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Distinguishing Single-Metal Nanoparticles with Subdiffraction Spatial Resolution Using Variable-Polarization Fourier Transform Nonlinear Optical Microscopy

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Chemical & Biomedical Imaging 2023年第1期1卷 91-98页

作者： Megan A.Steves kenneth l.knappenberger,jr Department of Chemistry The Pennsylvania State UniversityUniversity ParkPennsylvania 16802United States California Institute for Quantitative Biosciences University of CaliforniaBerkeleyBerkeleyCalifornia 94720United States

The development and use of interferometric variablepolarization Fourier transform nonlinear optical(vpFT-NlO)imaging to distinguish colloidal nanoparticles colocated within the optical diffraction limit is *** a collinear train of phase-stabilized pulse pairs with orthogonal electric ffeld vectors,the polarization of nonlinear excitation ffelds are controllably modulated between linear,circular,and various elliptical *** modulation is achieved by precise control over the time delay separating the orthogonal pulse pairs to within hundreds of *** resultant emission from gold nanorods is imaged to a 2D array detector and correlated to the excitation ffeld polarization and plasmon resonance frequency by Fourier *** nanorods with length-to-diameter aspect ratios of 2 support a longitudinal surface plasmon resonance at approximately 800 nm,which is resonant with the excitation fundamental carrier *** in the intrinsic linear and circular dichroism resulting from variation in their relative alignment with respect to the laboratory frame enable optical differentiation of nanorods separated within 50 nm,which is an approximate 5-fold improvement over the diffraction limit of the *** experimental results are supported by analytical *** addition to subdiffraction spatial resolution,the vpFT-NlO method intrinsically provides the polarization-and frequency-dependent resonance response of the nanoparticles�providing spectroscopic information content along with super-resolution imaging capabilities.

关键词： nonlinear optics polarization circular dichroism imaging Fourier transform spectroscopy plasmons super-resolution microscopy

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Elevated temperature intensity,timing,and duration of exposure affect soybean internode elongation,mainstem node number,and pod number per plant

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The Crop Journal 2018年第2期6卷 148-161页

作者： leon Hartwell Allen jr. lingxiao Zhang kenneth J.Boote Bernard A.Hauser U.S.Department of Agriculture-Agricultural Research Service GainesvilleFL 32608USA Department of Agronomy University of FloridaGainesvilleFL 32611USA Department of Biology University of FloridaGainesvilleFL 32611USA

A study was conducted in four compartments of a polycarbonate greenhouse at Gainesville,Fl, USA to investigate how a soybean(Glycine max l. Merr.) cultivar, Maverick(maturity group III, indeterminate), responded to three elevated temperatures, ElT,(day/night of 34/26 °C, 38/30 °C, and 42/34 °C) in comparison to a control growth temperature(30/22 °C).Carbon dioxide(CO_2) concentration was maintained at 700 μmol mol^(-1) in each compartment by a processor controlled air-sampling and CO_2-injection system. Three sequential experiments were conducted at different times of year(summer, autumn, and early spring)to investigate the effect of intensity, timing, and duration of ElT on soybean node number,internode elongation, mainstem length, and number of pods set per plant. At the control temperature, the soybean plants grown in the polycarbonate greenhouse were taller than field-grown plants. When plants were grown under continuous ElT applied soon after sowing or at initial flowering, the number of nodes increased with increasing ElT intensity,whereas the length of individual internodes decreased. When ElT treatment was applied during the beginning of flowering stage(R1–R2) or earlier, more nodes were produced and the length of affected internodes was decreased. When the ElT was imposed later at reproductive stage R5+ just before the beginning of seed filling, effects on node numbers and internode lengths were negligible. Short-term(10-day) duration of ElT applied at four stages from V3 to R5+ did not significantly affect final mean numbers of nodes or mean mainstem lengths. Possible mechanisms of elevated temperature effects on soybean internode elongation and node number(internode number) are discussed. Total pod numbers per plant increased linearly with mainstem node numbers and mainstem ***, total pod numbers per plant were greatest at 34/26 °C rather than at the control temperature of 30/22 °C(and remained high at 38/30 °C). Mild increases in temperatu

关键词： Elevated temperature Internode elongation Node number Pod yield Soybean phenology

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Forage and breed effects on behavior and temperament of pregnant beef heifers

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Journal of Animal Science and Biotechnology 2013年第3期4卷 165-169页

