 with PS 0-2. CONCLUSION: Age wou

关键词： Acute myeloid leukemia Elderly Adverse prognostic factor Overall survival Population-based study

用双靶对接方法产生高强度7.9nm类镍钕X射线激光

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中国激光 1999年第4期26卷 299-302页

作者：王世绩顾援林尊琪黄关龙唐华泾张国平加藤义章大道博行今仁武臣濑崎秀平广濑真吾村井健介高功率激光物理国家实验室中国科学院上海光机所上海201800 北京应用物理与计算数学研究所日本大阪大学激光工程研究所日本大阪工业技术研究所

采用双弯曲靶对接技术和多脉冲驱动,结合新型线聚焦系统,在大阪大学激光工程研究所的Gekko装置上进行了类镍钕软X射线激光实验,以相对较低的驱动能量,获得了高强度的7.9nm软X射线激光输出。

关键词：类镍钕软X射线激光双弯曲靶对接激光技术

利多卡因缓释片用于术后疼痛：从基础研究到临床试验

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实用疼痛学杂志 2016年第2期12卷 83-90页

作者：户部贤小杉谦介钤木敏之须藤贵史斋藤繁刘华琴赵艾华日本国群马大学病院集中治疗部群马大学大学院医学系研究科头口腔科学分野群马大学病院麻醉神经科学河北医科大学第四医院麻醉科石家庄市050011

引言日本现在主要的术后镇痛方式有静脉患者自控镇痛（ivPCA）和周围神经阻滞。鉴于ivPCA使用阿片受体激动剂有明显的副作用和单次区域阻滞作用时间有限，我们现已制成了利多卡因缓释片（SRLS），可以持续释放利多卡因达几日之久，并应... 详细信息

引言日本现在主要的术后镇痛方式有静脉患者自控镇痛（ivPCA）和周围神经阻滞。鉴于ivPCA使用阿片受体激动剂有明显的副作用和单次区域阻滞作用时间有限，我们现已制成了利多卡因缓释片（SRLS），可以持续释放利多卡因达几日之久，并应用大鼠模型和在志愿者身上证实了这种缓释片的有效性和安全性。目的评价利多卡因缓释片（SRLS）用于拔牙患者术后镇痛的有效性和安全性。方法我们设计的是单盲临床研究。研究对象为拟行拔牙术的患者，随机分为5组：常规治疗组、不含利多卡因片组和3个不同剂量SRLS组。同一名牙科医生拔出下颌阻生齿后，把SRLS置于缺损处。应用疼痛视觉模拟评分法（VAS）评价有效性，并观察镇痛药物的剂量和患者的满意度。结果我们计划入组100例患者，已经完成了80例。虽然无法显示最终的数据，但是未发现SRLS的副作用。结论我们10年前就开始进行单独使用利多卡因缓释片治疗术后疼痛的研究。现在这一方案已开始应用于患者。

关键词：利多卡因缓释片疼痛,手术后镇痛,患者控制动物实验临床试验