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The Role of Toxicology in Evaluating Marketing Applications for Prescription Drug Products in the United States

毒理学杂志 2005年第S1期 169-170页

作者： kenneth l Hastings,P.H.,D.A.B.T. Associate Director Office of New Drugs Center for Drug Evaluation and Research US Food and Drug Administration Associate Director Office of New Drugs Center for Drug Evaluation and Research US Food and Drug Administration Dr. Associate Director Office of New Drugs Center for Drug Evaluation and Research US Food and Drug Administration

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The Role of Toxicology in Evaluating Marketing Applications for Prescription Drug Products in the United States

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毒理学杂志 2005年第A3期19卷 169-170页

作者： kenneth l Hastings P.H. D.A.B.T. Associate Director Office of New Drugs Center for Drug Evaluation and Research US Food and Drug Administration Associate Director Office of New Drugs Center for Drug Evaluation and Research US Food and Drug Administration Dr.Associate Director Office of New Drugs Center for Drug Evaluation and Research US Food and Drug Administration

In the United States, in order to market a prescription drug product studies need to be conducted to demonstrate safety and efficacy.

关键词：毒物学临床应用处方药代谢产物

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Minto large Igneous Province: A 2.00 Ga Mafic Magmatic Event in the Eastern Superior Craton Based on U-Pb Baddeleyite Geochronology and Paleomagnetism

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Acta Geologica Sinica(English Edition) 2016年第S1期90卷 69-70页

作者： Michael A.HAMIlTON Jean GOUTIER kenneth l.BUCHAN Jack Satterly Geochronology lab Dept.of Earth Sciences University of Toronto Géologie Québec - Ministère de l'énergie et des Ressources naturelles Geological Survey of Canada

A precise U-Pb baddeleyite age of 1999±2 Ma has been obtained for the NNW trending lac Shpogan dyke swarm of the James Bay area of the eastern Superior *** the age of the swarm was only

关键词： Pb A 2.00 Ga Mafic Magmatic Event in the Eastern Superior Craton Based on U-Pb Baddeleyite Geochronology and Paleomagnetism Minto large Igneous Province Bay Ga

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Tree wave migration across an elevation gradient in the Altai Mountains,Siberia

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Journal of Mountain Science 2017年第3期14卷 442-452页

作者： Viacheslav I.KHARUK Sergei T.IM Maria l.DVINSKAYA kenneth J.RANSON Il'ya A.PETROV Sukachev Institute of Forest SB RAS KrasnoyarskRussia Siberian Federal University KrasnoyarskRussia M.F.Reshetnev Siberian State Aerospace University KrasnoyarskRussia NASA's Goddard Space Flight Center GreenbeltMarylandUSA

The phenomenon of tree waves （hedges and ribbons） formation within the alpine ecotone in Altai Mountains and its response to observed air temperature increase was considered. At the upper limit of tree growth Siberian pine （Pinus sibirica） forms hedges on windward slopes and ribbons on the leeward ones. Hedges were formed by prevailing winds and oriented along winds direction. Ribbons were formed by snow blowing and accumulating on the leeward slope and perpendicular to the prevailing winds, as well as to the elevation gradient. Hedges were always linked with microtopography features, whereas ribbons were not. Trees are migrating upward by waves and new ribbons and hedges are forming at or near tree line, whereas at lower elevations ribbons and hedges are being transformed into dosed forests. Time series of high-resolution satellite scenes （from 1968 to 2OlO） indicated an upslope shift in the position ribbons averaged 155＋26 m （or 3-7 m yr^-1） and crown closure increased （about 35%-90%）. The hedges advance was limited by poor regeneration establishment and was negligible. Regeneration within the ribbon zone was approximately 2.5 times （5060 vs 2120 ha^-1） higher then within the hedges zone. During the last four decades, Siberian pine in both hedges and ribbons strongly increased its growth increment, and recent tree growth rate for 50 year-old trees was about twice higher than those recorded for similarly-aged trees at the beginning of the 20^th century. Hedges and ribbons are phenomena that are widespread within the southern and northern Siberian Mountains.