作者： Angela R Mays Michael l looper Benjamin C Williamson kenneth P Coffey Wayne K Coblentz Glen E Aiken Charles F Rosenkrans jr Department of Animal Science University of ArkansasFayetteville AR 72701 USA Department of Agricultural Sciences Morehead StateUniversity327 Reed Hall Morehead KY 40351 USA USDA-ARS US Dairy Forage Research CenterMarshfield WI 54449 USA USDA-ARS Forage Animal Production Research UnitLexingtonKY 40546 USA

Background： Integration of behavioral observations with traditional selection schemes may lead to enhanced animal well-being and more profitable forage-based cattle production ***-influenced（BR;n = 64） and Gelbvieh × Angus（GA;n = 64） heifers consumed either toxic endophyte-infected tall fescue（E＋） or one of two nontoxic endophyte-infected tall fescue（NT） cultivars during two *** were weighed at midpoint and termination of *** behavior（grazing,resting in the shade,lying,or standing without grazing） was recorded（n = 13 visual observations per yr in June and July） for each *** yr 2,exit velocity（EV） and serum prolactin（PRl） were ***： Grazing behavior was influenced（P 0.05） by an interaction between fescue cultivar and breed *** × Angus heifers assigned to E＋ pastures had the lowest percentage of animals grazing and the largest percentage of animals resting in the ***-influenced heifers had faster EV（P 0.001） than GA heifers（0.52 vs.0.74 ± 0.04 s/m,respectively）.Body weight（BW） was affected（P 0.01） by an interaction of tall fescue cultivar and d,and an interaction of tall fescue cultivar and breed *** grazing NT pastures were heavier（P 0.01） than heifers grazing E＋ pastures at midpoint and *** × Angus heifers grazing NT pastures were heavier（P 0.01） than GA and BR heifers grazing E＋ and BR heifers grazing NT *** interaction of forage cultivar and breed type occurred on serum PRl（P 0.01）.Conclusion： Collectively fescue cultivar,EV,and concentrations of serum PRl were associated with grazing *** grazing NT pastures were observed to be grazing more than heifers assigned to E＋ pastures,regardless of breed type,which may have contributed to changes in BW and average daily gain（ADG） in *** of behavioral observations along with traditional selection schemes may lead to enhanced animal well-being and more profitable forage-based cattle prod

关键词： Cattle Endophyte-infected tall fescue Grazing behavior Prolactin Temperament

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Management and prevention of acute and chronic lateral ankle instability in athletic patient populations

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World Journal of Orthopedics 2015年第2期6卷 161-171页

作者： Brendan J Mc Criskin kenneth l Cameron Justin D Orr Brian R Waterman Department of Orthopaedic Surgery and Rehabilitation William Beaumont Army Medical Center the John A. Feagin jr Sports Medicine Fellowship Keller Army HospitalUS Military AcademyWest Point

Acute and chronic lateral ankle instability are common in high-demand patient populations. If not managed appropriately, patients may experience recurrent instability, chronic pain, osteochondral lesions of the talus, premature osteoarthritis, and other significantlong-term disability. Certain populations, including young athletes, military personnel and those involved in frequent running, jumping, and cutting motions, are at increased risk. Proposed risk factors include prior ankle sprain, elevated body weight or body mass index, female gender, neuromuscular deficits, postural imbalance, foot/ankle malalignment, and exposure to at-risk athletic activity. Prompt, accurate diagnosis is crucial, and evidence-based, functional rehabilitation regimens have a proven track record in returning active patients to work and sport. When patients fail to improve with physical therapy and external bracing, multiple surgical techniques have been described with reliable results, including both anatomic and nonanatomic reconstructive methods. Anatomic repair of the lateral ligamentous complex remains the gold standard for recurrent ankle instability, and it effectively restores native ankle anatomy and joint kinematics while preserving physiologic ankle and subtalar motion. Further preventative measures may minimize the risk of ankle instability in athletic cohorts, including prophylactic bracing and combined neuromuscular and proprioceptive training programs. These interventions have demonstrated benefit in patients at heightened risk for lateral ankle sprain and allow active cohorts to return to full activity without adversely affecting athletic performance.

