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Toward implantable devices for angle-sensitive,lens-less,multifluorescent,single-photon lifetime imaging in the brain using Fabry-Perot and absorptive color filters

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Light(Science & Applications) 2022年第2期11卷 197-211页

作者： Adriaan j.Taal Changhyuk Lee j.ebin Choi Bj.rn Hellenkamp kenneth L.Shepard Columbia University-Department of Electrical Engineering 500W.120th St.Mudd 1310New York 10027 NYUSA Korea Institute of Science and Technology-Brain Science Institute 5 Hwarang-ro 14-gilSeongbuk-guSeoul 02792Republic of Korea

Implantable image sensors have the potential to revolutionize *** to their small form factor requirements;however,conventional filters and optics cannot be *** limitations obstruct highresolution imaging of large neural *** advances in angle-sensitive image sensors and single-photon avalanche diodes have provided a path toward ultrathin lens-less fluorescence imaging,enabling plenoptic sensing by extending sensing capabilities to include photon arrival time and incident angle,thereby providing the opportunity for separability of fluorescence point sources within the context of light-field microscopy(LFM).However,the addition of spectral sensitivity to angle-sensitive LFM reduces imager resolution because each wavelength requires a separate pixel ***,we present a 1024-pixel,50μm thick implantable shank-based neural imager with color-filtergrating-based angle-sensitive *** angular-spectral sensitive front end combines a metal–insulator–metal(MIM)Fabry–Perot color filter and diffractive optics to produce the measurement of orthogonal light-field information from two distinct colors within a single *** result is the ability to add independent color sensing to LFM while doubling the effective pixel *** implantable imager combines angular-spectral and temporal information to demix and localize multispectral fluorescent *** this initial prototype,this is demonstrated with 45μm diameter fluorescently labeled beads in scattering *** lifetime imaging is exploited to further aid source separation,in addition to detecting pH through lifetime changes in fluorescent *** these initial fluorescent targets are considerably brighter than fluorescently labeled neurons,further improvements will allow the application of these techniques to in-vivo multifluorescent structural and functional neural imaging.

关键词： filters lifetime angle

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Revascularization and outcomes in Veterans with moderate to severe ischemia on myocardial perfusion imaging

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Military Medical Research 2017年第3期4卷 127-131页

作者： David E.Winchester Alexander j.Bolanos Anita Wokhlu Rebecca j.Beyth Leslee j.shaw Malcom Randall VAMC North Florida/South Georgia Veterans Health System Division of Cardiovascular Medicine University of Florida College of Medicine Malcom Randall VAMC Department of Medicine University of Florida College of Medicine Division of General Internal Medicine University of Florida College of Medicine Division of Cardiology Emory University School of Medicine

Background： The prevalence of ischemia on nuclear myocardial perfusion imaging （MPI） has been decreasing. Recent research has questioned the benefit of invasive revascularization for patients with moderate to severe ischemia. We hypothesized that patients with moderate to severe ischemia could routinely undergo successful revascularization. Methods： We analyzed data from 544 patients who underwent an MPI at a single academic Veterans Affairs Medical Center. Patients with moderate to severe ischemia, defined as a summed difference score （SDS） 8 or greater, were compared to the rest of the cohort. Results： Of the total cohort （n=544）, 39 patients had MPI studies with resultant moderate to severe ischemia. Patients with ischemia were more likely to develop coronary artery disease （74.4% versus 38.8%, P〈0.0001） and have successful revascularization （38.5% versus 4.0%, P〈0.0001） during the following year. Revascularization was attempted in 31 patients with moderate to severe ischemia, though only 15（47%） of these attempts were successful, Ischemia was predictive of myocardial infarction （5.1% versus 0.8%, P=0.01） within I year. Conclusion： Moderate to severe ischemia is an uncommon finding in a contemporary nuclear laboratory. Among patients with ischemia, revascularization is typically attempted but is frequently unsuccessful. Trial registration： This trial does not appear on a registry as it is neither randomized nor prospective.

