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Osteocyte egln1/Phd2 links oxygen sensing and biomineralization via FGF23

Bone Research 2023年第1期11卷 178-192页

作者： Megan L.Noonan Pu Ni emmanuel Solis Yamil G.Marambio Rafiou Agoro Xiaona Chu Yue Wang Hongyu Gao Xiaoling Xuei erica L.Clinkenbeard Guanglong Jiang Sheng Liu Steve Stegen Geert Carmeliet William R.Thompson Yunlong Liu Jun Wan kenneth e.white Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN46202USA Laboratory of Clinical and experimental endocrinology Department of Chronic Diseases and MetabolismKU Leuven3000LeuvenBelgium Department of Physical Therapy Indiana University School of MedicineIndianapolisIN46202USA Department of Anatomy Cell Biologyand PhysiologyIndiana University School of MedicineIndianapolisIN46202USA Center for Computational Biology and Bioinformatics Indiana University School of MedicineIndianapolisIN46202USA Departments of Medicine/Division of Nephrology Indiana University School of MedicineIndianapolisIN46202USA

Osteocytes act within a hypoxic environment to control key steps in bone ***23,a critical phosphate-regulating hormone,is stimulated by low oxygen/iron in acute and chronic diseases,however the molecular mechanisms directing this process remain *** goal was to identify the osteocyte factors responsible for FGF23 production driven by changes in oxygen/iron ***-inducible factor-prolyl hydroxylase inhibitors(HIF-PHI)which stabilize HIF transcription factors,increased Fgf23 in normal mice,as well as in osteocyte-like cells;in mice with conditional osteocyte Fgf23 deletion,circulating i FGF23 was *** inducible MSC cell line(‘MPC2’)underwent FG-4592 treatment and ATACseq/RNAseq,and demonstrated that differentiated osteocytes significantly increased HIF genomic accessibility versus progenitor *** genomics also revealed increased prolyl hydroxylase egln1(Phd2)chromatin accessibility and expression,which was positively associated with osteocyte *** mice with chronic kidney disease(CKD),Phd1-3 enzymes were suppressed,consistent with FGF23 upregulation in this *** loss of Phd2 from osteocytes in vivo resulted in upregulated Fgf23,in line with our findings that the MPC2 cell line lacking Phd2(CRISPR Phd2-KO cells)constitutively activated Fgf23 that was abolished by HIF1α*** vitro,Phd2-KO cells lost iron-mediated suppression of Fgf23 and this activity was not compensated for by Phd1 *** sum,osteocytes become adapted to oxygen/iron sensing during differentiation and are directly sensitive to bioavailable ***,Phd2 is a critical mediator of osteocyte FGF23 production,thus our collective studies may provide new therapeutic targets for skeletal diseases involving disturbed oxygen/iron sensing.

关键词： FGF23 collective adapted

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The molecular mechanisms of FGF23 regulating phosphate homeostasis

The molecular mechanisms of FGF23 regulating phosphate homeo...

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中华医学会第十二次全国内分泌学学术会议

作者： Xijie Yu Kun Zhang Yaxi Chen Haoming Tian kenneth e.white Laboratory of endocrinology and Metabolism West China HospitalSichuan University Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202

Fibroblast growth factor 23(FGF23) is a circulating factor that plays critical roles in phosphate and vitamin D metabolism. FGF23 is predominately produced by osteocytes/osteoblasts and exerts its biological functions by interacting with FGFR-klotho *** functions of FGF23 are to suppress the expressions of NPT2aand NPT2b in the renal proximal tubular

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Why ecosystem characteristics predicted from remotely sensed data are unbiased and biased at the same time-and how this affects applications

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Forest ecosystems 2024年第1期11卷 24-31页

作者： Goran Ståhl Terje Gobakken Svetlana Saarela Henrik J.Persson Magnus ekstrom Sean P.Healey Zhiqiang Yang Johan Holmgren eva Lindberg kenneth Nystrom emanuele Papucci Patrik Ulvdal Hans OleØrka erik Næsset Zhengyang Hou Håkan Olsson Ronald e.McRoberts Department of Forest Resource Management Swedish University of Agricultural Sciences90183UmeåSweden Faculty of environmental Sciences and Natural Resource Management Norwegian University of Life SciencesÅsNorway USDA Forest Service Rocky Mountain Research StationOgdenUTUSA The Key Laboratory for Silviculture and Conservation of Ministry of education Beijing Forestry UniversityBeijing100083China Department of Forest Resources University of MinnesotaSt.PaulMNUSA