关键词： Ankle instability Athlete Treatment Epidemiology Prevention lateral Sprain

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Activation of RAS/MAPK pathway confers MCl-1 mediated acquired resistance to BCl-2 inhibitor venetoclax in acute myeloid leukemia

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Signal Transduction and Targeted Therapy 2022年第3期7卷 856-868页

作者： Qi Zhang Bridget Riley-Gillis lina Han Yanan Jia Alessia lodi Haijiao Zhang Saravanan Ganesan Rongqing Pan Sergej N.Konoplev Shannon R.Sweeney Jeremy A.Ryan Yulia Jitkova kenneth Dunner jr Shaun E.Grosskurth Priyanka Vijay Sujana Ghosh Charles lu Wencai Ma Stephen Kurtz Vivian R.Ruvolo Helen Ma Connie CWeng Cassandra lRamage Natalia Baran Ce Shi Tianyu Cai Richard Eric Davis Venkata l.Battula Yingchang Mi Jing Wang Courtney D.DiNardo Michael Andreeff Jeffery W.Tyner Aaron Schimmer Anthony letai Rose Ann Padua Carlos E.Bueso-Ramos Stefano Tiziani Joel leverson Relja Popovic Marina Konopleva Department of leukemia The University of Texas MD Anderson Cancer CenterHoustonTXUSA AbbVie Inc. North ChicagoILUSA Institute of Hematology Chinese Academy of Medical Sciences&Peking Union Medical CollegeTianjinChina Department of Nutritional Sciences Department of PediatricsDepartment of OncologyDell Medical SchoolThe University of Texas at AustinAustinTX 78712USA Department of Cell Developmental&Cancer BiologyDivision of Hematology&Medical OncologyKnight Cancer InstituteOregon Health&Science UniversityPortlandORUSA Universite de Paris Institut de la Recherche Saint-Louis(IRSL)Inserm Unit 1131ParisFrance Dana-Farber Cancer Institute BostonMAUSA Department of Hematopathology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Princess Margaret Cancer Center TorontoONCanada High Resolution Electron Microscopy Facility The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Bioinformatics&Computational Biology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Hematology The First Hospital Affiliated Harbin Medical UniversityHarbinChina Department of lymphoma&Myeloma Research The University of Texas MD Anderson Cancer CenterHoustonTXUSA

Despite high initial response rates,acute myeloid leukemia(AMl)treated with the BCl-2-selective inhibitor venetoclax(VEN)alone or in combinations commonly acquires *** performed gene/protein expression,metabolomic and methylation analyses of isogenic AMl cell lines sensitive or resistant to VEN,and identified the activation of RAS/MAPK pathway,leading to increased stability and higher levels of MCl-1 protein,as a major acquired mechanism of VEN resistance.

关键词： acute myeloid acquired

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YPED: An Integrated Bioinformatics Suite and Database for Mass Spectrometry-based Proteomics Research

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Genomics, Proteomics & Bioinformatics 2015年第1期13卷 25-35页

作者： Christopher M.Colangelo Mark Shifman Kei-Hoi Cheung Kathryn l.Stone Nicholas J.Carriero Erol E.Gulcicek TuKiet T.lam Terence Wu Robert D.Bjornson Can Bruce Angus C.Nairn Jesse Rinehart Perry l.Miller kenneth R.Williams W.M.Keck Foundation Biotechnology Resource laboratory School of Medicine Yale University Department of Molecular Biophysics & Biochemistry Yale University Yale Center for Medical Informatics School of Medicine Yale University Department of Anesthesiology School of Medicine Yale University Department of Emergency Medicine School of Medicine Yale University VA Connecticut Healthcare System W.M. Keck Foundation Biotechnology Resource laboratory School of Medicine Yale University Department of Computer Science Yale University Yale Center for Genome Analysis West Campus Yale University Yale West Campus Analytical Core West Campus Yale University Yale Bioinformatics Resource School of Medicine Yale University Department of Psychiatry School of Medicine Yale University Department of Cellular & Molecular Physiology School of Medicine Yale University Systems Biology Institute Yale University

We report a significantly-enhanced bioinformatics suite and database for proteomics research called Yale Protein Expression Database（YPED） that is used by investigators at more than 300 institutions worldwide. YPED meets the data management, archival, and analysis needs of a high-throughput mass spectrometry-based proteomics research ranging from a singlelaboratory, group of laboratories within and beyond an institution, to the entire proteomics community. The current version is a significant improvement over the first version in that it contains new modules for liquid chromatography–tandem mass spectrometry（lC–MS/MS） database search results, label and label-free quantitative proteomic analysis, and several scoring outputs for phosphopeptide site localization. In addition, we have added both peptide and protein comparative analysis tools to enable pairwise analysis of distinct peptides/proteins in each sample and of overlapping peptides/proteins between all samples in multiple datasets. We have also implemented a targeted proteomics module for automated multiple reaction monitoring（MRM）/selective reaction monitoring（SRM） assay development. We have linked YPED＇s database search results and both label-based and label-free fold-change analysis to the Skyline Panorama repository for online spectra visualization. In addition, we have built enhanced functionality to curate peptide identifications into an MS/MS peptide spectral library for all of our protein database search identification results.