关键词： Myocardial ischemia Nuclear myocardial perfusion imaqinq Veterans Revascularization

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A biomass based photonic crystal made of "konj.c tofu"

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Chinese Chemical Letters 2021年第1期32卷 587-590页

作者： Wenxin Zhang Min Xue kenneth j.Shea Lili Qiu Zhibin Xu j.ng Fan Dan Yan Zihui Meng School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing 100081China Department of Chemistry University of California IrvineCA 92697United States

Konj.c tofu is a traditional Chinese food whose main ingredient is the water-soluble polysaccharide from konj.c tubers-konj.c glucomannan(KGM).Herein we report an interpenetrating double network polymeric film by crosslinking KGM and polyvinyl alcohol(PVA) with glutaraldehyde under acidic *** was introduced into the hydrogel system as a hard skeleton,which not only maintained the biocompatibility of KGM,but also gave the hydrogel superior mechanical properties and solvent *** a colloidal array inside the above film,we obtained a new type of biomass based photonic crystal that is sensitive to a variety of physical and chemical stimulus,especially for *** photonic crystal responds to metha nol and methanol vapo r,and has the ability to detect methanol in gasoline,which has a good application prospect.

关键词： Photonic crystals Konj.c glucomannan Hydrogel Interpenetrating double network Sensor

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Stem cell therapy for the treatment of Leydig cell dysfunction in primary hypogonadism

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World j.urnal of Stem Cells 2016年第10期8卷 306-315页

作者： Taylor C Peak Nora M Haney William Wang kenneth j.DeLay Wayne j.Hellstrom Department of Urology School of MedicineTulane University

The production of testosterone occurs within the Leydig cells of the testes. When production fails at this level from either congenital, acquired, or systemic disorders,the result is primary hypogonadism. While numerous testosterone formulations have been developed, none are yet fully capable of replicating the physiological patterns of testosterone secretion. Multiple stem cell therapies to restore androgenic function of the testes are under investigation. Leydig cells derived from bone marrow, adipose tissue, umbilical cord, and the testes have shown promise for future therapy for primary hypogonadism. In particular, the discovery and utilization of a group of progenitor stem cells within the testes, known as stem Leydig cells(SLCs), has led not only to a better understanding of testicular development, but of treatment as well. When combining this with an understanding of the mechanisms that lead to Leydig cell dysfunction, researchers and physicians will be able to develop stem cell therapies that target the specific step in the steroidogenic process that is deficient. The current preclinical studies highlight the complex nature of regenerating this steroidogenic process and the problems remain unresolved. In summary, there appears to be two current directions for stem cell therapy in male primary hypogonadism. The first method involves differentiating adult Leydig cells from stem cells of various origins from bone marrow, adipose, or embryonic sources. The second method involves isolating, identifying, and transplanting stem Leydig cells into testicular tissue. Theoretically, in-vivo re-activation of SLCs in men with primary hypogonadism due to age would be another alternative method to treat hypogonadism while eliminating the need for transplantation.

关键词： Stem cell therapy Leydig cells Primary hypogonadism Stem Leydig cells Testosterone Bone marrow-derived stem cells Adipose-derived mesenchymal stem cells

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Expanding beyond endoscopy: A review of non-invasive modalities in Barrett’s esophagus screening and surveillance

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World j.urnal of Gastroenterology 2022年第32期28卷 4516-4526页

作者： Dariush Shahsavari Praneeth Kudaravalli j.hn Erikson L Yap kenneth j.Vega Division of Gastroenterology and Hepatology Augusta University-Medical College of GeorgiaAugustaGA 30912United States

Barrett’s esophagus(BE)is a condition that results from replacement of the damaged normal squamous esophageal mucosa to intestinal columnar mucosa and is the most significant predisposing factor for development of esophageal *** guidelines recommend endoscopic evaluation for screening and surveillance based on various risk factors which has limitations such as invasiveness,availability of a trained specialist,patient logistics and ***-nasal endoscopy is a less invasive modality but still has similar limitations such as limited availability of trained specialist and ***-endoscopic modalities,in comparison,require minimal intervention,can be done in an office visit and has the potential to be a more ideal choice for mass public screening and surveillance,particularly in patents at low risk for *** include newer generations of esophageal capsule endoscopy which provides direct visualization of BE,and tethered capsule endomicroscopy which can obtain high-resolution images of the *** cell collection devices coupled with biomarkers have been used for BE ***,in combination with TFF3,as well as EsophaCap and EsoCheck have shown promising results in various studies when used with various *** modalities including circulatory microRNAs and volatile organic compounds that have demonstrated favorable *** of these cell collection methods for BE surveillance is a potential area of future research.

