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忘记呼吸的小镇

作者： (加)肯尼斯·j. 哈维(kenneth j. Harvey)

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前列腺癌骨髓小生境：不仅仅是“沃土”

Asian j.urnal of Andrology 2012年第3期14卷 423-427,I0007页

作者： Elisabeth A Pedersen Yusuke Shiozawa kenneth j.Pienta Russell S Taichman Department of Periodontics and Oral Medicine University of Michigan School of Dentistry Ann Arbor M148109-1078 USA Departments of Urology and Internal Medicine University of Michigan Medical School Ann Arbor MI 48109-1078 USA

The hematopoietic stem cell （HSC） niche in the bone marrow has been studied extensively over the past few decades, yet the bone marrow microenvironment that supports the growth of metastatic prostate cancer （PCa） has only been recently considered to be a specialized ＇niche＇ as well. New evidence supports the fact that disseminated tumor cells （DTCs） of PCa actually target the HSC niche, displace the occupant HSCs and take up residence in the pre-existing niche space. This review describes some of the evidence and mechanisms by which DTCs act as molecular parasites of the HSC niche. Furthermore, the interactions between DTCs, HSCs and the niche may provide new targets for niche-directed therapy, as well as insight into the perplexing clinical manifestations of metastatic PCa disease.

关键词： dormancy hematopoietic stem cell metastasis niche osteoblasts prostate cancer

Retrograde j.j.noduodenogastric intussusception due to a replacement percutaneous gastrostomy tube presenting as upper gastrointestinal bleeding

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World j.urnal of Gastroenterology 2007年第39期13卷 5282-5284页

作者： Eric Ibegbu Manish Relan kenneth j.Vega Divisions of Gastroenterology and General Internal Medicine University of Florida Health Science Center/Jacksonville Jacksonville FL32207 United States

Percutaneous endoscopic gastrostomy (PEG) tube complications can be serious or life threatening. Retrograde intussusception is a very rare complication of PEG tubes with only 9 cases reported in the literature. We describe a case of retrograde intussusception, associated with the use of a Foley catheter as a replacement gastrostomy tube, presenting with upper gastrointestinal bleeding. To our knowledge, this is the first reported case of PEG-related retrograde intussusception successfully managed in a non-surgical manner. Retrograde intussusception likely occurred due to migration of the replacement tube with resultant securing and invagination of the proximal j.j.num when the gastrostomy tube was anchored to the abdominal wall.

关键词：经皮内镜胃造瘘术肠套叠胃肠出血治疗方法

ROTATION OF THE HUANAN BLOCK, SOUTH CHINA

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Chinese Science Bulletin 1992年第22期37卷 1899-1902页

作者：陈海泓孙枢李继亮 kenneth j. HSU FRIEDRICH HELLER j.N DOBSON Laboratory of lithosphere Tectomic Euolution Instiute of Geology Academia SinicaBeijing 100029PRC Swiss Federal Institute of Technology Zurich

Extensive paleomagnetic studies in the Yangtze Block of South China has been performed since the 1980s, and the Phanerozoic APW (apparent polar wander)path has been established based on a large amount of data obtained. However, the Huanan Block in southeastern region still remains unknown paleomagnetically. In order to further understand the plate tectonic patterns and evolutional history prio Mesozoic collision of the

关键词： paleomagnetism Huanan Block Late Paleozoic counterclockwise rotation

The Roles of Different CLE Domains in Arabidopsis CLE Polypeptide Activity and Functional Specificity

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Molecular Plant 2010年第4期3卷 760-772页

作者： Ling Meng kenneth C. Ruth j.nnifer C. Fletcher Lewis Feldman Department of Plant and Microbial Biology 111 Koshland Hall University of California Berkeley CA 94720-3102 USA Plant Gene Expression Center USDA-UC Berkeley 800 Buchanan Street Albany CA 94710 USA