关键词： Ribbon forest Hedges Siberian forests Alpine treeline Tree waves Siberian pine AltaiMountains

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Understanding voltage hysteresis and decay during anionic redox reaction in layered transition metal oxide cathodes:A critical review

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Nano Research 2023年第3期16卷 3766-3780页

作者： Wei Zheng Gemeng liang Shilin Zhang kenneth Davey Zaiping Guo School of Chemical Engineering&Advanced Materials The University of AdelaideAdelaideSA 5005Australia

The emergence of anionic redox reactions in layered transition metal oxide cathodes provides practical opportunity to boost the energy density of rechargeable ***,the activation of anionic redox reaction in layered oxides has significant voltage hysteresis and decay that reduce battery performance and limit ***,we critically review the up-todate development of anionic redox reaction in layered oxide cathodes,summarize the proposed reaction mechanism,and unveil their connection to voltage hysteresis and decay based on the state-of-the-art *** addition,advances associated with various modification approaches to mitigate the voltage hysteresis/decay in layered transition metal oxide cathodes are also ***,we conclude with an appraisal of further research directions including rational design of high-performance layered oxide cathodes with reversible anionic redox reactions and suppressed voltage hysteresis/*** will be of immediate benefit to the development of layered oxide cathodes for high performance rechargeable batteries.

关键词： anionic redox reaction voltage hysteresis voltage decay layered transition metal oxides li-ion battery Na-ion battery

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Management and prevention of acute and chronic lateral ankle instability in athletic patient populations

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World Journal of Orthopedics 2015年第2期6卷 161-171页

作者： Brendan J Mc Criskin kenneth l Cameron Justin D Orr Brian R Waterman Department of Orthopaedic Surgery and Rehabilitation William Beaumont Army Medical Center the John A. Feagin Jr Sports Medicine Fellowship Keller Army HospitalUS Military AcademyWest Point

Acute and chronic lateral ankle instability are common in high-demand patient populations. If not managed appropriately, patients may experience recurrent instability, chronic pain, osteochondral lesions of the talus, premature osteoarthritis, and other significantlong-term disability. Certain populations, including young athletes, military personnel and those involved in frequent running, jumping, and cutting motions, are at increased risk. Proposed risk factors include prior ankle sprain, elevated body weight or body mass index, female gender, neuromuscular deficits, postural imbalance, foot/ankle malalignment, and exposure to at-risk athletic activity. Prompt, accurate diagnosis is crucial, and evidence-based, functional rehabilitation regimens have a proven track record in returning active patients to work and sport. When patients fail to improve with physical therapy and external bracing, multiple surgical techniques have been described with reliable results, including both anatomic and nonanatomic reconstructive methods. Anatomic repair of the lateral ligamentous complex remains the gold standard for recurrent ankle instability, and it effectively restores native ankle anatomy and joint kinematics while preserving physiologic ankle and subtalar motion. Further preventative measures may minimize the risk of ankle instability in athletic cohorts, including prophylactic bracing and combined neuromuscular and proprioceptive training programs. These interventions have demonstrated benefit in patients at heightened risk for lateral ankle sprain and allow active cohorts to return to full activity without adversely affecting athletic performance.

关键词： Ankle instability Athlete Treatment Epidemiology Prevention lateral Sprain

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Pterygium associated with light-emitting diode use:a case report

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Annals of Eye Science 2022年第4期7卷 65-68页

作者： Fiona S.lau Stephanie l.Watson kenneth Gek-Jin Ooi Ophthalmology Department Prince of Wales HospitalRandwickNSWAustralia Faculty of Medicine School of Medical SciencesUniversity of New South WalesRandwickNSWAustralia Cornea Unit Sydney Eye HospitalSydneyNSWAustralia Save Sight Institute Discipline of OphthalmologySydney Medical SchoolThe University of SydneySydneyNSWAustralia Sydney Eye Clinic DarlinghurstNSWAustralia

