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Effect of transplant center volume on post-transplant survival in patients listed for simultaneous liver and kidney transplantation

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World journal of Hepatology 2018年第1期10卷 134-141页

作者： Rohan M Modi Dmitry Tumin Andrew j Kruger Eliza W Beal Don Hayes jr james Hanje Anthony j Michaels kenneth Washburn Lanla F Conteh Sylvester M Black Khalid Mumtaz Department of Internal Medicine Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Anesthesiology and Pain Medicine Nationwide Children’s HospitalColumbusOH 43205United States Department of General Surgery Division of TransplantationOhio State University Wexner Medical CenterColumbusOH 43210United States Comprehensive Transplant Center Ohio State University Wexner Medical CenterColumbusOH 43210United States Section of Pulmonary Medicine Nationwide Children’s HospitalColumbusOH 43205United States Department of Internal Medicine Division of GastroenterologyHepatology and NutritionOhio State University Wexner Medical CenterColumbusOH 43210United States

AIM To examine the effect of center size on survival differences between simultaneous liver kidney transplantation(SLKT) and liver transplantation alone(LTA) in SLKT-listed *** The United Network of Organ Sharing database was queried for patients ≥ 18 years of age listed for SLKT between February 2002 and December 2015. Posttransplant survival was evaluated using stratified Cox regression with interaction between transplant type(LTA vs SLKT) and center *** During the study period, 393 of 4580 patients(9%) listed for SLKT underwent a LTA. Overall mortality was higher among LTA recipients(180/393, 46%) than SLKT recipients(1107/4187, 26%). The Cox model predicted a significant survival disadvantage for patients receiving LTA vs SLKT [hazard ratio, hazard ratio(HR) = 2.85; 95%CI: 2.21, 3.66; P < 0.001] in centers performing 30 SLKT over the study period. This disadvantage was modestly attenuated as center SLKT volume increased, with a 3% reduction(HR = 0.97; 95%CI: 0.95, 0.99; P = 0.010) for every 10 SLKs *** In conclusion, LTA is associated with increased mortality among patients listed for SLKT. This difference is modestly attenuated at more experienced centers and may explain inconsistencies between smaller-center and larger registry-wide studies comparing SLKT and LTA outcomes.

关键词： Kidney transplantation Center volume Mortality Liver transplantation United network for organ sharing

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Applied statistics for public administration 5th ed.

Applied statistics for public administration

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2002年

作者： Meier kenneth j.

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The 8051 microcontroller

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1000年

作者： kenneth j. Ayala.

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Kinematics, dynamics, and design of machinery

Kinematics, dynamics, and design of machinery

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1999年

作者： Waldron kenneth j.

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Biomass Production of Cup Plant (<i>Silphium perfoliatum</i>L.) in Response to Variation in Plant Population Density in the North Central USA

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American journal of Plant Sciences 2019年第6期10卷 904-910页

作者： Arvid Boe kenneth A. Albrecht Paul j. johnson jixiang Wu Agronomy Horticulture and Plant Science Department South Dakota State University Brookings SD USA Department of Agronomy University of Wisconsin Madison WI USA Insect Biodiversity Laboratory South Dakota State University Brookings SD USA

The North American genus Silphium is receiving global attention for its potential in the development of new food, forage, and industrial crops, including cellulosic biomass for biofuel. Little is known about the effect of plant population density on biomass production in large, coarse perennial forbs. Our objective was to evaluate the effect of variation in plant density on biomass production and stand morphology of cup plant (Silphium perfoliatum L.). Plant population densities of 17,000, 34,000, and 68,000 plants ha-1 were evaluated for biomass production in a single-harvest per annum system for three years at Brookings, SD and Arlington, WI. Biomass increased linearly by 43% between the low and high density at Brookings;whereas, at Arlington, response to variation in plant density was year dependent. Shoots plant-1 was inversely related to plant density with linear regression explaining >95% of the variation. Our results strongly suggested that further studies of effects of plant population density on biomass production in cup plant should include evaluation of, in addition to, densities higher than 68,000 plants ha-1.

关键词： Biofuel Shoot Density Shoots Plant-1 Stand Morphology Cup Plant Moth Eucosma giganteana Riley Biotic Stress Abiotic Stress

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Appearance of aseptic vascular grafts after endovascular aortic repair on[(18)F]fluorodeoxyglucose positron emission tomography/computed tomography

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世界放射学杂志:英文版(电子版) 2023年第8期15卷 241-249页

作者： Paige Bennett Maria Bernadette Tomas Christopher F Koch kenneth j Nichols Christopher j Palestro Department of Radiology LIJMC Northwell HealthNew Hyde ParkNY 11040United States Department of Radiology Zucker School of Medicine at Hofstra/NorthwellHempsteadNY 11549United States Division of Nuclear Medicine and Molecular Imaging Department of RadiologyNorthwell HealthNew Hyde ParkNY 11040United States

