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Non Selective Inhibition of COX Activity Reversed Inflammation and Reactive Oxygen Radicals Mediated Prostate Cancer Risk and Decreased Disease Progression in Preclinical Model

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Journal of Cancer Therapy 2016年第1期7卷 41-49页

作者： Maxwell omabe kenneth nwobini omabe Clement Ademola Famurewa Alberta Egwu Okorocha Grace Maxwell omabe Tumor Immunology Group Division of Oncology Cancer Research Division Department of Pathology and Laboratory Medicine University of Saskatchewan Saskatoon Canada Molecular Pathology and Cancer Biology Research Group Chemical Pathology Division Department of Medical Laboratory Sciences Faculty of Health Science Ebonyi State University Ebonyi Nigeria Department of Biochemistry and Molecular Biology Faculty of Natural Sciences Federal University Ndufu Alike Ikwo Nigeria Department of Medical Biochemistry Faculty of Basic Medical Sciences Federal University Ndufu Alike Ikwo Nigeria Department of Physiology Faculty of Basic Medical Sciences Ebonyi State University Ebonyi Nigeria

Prostate cancer (PCa) represents the most frequent urologic diagnosis in elderly males. We have previously shown that exposure of prostate to lipopolysaccharide (LPS) promotes cancer risk. We investigated the effect of non-selective cyclooxygenase (COX) inhibition on prostate inflammation-mediated cancer risk in vivo. The prostates of male rats were inoculated with E. coli as sources of inflammatory molecules (LPS) and were treated with COX inhibitor, aspirin 2 mg/Kg orally for 14 days or PBS. Oxidative stress was induced with two 2 mls of hydrogen peroxide orally twice daily or PBS for 14 days;they were either treated with COX inhibitor or PBS for another 14 days. Blood was collected and analyzed for acid phosphatase and PSA. Data showed presences of LPS in the prostate of the rats resulted in gradual increase in PSA when compared to control (P 2O2 had 2.5 fold increase in acid phosphatase (ACP) compared control (P < 0.0001), and by inhiting COX activity, a statistically significant reduction in ACP from 11.2 IU/L ± 0.67 to 5.7 IU/L ± 0.347 (P < 0.0034) was observed. Thus since increased in PSA was associated to cancer risk, our data suggested that inflammation mediated prostate cancer risk was reversible by Inhibition of COX Activity in rats.

关键词： Inflammation Prostate Cancer Reactive Oxygen Species

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Xenobiotics-Induced Liver Damage Is Biochemically Abrogated by Treatment with Lipophilic Extracts of <i>Moringa oleifera in Vivo</i>

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Health 2018年第3期10卷 313-325页

作者： Maxwell omabe kenneth nwobini omabe David Igwe Ogbonnaya Chukwu John Samuel Kalu Uchenna Sunday Elom Department of Oncology Cancer Research Division Immunology Group University of Saskatchewan Saskatoon Canada Diagnostic Molecular Biology Research Group Molecular Pathology and Immunology Division Chemical Pathology & Histopathology Unit Department of Medical Laboratory Sciences School of Biomedical Science Faculty of Health Science Ebonyi State University Abakaliki Nigeria Department of Molecular Biology Faculty of Natural Sciences Federal University Abakaliki Nigeria Department of Trauma and Orthopaedic Rotherham NHS Trust Rotherham UK Department of Medical Biochemistry Faculty of Basic Medical Sciences Federal University Abakaliki Nigeria

Context Drug-induced hepatotoxicity represents a significant proportion of liver disease cases. Currently, there is no effective treatment. To date efforts to identify treatment regimen that can reverse progressive damage have not been successful. We have previously shown that extract from Moringa (M) oleifera possesses clinically relevant antidiabetic and electrolyte modulators. Objective The aim of the current studies is to create experimental model of xenobiotic induced liver damage and investigate if treatment with lipophilic extract of M. oleifera could biochemically reverse progressive liver damage. Materials and Method For two groups of healthy rats, 7 in each group received 200 mg of extract or vehicle twice daily for 14 days. Acute toxicity, hepatotoxicity and hematologic/endothelial toxicity were monitored. Then 30 rats weighing 130 - 200 g received repeated dose of acetaminophen (xenobiotics) (640 mg/kg) for 5 days. Hepatotoxicity was confirmed biochemically by an established protocol. Treatment with M. oleifera extract resulted in mean weight of 132.2 ± 5.05 compared to the control with 134.1 ± 5.08 (P > 0.8115) among the healthy rats. Their LDH levels were 170.7 ± 13.02 and 133.8 ± 7.17 (P > 0.0698) for controls group, while the mean serum (ALT) level was 12.4 ± 1.2 or 25.6 ± 5.644 (P M. oleifera resulted in 100% biochemical recovery from hepatitis compared to the control group (P M. oleifera could effectively and biochemically abrogate xenobiotics induced liver damage in animal model.

关键词： Phytopharmaceuticals Phytomedicine Drug Discovery Inflammation Alanine-Aminotransferase Haematological Toxicity Lactate Dehydrogenase Hepatitis

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