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SRT1720, a SIRT1 Activator, Aggravates Bleomycin-Induced Lung Injury in Mice

food and Nutrition Sciences 2012年第2期3卷 157-163页

作者： Shingo Imanishi Ryuji Hayashi Tomomi Ichikawa kensuke Suzuki Masakiyo Sasahara Takashi Kondo Hirofumi Ogawa Kazuyuki Tobe Department of Pathology Graduate School of Medicine and Pharmaceutical Sciences University of Toyama Toyama Japan Department of Radiological Sciences Graduate School of Medicine and Pharmaceutical Sciences University of Toyama Toyama Japan. first Department of Internal Medicine Graduate School of Medicine and Pharmaceutical Sciences University of Toyama Toyama Japan

Diagnosis and management of interstitial lung diseases (ILDs), caused by lung epithelial injury followed by apoptosis, are often challenging. It has been controversial whether the SIRT1 protein, a principal modulator of longevity due to caloric restriction, ameliorates or aggravates ILD in animal models. Here we examined the effect of SRT1720, a syn- thetic activator of SIRT1, on bleomycin-induced lung injury in a mouse model and apoptosis in cultured epithelial cells. Oral intubation of SRT1720 over a period of 15 days caused body weight loss and a high mortality rate among bleomy- cin-treated mice. Histological examinations showed that the SRT1720 load increased fibrosis in the bleomycin-treated lung. An analysis of bronchoalveolar lavage fluid revealed remarkably increased numbers of inflammatory cells in the SRT1720-treated group. Moreover, the apoptosis of A549 lung cancer cells, caused by X-ray irradiation and an anti-fas activating antibody, was promoted by SRT1720. These results indicate that SRT1720 not only aggravates bleomy- cin-induced ILD, but stimulates the apoptosis of physically and biologically stimulated A549 cells. While SIRT1 acti- vators are considered promising for the treatment of conditions such as diabetes mellitus, fatty liver, and chronic ob- structive pulmonary diseases, an excess of food containing SIRT1 activators may be harmful depending on the disease state, especially in the case of acute inflammation.

关键词： Interstitial Lung Diseases (ILDs) Lung Injury SIRT1 Bleomycin X-Ray Irradiation Oxidative Stress

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纳米析出铁素体和贝氏体低碳钢应力应变特性研究

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钢铁钒钛 2016年第5期37卷 118-132页

作者： Naoya Kamikawa kensuke Sato Goro Miyamoto Mitsuhiro Murayama Nobuaki Sekido Kaneaki Tsuzaki Tadashi furuhara 日本东北大学材料研究所日本宫城县仙台市980.8577 日本东北大学日本宫城县仙台市980.8577 美国弗吉尼亚理工大学材料科学与工程系美国弗吉尼亚州布莱克斯堡VA24061 日本国家材料科学研究院日本茨城果筑波市305-0047 日本九州大学机械工程科学系日本福冈市819-0395

系统研究了存在纳米尺寸碳化钒析出的铁素体和贝氏体相低碳钢的应力-应变行为。通过奥氏体/铁素体转变并结合相间析出制取组织为铁素体相的试样,通过奥氏体/贝氏体转变,随后进行时效制取贝氏体相试样。两种试样的应力-应变曲线具有几个... 详细信息

系统研究了存在纳米尺寸碳化钒析出的铁素体和贝氏体相低碳钢的应力-应变行为。通过奥氏体/铁素体转变并结合相间析出制取组织为铁素体相的试样,通过奥氏体/贝氏体转变,随后进行时效制取贝氏体相试样。两种试样的应力-应变曲线具有几个共同特征:高屈服应力、相对低的加工硬化特性以及足够高的伸长率。根据组织参数计算了溶质原子、晶界、位错和析出物对强度的贡献,并将计算结果与试验测定的应力结果进行对比。溶质原子和晶界强化贡献可以简单地相加,而位错和析出物对强度的贡献大小应表示为两者平方和的平方根。纳米尺寸碳化物在拉伸变形早期阶段可能充当位错增生源的作用,而在变形后期则加速位错湮灭。这种增加型动态回复可能造成铁素体相和贝氏体相这两种钢都具有相当高的伸长率。