The CLE （CLVATA3/ESR-related） family of plant polypeptide signaling molecules shares a conserved 14-aminoacid （aa） motif, designated the CLE motif, which recent studies suggest is sufficient for CLE function in vitro. In this study, we report that Arabidopsis CLE proteins can function in a tissue-specific manner and confirm some CLE factors can act through different receptors. Using domain swapping, we show for the first time that the CLE motif likely determines much of the functional tissue-specificity of the proteins in planta. However, we also provide evidence in support of the new view that sequences outside the CLE motif （14 aa） contribute to CLE function and functional specificity in vivo. Additionally, we report that deletion of the putative signal peptide from different CLE proteins completely inactivates CLE function in vivo, whereas exchanging the CLE signal peptides with a conventional signal peptide from a rice glycine-rich cell wall protein also influences CLE function. We thus propose that the CLE motif itself determines its functional tissue-specificity by dic- tating the direct recognition and interaction of each CLE peptide with its optimal receptor（s）, whereas the receptor（s） may be available in a tissue-specific manner. On the other hand, the sequences outside the CLE motif may influence CLE function by affecting the processing of CLE peptides, resulting in a change in the availability and/or abundance of CLE peptides in specific tissues and/or cells.

关键词： Arabidopsis cell signaling CLE meristem polypeptide protein domain.

A High-throughput Genomic Tool： Diversity Array Technology Complementary for Rice Genotyping

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j.urnal of Integrative Plant Biology 2006年第9期48卷 1069-1076页

作者： Yong Xie kenneth McNally Cheng-Yun Li Hei Leung You-Yong Zhu National Center for Agro-biodiversity Yunnan Agricultural University Kunming 650201 China Genetic Resources Center International Rice Research Institute DAPO P.O. Box 7777 Metro Manila Philippines Entomology and Plant Pathology Division International Rice Research Institute DAPO P.O. Box 7777 Metro Manila Philippines

Diversity array technology （DART^TM） was a genotyping tool characterized gel-independent and high throughput. The main purpose of present study is to validate DArT for rice （Oryza sativa L.）genotyping in a high throughput manner. Technically, the main obj.ctive was to generate a rice general purpose gene pool, and optimize this genomic tool in order to evaluate rice germplasm genetic diversity. To achieve this, firstly, a generalpurpose DArT array was developed. Ten representatives from 24 varieties were hybridized with the general-purpose array to determine the informativeness of the clones printed on the array. The informative 1 152 clones were re-arrayed on a slide and used to fingerprint 17 of 24 germplasms. Hybridizing targets prepared from the germplasm to be assayed to the DNA array gave DNA fingerprints of germplasms. Raw data were normalized and transformed into binary data, which were then analyzed by using NTSYSpc （Numerical taxonomy system for cluster and ordination analysis, v. 2.02j. software package. The graphically displayed dendrogram derived from the array experimental data was matched with simple sequence repeats genotyping outline and varieties＇ pedigree deviation of the different varieties. Considering DArT is a sequence-independent genotyping approach, it will be applied in studies of the genetic diversity and the gene mapping of diverse of organisms, especially for those crops with less-developed molecular markers.

关键词： amplified fragment length polymorphisms diversity array technology genome complexity reduction microarray rice genotyping

The Fossils in Shangxi Group and Its Implication for Tectonics, Southern Anhui, China

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Science China Chemistry 1994年第3期37卷 366-376页

作者：徐树桐陈冠宝陶正石永红孙枢 kenneth j.Hsu 尹磊明欧阳舒廖卓庭 Anhui Institute of Geology Hefei 230001 PRC Institute of Geology Academia Sinica Beijing 100029 PRC Swiss Federal Institute of Technology CH-8092 Zurich Switzerland Nanj.ng Institute of Geology and Palaeontolgy Academia Sinica Nanjing 210008 PRC

The Shangxi Group is the local name in southern Anhui Province and it is believed to be the equivalence of the well-known Banxi Group in Hunan Province, southern China. So the area occupied by the Shangxi Group was regarded as a part of the "j.angnan old land" of Presinian till it was challenged by the present authors years ago. After we postulated that there may be some strata of Palaeozoic Era in Shangxi Group, some microfossils and then macrofossils of Palaeozoic were found in some part of it. The macrof os-sils, Lingula sp. , Conulariid and the microfossils indicate that most units of the Shangxi Group are Palaeozoic strata. Based on the discovery of these fossils and the recognition of the tectonic-setting of the different tectono-petrologic units in the Shangxi Group, three different stratigraphic sequences (island-arc volcanics, back-arc sediments and the cover of passive margin of Yangtze Continental Plate) are established and the tectonic evolution of them is postulated in the present paper.