关键词： Proteomics Database Bioinformatics Mass spectrometry Repository Spectral library

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急性缺血性卒中患者早期处理指南：美国心脏协会／美国卒中协会对医疗专业人员的指南

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国际脑血管病杂志 2013年第7期21卷 481-516页

作者： Edward C. Jauch Jeffrey l. Saver Harold P. Adams Askiel Bruno J.J. (Buddy) Connors Bart M. Demaerschalk Pooja Khatri Paul W. McMullan jr, Adnan I. Qureshi kenneth Rosenfield Phillip A. Scott Debbie R. Summers David Z. Wang Max Wintermark Howard Yonas 李海峰(译) 岳耀先(译) 王琦(译) 张贤军(译) 丁晓君(译) 不详青岛大学医学院附属医院神经内科 266003

背景和目的作者提供了关于成年急性缺血性卒中患者评估和治疗方面的现有证据和处理推荐的一份概述。目标读者为涉及急性缺血性卒中患者发病48h内诊治的院前诊疗人员、医生、综合医疗保健人员和医院管理者。该指南将取代先前的2007年版... 详细信息

背景和目的作者提供了关于成年急性缺血性卒中患者评估和治疗方面的现有证据和处理推荐的一份概述。目标读者为涉及急性缺血性卒中患者发病48h内诊治的院前诊疗人员、医生、综合医疗保健人员和医院管理者。该指南将取代先前的2007年版指南及其2009年更新版。方法著述委员会成员由美国卒中协会卒中委员会的科学声明监督委员会指定，代表各个领域的医疗专家。在形成共识的整个过程中，严格遵循美国心脏协会的利益冲突原则。委员会成员被分配给与其专业领域相关的内容，对卒中文献进行回顾，重点为前一版指南发表之后的文献，然后按照美国心脏协会卒中委员会的证据强度分级方案起草推荐意见。结果本指南的目的是减少卒中相关的残疾和死亡。本指南支持卒中医疗体系的全局性概念以及从患者识别、急救医疗服务激活、转送和分诊到急诊室和卒中单元内最初数小时诊治的卒中诊治细节。本指南讨论了早期卒中评估和一般治疗、缺血性卒中治疗、特殊干预措施，如再灌注策略以及脑复苏的一般生理学干预原则。结论由于许多推荐意见基于有限的证据，还迫切需要对急性缺血性卒中的治疗做进一步的研究。

关键词： AHA科学声明急性脑梗死急诊医疗服务再灌注卒中组织型纤溶酶原激活剂

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Correction: Activation of RAS/MAPK pathway confers MCl-1 mediated acquired resistance to BCl-2 inhibitor venetoclax in acute myeloid leukemia

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1860-1860页

作者： Qi Zhang Bridget Riley-Gillis lina Han Yannan Jia Alessia lodi Haijiao Zhang Saravanan Ganesan Rongqing Pan Sergej N.Konoplev Shannon R.Sweeney Jeremy A.Ryan Yulia Jitkova kenneth Dunner jr Shaun E.Grosskurth Priyanka Vijay Sujana Ghosh Charles lu Wencai Ma Stephen Kurtz Vivian R.Ruvolo Helen Ma Connie C.Weng Cassandra l.Ramage Natalia Baran Ce Shi Tianyu Cai Richard Eric Davis Venkata l.Battula Yingchang Mi Jing Wang Courtney D.DiNardo Michael Andreeff Jeffery W.Tyner Aaron Schimmer Anthony letai Rose Ann Padua Carlos E.Bueso-Ramos Stefano Tiziani Joel leverson Relja Popovic Marina Konopleva The University of Texas MD Anderson Cancer Center Department of Leukemia Houston USA (GRID:grid.240145.6) (ISNI:0000 0001 2291 4776) AbbVie Inc. North Chicago USA (GRID:grid.431072.3) (ISNI:0000 0004 0572 4227) The University of Texas MD Anderson Cancer Center Department of Leukemia Houston USA (GRID:grid.240145.6) (ISNI:0000 0001 2291 4776) Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Hematology Tianjin China (GRID:grid.506261.6) (ISNI:0000 0001 0706 7839) The University of Texas at Austin Department of Nutritional Sciences Department of Pediatrics Department of Oncology Dell Medical School Austin USA (GRID:grid.89336.37) (ISNI:0000 0004 1936 9924) Oregon Health & Science University Department of Cell Developmental &amp Cancer Biology Division of Hematology &amp Medical Oncology Knight Cancer Institute Portland USA (GRID:grid.5288.7) (ISNI:0000 0000 9758 5690) Université de Paris Institut de la Recherche Saint-Louis (IRSL) Inserm Unit 1131 Paris France (GRID:grid.508487.6) (ISNI:0000 0004 7885 7602) Dana-Farber Cancer Institute Boston USA (GRID:grid.65499.37) (ISNI:0000 0001 2106 9910) The University of Texas MD Anderson Cancer Center Department of Hematopathology Houston USA (GRID:grid.240145.6) (ISNI:0000 0001 2291 4776) Princess Margaret Cancer Center Toronto Canada (GRID:grid.415224.4) (ISNI:0000 0001 2150 066X) The University of Texas MD Anderson Cancer Center High Resolution Electron Microscopy Facility Houston USA (GRID:grid.240145.6) (ISNI:0000 0001 2291 4776) The University of Texas MD Anderson Cancer Center Department of Bioinformatics &amp Computational Biology Houston USA (GRID:grid.240145.6) (ISNI:0000 0001 2291 4776) The University of Texas MD Anderson Cancer Center Department of Leukemia Houston USA (GRID:grid.240145.6) (ISNI:0000 0001 2291 4776) The First Hospital Affiliated Harbin Medical University Department of Hematology Harbin China (GRID:grid.410736.7) (ISNI:0000 0001 2204 9268) The University of Texas MD

