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APPL2 Negatively Regulates Olfactory Functions by Switching Fate Commitments of Neural Stem Cells in Adult Olfactory Bulb via Interaction with Notch1 Signaling

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Neuroscience Bulletin 2020年第9期36卷 997-1008页

作者： Chong Gao Tingting yan Xingmiao Chen kenneth k.y.Cheng Aimin Xu Jiangang Shen School of Chinese Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongPok Fu LamHong Kong SARChina State key Laboratory of Pharmaceutical Biotechnology The University of Hong KongPok Fu LamHong Kong SARChina Department of Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongPok Fu LamHong Kong SARChina Department of Health Technology and Informatics The Hong Kong Polytechnic UniversityHung HomHong Kong SARChina

Adult olfactory neurogenesis plays critical roles in maintaining olfactory ***-generated neurons in the subventricular zone migrate to the olfactory bulb(OB) and determine olfactory discrimination,but the mechanisms underlying the regulation of olfactory neurogenesis remain *** previous study indicated the potential of APPL2(adaptor protein,phosphotyrosine interacting with PH domain and leucine zipper 2) as a modulating factor for neurogenesis in the adult olfactory *** the present study,we report how APPL2 affects neurogenesis in the OB and thereby mediates olfactory discrimination by using both in vitro neural stem cells(NSCs) and an in vivo animal model-APPL2 transgenic(Tg) *** the in vitro study,we found that APPL2 overexpression resulted in NSCs switching from neuronal differentiation to gliogenesis while APPL2 knockdown promoted *** the in vivo study,APPL2 Tg mice had a higher population of glial cells and dampened neuronal production in the olfactory system,including the corpus callosum,OB,and rostral migratory *** APPL2 Tg mice displayed impaired performance in olfactory discrimination tests compared with wild-type ***,we found that an interaction of APPL2 with Notch1 contributed to the roles of APPL2 in modulating the neurogenic lineage-switching and olfactory *** conclusion,APPL2 controls olfactory discrimination by switching the fate choice of NSCs via interaction with Notch1 signaling.

关键词： APPL2 Neurogenesis Olfactory bulb Notch1 signaling

Strategies to increase the resectability of hepatocellular carcinoma

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World Journal of Hepatology 2015年第18期7卷 2147-2154页

作者： wong Hoi She kenneth SH Chok Department of Surgery the University of Hong Kong

Hepatocellular carcinoma(HCC) is best treated by liver transplantation, but the applicability of transplantation is greatly limited. Tumor resection in partial hepatectomy is hence resorted to. However, in most parts of the world, only 20%-30% of HCCs are resectable. The main reason for such a low resectability is a future liver remnant too small to be sufficient for the patient. To allow more HCC patients to undergo curative hepatectomy, a variety of ways have been developed to increase the resectability of HCC, mainly ways to increase the future liver remnants in patients through hypertrophy. They include portal vein embolization, sequential transarterial chemoembolization and portal vein embolization, staged hepatectomy, two-staged hepatectomy with portal vein ligation, and Associating Liver Partition and Portal Vein Ligation in Staged Hepatectomy. Herein we review, describe and evaluate these different ways, ways that can be life-saving.

关键词： Hepatocellular carcinoma Hepatectomy Portal vein l

Mechanosynthesis and mechanochemical treatment of bismuth-doped vanadium phosphorus oxide catalysts for the partial oxidation of n-butane to maleic anhydride

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Journal of Natural Gas Chemistry 2008年第3期17卷 232-237页

作者： y. H. Taufiq-yap y.C. wong y. kamiya W.J. Tang Putra Center for Catalysis Science and Technology Department of Chemistry Faculty of Science Universiti Putra Malaysia 43400 UPM Serdang Selangor Darul Ehsan Malaysia Graduate School of Environmental Science Hokkaido Universit3 Sapporo 060-0810 Japan

Three Bi-doped vanadyl pyrophosphate catalysts were prepared via dihydrate route （VPD method）, which consisted of different preparation methods including mechanosynthesis, mechanochemical treatment, and the conventional reflux method. The catalysts produced by the above three methods were characterized by x-ray diffraction （XRD）, scanning electron microscopy （SEM）, and temperature programmed reduction （TPR）. Catalytic evaluation for the partial oxidation of n-butane to maleic anhydride （MA） was also carried out. The XRD patterns of all the Bi-doped catalysts showed the main peaks of pyrophosphate phase. Lower intensity peaks were observed for the mechanochemically treated Bi-doped catalyst （VPDBiMill） with two additional small peaks corresponding to the presence of a small amount of V5＋ phase. The TPR profiles showed that the highest amount of active oxygen species, i.e, V4＋–O- pair, responsible for n-butane activation, was removed from VPDBiMill. Furthermore, from the catalytic test results, the graph of selectivity to MA as a function of the conversion of n-butane demonstrated that VPDBiMill was the most selective catalyst. This suggests that the mechanochemical treatment of vanadium phosphate catalyst （VPDBiMill） is a potential method to improve the catalytic properties for the partial oxidation of n-butane to maleic anhydride.