关键词： Barrett’s esophagus Screening Surveillance Non-endoscopic Cytosponge Esophacap Esocheck

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Scoring microvascular invasion in hepatocellular carcinoma:are we meeting the grade?

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 184-187页

作者： Derek j.Erstad kenneth K.Tanabe Division of Surgical Oncology Baylor College of MedicineHoustonTXUSA Division of Gastrointestinal and Oncologic Surgery Harvard Medical School and Massachusetts General HospitalBostonMAUSA

Hepatocellular carcinoma(HCC)is the second leading cause of cancer-related mortality and has rising global incidence(1).A perplexing aspect of this disease is the high rate of recurrence(50-70%)after curative-intent,margin negative surgical resection(2).While de novo HCC arising from baseline chronic liver inj.ry is a driver of late recurrences,most recurrences occur over a short interval and are thought to be spread from the index malignancy.

关键词： Microvascular invasion(MVI) hepatocellular carcinoma(HCC) hepatectomy

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Engineered polymer nanoparticles incorporating L-amino acid groups as affinity reagents for fibrinogen

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j.urnal of Pharmaceutical Analysis 2021年第5期11卷 596-602页

作者： Yongyan Zhu Ruixuan Liu Dengyu Wu Qianqian Yu kenneth j.Shea Quanhong Zhu School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou510515China Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics Guangzhou510515China Guangdong Provincial Engineering Laboratory of Chinese Medicine Preparation Technology Guangzhou510515China Department of Chemistry University of CaliforniaIrvineCA92697USA

Synthetic polymer hydrogel nanoparticles(NPs)were developed to function as abiotic affinity reagents for *** NPs were made using both temperature-sensitive N-isopropyl acrylamide(NIPAm)and L-amino acid *** kinds of L-amino acids were acryloylated to obtain functional monomers:L-phenylalanine(Phe)and L-leucine(Leu)with hydrophobic side chains,L-glutamic acid(Glu)with negative charges,and L-lysine(Lys)and L-arginine(Arg)with positive *** incubating the NPs with fibrinogen,g-globulin,and human serum albumin(HSA)respectively,the NPs that incorporated Nacryloyl-Arg monomers(AArg@NPs)showed the strongest and most specific binding affinity to fibrinogen,when compared with g-globulin and ***,the fibrinogen-AArg binding model had the best docking scores,and this may be due to the interaction of positively charged AArg@NPs and the negatively charged fibrinogen D domain and the hydrophobic interaction between *** specific adsorption of AArg@NPs to fibrinogen was also confirmed by the immunoprecipitation assay,as the AArg@NPs selectively trapped the fibrinogen from a human plasma protein ***@NPs had a strong selectivity for,and specificity to,fibrinogen and may be developed as a potential human fibrinogen-specific affinity reagent.

关键词： Synthetic polymer nanoparticles Amino-acid monomers Arginine Fibrinogen Affinity reagent Protein interaction

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议程设置理论与后大众媒体时代的民意研究

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国际新闻界 2004年第4期 5-9页

作者： Donald L. shaw,Donald L. shaw,Bradley j. Hamm 美国北卡罗莱纳大学美国北卡罗莱纳大学美国伊降大学

关于媒体与民意的理论大部分提出于 1 93 0到 1 980年之间 ,这是一个仅仅拥有传统信息选择方式的时代。麦库姆斯和肖 (1 972 )最初提出议程设置理论时 ,用北卡罗莱纳州的教堂山 (ChapelHill)社区作为研究对象 ,而现在那里的媒介使用情... 详细信息