Correction to:Signal Transduction and Targeted Therapy(2022)7:1–13,https://***/10.1038/s41392-021-00870-3 In the original version of this article,given name of 4th author Yannan Jia was incorrectly published as Yanan *** original article has been *** Access This article is licensed under a Creative Commons Attribution 4.0 International license,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source.

关键词： myeloid Therapy resistance

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ACC／AHA2006年非心脏手术围手术期心血管评估指南更新：关于围手术期β-受体阻滞剂使用的专题更新--美国心脏病学会／美国心脏协会医疗指南工作组报告（非心脏手术围手术期心血管评估2002指南更新编写委员会）

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麻醉与镇痛 2008年第1期4卷 2-10页

作者： lee A. Fleisher, MD, FACC Joshua A. Beckman, MD, FACC kenneth A. Brown, MD, FACC, FAHA Hugh Calkins, MD, FACC, FAHA EUiott l. Chaikof, MD, PhD Kirsten E. Fleischmann, MD, MPH, FACC William K. Freeman, MD, FAC James B. Froehlich, MD, MPH, FACC Edward K. Kasper, MD, FACC Judy K Kersten, MD, FACC Barbara Riegel, DNSc, RN, FAHA John F. Robb, MD, FACC 李恒(译) 阎哲(译) 杨承祥(校) Society for Vascular Medicine and Biology Official Representative American Society of Nuclear Cardiology Official Representative Heart Rhythm Society Official Representative Society for Vascular Surgery Official Representative American Society of Echocardiography Official Representative Society of Cardiovascular Anesthesiologists Official Representative Society for Cardiovascular Angiography and Interventions Official Representative 不详

美国心脏病学会／美国心脏协会（ACC／AHA）医疗指南工作组尽力避免因编写委员会成员与企业的关系或个人利益而导致的任何实际的、可能的，或者是已发现的利益冲突。编写委员会的所有成员以及本文件的同行评议人必须对可能被视为是实际... 详细信息

美国心脏病学会／美国心脏协会（ACC／AHA）医疗指南工作组尽力避免因编写委员会成员与企业的关系或个人利益而导致的任何实际的、可能的，或者是已发现的利益冲突。编写委员会的所有成员以及本文件的同行评议人必须对可能被视为是实际上或是潜在的利益冲突进行声明。工作组对以上声明进行审查。在每次会议上，这些声明必须口头汇报给编写委员会的每位成员；当发生变动时，编写委员会对声明进行更新并再次核查。编写委员会成员和企业的关系见附表1，同行评议人与企业的关系见附表2。本指南旨在确定在大多数情形下满足大部分患者需求的方案。指南反映了对当前可获得的科学文献进行系统分析后专家们达成的共识，其目的在于提高医疗质量。如果将指南用于管理／投资决策，其终极目标应是医疗质量得到提高并服务于患者。关于具体患者的医疗问题，必须由医疗人员和患者根据具体情况共同做出最终决定。Sidney C Smith，jr．，MD，FACC，FAHA ACC／AHA医疗指南工作组主席Elliot ***，MD，FACC，FAHA

关键词： ACC/AHA 美国心脏病学会美国心脏协会医疗指南 β-受体阻滞剂委员会工作组非心脏手术

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