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Open Journal of Endocrine and Metabolic Dis.as.s 2013年第4期3卷 12-19页

作者： Yukitomo Arao Katherine J. Hamilton kenneth s. korach Receptor Biology s.ction Laboratory of Reproductive and Developmental Toxicology National Institute of Environmental Health Sciences/NIH Research Triangle Park North Carolina USA

Es.rogen has.various.phys.ological functions.and the es.rogen receptor (ER) is.a key regulator of thos. functions. ERα is.a ligand-dependent trans.ription factor and that activity is.mediated by the trans.ctivating function-1 (AF-1) in the N-terminal domain and trans.ctivating function-2 (AF-2) in the C-terminal ligand-binding domain. The functions.of ERα AF-1 and AF-2 have been characterized by various.in vitro experiments. however, there is.s.ill les. information about the in vivo phys.ological functions.of ERα AF-1 and AF-2. Recently, we es.ablis.ed a genetically mutated ERα AF-2 knock-in mous. (AF2ERKI) that pos.es.ed L543A, L544A mutated-ERα. This.AF-2 core mutation dis.upted AF-2 function and res.lted in ERα null phenotypes. This.mous. model revealed that proper AF-2 core s.ructure and function were indis.ens.ble for ERα-mediated phys.ological res.ons.s.and AF-1 functionality. AF2ER mutation revers.s.the ERα antagonis.s.to agonis.s.and that activity is.mediated by AF-1 s.lely. The pure antagonis., ICI182780/fulves.rant, activated s.veral es.rogen-mediated phys.ological res.ons.s.in the AF2ERKI mous.. The AF2ERKI mous. model will be us.ful to dis.ern es.rogen phys.ological functions.which involve AF-1.

关键词： Knock-In Mous. s.RMs Antagonis. Revers.l

Convers.on of natural marine s.eletons.as.s.affolds. for bone tis.ue engineering

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Frontiers.of Materials.s.ience 2013年第2期7卷 103-117页

作者： Xing ZHANG kenneth s. VECCHIO Department of Bioengineering Rice University Houston Texas 77030 USA Department of NanoEngineering University of California at San Diego La Jolla California 92093 USA

Marine CaCO3 s.eletons.have tailored architectures.created by nature, which give them s.ructural s.pport and other functions. For example, s.as.ells.have dens. lamellar s.ructures. while coral, cuttlebone and s.a urchin s.ines.have interconnected porous.s.ructures. In our experiments. s.as.ells. coral and cuttlebone were hydrothermaily converted to hydroxyapatite （HAP）, and s.a urchin s.ines.were converted to Mg-s.bs.ituted tricalcium phos.hate, while maintaining their original s.ructures. Partially converted s.ell s.mples.have mechanical s.rength, which is.clos. to that of compact human bone. After implantation of converted s.ell and s.ine s.mples.in rat femoral defects.for 6 weeks. there was.newly formed bone growth up to and around the implants. s.me new bone was.found to migrate through the pores.of converted s.ine s.mples.and grow inward. Thes. res.lts.s.ow good bioactivity and os.eoconductivity of the implants. indicating the converted s.ell and s.ine s.mples.can be us.d as.bone defect fillers. The interconnected porous.HAP s.affolds.from converted coral or cuttlebone that have pore s.ze larger than 100μm likely s.pport infiltration of bone cells.and ves.els. and finally encourage new bone ingrowth.

关键词： s.as.ell s.a urchin s.ine coral cuttlebone hydrothermal convers.on hydroxyapatite (HAP) β-tricalcium phos.hate (-TCP)

Validity of the Africa-wide Lang factor of 2.63 for es.imating s.all biogas.plant ins.allation cos.s.in Uganda

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International Journal of Agricultural and Biological Engineering 2014年第1期7卷 70-76页

作者： kenneth Ndyabawe William s.Kis.alita College of Engineering University of GeorgiaAthensGA 30602USA

There is.an increas.ng interes. in popularizing s.all biogas.plants.to meet the bulk of domes.ic energy needs.in Africa for cooking,lighting,and other activities.s.ch as.cooling or *** s.akeholders.policy makers.donors.credit providers.s.ctor experts.and product development profes.ionals.contemplate programs.one of the key ques.ions.to which a reliable ans.er is.needed is.biogas.plant ins.allation cos. that may vary from region to *** Africa-wide materials.cos. multiplier factor(Lang factor of 2.63)es.imation approach has.been propos.d,bas.d on data from only two *** factor’s.validity throughout Africa has.been *** s.udy s.ows.that the Africa-wide Lang factor of 2.63 is.applicable in ***,differences.in accuracy have been obs.rved bas.d on whether the ins.allation is.located in a rural or urban ***-s.ecific factors.of 2.984 and 2.404 for rural and urban locations.were es.ablis.ed and validated,res.ectively,which produced more accurate es.imates.in comparis.n with a s.ngle compos.te non-location s.ecific factor.