关于媒体与民意的理论大部分提出于 1 93 0到 1 980年之间 ,这是一个仅仅拥有传统信息选择方式的时代。麦库姆斯和肖 (1 972 )最初提出议程设置理论时 ,用北卡罗莱纳州的教堂山 (ChapelHill)社区作为研究对象 ,而现在那里的媒介使用情况也已经发生了巨变。当我们迎来议程设置理论提出 3 0周年的时候 ,教堂山的受众现在面临的信息选择令人惊叹。在 2 0世纪 90年代 ,肖提出 ,美国的大众媒介已经经历了“兴和衰”(riseandfall)。肖认为 ,大众媒体时代结束于 2 0世纪 80年代。议程设置研究是否能像之前的 3 0年那样 ,继续开展下去 ?当受众使用着上百个信息来源时 ,议程设置和民意研究会产生何种变化 ?这是本文将要回答的问题

关键词：议程设置理论后大众媒体时代民意研究

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Effects of fertilization on the growth dominance of Inland Northwest forests of the United States

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Forest Ecosystems 2022年第3期9卷 407-416页

作者： Cen Chen Andrew SNelson Terry shaw Mark Kimsey University of Idaho Department of ForestRangeland and Fire SciencesMoscowID83844USA

Large trees have disproportionally large competitive advantage in access to light, which has been proposed to increase growth dominance of large trees (e.g., a larger proportion of volume growth than standing volume is in large trees in a stand). Tree growth may also be limited by the availability of other resources besides *** deficiency, especially of nitrogen, is considered common among temperate forests including mixedconifer forests of the Inland Northwest of the United States. Data from a long-term forest nutrition study across four Inland Northwest states were analyzed to evaluate nitrogen×potassium fertilization?s effects on growth dominance over an eight-year period following treatment. Our results show that growth dominance varied substantially across plots in each vegetation series and fertilization treatment, and its mean values generally were at minuscule magnitudes, negative, and not significantly different from 0. We propose that this lack of a clear pattern in growth dominance was the result of the mixed-species composition where shade-tolerant species remained in lower crown positions, yet their relative growth kept pace with large trees. Limited moisture availability at dry sites may have hampered the development of growth dominance. Growth dominance also was lowered by mortality observed among relatively large trees. The largely negative growth dominance across fertilization treatments indicated that small trees seem to have maintained higher relative growth rates than large trees, even if absolute growth was higher among large trees. In the case fertilization does improve stand growth, a significant part of this improved growth will be lost in density-dependent mortality over time if not captured through thinning/harvesting.

关键词： Stand dynamics Forest management Nitrogen Potassium Douglas-fir Mixed conifer

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Case study approach to modeling historical disinfection by-product exposure in Iowa drinking waters

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j.urnal of Environmental Sciences 2017年第8期29卷 183-190页

作者： Stuart W.Krasner kenneth P.Cantor Peter j.Weyer Mariana Hildesheim Gary Amy Metropolitan Water District of Southern California Water Quality La Verne CA 91750 USA National Cancer Institute National Institutes of Health Bethesda MD 20892 USA Center for Health Effects of Environmental Contamination(CHEEC) University of Iowa Coralville IA 52242 USA Medical Research Solutions LLC Montgomery Village MD 20886 USA College of Engineering Computing and Applied SciencesClemson University Clemson SC 29631 USA

In the 1980 s, a case–control epidemiologic study was conducted in Iowa（USA） to analyze the association between exposure to disinfection by-products（DBPs） and bladder cancer risk. Trihalomethanes（THMs）, the most commonly measured and dominant class of DBPs in drinking water, served as a primary metric and surrogate for the full DBP *** THM exposure was calculated, based on rough estimates of past levels in Iowa. To reduce misclassification, a follow-up study was undertaken to improve estimates of past THM levels and to re-evaluate their association with cancer risk. In addition, the risk associated with haloacetic acids, another class of DBPs, was examined. In the original analysis, surface water treatment plants were assigned one of two possible THM levels depending on the point of chlorination. The re-assessment considered each utility treating surface or groundwater on a case-by-case basis. Multiple treatment/disinfection scenarios and water quality parameters were considered with actual DBP measurements to develop estimates of past levels. The highest annual average THM level in the re-analysis was156 μg/L compared to 74 μg/L for the original analysis. This allowed the analysis of subj.cts exposed at higher levels（〉 96 μg/L）. The re-analysis established a new approach, based on case studies and an understanding of the water quality and operational parameters that impact DBP formation, for determining historical exposure.

关键词： Disinfection by-products Trihalomethanes Haloacetic acids Exposure assessment Epidemiology Bladder cancer

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