关键词：低碳钢碳化钒纳米析出相间析出时效力学性能

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东亚世界的形成与中国皇权——以六朝时期为重点

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南京师大学报（社会科学版） 2010年第4期 70-78,85页

作者：葭森健介张宇日本德岛大学总合科学部空军雷达学院政教室

中国的汉与六朝时期,日本和朝鲜都开始接受汉字、儒教、礼制,与中国一道构成了东亚世界。一方面,中国皇帝为巩固国内统治,需要利用周边民族的朝贡来提高自身权威;另一方面,由于倭国在从分裂走向统一及统一后不断与朝鲜半岛政权合纵连横... 详细信息

中国的汉与六朝时期,日本和朝鲜都开始接受汉字、儒教、礼制,与中国一道构成了东亚世界。一方面,中国皇帝为巩固国内统治,需要利用周边民族的朝贡来提高自身权威;另一方面,由于倭国在从分裂走向统一及统一后不断与朝鲜半岛政权合纵连横的纷争中,为使自己处于优势位置,也有必要利用中国皇帝的权威。正是在这种利益关联的互动中,形成了以中国为中心的古代东亚的国际关系。此外,周边诸国为了提高自身的国际地位,也接受了中国的价值观,特别是基于礼的文化。

关键词：古代东亚汉文化倭国国际关系

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Selection of Hammering Sound Collection Devices for the Development of Total Hip Arthroplasty Support Systems

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Journal of Biomedical Science and Engineering 2022年第7期15卷 179-186页

作者： Rina Sakai Katsufumi Uchiyama Shun Nishizawa Tomomi Mizuhashi Takeaki Yamamoto Kazuhiro Yoshida kensuke fukushima Naonobu Takahira Masanobu Ujihira Department of Medical Engineering and Technology Kitasato University School of Allied Health Sciences Kanagawa Japan Kitasato University Graduate School of Medical Sciences Kanagawa Japan Department of Orthopedic Surgery Kitasato University School of Medicine Kanagawa Japan Department of Clinical Engineering St. Luke’s International Hospital Tokyo Japan Department of Orthopedic Surgery St. Marianna University School of Medicine Kanagawa Japan

In total hip arthroplasty, intraoperative femoral fractures can be avoided by analyzing the hammering sounds from the stem inserted into the femur. This procedure is based on a hammering test that makes use of the fact that sound depends on the stability of the object. This technique is generally used in engineering. A system designed to avoid excessive stem hammering by predicting the intraoperative fracture risk based on this technique and software for real-time spectra analysis has been developed with repetitive improvements. The remaining technical challenge lies in selecting an appropriate sound collection device and building a compact and easy unit for use. This study reviewed the types of directional microphones suitable for the sound collection system to develop a practical THA support system. four types of microphones based on selected methods were used to collect and compare the peak frequencies of the hammering sounds and make comparisons between them, and the built system was used to conduct clinical trials. for miniaturization and operational ease of the unit, plug-in unidirectional microphones are appropriate. However, no laboratory-level data has been collected, and thus, further data accumulation is necessary.