BACKGROUND Diagnosis of prosthetic vascular graft infection with[(18)F]fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT)allows for early detection of functional changes associated with infection,based on increased glucose utilization by activated macrophages and *** vascular grafts,like all foreign bodies,can stimulate an inflammatory response,which can present as increased activity on 18F-FDG PET/***,distinguishing aseptic inflammation from graft infection,though important,can be *** the case of endovascular aneurysm repair(EVAR),a minimally invasive procedure involving the transfemoral insertion of an endoprosthetic stent graft,the normal postoperative appearance of these grafts on 18F-FDG PET/CT can vary over time,potentially confounding study *** To investigate the visual,semiquantitative,and temporal characteristics of aseptic vascular grafts in patients status post *** In this observational retrospective cohort study,patients with history of EVAR who underwent 18F-FDG PET/CT for indications other than infection were identified *** patients were asymptomatic for graft infection-no abdominal pain,fever of unknown origin,sepsis,or leukocytosis-at the time of imaging and for≥2 mo after each PET/*** studies such as CT for each patient were also reviewed,and any patients with suspected or confirmed vascular graft infection were *** hundred two scans performed on 43 patients(34 males;9 females;age=77±8 years at the time of the final PET/CT)were retrospectively *** 43 patients had an abdominal aortic(AA)vascular graft,40 patients had a right iliac(RI)limb graft,and 41 patients had a left iliac(LI)limb *** patients had 1 PET/CT and 21 patients had from 2 to 9 PET/*** were imaged between 2 mo to 168 mo(about 14 years)post *** grafts were imaged within 6 mo of placement,including three that were imaged wit

关键词： Aseptic vascular grafts Endovascular aortic repair [(18)F]fluorodeoxyglucose positron emission tomography/computed tomography

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Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor

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Cell Research 2006年第9期16卷 750-758页

作者： SeakwooLee KevinKDesai kenneth A Iczkowski Robert G Newcomer Kevin j Wu Winston W Tan MarkDRoycik Qing-XiangAmySang Department of Chemistry and Biochemistry and Institute of Molecular Biophysics Florida State UniversityTallahasseeFL 32306USA Department of Pathology and Laboratory Medicine Veterans Affairs Medical CenterGainesvilleFL 32608USA Department of PathologyImmunologyand Laboratory of MedicineUniversity of Florida College of MedicineGainesvilleFL 32610USA Department of Pathology MedicineMayo ClinicJacksonvilleFL 32224USA Department of Internal Medicine Hematology/Oncology Mayo ClinicJacksonvilleFL 32224USA

The identification of novel biomarkers for early prostate cancer diagnosis is highly important because early detectionand treatment are critical for the medical management of *** in the continuity of both the basal celllayer and basement membrane is essential for the progression of high-grade prostatic intraepithelial neoplasia (HGPIN)to invasive adenocarcinoma in human *** molecules involved in the conversion to an invasive phenotype arethe subject of intense *** have previously reported that matrix metalloproteinase-26 (MMP-26) promotes theinvasion of human prostate cancer cells via the cleavage of basement membrane proteins and by activating the zymogenform of ***,we have found that tissue inhibitor of metalloproteinases-4 (TIMP-4) is the most potentendogenous inhibitor of *** we demonstrate higher (p<0.0001) MMP-26 and TIMP-4 expression in HGPINand cancer,compared to non-neoplastic *** expression levels are highest in HGP1N,but decline in invasive cancer(p<0.001 for each) in the same *** staining of serial prostate cancer tissue sections suggestscolocalization of MMP-26 and *** present study indicates that MMP-26 and TIMP-4 may play an integral roleduring the conversion of HGPIN to invasive cancer and may also serve as markers for early prostate cancer diagnosis.

关键词： matrix metalloproteinase-26 tissue inhibitor of metalloproteinases-4 high-grade prostatic intraepithelial neoplasia prostate cancer biomarkers early diagnosis immunohistochemistry co-immunoprecipitation

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Biomass Production of Monocultures and Mixtures of Cup Plant and Native Grasses on Prime and Marginal Cropland

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American journal of Plant Sciences 2019年第6期10卷 911-924页

作者： Arvid Boe kenneth A. Albrecht Paul j. johnson jixiang Wu Department of Agronomy Horticulture and Plant Science South Dakota State University Brookings SD USA Department of Agronomy University of Wisconsin Madison WI USA Insect Biodiversity Laboratory South Dakota State University Brookings SD USA