关键词： mechanosynthesis mechanochemical treatment bismuth vanadyl pyrophosphate

Ophthalmology in the time of COVID-19: experience from Hong kong Eye Hospital

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International Journal of Ophthalmology(English edition) 2020年第6期13卷 851-859页

作者： Stephanie S.L.Cheung Cherie y.k.wong Jason C.k.Chan Carmen k.M.Chan N.M.Lam Hunter k.L.yuen Victoria W.y.wong Chi Wai Tsang Clement C.y.Tham Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongHong Kong SARChina Hong kong Eye Hospital Hong Kong SARChina

AIM:To review international guidelines and to share our infection control experience during the coronavirus disease 2019(COVID-19)pandemic at a tertiary eye centre in Hong ***:Infection control guidelines and recommendations from international ophthalmological bodies are reviewed and *** measures at our hospital were drawn up as per international and local health authorities’guidelines and implemented with the collaboration of doctors,nurses and administrative ***:The aims of our infection control measures are to 1)minimize cross-infection within the hospital;2)protect and support hospital staff;3)ensure environmental *** minimize the risk of cross-infection,outpatient attendance and elective surgery have been reduced by 40%,and general anesthesia procedures were reduced by 90%.Patients entering the hospital are screened for fever,travel history,contact and cluster history,and COVID-19 related *** protect and support hospital staff,we ensure provision of adequate personal protective equipment(PPE)and provide clear guidelines on the level of PPE needed,depending on the clinical *** protective measures include provision of work uniforms,easy access to alcohol-based hand rub,opening new lunch areas,implementation of self-monitoring and self-reporting systems,and communication via online education and ***,environmental control is achieved by ensuring regular disinfection of the hospital premise,enhancing ventilation,and usage of disposable ophthalmic ***:Our multi-pronged approach to infection control is,so far,successful in minimizing infection risks,while allowing the maintenance of essential ophthalmic services.

关键词： COVID-19 coronavirus SARS-CoV-2 ophthalmology infection control Hong kong

Periodicity and Stability in Periodic n-Species Lotka-Volterra Competition System with Feedback Controls and Deviating Arguments

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Acta Mathematica Sinica,English Series 2003年第4期19卷 801-822页

作者： MengFAN keWANG PatriciaJ.y.wong RaviP.AGARWAL DepartmentofMathematics KeyLaboratoryforVegetationEcologyoftheEducationMinistryofP.R.China NortheastNormalUniversity Changchun130024P.R.China SchoolofElectricalandElectronicEngineering NanyangTechnologicalUniversitySingapore639798Singapore DepartmentofMathematicalSciences FloridaInstituteofTechnologyMelbourneFlorida32901-6975USA

By using the method of coincidence degree and Lyapunov functional, a set ofeasily applicable criteria are established for the global existence and global asymptotic stabilityof strictly positive (componentwise) periodic solution of a periodic n-species Lotka-Volterracompetition system with feedback controls and several deviating arguments. The problem considered inthis paper is in many aspects more general and incorporate as special cases various problems whichhave been studied extensively in the literature. Moreover, our new criteria, which improve andgeneralize some well known results, can be easily checked.

关键词： strictly positive periodic solutions globally asymptotic stability Lotka-Volterra competition system feedback controls deviating arguments coincidence degree Lyapunov functional

Design and fabrication of automated sedimentation-based separation and siphon-based extraction for detection of allergic reaction on a centrifugal microfluidic disc

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Chinese Optics Letters 2010年第10期8卷 957-959页

作者： Q. L. Chen H. P. Ho k. L. Cheung S. k. kong y. k. Suen y. W. kwan C. k. wong Center for Advanced Research in Photonics and Department of Electronic Engineering The Chinese University of Hong Kong Hong Kong China Department of Biochemistry The Chinese University of Hong Kong Hong Kong China School of Biomedical Sciences The Chinese University of Hong Kong Hong Kong China Department of Chemical Pathology The Chinese University of Hong Kong Hong Kong China

We report the design and fabrication of a novel and fully integrated polymer-based centrifugal microfluidic disc for rapid automatic allergens detection. All essential steps for a single test including flow valving, sequencing, mixing, separation, extraction, and sedimentation for final detection are automatically conducted within 30 min on a centrifugal microfluidic disc. Our design features a siphon-based valving and analyte extraction structure where the released analyte is separated and subsequently extracted by a siphon valve into the detection chamber. Incorporating the siphon valve and a series of capillary valves, we realize automated detection of allergic reaction on a centrifugal microfluidic disc.