关键词： Intraoperative fractures Total Hip Arthroplasty Hammering Sound fourier Analysis Peak frequency

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Influence of Alloy Elements on the Osteoconductivity of Anodized Ti-29Nb-13Ta-4.6Zr Alloy

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Journal of Biomaterials and Nanobiotechnology 2013年第3期4卷 229-236页

作者： Dai Yamamoto Atsushi Waki kensuke Kuroda Ryoichi Ichino Masazumi Okido Masato Ueda Masahiko Ikeda Mitsuo Niinomi Azusa Seki Department of Materials Science & Engineering Graduate School of Engineering Nagoya University Nagoya Japan EcoTopia Science Institute Nagoya University Nagoya Japan faculty of Chemistry Materials and Bioengineering Kansai University Suita Japan Hamri Co. Ltd. Tokyo Japan Institute for Materials Research Tohoku University Sendai Japan

Anodizing is expected to be an effective method to improve the osteoconductivity of the Ti-29Nb-13Ta-4.6Zr (TNTZ) alloy because the bioactivity of anodized Ti is good. However, it is not known how the alloy elements influence the surface roughness, composition, hydrophilicity, and osteoconductivity of the anodized film on the Ti alloy. In this study, we investigated the effects of anodizing on the surface properties and the osteoconductivity of the anodized TNTZ alloy, focusing on the functions of the individual alloy elements. The anodized oxides of the Nb, Ta, and Zr metals were hydrophobic at all the voltages applied, in contrast to the anodized oxide of Ti. As well as pure Ti, a TiO2-based oxide film formed on TNTZ after anodizing. However, the oxide film also contained large amounts of Nb species and the molar Nb/Ti ratio in the TNTZ alloy was high, which makes the surface more hydrophobic than the anodized oxide on Ti. In vivo tests showed that the osteoconductivity of the TNTZ alloy was sensitive to both its surface roughness and hydrophilicity. When the TNTZ alloy was anodized, the process increased either the surface hydrophobicity or the surface roughness at the voltage used in this study. These changes in the surface properties did not improve its osteoconductivity.

关键词： Ti-29Nb-13Ta-4.6Zr Anodizing Titanium Dioxide Alloy Element Hydrophilicity Osteoconductivity

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Early-diverging fungal phyla:taxonomy,species concept,ecology,distribution,anthropogenic impact,and novel phylogenetic proposals

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fungal Diversity 2021年第4期109卷 59-98页

作者： Kerstin Voigt Timothy Y.James Paul M.Kirk AndréL.C.M.de A.Santiago Bruce Waldman Gareth W.Griffith Minjie fu Renate Radek Jürgen f.H.Strassert Christian Wurzbacher Gustavo Henrique Jerônimo David R.Simmons kensuke Seto Eleni Gentekaki Vedprakash G.Hurdeal Kevin D.Hyde Thuong T.T.Nguyen Hyang Burm Lee Jena Microbial Resource Collection Leibniz Institute for Natural Product Research and Infection BiologyAdolf-Reichwein-Straße 2307745 JenaGermany Institute of Microbiology Faculty of Biological SciencesFriedrich Schiller University JenaNeugasse 2507743 JenaGermany Department of Ecology and Evolutionary Biology University of MichiganAnn ArborMI 48109USA Biodiversity Informatics and Spatial Analysis Jodrell LaboratoryRoyal Botanic Gardens KewSurrey TW93DSUK Department of Mycology Federal University of PernambucoAv.Da Engenharias/nRecifePE 50740-4600Brazil School of Biological Sciences Seoul National UniversitySeoul 08826South Korea Department of Integrative Biology Oklahoma State UniversityStillwaterOK 74078USA Institute of Biological Environmentaland Rural Sciences(IBERS)Aberystwyth UniversityAberystwyth SY233DDWalesUK Institute of Biology/Zoology Evolutionary BiologyFreie Universität Berlin14195 BerlinGermany Leibniz Institute of freshwater Ecology and Inland fisheries Ecosystem Research12587 BerlinGermany Department of Civil Geo and Environmental EngineeringTechnical University of MunichGarchingGermany School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Center of Excellence in fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Environmental Microbiology Lab Department of Agricultural Biological ChemistryCollege of Agriculture&Life SciencesChonnam National UniversityGwangju 61186South Korea