To date, most candidate systems for producing herbaceous cellulosic biomass have been composed of monocultures of perennial or annual grasses. Ecosystem goods and services provided from these biomass feedstock production systems could be increased dramatically with mixing of one or more forb species that would increase biodiversity and provide habitat for pollinators. Cup plant (Silphium perfoliatum L.) is featured with many desirable characteristics, such as high biomass potential, adaptation to marginal soils, and attractiveness to pollinators, desirable in a dicot species to grow in mixtures with perennial warm-season grasses. The objective of this study was to compare cup plant, switchgrass (Panicum virgatum L.), and prairie cordgrass (Spartina pectinata Link) monocultures to their mixtures for biomass production on prime and poorly drained marginal crop land for two years in both South Dakota and Wisconsin. In Wisconsin, monocultures of prairie cordgrass and cup plant and their mixture produced more biomass (8.1 Mg·ha-1) than the switchgrass monoculture and switchgrass/cup plant mixture (5.3 Mg·ha-1) on both prime and marginal land. While in South Dakota, drought and meristem destruction by the cup plant moth (Eucosma giganteana Riley) caused large reductions in biomass production (1.7 Mg·ha-1) in both years, with the switchgrass/cup plant mixture on marginal land having the highest yield (2.1 Mg·ha-1). Our study showed binary mixtures of cup plant and native warm-season grasses have great potential for increasing biodiversity and other ecosystem goods and services, relative to monocultures, for sustainable biomass feedstock production on poorly drained marginal land in the northcentral USA.

关键词： Silphium perfoliatum L. Switchgrass Panicum virgatum L. Prairie Cordgrass Spartina pectinata Link Bioenergy Pollinators Eucosma giganteana Riley Ecosystem Goods and Services

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Fluorescence Intensity Decay Shape Analysis Microscopy （FIDSAM） for Quantitative and Sensitive Live-Cell Imaging： A Novel Technique for Fluorescence Microscopy of Endogenously Expressed Fusion-Proteins

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Molecular Plant 2010年第3期3卷 555-562页

作者： Frank Schleifenbaum Kirstin Elgass Marcus Sackrow Katharina Caesar kenneth Berendzen Alfred j. Meixner Klaus Hatter Center for Plant Molecular Biology Department of Plant Physiology University of Tubingen Auf der Morgenstelle 1 72076 Tubingen Germany Institute of Physical and Theoretical Chemistry University of Tubingen Auf der Morgenstelle 8 72076 Tubingen Germany

Fluorescent studies of living plant cells such as confocal microscopy and fluorescence lifetime imaging often suffer from a strong autofluorescent background contribution that significantly reduces the dynamic image contrast and the quantitative access to sub-cellular processes at high spatial resolution. Here, we present a novel technique--fluorescence intensity decay shape analysis microscopy （FIDSAM） to enhance the dynamic contrast of a fluorescence image of at least one order of magnitude. The method is based on the analysis of the shape of the fluorescence intensity decay （fluorescence lifetime curve） and benefits from the fact that the decay patterns of typical fluorescence label dyes strongly differ from emission decay curves of autofluorescent sample areas. Using FIDSAM, we investigated Arabidopsis thaliana hypocotyl cells in their tissue environment, which accumulate an eGFP fusion of the plasma membrane marker protein LTI6b （LTI6b-eGFP） to low level. Whereas in conventional confocal fluorescence images, the membranes of neighboring cells can hardly be optically resolved due to the strong autofluorescence of the cell wall, FIDSAM allows for imaging of single, isolated membranes at high spatial resolution. Thus, FIDSAM will enable the sub-cellular analysis of even low-expressed fluorophoretagged proteins in living plant cells. Furthermore, the combination of FIDSAM with fluorescence lifetime imaging provides the basis to study the local physico-chemical environment of fluorophore-tagged biomolecules in living plant cells.

关键词： Cell structure cell walls membrane proteins high-resolution fluorescence microscopy.

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Rectification of RF Fields in Load Dependent Coupled Systems: Application to Non-Invasive Electroceuticals

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journal of Biomedical Science and Engineering 2016年第2期9卷 112-121页

作者： Sree N. Koneru Charles R. Westgate kenneth j. McLeod Clinical Science and Engineering Research Laboratory Binghamton University Binghamton NY USA Department of Electrical and Computer Engineering Binghamton University Binghamton NY USA

Electroceuticals are medical devices that employ electric signals to alter the activity of specific nerve fibers to achieve therapeutic effects. The rapid growth of RF microelectronics has resulted in the development of very small, portable, and inexpensive shortwave and microwave radio frequency (RF) amplifiers, raising the possibility of utilizing these new RF technologies to develop non-contact electroceutical devices. However, the bio-electromagnetics literature suggests that beyond 10 MHz, RF fields cannot influence biological tissue, beyond simple heating, because effective demodulation mechanisms at these frequencies do not exist in the body. However, RF amplifiers operating at or near saturation have non-linear interactions with complex loads, and if body tissue creates a complex loading condition, the opportunity exists for the coupled system to produce non-linear effects, that is, the equivalent of demodulation may occur. Correspondingly, exposure of tissue to pulsed RF energy could result in the creation of low frequency demodulation components capable of influencing tissue activity. Here, we develop a one-dimen- sional, numerical simulation to investigate the complex loading conditions under which such demodulation could arise. Applying these results in a physical prototype device, we show that up to7.5% demodulation can be obtained for a 40 MHz RF field pulsed at 1 KHz. Implications for this research include the possibility of developing wearable, electromagnetic electroceutical de- vices.

关键词： RF Demodulation in Tissue Non-Linear Coupling Complex Load-Line Electroceuticals Neuromodulation Stochastic Resonance

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