Background:Pterygium is a sun-related ocular surface disease secondary to ultraviolet(UV)radiation *** occupational UV exposure is known to occur secondary to sun *** present a unique case of pterygium associated with indoor occupational light-emitting diode(lED)exposure not previously described in the *** Description:A mobile phone repairer presented with blurred vision and a superotemporal pterygium of his dominant left eye associated with a magnifying glass lED work lamp was *** was excised routinely with conjunctival autografting to the *** confirmed benign pterygium and recovery was uncomplicated with resolution of ***:The development of pterygium in our patient may have arisen due to the lED lamp’s wavelengths possibly falling within the UV as well as the upper end of the visible light radiation *** the increasing reliance on lED light sources in modern life,ocular conditions arising from exposure to these radiation sources may now need to be listed in the differential diagnoses of patients with *** UV protection counselling for these types of lights may also now need to be considered.

关键词： Pterygium light-emitting diode(lED) ultraviolet light damage ocular surface disease case report

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Map of Mafic Dyke Swarms and Related Units of Russia and Adjacent Regions

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Acta Geologica Sinica(English Edition) 2016年第S1期90卷 22-23页

作者： Richard E.ERNST kenneth l.BUCHAN Svetlana BOTSYUN Department of Earth Sciences Carleton University Faculty of Geology and Geography Tomsk State University Geological Survey of Canada Natural Resources Canada laboratoire des Sciences du Climat et de l'Environnement LSCE/IPSL CEA-CNRS-UVSQ Université Paris-Saclay

Work is currently underway to produce a map in Arc GISTM 10 of the mafic dyke swarms and related units(volcanics,sills and layered intrusions)of Russia and adjacent regions at a scale of 1:5,000,*** the past

关键词： Map of Mafic Dyke Swarms and Related Units of Russia and Adjacent Regions

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Today the Sheep...

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英语学习 1997年第9期 31-34页

作者： kenneth l. Woodward

...Tomorrow the shepherd? Before science getsthere, ethicists want some hard questions asked and an-swered.

关键词：伦理学家克隆技术 Today the Sheep

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Corrigendum:Edible seaweed-derived constituents:an undisclosed source of neuroprotective compounds

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Neural Regeneration Research 2021年第12期16卷 2564-2568页

作者： Melissa Schepers Nikita Martens Assia Tiane kenneth Vanbrabant Hong-Bing liu Dieter lütjohann Monique Mulder Tim Vanmierlo Department of Neuroimmunology Biomedical Research InstituteHasselt UniversityEuropean Graduate School of Neuroscience(EURON)HasseltBelgium Department of Psychiatry&Neuropsychology Division of Translational NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityEuropean Graduate School of Neuroscience(EURON)MaastrichtThe Netherlands Department of Internal Medicine Laboratory of Vascular MedicineErasmus MC University Medical CenterRotterdamthe Netherlands Institue for Clinical Chemistry and Clinical Pharmacology BonnGermany Key laboratory of Marine Drugs Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdaoShandong ProvinceChina

Edible marine algae,or seaweeds,are a rich source of several bioactive compounds including phytosterols,carotenoids,and *** the last decades,seaweedderived constituents turned out to not only reside in the systemic circulation,but are able to cross the blood-brain barrier to exert neuro-active functions both in homeostatic and pathological ***,seaweed-derived constituents have gained increasing interest for their neuro-immunomodulatory and neuroprotective properties,rendering them interesting candidates for the management of several neurodegenerative *** particular seaweed-derived phytosterols gained interest for the treatment of neurodegenerative disorders as they potentiate neuroplasticity,enhance phagocytic clearance of neurotoxic peptides and have anti-inflammatory ***,the antiinflammatory and anti-oxidative properties of other constituents including carotenoids,phenols and polysaccharides have recently gained more *** this review,we provide an overview of a selection of the described neuro-active properties of seaweed-derived constituents with a focus on phytosterols.

关键词： algae carotenoids neuro-active phenols phytosterols polysaccharides seaweed

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