The increasing number of new fungal species described from all over the world along with the use of genetics to define taxa,has dramatically changed the classification system of early-diverging fungi over the past several *** number of phyla established for non-Dikarya fungi has increased from 2 to ***,to date,both the classification and phylogeny of the basal fungi are still *** this article,we review the recent taxonomy of the basal fungi and re-evaluate the relationships among early-diverging lineages of fungal *** also provide information on the ecology and distribu-tion in Mucoromycota and highlight the impact of chytrids on amphibian *** concepts in Chytridiomycota,Aphelidiomycota,Rozellomycota,Neocallimastigomycota are discussed in this *** preserve the current application of the genus Nephridiophaga(Chytridiomycota:Nephridiophagales),a new type species,Nephridiophaga blattellae,is proposed.

关键词： Early-diverging fungi Evolution Nuclear large subunit(LSU/28S) Nuclear small subunit(SSU/18S) Molecular phylogeny

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Self-Reported Prevalence and Socio-Demographic Determinants of Multiple Parasitic Infection among Schooling Adolescents in Nigeria

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Advances in Infectious Diseases 2014年第1期4卷 8-17页

作者： Jephtha C. Nmor Judith Nmor Prosper Omah Nwaka H. Kehi kensuke Goto Junko Toyosawa Daisuke fujita Department of Animal and Environmental Biology Delta State University Abraka Nigeria Department of Eco-Epidemiology Institute of Tropical Medicine (NEKKEN) Nagasaki University Nagasaki Japan Department of Nutrition Sciences Siebold University Nagasaki Japan National Mental Support Center for School Crisis Osaka Kyoiku University Osaka Japan National Mental Support Center for School Crisis Osaka Kyoiku University Osaka Japan Department of Animal and Environmental Biology Delta State University Abraka Nigeria

Background: Despite the rising burden of parasitic infections among young schooling adolescents in sub-Saharan Africa, insufficient attention has been paid to school-health. This study examined the self-reported prevalence of major parasitic infections and its association with key socio-demographic factors among young schooling adolescents in Southern Nigeria. Methods: An interviewer-administered school-based survey of students attending schools in Southern Nigeria was conducted in 2013. The study sample involved 585 students (60.9% male, 39.2% female and overall mean age of 15 years). The outcome variable was the self-reported presence of parasitic infection suffered within the past twelve months. The exposure variables were socio-demographic characteristics: age, sex, geolocality, school ownership, parents’ level of education and occupation. Association between the number of parasitic infections and socio-demographic factors were examined, and multivariate logistic regression was used to determine socio-demographic factors predictive of the presence of parasitic infections. Results: The most prevalent parasitic diseases reported across the sample were malaria (46.9%) and helminthiasis (27.7%). Over a quarter (38.5%) had one infectious disease, while about half (40.3%) reported had more than two infectious diseases. In the study sample, the number of parasitic diseases differed significantly by sex (p = 0.0344), age (p = 0.0483), geolocality (p = 0.0001), school ownership (p = 0.0012) and parents’ occupation (p = 0.0199). Multivariate logistic regression analysis showed that attending private school was negatively associated with the presence of parasitic diseases (β = ?0.9129, p = 0.0022). Conclusion: The high prevalence of multiple parasitic infections among the study population is worrisome and should be considered as a school-health concern. Concerted efforts are highly needed to develop school-health intervention programs for addressing the high prevalence of

关键词： Parasitic Diseases Socio-Demographic factors Students Nigeria Africa

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DEVELOPMENT Of LIfE-CONTROLLABLE-SMART（ LCS） CONCRETE USING RECYCLED PET RESIN BLOCKS

DEVELOPMENT OF LIFE-CONTROLLABLE-SMART（ LCS） CONCRETE USIN...

