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丛书名：国外电子与通信教材系列

2004年

作者： (加)Adel S.Sedra kenneth C.Smith

本书由三个部分构成: 第一部分介绍器件和基本电路;第二部分讲解模拟电路;第三部分介绍数字电路。

ISBN: (数字)7120000845

ISBN: (纸本)7120000845

本书由三个部分构成: 第一部分介绍器件和基本电路;第二部分讲解模拟电路;第三部分介绍数字电路。

关键词： Integrated circuits.

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用于ESM系统设计的压缩接收机

电子信息对抗技术 1987年第4期 18-27页

作者： Klaus d.Breuer James J.Whelehan kenneth Ross 李振初

自从1958年伊顿公司的 W·怀特发明压缩接收机以来,它一直被视为电子战系统中的一种有很大潜力的信号分析手段。它能工作在较宽的射频频带上,并能提供每个存在的辐射源的有关数据,例如频率和幅度。

关键词：压缩接收机微扫接收机色散延迟线 ESM 接收机带宽输出脉冲电子战系统电子对抗系统信道化接收机非搜索式接收机射频脉冲电磁脉冲

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特种纤维的鉴别

中国纤检 1982年第5期 40-45页

作者： kenneth d.Langley Thomas A.Kennedy 万方汤加乐

由于特种纤维的价格昂贵,且常与羊毛混用,因此需要一种能区分这两类纤维的方法。某些有光羊毛,粗细均匀且鳞片较长,象马海毛,但是在鳞片厚度和光泽等方面却与马海毛有明显的差别。山羊绒(开士米)和驼毛很细,直径略有些不匀整,但山羊绒... 详细信息

由于特种纤维的价格昂贵,且常与羊毛混用,因此需要一种能区分这两类纤维的方法。某些有光羊毛,粗细均匀且鳞片较长,象马海毛,但是在鳞片厚度和光泽等方面却与马海毛有明显的差别。山羊绒(开士米)和驼毛很细,直径略有些不匀整,但山羊绒的鳞片宽,而驼毛的鳞片几乎呈鼓形。羊驼和安哥拉兔毛的纤维鳞片截然不同,毛髓特征也各不相同。

关键词：开士米驼毛纤维

Primary 4-3-oxosteroid 5β-reductase deficiency:Two cases in China

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World Journal of Gastroenterology 2012年第47期18卷 7113-7117页

作者： Jing Zhao Ling-Juan Fang kenneth dR Setchell Rui Chen Li-Ting Li Jian-She Wang Center for Pediatric Liver diseases Children's Hospital of Fudan University department of Pathology and Laboratory Medicine Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States department of Pediatrics Jinshan Hospital of Fudan University

Aldo-keto reductase 1d1(AKR1d1) deficiency,a rare but life-threatening form of bile acid deficiency,has not been previously described in ***,we describe the first two primary 4-3-oxosteroid 5β-reductase deficiency patients in China's Mainland diagnosed by fast atom bombardment-mass spectroscopy of urinary bile acids and confirmed by genetic analysis.A high proportion of atypical 3-oxo-4-bile acids in the urine indicated a deficiency in 4-3-oxosteroid 5β-*** of the coding exons and adjacent intronic sequence of the AKR1d1 gene were sequenced using peripheral lymphocyte genomic dNA of two patients and one of the patient's *** patient exhibited compound heterozygous mutations:c.396C>A and c.722A>T,while the other was heterozygous for the mutation c.797G>*** on these mutations,a diagnosis of primary 4-3-oxosteroid 5β-reductase deficiency could be *** ursodeoxycholic acid treatment and fat-soluble vitamin supplements,liver function tests normalized rapidly,and the degree of hepatomegaly was markedly reduced in both patients.

关键词： Primary 4-3-oxosteroid 5β-reductase gene Cholestasis Bile acid therapy Aldo-keto reductase 1d1 Bile acid synthetic defects