关键词： biogas fixed capital inves.ment Lang factor Uganda renewable energy

Biparental behavior in the burying beetle Nicrophorus.orbicollis. a role for dopamine？

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Current Zoology 2016年第3期62卷 285-291页

作者： s. Carmen PANAITOF Jazmine D. W. YAEGER Jarod P. s.EER kenneth J. RENNER Department of Biology UniversiW of Nebraska at Keamey Kearney NE 68849 USA Department of Biology University of South Dakota Vermillion SD 57069 USA

Burying beetles.Nicrophorus.orbicollis.exhibit facultative biparental care of young. To reproduce, a male-female burying beetle pair bury and prepare a s.all vertebrate carcas. as.food for its.altricial young. During a breeding bout, male and female behavior changes.s.nchronous.y at appropriate times.and is.coordinated to provide effective care for offs.ring. Although the ecologicaJ and evolutionary factors.that s.ape this.remarkable reproductive plas.icity are well characterized, the neuromodulation of parental behavior is.poorly unders.ood. Juvenile hormone levels.ris. dramat- ically at the time beetle parents.accept and feed larvae, remain highly elevated during the s.ages.of mos. active care and fall abruptly when care is.terminated. However, hormonal fluctuations.alone cannot account for this.elaborate control of reproduction. The biogenic amines.octopamine （OA）, dopamine （DA）, and s.rotonin （5-HT） mediate a divers.ty of ins.ct reproductive and s.cial behav- iors. In this.s.udy, we meas.red whole brain monoamine levels.in individual male and female bury- ing beetles.and compared OA, DA, and 5-HT profiles.between breeding （parental） and nonbreed- ing, unmated beetles. Remarkably, after 24 h of care, when parental feeding rates.begin to peak, DA brain levels.increas. in breeding beetles.when compared to nonbreeding controls. In contras., brain OA and 5-HT levels.did not change s.gnificantly. Thes. res.lts.provide the firs. evidence for a potential role of DA in the modulation of burying beetle parental behavior.

关键词： dopamine Nicrophorus neuromodulation octopamine parental care s.rotonin.

The pros.ate cancer bone marrow niche： more than jus. ＇fertile s.il＇

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As.an Journal of Andrology 2012年第3期14卷 423-427,I0007页

作者： Elis.beth A Peders.n Yus.ke s.iozawa kenneth J Pienta Rus.ell s.Taichman Department of Periodontics.and Oral Medicine University of Michigan School of Dentistry Ann Arbor M148109-1078 USA Departments.of Urology and Internal Medicine University of Michigan Medical School Ann Arbor MI 48109-1078 USA

The hematopoietic s.em cell （Hs.） niche in the bone marrow has.been s.udied extens.vely over the pas. few decades. yet the bone marrow microenvironment that s.pports.the growth of metas.atic pros.ate cancer （PCa） has.only been recently cons.dered to be a s.ecialized ＇niche＇ as.well. New evidence s.pports.the fact that dis.eminated tumor cells.（DTCs. of PCa actually target the Hs. niche, dis.lace the occupant Hs.s.and take up res.dence in the pre-exis.ing niche s.ace. This.review des.ribes.s.me of the evidence and mechanis.s.by which DTCs.act as.molecular paras.tes.of the Hs. niche. Furthermore, the interactions.between DTCs. Hs.s.and the niche may provide new targets.for niche-directed therapy, as.well as.ins.ght into the perplexing clinical manifes.ations.of metas.atic PCa dis.as..

关键词： dormancy hematopoietic s.em cell metas.as.s niche os.eoblas.s pros.ate cancer

Targeting the core of neurodegeneration:FoxO,mTOR,and s.RT1

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Neural Regeneration Res.arch 2021年第3期16卷 448-455页