关键词： Adaptive optics Diffuse optical imaging Photolithography Polydimethylsiloxane Polymethyl methacrylate

Engineered polycaprolactone–magnesium hybrid biodegradable porous scaffold for bone tissue engineering

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Progress in Natural Science:Materials International 2014年第5期24卷 561-567页

作者： Hoi Man wong Paul k.Chu Frankie k.L.Leung kenneth M.C.Cheung keith D.k.Luk kelvin W.k.yeung Department of Orthopaedics and Traumatology The University of Hong Kong Shenzhen key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen Hospital Department of Physics and Materials Science City University of Hong Kong Peking University Shenzhen Institution

In this paper, we describe the fabrication of a new biodegradable porous scaffold composed of polycaprolactone(PCL) and magnesium(Mg)micro-particles. The compressive modulus of PCL porous scaffold was increased to at least 150% by incorporating 29% Mg particles with the porosity of 74% using Micro-CT analysis. Surprisingly, the compressive modulus of this scaffold was further increased to at least 236% when the silane-coupled Mg particles were added. In terms of cell viability, the scaffold modified with Mg particles significantly convinced the attachment and growth of osteoblasts as compared with the pure PCL scaffold. In addition, the hybrid scaffold was able to attract the formation of apatite layer over its surface after 7 days of immersion in normal culture medium, whereas it was not observed on the pure PCL scaffold. This in vitro result indicated the enhanced bioactivity of the modified scaffold. Moreover, enhanced bone forming ability was also observed in the rat model after 3 months of implantation. Though bony in-growth was found in all the implanted scaffolds. High volume of new bone formation could be found in the Mg/PCL hybrid scaffolds when compared to the pure PCL scaffold. Both pure PCL and Mg/PCL hybrid scaffolds were degraded after 3 months. However, no tissue inflammation was observed. In conclusion, these promising results suggested that the incorporation of Mg micro-particles into PCL porous scaffold could significantly enhance its mechanical and biological properties. This modified porous bio-scaffold may potentially apply in the surgical management of large bone defect fixation.

关键词： Magnesium Polycaprolactone Biodegradability Biocompatibility Mechanical properties

Using benthic macrofauna to assess environmental quality of four intertidal mudflats in Hong kong and Shenzhen Coast

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Acta Oceanologica Sinica 2003年第2期22卷 309-319页

作者： CaiLizhe NoraF.y.Tam TeresaW.y.wong MaLi Gaoyang yuk-Shanwong ResearchLabortoryofSEDCofMarineEnvironmentalScience EnivonmentalScienceResearchCenterXiamenUniversityXiamen361005China DepartmentofBiologyandChermistryandCenterforCoastalPollutionControl CityUniversityofHongKongHKSARChina

Intertidal zone is a significant wetland between land and ocean. It plays an important rolein maintaining local ecological balance. Both Mai Po and Futian intertidal mudflats are located in Shenzhen Bay and are important 'refueling' point along the East Asian/Australian flyway of migratory birds. The environmental quality of Mai Po and Futian mudflats have aroused great concern due to rapid economic developments in Hong kong and Shenzhen in recent decades. Macroinfauna of Mai Po and Futian mudflats was investigated in December 2000 and the faunal data were used to assess their environmental quality. Two other mudflats, namely Ma Wan Typhoon Shelter (a more disturbed area) and Luk keng intertidal mudflat (a place with relatively less human disturbance), were also sampled for macroinfauna and used as reference mudflats. Shannon - Weaver species diversity index (Isd), biotic coefficient (Cb) and macrofaunal pollution index (Imp) of the macrofauna community on four intertidal mudflats were used to determine their environmental quality. The results showed that Luk keng intertidal mudflat was unpolluted, Mai Po and Futian mudflats were slightly polluted, and Ma Wan was moderately polluted. The pollution in Ma Wan Typhoon Shelter mainly came from various types of rubbish and fishing boats that disturbed the sediment, while pollution sources in Mai Po and Futian mudflats were discharges of industrial water, municipal sewage and from nearby rivers.

关键词： Biotic index macrofauna intertidal mudflat environmental quality

TRIBOLOGICAL AND HIGH SPEED TURNING PERFORMANCE IN Ti_(1-x)Al_(x)N COATINGS PREPARED By CLOSE-FIELD UNBALANCED MAGNETRON SPUTTERING

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Acta Metallurgica Sinica(English Letters) 2005年第3期18卷 254-260页

作者： P.W.Shum M.Escursell T.H.wong k.y.Li Z.F.Zhou y.G.Shen Advanced Coatings Applied Research Laboratory(ACARL) Department of Manufacturi ng Engineering and Engineering ManagementCity University of Hong KongKowloonHong KongChina

Titanium-aluminium-nitride(Ti_(1-x)Al_(x)N)coatings were deposited by close-field un balanced magnetron sputtering on M42 steel substrates and WC-6wt%Co inserts at 450℃.The tribological behavior was analyzed by sliding against steel and WC-6wt%Co balls,while the turning performance was evaluated by a conventional tu rning machine at high cutting speeds without using *** the tribological tests,the formation of transfer layer and the variations of hardness of the co atings played an important role for sliding against steel *** the coating s sliding against WC-6wt%Co balls,the Ti-Al-N coatings showed a similar frictio n coefficient,but the TiN coating exhibited a lower *** difference could be explained by the tri-oxidation wear *** the turning tests,a super ior cutting performance of the coating was found at x=0.45,which endured 38 min utes before the tool flank wear reached the maximum value of 0.3mm,whereas only 20 minutes were endured for the TiN *** excellent performance of the c oatings in the turning tests could be explained by the enhanced mechanical prope rties and oxidation/diffusion resistance of the coatings.

关键词： hardness Ti-Al-N coating tribology turning test wear test