地下水铀污染的原位微生物还原与固定：在美国能源部田纳西橡树岭放射物污染现场的试验

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环境科学学报 2011年第3期31卷 449-459页

作者：吴唯民 Jack Carley david Watson 顾宝华 Scott Brooks Shelly d.Kelly kenneth Kemner Joy d.van Nostrand 吴力游许玫英周集中罗剑 Erick Cardenas 黄家琪 Matthew W.Fields Terence L.Marsh James M.Tiedje Stefan J.Green Joel E.Kostka Peter K.Kitanidis Philip M.Jardme CraigS.Criddle 美国斯坦福大学土木与环境工程系 StanfordCA94305USA 美国橡树岭国家实验室环境科学部 OakRidgeTN37831USA 美国阿岗国家实验室生物科学部 ArgonneIL60439USA 美国俄克拉荷马大学植物-与微生物学系 NormanOK73019USA 广东省微生物研究所广州510070 美国乔冶亚理工学院土木与环境工程系 AtlantaGA30332USA 美国密歇根州立大学微生物生态中心 EastLansingMI48823USA 美国蒙大拿州立大学生物膜工程中心 BozemanMT59717USA 美国佛罗里达州立大学地球海洋大气科学系 TallahasseeFL32306USA 美国田纳西大学生物系统工程与土壤科学系 KnoxvilleTN37996USA

总结了美国斯坦福大学和橡树岭国家实验室等在美国能源部田纳西州橡树岭综合试验基地进行的铀污染原位微生物修复阶段性试验结果.本试验利用微生物以乙醇为电子供体还原地下水和沉积物中的六价铀为不溶解的四价铀,使之原位固定化.随后... 详细信息

总结了美国斯坦福大学和橡树岭国家实验室等在美国能源部田纳西州橡树岭综合试验基地进行的铀污染原位微生物修复阶段性试验结果.本试验利用微生物以乙醇为电子供体还原地下水和沉积物中的六价铀为不溶解的四价铀,使之原位固定化.随后通过加入溶解氧和硝酸盐来试验微生物还原后的地下水层中还原固定态铀的稳定性.通过预处理和长期间隔注入乙醇溶液,地下水中铀浓度从40～60mg·L-1降至0.03mg·L-1以下,达到了美国环保署饮用水的标准.还原的四价铀主要以U(Ⅳ)-Fe复合物的形态存在.结果表明,固定化后的四价铀只有在厌氧条件下才是稳定的,溶解氧和硝酸盐侵入地下水层后会使固定化的四价铀重新氧化为溶解态的六价铀.在试验过程中,采用多种分子生物学方法检测了微生物种群的变化和与铀氧化还原反应有关的功能微生物.本研究表明,在维持试验系统无氧和无硝酸盐的条件下,通过添加乙醇为电子供体可有效地促进地下水中土著功能微生物的活性,从而实现铀的原位还原固定与稳定.

关键词：铀污染微生物还原原位生物修复地下水沉积物

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Biparental behavior in the burying beetle Nicrophorus orbicollis： a role for dopamine？

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Current Zoology 2016年第3期62卷 285-291页

作者： S. Carmen PANAITOF Jazmine d. W. YAEGER Jarod P. SPEER kenneth J. RENNER department of Biology UniversiW of Nebraska at Keamey Kearney NE 68849 USA department of Biology University of South Dakota Vermillion SD 57069 USA

Burying beetles Nicrophorus orbicollis exhibit facultative biparental care of young. To reproduce, a male-female burying beetle pair bury and prepare a small vertebrate carcass as food for its altricial young. during a breeding bout, male and female behavior changes synchronously at appropriate times and is coordinated to provide effective care for offspring. Although the ecologicaJ and evolutionary factors that shape this remarkable reproductive plasticity are well characterized, the neuromodulation of parental behavior is poorly understood. Juvenile hormone levels rise dramat- ically at the time beetle parents accept and feed larvae, remain highly elevated during the stages of most active care and fall abruptly when care is terminated. However, hormonal fluctuations alone cannot account for this elaborate control of reproduction. The biogenic amines octopamine （OA）, dopamine （dA）, and serotonin （5-HT） mediate a diversity of insect reproductive and social behav- iors. In this study, we measured whole brain monoamine levels in individual male and female bury- ing beetles and compared OA, dA, and 5-HT profiles between breeding （parental） and nonbreed- ing, unmated beetles. Remarkably, after 24 h of care, when parental feeding rates begin to peak, dA brain levels increase in breeding beetles when compared to nonbreeding controls. In contrast, brain OA and 5-HT levels did not change significantly. These results provide the first evidence for a potential role of dA in the modulation of burying beetle parental behavior.

关键词： dopamine Nicrophorus neuromodulation octopamine parental care serotonin.