Remotely sensed data are frequently used for predicting and mapping ecosystem characteristics,and spatially explicit wall-to-wall information is sometimes proposed as the best possible source of information for ***,wall-to-wall information typically relies on model-based prediction,and several features of model-based prediction should be understood before extensively relying on this type of *** such feature is that model-based predictors can be considered both unbiased and biased at the same time,which has important implications in several areas of *** this discussion paper,we first describe the conventional model-unbiasedness paradigm that underpins most prediction techniques using remotely sensed(or other)auxiliary *** this point of view,model-based predictors are typically ***,we show that for specific domains,identified based on their true values,the same model-based predictors can be considered biased,and sometimes severely *** suggest distinguishing between conventional model-bias,defined in the statistical literature as the difference between the expected value of a predictor and the expected value of the quantity being predicted,and design-bias of model-based estimators,defined as the difference between the expected value of a model-based estimator and the true value of the quantity being *** show that model-based estimators(or predictors)are typically design-biased,and that there is a trend in the design-bias from overestimating small true values to underestimating large true ***,we give examples of applications where this is important to acknowledge and to potentially make adjustments to correct for the design-bias *** argue that relying entirely on conventional model-unbiasedness may lead to mistakes in several areas of application that use predictions from remotely sensed data.

关键词： Bias Model-based inference Design-based inference

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Long-term impact of artificial intelligence on colorectal adenoma detection in high-risk colonoscopy

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World Journal of Gastrointestinal endoscopy 2024年第6期16卷 335-342页

作者： kenneth W Chow Matthew T Bell Nicholas Cumpian Maryanne Amour Ryan H Hsu Viktor e eysselein Neetika Srivastava Michael W Fleischman Sofiya Reicher Department of Medicine Harbor-UCLA Medical CenterTorranceCA 90502United States Department of Bioengineering Jacobs School of EngineeringUniversity of CaliforniaSan DiegoLa JollaCA 92093United States Department of Gastroenterology Harbor-UCLA Medical CenterTorranceCA 90502United States

BACKGROUND Improved adenoma detection rate(ADR)has been demonstrated with artificial intelligence(AI)-assisted ***,data on the real-world appli-cation of AI and its effect on colorectal cancer(CRC)screening outcomes is *** To analyze the long-term impact of AI on a diverse at-risk patient population undergoing diagnostic colonoscopy for positive CRC screening tests or *** AI software(GI Genius,Medtronic)was implemented into the standard proced-ure protocol in November *** was collected on patient demographics,procedure indication,polyp size,location,and *** screening outcomes were evaluated before and at different intervals after AI introduction with one year of *** We evaluated 1008 colonoscopies(278 pre-AI,255 early post-AI,285 established post-AI,and 190 late post-AI).The ADR was 38.1%pre-AI,42.0%early post-AI(P=0.77),40.0%established post-AI(P=0.44),and 39.5%late post-AI(P=0.77).There were no significant differences in polyp detection rate(PDR,baseline 59.7%),advanced ADR(baseline 16.2%),and non-neoplastic PDR(baseline 30.0%)before and after AI *** In patients with an increased pre-test probability of having an abnormal colonoscopy,the current generation of AI did not yield enhanced CRC screening metrics over high-quality *** the potential of AI in colonoscopy is undisputed,current AI technology may not universally elevate screening metrics across all situations and patient *** studies that analyze different AI systems across various patient populations are needed to determine the most effective role of AI in optimizing CRC screening in clinical practice.

关键词： Artificial intelligence Colonoscopy Adenoma detection rate Screening Colorectal adenoma

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Adding Value to Crop Production Systems by Integrating Forage Cover Crop Grazing

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American Journal of Plant Sciences 2024年第3期15卷 180-192页

作者： Robert B. Mitchell Daren D. Redfearn kenneth P. Vogel Terry J. Klopfenstein Galen erickson P. Stephen Baenziger Bruce e. Anderson Mary e. Drewnoski Jay Parsons Steven D. Masterson Marty R. Schmer Virginia L. Jin USDA-ARS Wheat Sorghum and Forage Research Unit University of Nebraska-Lincoln Lincoln NE USA Department of Agronomy and Horticulture University of Nebraska-Lincoln Lincoln NE USA Department of Animal Science University of Nebraska-Lincoln Lincoln NE USA Department of Agricultural economics University of Nebraska-Lincoln Lincoln NE USA USDA-ARS Agroecosystem Management Research Unit University of Nebraska-Lincoln Lincoln NE USA

