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Incidence trends and predictors for cost and average lengths of stay in colorectal cancer surgery

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World Journal of Gastroenterology 2014年第2期20卷 532-538页

作者： Daw-Shyong Perng I-cheng Lu Hon-Yi Shi Chih-Wen Lin Kuang-Wen Liu Ya-Fen Su king-Teh Lee Department of Medicine E-Da Hospital I-Show University Graduate Institute of Healthcare Administration Kaohsiung Medical University Division of Colorectal Surgery Department of SurgeryE-Da Hospital

AIM:To evaluate the changing trends and outcomes of colorectal cancer(CRC)surgery performed at a large single institution in ***:This study retrospectively analyzed 778patients who received colorectal cancer surgery at E-Da Hospital in Taiwan from 2004 to *** patients were from health examination,inpatient or emergency *** following attributes were analyzed in patients who had undergone CRC surgical procedures:gender,age,source,surgical type,tumor number,tumor size,number of lymph node metastasis,pathologic differentiation,chemotherapy,distant metastases,tumor site,tumor stage,average hospitalization cost and average lengths of stay(ALOS).The odds ratio and95%confidence intervals were calculated to assess the relative rate of *** models were employed to predict average hospitalization cost and ***:The study sample included 458(58.87%)males and 320(41.13%)females with a mean age of64.53 years(standard deviation,12.33 years;range,28-86 years).The principal patient source came from inpatient and emergency room(96.02%).The principal tumor sites were noted at the sigmoid colon(35.73%)and rectum(30.46%).Most patients exhibited a tumor stage of 2(37.28%)or 3(34.19%).The number of new CRC surgeries performed per 100000 persons was12.21 in 2004 and gradually increased to 17.89 in 2009,representing a change of 46.52%.During the same period,the average hospitalization cost and ALOS decreased from$5303 to$4062 and from 19.7 to 14.4 d,*** following factors were associated with considerably decreased hospital resource utilization:age,source,surgical type,tumor size,tumor site,and tumor ***:These results can be generalized to patient populations elsewhere in Taiwan and to other countries with similar patient profiles.

关键词： Colorectal cancer Average hospitalization cost Average lengths of stay Incidence trend Colorectal cancer surgery

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“法后王”:荀子对孔孟国家伦理的逻辑改造

哈尔滨学院学报 2024年第5期45卷 21-26页

作者：李成彬哈尔滨学院文法学院黑龙江哈尔滨150086

在儒家传统思想中,家庭伦理与国家政治伦理重合,所以,在血亲氏族制国家中,一国之君同时也是一家之长,君臣关系就是父子关系。但到了春秋战国,由于血缘氏族制国家向地域国家转型,这种国家伦理思想遭遇困境。面对困境,孔孟选择坚持,而荀... 详细信息

在儒家传统思想中,家庭伦理与国家政治伦理重合,所以,在血亲氏族制国家中,一国之君同时也是一家之长,君臣关系就是父子关系。但到了春秋战国,由于血缘氏族制国家向地域国家转型,这种国家伦理思想遭遇困境。面对困境,孔孟选择坚持,而荀子则适时改变。他以逻辑的方式消解了家庭伦理在国家政治中的基础地位,在宇宙的大背景之下把“气”“知”“义”当作客观标准,将万物划分为水火、草木、禽兽和人类四个层次,证明人类最贵,从而确立了人对万物的统治依据;而在社会之中,再通过自然的生物之人和君师治下的社会之人的区分,强调社会之人高于生物之人,最终证明,君最贵,从而确立了君的统治依据。由于国家伦理思想的修正必然引起现实政治操作的改变,于是“法后王”思想就应运而生,这是荀子逻辑改造传统国家伦理思想的必然结果,而且,本身也是逻辑方法的运用,对现代国家治理有很强的借鉴意义。

关键词：法后王法先王国家伦理归纳演绎操术

Voltage Generated Characteristics of Piezoelectric Ceramics Cymbal Transducer

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Journal of Materials Science and Chemical Engineering 2014年第10期2卷 32-37页