关键词： j.angnan old land fossil tectono-petrolagic unit.

Vaginal Hyperplasia and Progressive Vaginal Fold Prolapse in a Bullmastiff Bitch

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Open j.urnal of Veterinary Medicine 2020年第5期10卷 55-63页

作者： kenneth O. Anya Chike F. Oguej.ofor Theophilus O. Nnaj. Ikechukwu j. Udeani Department of Veterinary Obstetrics and Reproductive Diseases Faculty of Veterinary Medicine University of Nigeria Nsukka Nigeria Department of Veterinary Surgery Faculty of Veterinary Medicine University of Nigeria Nsukka Nigeria Veterinary Teaching Hospital Faculty of Veterinary Medicine University of Nigeria Nsukka Nigeria

Canine reproductive problems constitute some of the most challenging cases encountered in small animal veterinary practice. This is usually complicated in breeding dogs by the unwillingness of clients to give consent for surgical interventions, due to the fear of loss of reproductive function. In this case, a two-year-old Bullmastiff bitch was presented to the Veterinary Teaching Hospital with a mass protrusion from the vulva. Clinical examination revealed an eversion of a tongue-shaped vaginal tissue from the floor of the vaginal wall which subsequently progressed to an eversion of the complete vaginal circumference forming a doughnut-shaped mass. Investigations carried out included ultrasonography, hematology, hormonal assay, vaginal cytology, vaginal swab microbial culture and antimicrobial sensitivity test. A diagnosis of vaginal fold prolapse (type III) which progressed from a type II prolapse was made. Due to the client’s initial disinclination to a surgical intervention, the approach to the case evolved from a conservative management to an eventual surgical correction. There was a request to preserve the reproductive function of the bitch, therefore ovariohysterectomy was declined and the case was managed by surgical excision of the prolapsed vaginal mass under general anesthesia. A peri-vulvar purse string suture was placed temporarily to restrict any further prolapse. Histopathological evaluation of the excised vaginal tissue confirmed marked hyperplasia of the stratified squamous epithelium with intracellular edema and spongiosis. There was focal ulceration of vaginal mucosa with neutrophilic infiltration. The lamina propria showed reduced cellular density with loose and edematous connective tissue. Post-surgical care included daily care of surgical wound and the administration of analgesic, antibiotic and vitamin supplements. Subsequently, there was no recurrence of the condition in the bitch which came into estrus 27 weeks post-surgery, and was bred with

关键词： Vaginal Hyperplasia Vaginal Fold Prolapse Vaginal Surgery Bitch Estrus

Biologically Enabled Syntheses of Nanostructured 3-D Sensor Materials:the Potential for 3-D Genetically Engineered Microdevices (3-D GEMs)

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稀有金属材料与工程 2006年第A3期35卷 13-14页

作者： kenneth H. Sandhage Samuel Shian Christopher S. Gaddis Michael R. Weatherspoon Ye Cai Sehoon Yoo Michael S. Haluska Robert L. Snyder Ying Liu Meilin Liu Nicholas Ferrell Derek j. Hansford Mark Hildebrand Brian Palenik School of Materials Science and Engineering Georgia Institute of Technology Atlanta GA USA Biomedical Engineering Department the Ohio State University Columbus OH USA Microbiology Department Scripps Institution of Oceanography University of California at San Diego La Jolla CA USA

Three-dimensional (3-D)self-assembly of nanos- tructures and nanodevices on a large scale remains a grand quest for *** nanostructured assemblies with controlled 3-D shapes can exhibit attractive properties for sensor and other applications. Protocols for 3-D self-assembly that can be scaled up for mass production on a large up to tonnage)scale, while preserving morphological features on a small (down to nanometer)scale,are needed to allow for widespread use of 3-D nanostructures in advanced ***,these often conflicting requirements of scalability and precision pose a difficult challenge for synthetic (man-made)processing routes.

关键词： D GEMs Biologically Enabled Syntheses of Nanostructured 3-D Sensor Materials