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Characteristics of normal human retinal pigment epithelium cells with extremes of autofluorescence or intracellular granule count

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Annals of Eye Science 2021年第1期6卷 11-19页

作者： Katharina Bermond Andreas Berlin Ioana-Sandra Tarau Christina Wobbe rainer Heintzmann Christine A.Curcio kenneth r.sloan Thomas Ach Department of Ophthalmology University Hospital WürzburgWürzburgGermany Department of Ophthalmology Ludwigshafen HospitalLudwigshafenGermany Leibniz Institute of Photonic Technology JenaGermany Institute of Physical Chemistry and Abbe Center of Photonics Friedrich-Schiller University JenaJenaGermany Department of Ophthalmology University of Alabama at BirminghamBirminghamALUSA Department of Ophthalmology University Hospital BonnBonnGermany

Background:Cells of the retinal pigment epithelium(rPE)accumulate different kinds of granules(lipofuscin,melanolipofuscin,melanosomes)within their cell bodies,with lipofuscin and melanolipofuscin being autofluorescent after blue light *** amounts of lipofuscin granules within the rPE have been associated with the development of rPE cell death and age-related macular degeneration(AMD);however,this has not been confirmed in histology so ***,based on our previous dataset of rPE granule characteristics,we report the characteristics of rPE cells from human donor eyes that show either high or low numbers of intracellular granules or high or low autofluorescence(AF)***:rPE flatmounts of fifteen human donors were examined using high-resolution structured illumination microscopy(Hr-SIM)and laser scanning microscopy(LSM).Autofluorescent granules were analyzed regarding AF phenotype and absolute number of *** addition,total AF intensity per cell and granule density(number of granules per cell area)were *** the final analysis,rPE cells with total granule number below 5th or above the 95th percentile,or a total AF intensity±1.5 standard deviations above or below the mean were included,and compared to the average rPE cell at the same *** are presented as mean±standard ***:Within 420 rPE cells examined,42 cells were further analyzed due to extremes regarding total granule *** addition,20 rPE cells had AF 1.5 standard deviations below,28 rPE cells above the mean local AF *** granules predominate in rPE cells with low granule content and low AF *** cells with high granule content have nearly twice(1.8 times)as many granules as an average rPE ***:In normal eyes,outliers regarding autofluorescent granule load and AF intensity signals are rare among rPE cells,suggesting that granule deposition and subsequent AF follows intrinsic control mechanisms at a cellul

关键词： retinal pigment epithelium(rPE) granules autofluorescence(AF) lipofuscin melanolipofuscin melanosomes

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repurposing FDA-approved drugs for SArS- CoV-2 through an ELISA-based screening for the inhibition of rBD/ACE2 interaction

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Protein & Cell 2021年第7期12卷 586-591页

作者： Wenyu Fu Yujianan Chen Kaidi Wang Aubryanna Hettinghouse Wenhuo Hu Jing-Quan Wang Zi-Ning Lei Zhe-Sheng Chen kenneth A.Stapleford Chuan-ju Liu Department of Orthopaedic Surgery New York University Medical Center301 East 17th StreetNew YorkNY 10003USA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Department of Pharmaceutical Science College of Pharmacy and Health SciencesSt.John’s UniversityNew YorkNY 11439USA Department of Microbiology New York University School of MedicineNew YorkNY 10016USA Department of Cell Biology New York University School of MedicineNew YorkNY 10016USA

Dear Editor,The ongoing coronavirus disease 2019(COVID-19)global pandemic is caused by a novel coronavirus,severe acute respiratory syndrome coronavirus 2(SArS-CoV-2),which instigates severe and often fatal *** of September 4th,2020,more than 26 million cases of COVID-19 and almost 900,000 deaths have been reported to *** on Kissler and colleagues’modeled projections of future viral transmission scenarios,a resurgence in SArS-CoV-2 could occur over the next five years(Kissler et al.,2020).

关键词： ACE2 drugs acute

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Considerations and Experience in the Treatment of Lung Cancer with VMAT SBrT + DIBH in Arms-Down Position

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International Journal of Medical Physics, Clinical Engineering and radiation Oncology 2021年第2期10卷 69-80页

作者： Yulin Song Boris Mueller kenneth Dow Ziad Saleh Xiaoli Tang Melissa Zinovoy Daphna Gelblum Borys Mychalczak Department of Medical Physics Memorial Sloan Kettering Cancer Center New York USA Department of radiation Oncology Memorial Sloan Kettering Cancer Center New York USA

The arms-up position is the most common treatment position adopted for lung cancer patients treated with radiation therapy. However, many elderly or frail patients have shoulder problems and cannot tolerate such an overstretched position for an extended period. Therefore, the arms-down position becomes the only alternative for this group of patients during radiation therapy. Even though the arms-down position is not ideal, it does provide a stable and comfortable patient immobilization position for radiation treatments that require a longer delivery time, such as stereotactic body radiation therapy (SBrT). In this study, we designed a protocol to treat lung cancer patients with VMAT stereotactic body radiation therapy (VMAT SBrT) and deep inspiration breath-hold (DIBH) in the arms-down position. Our initial clinical experience with this protocol indicates that it is reliable for patient immobilization and accurate in delivered dosimetry.

关键词： Lung Cancer VMAT SBrT DIBH Arms-Down Position

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