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作者： Takayuki Kusaka Hironori Namiki Kei Urabe Hiromasa Takeno Yukio Tada Masaki Hojo Keiko Watanabe kensuke Okubo Department of Mechanical Engineering Ritsumeikan UniversityJapan Kyobashi Corporation Japan National Institute of Advanced Industrial Science and Technology Japan Department of Electrical and Electronics Engineering Kobe UniversityJapan Keikon Corporation Japan Department of Mechanical Engineering Kyoto UniversityJapan Department of Mechanical Engineering Ritsumeikan UniversityJapan Department of Mechanical Engineering Ritsumeikan UniversityJapan

＜正＞A functional concrete, named "Life-Controllable-Smart" concrete, has been developed on the basis of the composite technology. The material, which was a kind of composite materials consisting of concrete and recycled PET blocks, could be easily and safely broken on demand by irradiating 2. 45 GHz microwave. The breakability, heatability, flowability and strength of the LCS concrete were investigated to improve the total performance of the material. Numerical and experimental results showed that the LCS concrete could be broken by heating up to 50-90 K above the room temperature, when the volume fraction of PET blocks was controlled within a range of 2% -5 % , where the compressive strength was reduced by 10% -20 %. The casting flowability of the LCS concrete could be adequately controlled by mixing a cellulose ether type thickener. The microwave heatability of the PET blocks could be effectively improved by mixing carbon milled fibers. Moreover, the applicability of the LCS concrete to temporary constructions was studied.

关键词： Smart Materials Microwave Heating Composite Concrete, PET

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阴离子表面活性剂——月桂醇产品

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日用化学品科学 1987年第2期 11-17页

作者： kensuke Takei 梁志能汪皑

引言脂肪醇和AEO的硫酸化分别生成脂肪醇硫酸盐（AS）和脂肪醇醚硫酸盐（ES）(图1)。它们是典型的阴离子表面活性剂,其去污性能取决于烷基链长,氧化乙烯（EO）链长和阳离子的性质。 C12AS具有优良的起泡能力和生物降解性,已广泛用于洗... 详细信息

引言脂肪醇和AEO的硫酸化分别生成脂肪醇硫酸盐（AS）和脂肪醇醚硫酸盐（ES）(图1)。它们是典型的阴离子表面活性剂,其去污性能取决于烷基链长,氧化乙烯（EO）链长和阳离子的性质。 C12AS具有优良的起泡能力和生物降解性,已广泛用于洗涤剂或乳化剂。C12AS-Na去污性能优良,在家庭和工业已有应用。

关键词：十六烯 AEO 脂肪醇硫酸化反应反应速率常数反应速率系数月桂醇十二烷基苯阴离子表面活性剂

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流动柱电极电解法测定黄酮化合物的氧化电位(英文)

流动柱电极电解法测定黄酮化合物的氧化电位(英文)

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作者：杨滨 kensuke Arai fumiyo Kusu School of Pharmacy Tokyo University of Pharmacy and Life Science 1432-1 HorinouchiHachiojiTokyo 192-0392Japan

The first oxidation potentials of a series of structurally related flavonoids,mostly having hydroxyl substituents, were investigated by employing cyclic voltammetry and flow-through column *** flow-through column packed with carbon fibers was useful for determining the half-wave potenital(E) of the flavonoids and the number of electrons(n-value) transferred in the oxidation *** potentials of the flavonoids were shown to be strongly dependent on their *** important determinants for the ease of oxidation are:1) ortho-trihydroxyl group(pyrogallol group);2) ortho-dihydroxyl group(catechol group);3) the presence of a 2,3-double bond in conjugation with 4-oxo and 3-hydroxyl groups;and 4)another addition of a resonance-effective *** relaton between the E values of the first oxidation step obtained from the hydrodynamic voltammograms and the antioxidant data(IC) in biological systems obtained from references was examined to determine whether the E value was an indicator of the biological *** was found that more negative E values of flavonoids were usually associated with decreasing IC *** findings suggest that the electrochemical properties of the flavonoids contribute to their antioxidant activity,and thus the E values of flavonoids can be used as indices of their antioxidant activities in biological systems.

关键词： flavonoids first Oxidation Potential Column Electrode Antioxidant Activity

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