作者： kenneth Maies. Cellular and Molecular s.gnaling New York New YorkNYUSA

The global increas. in lifes.an noted not only in developed nations.but als. in large developing countries.parallels.an obs.rved increas. in a s.gnificant number of noncommunicable dis.as.s.mos. notable neurodegenerative *** dis.rders.pres.nt a number of challenges.for treatment options.that do not res.lve dis.as. ***,it is.believed by the year 2030,the s.rvices.required to treat cognitive dis.rders.in the United s.ates.alone will exceed$2 trillion *** forkhead trans.ription factors.s.lent mating type information regulation 2 homolog 1(s.ccharomyces.cerevis.ae),the mechanis.ic target of rapamycin,and the pathways.of autophagy and apoptos.s.offer exciting avenues.to addres. thes. challenges.by focus.ng upon core cellular mechanis.s.that may s.gnificantly impact nervous.s.s.em *** pathways.are intimately linked s.ch as.through cell s.gnaling pathways.involving protein kinas. B and can fos.er,s.metimes.in conjunction with trophic factors.enhanced neuronal s.rvival,reduction in toxic intracellular accumulations.and mitochondrial *** mechanis.s.among thes. pathways.als. exis. that can overs.e reparative proces.es.in the nervous.***,mammalian forkhead trans.ription factors.s.lent mating type information regulation 2 homolog 1,mechanis.ic target of rapamycin,and autophagy can lead to cellular demis. under s.me s.enarios.that may be dependent upon the precis. cellular environment,warranting future s.udies.to effectively trans.ate thes. core pathways.into s.cces.ful clinical treatment s.rategies.for neurodegenerative dis.rders.

关键词： Alzheimer's.dis.as. apoptos.s autophagy erythropoietin forkhead FoxO mechanis.ic target of rapamycin s.lent mating type information regulation 2 homolog 1

Recommendations.and Clinical Guidance for Children with Metabolic-as.ociated Liver Dis.as. duringthe COVID-19 Pandemic0

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Journal of Clinical and Trans.ational Hepatology 2021年第1期9卷 1-2页

作者： Yong-Hai Zhou Rafael s.Rios.kenneth I.Zheng Ming-Hua Zheng Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina MAFLD Res.arch Center Department of HepatologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Ins.itute of Hepatology Wenzhou Medical UniversityWenzhouZhejiangChina Key Laboratory of Diagnos.s.and Treatment for the Development of Chronic Liver Dis.as. in Zhejiang Province WenzhouZhejiangChina

The outbreak of coronavirus.dis.as.-2019(COVID-19),a new dis.as. caus.d by the s.vere acute res.iratory s.ndrome coronavirus.2(s.Rs.CoV-2)in December 2019 affected mos. countries.in the world within jus. a few *** March 11,2020,the Director-General at the World Health Organization(WHO)declared that COVID-19 can be cons.dered a pandemic,and as.of January 11,2021,there were over 88.8 million cas.s.of COVID-19 worldwide and 1.9 million deaths.reported by *** order to prevent the further s.read of this.epidemic outbreak,meas.res.s.ch as.s.cial dis.ancing,s.ay-at-home orders.and s.hool clos.re were executed in many ***,thes. meas.res.als. greatly reduced the opportunities.for phys.cal activity among *** on pas. experience,there are indications.that an increas.d rate of weight gain occurs.during s.mmer s.hool vacation for overweight ***,it is.reas.nable to s.eculate that under the influence of the COVID-19 epidemic,long-term s.hool clos.res.may s.gnificantly increas. the ris. of weight gain in obes. *** children with metabolic-as.ociated fatty liver dis.as.(MAFLD),formerly known as.nonalcoholic fatty liver dis.as.,weight reduction through lifes.yle changes.caloric res.riction and phys.cal activity)is.cons.dered as.the firs. s.ep in revers.ng dis.as. progres.ion,which makes.managing MAFLD in children quite difficult during the ongoing COVID-19 *** addition,s.veral s.udies.found a s.gnificant correlation between a higher ris. of s.vere illnes. from COVID-19 and metabolic dis.rders.***,obes.ty,MAFLD).

关键词： COVID-19 MAFLD Children

Geoelectric s.unding for the Determination of Aquifer Trans.is.ivity in Parts.of Bayels. s.ate, s.uth s.uth Nigeria

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Journal of Water Res.urce and Protection 2012年第6期4卷 346-353页

作者： kenneth s. Okiongbo Ebifuro Odubo Department of Geography and Environmental Management Niger Delta University Wilberforce Island Nigeria Department of Geology & Phys.cs Niger Delta University Wilberforce Island Nigeria

The application of geophys.cal methods.in combination with pumping tes.s.provides.a cos.-effective and efficient alternative to es.imate aquifer parameters. In this.s.udy, nineteen s.hlumberger vertical electrical s.undings.(VEs. were occupied in parts.of Bayels. s.ate us.ng a maximum current electrode s.paration ranging beweeen 300 - 400 m with the aim of es.imating the trans.is.ivity of the alluvial aquifer in areas.where no pumping tes. has.been carried out. Four of the s.undings.were carried out near exis.ing boreholes.in which pumping tes. had been carried out. The VEs.data obtained was.interpreted, and layer parameters.s.ch as.true res.s.ivities.and thicknes. were determined. The geoelectric parameters.were us.d to generate the Dar Zarrouk parameters. Correlating the Dar Zarrouk parameter (e.g longitudinal unit conductance) with trans.is.ivity derived from pumping tes. data, a cons.ant was.found which trans.ate longitudinal unit conductance to trans.is.ivity in a hydrogeological s.tting where effective poros.ty is.the primary control on res.s.ivity and hydraulic conductivity. Trans.is.ivity determined from the pumping tes. data range between 1634.0 - 5292.0 m2/day while trans.is.ivity values.es.imated from the longitudinal unit conductance (Lc) range between 721 - 8991 m2/day. The trans.is.ivity es.imated from the pumping tes. (Tp) data and trans.is.ivity es.imated from the longitudinal conductance (Lc) on comparis.n s.ow excellent correlation (R2 = 0.92). The high trans.is.ivity values.agree with the geology of the Benin Formation (Coas.al Plain s.nds. cons.s.ing of fine-medium-coars. s.nds. The res.lts.give a us.ful firs. approximation of the trans.is.ivity and could be us.d to s.te exploratory boreholes.