作者： Long Wu Ming-cheng Chure king-Kung Wu Chia-cheng Tung Department of Electronics Engineering Far-East University Tainan City Chinese Taipei

In this study the relation between the generated open circuit output voltages of the piezoelectric ceramics Cymbal transducers with applied impact mechanical energy is studied. The output voltages of piezoelectric ceramics Cymbal transducers are increased with the increasing of the applied mechanical energy. Under the same impact mechanical energy, the generated open circuit output voltages of the piezoelectric ceramics Cymbal transducer is much higher than that of uncapped piezoelectric ceramics disk alone. The generated open circuit output voltages of the piezoelectric ceramics Cymbal transducer depend on the geometry parameters and the metal thickness of end-cap. The generated open circuit voltage of piezoelectric ceramics Cymbal transducer with thick metal thickness is small than that with thin metal thickness.

关键词： Cymbal Transducer Piezoelectric Energy Harvester

Probing dark matter particles from evaporating primordial black holes via electron scattering in the CDEX-10 experiment

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 83-91页

作者： Zhenhua Zhang Litao Yang Qian Yue Kejun Kang Yuanjing Li Haipeng An Greeshma C. Jianping Chang Yunhua Chen Jianping cheng Wenhan Dai Zhi Deng Changhao Fang Xinping Geng Hui Gong Qiuju Guo Tao Guo Xuyuan Guo Li He Shengming He Jinwei Hu Hanxiong Huang Tuchen Huang Lin Jiang S.Karmakar Haubin Li Hanyu Li Jianmin Li Jin Li Qianyun Li Renmingjie Li Xueqian Li Yulan Li Yifan Liang Bin Liao FongKay Lin ShinTed Lin Jiaxuan Liu Shukui Liu Yandong Liu Yu Liu Yuanyuan Liu Hao Ma Yucai Mao Qiyuan Nie Jinhua Ning Hui Pan Ningchun Qi Jie Ren Xichao Ruan Monoj Kumar Singh Tianxi Sun Changjian Tang Yang Tian Guangfu Wang Junzheng Wang Li Wang Qing Wang Yufeng Wang Yunxiang Wang Henry Tsz-king Wong Shiyong Wu Yucheng Wu Haoyang Xing Rui Xu Yin Xu Tao Xue Yulu Yan Nan Yi Chunxu Yu Haijun Yu Jianfeng Yue Ming Zeng Zhi Zeng Bingtao Zhang Fengshou Zhang Lei Zhang Zhenyu Zhang Jizhong Zhao Kangkang Zhao Minggang Zhao Jifang Zhou Zuying Zhou Jingjun Zhu CDEX Collaboration Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Institute of Physics Academia SinicaTaipei 11529China NUCTECH Company Beijing 100084China YaLong River Hydropower Development Company Chengdu 610051China College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875China College of Physics Sichuan UniversityChengdu 610065China School of Physics Peking UniversityBeijing 100871China Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413China Sino-French Institute of Nuclear and Technology Sun Yet-sen UniversityZhuhai 519082China School of Physics Nankai UniversityTianjin 300071China Department of Physics Banaras Hindu UniversityVaranasi 221005India Department of Physics Beijing Normal UniversityBeijing 100875China 不详

Dark matter(DM)is a major constituent of the ***,no definite evidence of DM particles(denoted as“χ”)has been found in DM direct detection(DD)experiments to *** is a novel concept of detectingχfrom evaporating primordial black holes(PBHs).We search forχemitted from PBHs by investigating their interaction with target *** examined PBH masses range from 1×10^(15)to 7×10^(16)g under the current limits of PBH abundance *** 205.4 kg·day data obtained from the CDEX-10 experiment conducted in the China Jinping Underground Laboratory,we exclude theχ-electron(χ-e)elastic-scattering cross sectionσ_(χe)~5×10^(-29)cm^(2)forχwith a mass■keV from our *** the higher radiation background but lower energy threshold(160 eV),CDEX-10 fills a part of the gap in the previous ***(m_(χ),σ_(χe))can be determined in the future,DD experiments are expected to impose strong constraints on fPBHfor large MPBHs.