In addition to their value as cereal grains, wheat (Triticum aestivum L.) and triticale (× Triticosecale Wittmack) are important cool-season annual forages and cover crops. Yearling steer (Bos taurus) performance was compared in the spring following autumn establishment as for age cover crops after soybean [Glycine max (L.) Merr.] grain harvest. Replicated pastures (0.4 ha) were no-till seeded in three consecutive years into soybean stubble in autumn, fertilized, and grazed the following spring near Ithaca, Ne, USA. each pasture (n = 3) was continuously stocked in spring with four yearling steers (380 ± 38 kg) for 17, 32, and 28 d in 2005, 2006, and 2007, respectively. In 2005, average daily gain (ADG) for steers grazing triticale exceeded the ADG for wheat by 0.31 kghd-1d-1. In 2006, wheat ADG exceeded that for triticale by 0.12 kghd-1d-1. In 2007, steers grazing wheat lost weight, while steers grazing triticale gained 0.20 kghd-1d-1. Based on the 3-year average animal gains valued at $1.32 kg-1, mean net return ($ ha-1 yr-1) was $62.15 for triticale and $22.55 for wheat. Since these grazed cover crops provide ecosystem services in addition to forage, grazing could be viewed as a mechanism for recovering costs and adds additional value to the system. Based on this 3-year grazing trial, triticale was superior to wheat and likely will provide the most stable beef yearling performance across years with variable weather for the western Cornbelt USA.

关键词： Cover crops Soybean Triticale Wheat

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Overview of the Global electricity System in Oman Considering energy Demand Model Forecast

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energy engineering 2023年第2期120卷 409-423页

作者： Ahmed Al-Abri kenneth e.Okedu Department of electrical and Communication engineering National University of Science and TechnologyPC 111MuscatSultanate of Oman Department of electrical and electronic engineering Nisantasi UniversityIstanbulTurkey

Lately,in modern smart power grids,energy demand for accurate forecast of electricity is gaining attention,with increased interest of *** is due to the fact that a good energy demand forecast would lead to proper responses for electricity *** addition,proper energy demand forecast would ensure efficient planning of the electricity industry and is critical in the scheduling of the power grid capacity and management of the entire power *** most power systems are been deregulated and with the rapid introduction and development of smart-metering technologies in Oman,new opportunities may arise considering the efficiency and reliability of the power system;like price-based demand response *** programs could either be a large scale for household,commercial or industrial ***,excellent demand forecasting models are crucial for the deployment of these smart metering in the power grid based on good knowledge of the electricity market ***,in this paper,an overview of the Oman regulatory regime,financial mechanism,price control,and distribution system security standard were *** so,the energy demand forecast in Oman was analysed,using the econometric model to forecasts its energy peak *** energy econometric analysis in this study describes the relationship between the growth of historical electricity consumption and macro-economic parameters(by region,and by tariff),considering a case study of Mazoon electricity Distribution Company(MZeC),which is one of the major power distribution companies in Oman,for effective energy demand in the power grid.

关键词： energy forecast energy demand load demand power grids electricity sector

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Synchrophasor-based real-time state estimation and situational awareness system for power system operation

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Journal of Modern Power Systems and Clean energy 2016年第3期4卷 370-382页

作者： Heng CHeN Lin ZHANG Jianzhong MO kenneth e.MARTIN electric Power Group Pasadena CA 91101 USA

State estimation is a critical functionality of energy management system(eMS) to provide power system states in real-time operations. However, problems such as failure to converge, prone to failure during contingencies,and biased estimates while system is under stressed condition occur so that state estimation results may not be *** unreliable results further impact downstream network and market applications, such as contingency analysis,voltage stability analysis, transient stability analysis, system alarming, and unit commitment. Thus, operators may lose the awareness of system condition in eMS. This paper proposes a fully independent and one-of-a-kind system by integrating linear state estimator into situational awareness applications based on real-time synchrophasor data. With guaranteed and accurate state estimation solution and advanced real-time data analytic and monitoring functionalities, the system is capable of assisting operators to assess and diagnose current system conditions for proactive and necessary corrective actions. The architecture, building components, and implementation of the proposed system are explored in detail. Two case studies with simulated data from the subsystems of electric Reliability Council of Texas(eRCOT) and Los Angeles Department of Water and Power(LADWP) are presented. The test results show the effectiveness and reliability of the system, and its value for realtime power system operations.