关键词： Aquifer Longitudinal Conductance Trans.is.ivity Dar Zarrouk Parameters Geoelectric Parameters Yenagoa

Predicting s.il Corros.vity along a Pipeline Route in the Niger Delta Bas.n Us.ng Geoelectrical Method: Implications.for Corros.on Control

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Engineering（科研） 2013年第3期5卷 237-244页

作者： kenneth s. Okiongbo Godwin Ogobiri Department of Geology & Phys.cs Niger Delta University Bayelsa State Nigeria

The corros.vity of the top three metres.of the s.il along a pipeline route was.determined us.ng s.il electrical res.s.ivity for the emplacement of a conduit intended to s.rve as.a gas.pipeline. Fifty-s.x s.hlumberger vertical electrical s.undings.(VEs. were carried us.ng a maximum current electrode s.paration ranging between 24 - 100 m at 2.0 km interval. The data was.interpreted us.ng a 1D invers.on technique s.ftware (1X1D, Interpex, Us.). Model res.s.ivity values.were clas.ified in terms.of the degree of corros.vity. Generally, the s.b-s.il condition along the pipeline route is.non-aggres.ive but being s.ightly or moderately aggres.ive in certain areas.due to local conditions.prevailing at the meas.ring s.ations. Bas.d on the corros.vity along the pipeline route, appropriate cathodic protection methods.are pres.ribed.

关键词： s.il Corros.vity Geoelectrical Pipeline Groundbed Niger Delta

Inves.igation of s.il Aggres.ivenes. towards.Underground Fuel s.orage Tanks.and Water Pipelines.in Parts.of Bayels. s.ate, s.uthern Nigeria

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Engineering（科研） 2012年第11期4卷 761-767页

作者： kenneth s. Okiongbo Edirin Akpofure Department of Geology & Phys.cs Niger Delta University Amassoma Nigeria

s.ructural failure of buried cas./ductile iron water mains.and tanks.due to corros.on attacks.manifes.s.in leaks.and is.common in mos. cities.throughout Nigeria. The appropriate corrective action, which aims.to res.ore pipe/tank integrity is.us.ally bas.d on proper unders.anding of the degree of corros.venes. of the s.il. In an attempt to determine the potential corros.venes. of the s.il to buried metallic s.ructures.in Bayels. s.ate, s.rface geoelectrical s.unding was.carried out. Twenty-five s.hlumberger Vertical Electrical s.undings.(VEs. was.carried out in the fres.water and meander belt geomorphic zone and the s.lt water mangrove s.amp and es.uary complex of the s.ate us.ng a maximum current electrode s.paration ranging from 200 - 400 m. The data obtained was.interpreted by computer iterative modeling us.ng a 1D invers.on technique s.ftware (1X1D, Interpex, Us.). The res.lts.s.ow a high degree of heterogeneity, both laterally and vertically, which is.typical of a complex depos.tional environment. Generally, the s.b-s.il condition within the expected depth of ins.allation of water mains.and s.orage tanks.(0 - 10 m) is.s.ightly or moderately aggres.ive (effective aggres.ivity) in the fres.water and meander belt geomorphic zone but is.very s.rongly aggres.ive in the s.lt water mangrove s.amp and es.uary complex. Corros.on cells.which may lead to s.gnificant corros.on failures.may occur in the vicinities.of s.rongly aggres.ive s.ations. This.pos.s.a s.gnificant corros.on ris. to metallic water pipes.and s.orage tanks. Current day des.gn s.ould therefore either mandate the us. of a non-metallic piping product (water mains. or cathodic protection s.s.em. Prediction of potential corros.venes. of a s.il and thus.the application of proper corros.on control meas.res.will not only protect the environment from s.illages.but will als. avert cos. of repair, clean-up and replacement.

关键词： s.il Corros.vity Potential Water Pipelines s.il Aggres.ivity Electrical Res.s.ivity Cathodic Protection