关键词： CDEX primordial black hole light dark matter particle dark matter-electron scattering high purity germanium detector

Fractionated evaluation of immunohistochemical hormone receptor expression enhances prognostic prediction in breast cancer patients treated with tamoxifen as adjuvant therapy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第1期11卷 1-9页

作者： Ching-hung LIN Huang-chun LIEN Fu-chang HU Yen-shen LU Sung-hsin KUO Ling-chu WE San-lin YOU Ann-lii cheng king-jen CHANG Department of Oncology National Taiwan University Hospital Taiwan Taipei 10016 Department of Pathology National Taiwan University Hospital Taiwan Taipei 10016 National Center of Excellence for General Clinical Trial and Research National Taiwan University Hospital Taiwan Taipei 1001 6 Graduate Institute of Epidemiology College of Public Health National Taiwan University Taiwan Taipei 10055 Department of Surgery National Taiwan University Hospital Taiwan Taipei 10016

Objective： To compare the prognostic prediction between dichotomized and fractionated evaluations of hormone receptor expressions. Methods： Patients with stages Ⅰ-Ⅲ breast cancers, who received adjuvant tamoxifen, were enrolled. The expression of estrogen receptor （ER） and progesterone receptor （PR） was evaluated by immu- nohistochemistry （IHC）. A fractionated score （F score）, the percentage of positive-staining nuclei （0=none, 1=1%-10% 2= 11%-30%, 3=31%-50%, 4=51%-70%, and 5=71%-100%）, was assigned to each case. The dichotomized scoring method defines an F score 〉1 as positive. The prognostic values of both scores were compared by multiple Cox＇s proportional hazard models of disease-free survival （DFS） and overall survival （OS）. Results： Four hundred and six- teen patients with a median follow-up of 78.0 months were included. F scores for ER and PR correlated directly with DFS and OS. Although both the dichotomized and fractionated ER and PR scores were significantly associated with DFS and OS in univariate analyses, only fractionated ER and PR scores remained as independent prognostic factors of DFS and OS in the final multiple Cox＇s proportional hazard models. Conclusion： Fractionated IHC hormone receptor expression evaluation enhances the prognostic prediction compared with a dichotomized assessment.

关键词： Breast cancer Fractionated evaluation Estrogen receptor Progesterone receptor

Imaging assessment after SBRT for hepatocellular carcinoma

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Hepatoma Research 2020年第7期6卷 78-85页

作者： Connie yip Tiffany Priyanthi Hennedige Gary JRCook Vicky Goh Radiation Oncology National Cancer Centre SingaporeSingapore 169610Singapore Oncologic Imaging National Cancer Centre SingaporeSingapore 169610Singapore Cancer Imaging King’s College LondonLondon WC2R 2LSUnited Kingdom

The use of stereotactic body radiotherapy(SBRT)in hepatocellular carcinoma(HCC)has increased over the past few ***,accurate evaluation of post-SBRT treatment response is essential to avoid over-treatment of responders as well as missing the opportunity to salvage *** are some intricate imaging differences after liver SBRT compared to those observed after conventional fractionated radiotherapy and other locoregional *** aim to review the imaging changes that occur following SBRT for HCC and their potential clinical implications.

关键词： Imaging liver stereotactic body radiotherapy hepatocellular carcinoma

“客流为王”背景下城市轨道交通客流引流策略研究

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现代城市研究 2024年第2期39卷 66-69页

作者：金铭杨涛程晓明施敏苏州轨道交通集团有限公司南京市城市与交通规划设计研究院股份有限公司

随着轨道交通报建政策总体收紧,对建成线路客流评估要求越来越高,然而很多城市轨道交通客流强度不理想,对政府补贴依赖度较高,城市轨道交通客流稳步增长和可持续发展任重道远。文章围绕轨道交通规划、设计、运营等多个角度,综合考虑近... 详细信息