关键词： Synchrophasor Linear state estimator Situational awareness Power system operation

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Clinical pharmacology relevant to older adults with cardiovascular disease

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Journal of Geriatric Cardiology 2015年第3期12卷 192-195页

作者： Jorge A Brenes-Salazar Laith Alshawabkeh kenneth e Schmader Joseph T Hanlon Daniel e Forman Department of Medicine Division of Cardiovascular Diseases Mayo Clinic Rochester MN USA Department of Medicine Division of Cardiovascular Medicine University of lowa Iowa City IA USA Department of Medicine Division of Geriatrics Duke University School of Medicine Durham NC USA Departments of Medicine (Division of Geriatric Medicine) Pharmacy and Epidemiology University of Pittsburgh Geriatric Research Education and Clini- cal Center and Center for Health Equity Research and Promotion VA Pittsburgh Health System Pittsburgh PA USA Department of Medicine (Divisions of Geriatric Medicine and Cardiology) University of Pittsburgh Medical Center Geriatric Research Education and Clinical Center VA Pittsburgh Health System Pittsburgh PA USA

Although older adults are generally among the highest users of cardiovascular medications, they are typically underrepresented or excluded from most efficacy and safety trials. Drug developers are usually reluctant to include many senior adults in randomized controlled clinical trials in part due to their high prevalence of multiple comorbidities, frailty, and polypharmacy; and to age-related pharmacokinetic and pharmacodynamic complexities. Consequently, there is often insufficient high quality evidence-based data to inform pharmacologic management of common cardiovascular conditions on older adults. In the absence of data, clinicians often rely on conceptual principles regarding metabolism and drug-drug interactions to minimize adverse drug events, but this is often not well-substantiated or standardized. A related challenge is poor cardiovascular medication adherence among older adults, and its detrimental impact on their health outcomes. In this brief review we highlight some aspects of these topics.

关键词：临床药理学心血管疾病老年人

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efficient above-band-gap light emission in germanium

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Chinese Optics Letters 2009年第4期7卷 271-273页

作者： kenneth e.Lee eugene A.Fitzgerald Lionel C.Kimerling Jurgen Michel Department of Materials Science and engineering Microphotonics CenterMassachusetts Institute of Technology

We report an above-band-gap radiative transition in the photoluminescence spectra of single crystalline Ge in the temperature range of 20-296 K. The temperature-independence of the peak position at -0.74 eV is remarkably different from the behavior of direct and indirect gap transitions in Ge. This transition is observed in n-type, p-type, and intrinsic single crystal Ge alike, and its intensity decreases with the increase of temperature with a small activation energy of 56 meV. Some aspects of the transition are analogous to III-V semiconductors with dilute nitrogen doping, which suggests that the origin could be related to an isoelectronic defect.

关键词： Activation energy Germanium Photoluminescence Semiconductor doping Single crystals

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A sandwich-like structure hybrid coating of cold galvanizing coating/polydopamine on hot-dip galvanized steel with enhanced adhesion and corrosion resistance

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Science China(Technological Sciences) 2023年第8期66卷 2381-2395页

作者： LI JiWen GAO NingJie ZHANG WanYu XU Long NWOKOLO kenneth Izuchukwu WU Hao LIU FuChun HAN en-Hou Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and engineering University of Science and Technology of ChinaShenyang 110016China Institute of Corrosion Science and Technology Guangzhou 510530China Jihua Laboratory Foshan Guangdong ProvinceFoshan 528000China

This study aims to enhance the adhesion strength and anti-corrosion performance of the cold galvanizing coating(CGC)applied on the hot-dip galvanized steel(HDG).Polydopamine(PDA)is deposited on the HDG surface with different time ranges and as an interlayer between CGC and HDG through covalent *** surface morphology and the covalent interaction between PDA/HDG are exhibited by scanning electron microscope(SeM),atomic force microscopy(AFM)and X-ray photoelectron spectroscopy(XPS).The pull-off adhesion tests before and after neutral slat spry tests show an enhanced dry adhesion strength and less adhesion loss of the hybrid CGC/PDA coated HDG compared with the direct CGC coated *** addition,open circuit potential(OCP)reveals that the corrosion protection performance of the hybrid CGC/PDA coated HDG increases by 200%(up to 201 d)and the corrosion density icorrattaining about 4.45×10^(-7)A/cm^(2).electrochemical impedance spectroscopy(eIS)measurements and X-ray diffraction(XRD)analysis confirm that the precipitate of the stable chelation formed by PDA and Zn^(2+)between CGC and HDG substrate can also improve the corrosion protection *** a strategy of strengthening adhesion and forming the chelate compound at the HDG surface promises a new route to corrosion protection of CGC on HDG.

关键词： dopamine zinc-rich coatings hot-dip galvanized steel corrosion protection chelate compound

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