随着轨道交通报建政策总体收紧,对建成线路客流评估要求越来越高,然而很多城市轨道交通客流强度不理想,对政府补贴依赖度较高,城市轨道交通客流稳步增长和可持续发展任重道远。文章围绕轨道交通规划、设计、运营等多个角度,综合考虑近期和远期措施,提出城市轨道交通客流提升的6大引流策略,以期促进城市轨道交通客流稳步提升,引导城市轨道交通健康可持续发展。

关键词：轨道客流交通需求管理引流策略交通规划

N, N-dimethyltryptamine, a natural psychedelic, rapidly improves spatial memory and hippocampal longterm potentiation: a potential rapid-acting therapy for dementia-associated wandering

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中国药理学与毒理学杂志 2023年第7期37卷 489-490页

作者： cheng Dan LEI Zhuogui Benjamin Chun-Kit TONG Catherine Kin CHIU LI Ying king-Ho CHEUNG ZHANG Zhangjin School of Chinese Medicine the University of HongKong Department of Neuroscience City University of HongKong School of Chinses Medicine and Mr. and Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research HongKong Baptist University Department of Psychology LKS Faculty of Medicine the University of HongKong Department of Chinese Medicine the University of Hong Kong-Shenzhen Hospital

There is no fast-acting treatment strategies against Alzheimer′s disease(AD), in particular dementia-related wandering. N, N-dimethyltryptamine(DMT) is a natural psychedelic that may have rapid-onset nootropic effects. In this study, 5 × FAD transgenic mice which recapitulated amyloid neuropathological features of AD received one single injection of 6 or 12 mg · kg-1DMT and tested at 0.5, 1, and 2 h thereafter in Y-maze for spatial memory. 5×FAD transgenic mice exhibited pronounced decreases in time spent, number entered, and distance travelled in the novel arm of Y-maze. DMT at 12 mg · kg-1partially or completely reversed the three behavioral indices at multiple time points, up to 2 h post injection. The rapid-onset behavioral improvement was consistent with pharmacokinetic analysis of DMT, showing approximately 30 min to reach the maximum concentration in the brain tissue. The transgenic mice also displayed dramatically impaired hippocampal long-term potentiation(LTP), an electrophysiological feature of memory formation and consolidation. DMT potently enhanced LTP and restored intracellular calcium activity, expression and phosphorylation of calcium/calmodulin-dependent protein kinase Ⅱ(CaMKⅡ) and AMPA-type glutamate receptor1(GluR1), the two key calcium-activated mediators involved in LTP induction. Adenosine triphosphate(ATP)is purinergic signalling molecules that are involved in LTP induction and maintenance. DMT rapidly increased mitochondrial ATP dynamics in in vivo and in vitro *** results suggest that DMT rapidly improve spatial memory and hippocampal LTP by restoring the CaMKⅡ-GluR1 signaling pathway and mitochondrial ATP production. It may be served as a fast-acting nootropic agent for the treatment of AD in particular wandering.

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乳腺癌的全球化趋势

抗癌之窗 2015年第5期 9-12页

作者： cheng-Har yip 吉隆坡东姑阿都拉曼医学院

在全球范围内，无论是发达国家还是发展中国家，乳腺癌是女性最常见的癌症。2012年，估计全球约有167万病例（2012GLOBOCAN）。从欧洲国家的96／10万到非洲的27／10万，不同地区发病率不同。2012年，乳腺癌是欠发达地区的主要死亡原因... 详细信息

在全球范围内，无论是发达国家还是发展中国家，乳腺癌是女性最常见的癌症。2012年，估计全球约有167万病例（2012GLOBOCAN）。从欧洲国家的96／10万到非洲的27／10万，不同地区发病率不同。2012年，乳腺癌是欠发达地区的主要死亡原因（32．4万例），是发达地区的第二大死因（19．8万例）。尽管发病率在发达国家已经稳定，而在发展中国家仍在不断上升。

关键词：乳腺癌全球化发展中国家地区发病率欠发达地区主要死亡原因发达国家欧洲国家