Identification and molecular characterization of two novel mutations in COL1A2 in two Chinese families with osteogenesis imperfecta

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Journal of Genetics and Genomics 2011年第4期38卷 149-156页

作者： Zhenping Xu Yulei Li Xiangyang Zhang Fanming Zeng Mingxiong Yuan Mugen Liu Qing kenneth Wang Jing Yu Liu Key Laboratory of Molecular Biophysics of the Ministry of Education Center for Human Genome ResearchCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Key Open Laboratory for Tissue Regeneration of Henan Universities Department of Life Science and TechniqueXinxiang Medical UniversityXinxiang 453003China department of Molecular Cardiology Cleveland ClinicClevelandOH 44195USA

Osteogenesis imperfecta（OI,also known as brittle bone disease）is caused mostly by mutations in two type I collagen genes,COL1A1 and COLIA2 encoding the pro-α1（I）and pro-α2（I）chains of type I collagen,*** Chinese families with autosomal dominant OI were identified and *** analysis revealed linkage of both families to COL1A2 on chromosome *** analysis was carried out using direct dNA sequence *** novel missense mutations,c.3350AG and c.3305GC,were identified in exon 49 of COL1A2 in the two families,*** c.3305GC mutation resulted in substitution of a glycine residue（G）by an alanine residue（A）at codon 1102（p.G1102A）,which was found to be mutated into serine（S）,argine（R）,aspartic acid（d）,or valine（V）in other *** c.3350AG variant may be a de novo mutation resulting in *** mutations co-segregated with OI in respective families,and were not found in 100 normal *** G1102 and Y1117 residues were evolutionarily highly conserved from zebrafish to *** analysis did not identify any mutation in the COX-2 gene（a modifier gene of OI）.This study identifies two novel mutations p.G1102A and p.Y1117C that cause OI,significantly expands the spectrum of COL1A2 mutations causing OI,and has a significant implication in prenatal diagnosis of OI.

关键词： Osteogenesis imperfecta Mutation COL1A2 COX-2

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Hepatitis C virus antigens enzyme immunoassay for one-step diagnosis of hepatitis C virus coinfection in human immunodeficiency virus infected individuals

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World Journal of Hepatology 2019年第5期11卷 442-449页

作者： Ke-Qin Hu Wei Cui Susan d Rouster kenneth E Sherman division of GI/Hepatology University of CaliforniaIrvineSchool of MedicineOrangeCA 92868United States division of digestive diseases University of Cincinnati College of MedicineCincinnatiOH 45267United States

BACKGROUNd Current diagnosis of hepatitis C virus(HCV)infection requires two sequential steps:testing for anti-HCV followed by HCV RNA PCR to confirm *** have developed a highly sensitive and specific HCV-antigens enzyme immunoassay(HCV-Ags EIA)for one-step diagnosis of viremic HCV *** To assess the clinical application of the HCV-Ags EIA in one-step diagnosis of viremic HCV infection in human immunodeficiency virus(HIV)-coinfected *** The study blindly tested HCV-Ags EIA for its performance in one-step diagnosing viremic HCV infection in 147 sera:10 without HCV or HIV infection;54 with viremic HCV monoinfection;38 with viremic HCV/HIV coinfection;and 45 with viremic HCV and non-viremic HIV *** Upon decoding,it was 100%accordance of HCV-Ags EIA to HCV infection status by HCV RNA PCR *** five sera with HCV infection,HCV RNA was as low as 50-59 IU/mL,and four out of five tested positive for HCV-Ags ***,it was also 100%accordance of HCV-Ags EIA to HCV infection status by HCV RNA PCR in 83 sera with HCV and HIV coinfection,regardless if HIV infection was active or *** The modified HCV-Ags EIA has a lower detection limit equivalent to serum HCV RNA levels of approximately 100 IU/*** is highly sensitive and specific in the setting of HIV coinfection,regardless of HIV infection status and Cd4 *** data support the clinical application of the HCV-Ags EIA in one-step diagnosis of HCV infection in HIV-infected individuals.

关键词： Hepatitis C virus Hepatitis C virus antigens Hepatitis C virus core antigen Hepatitis C virus diagnostic test diagnostic assay Enzyme immunoassay

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CT骨矿密度测定的方法研究

上海医学影像 2002年第1期11卷 13-15页

作者：王鸣鹏 kenneth d.Hopper Allen Kunselman 张国桢上海华东医院放射科 department of Radiology University HospitalPenn state UniversityPA 17033USA

目的作者对临床上常用的CT检查部位,腹部和盆腔作了临床应用性实验,以期能获得测量骨矿密度的简便方法。方法 26例患者(男13例,女13例),分别作了CT平扫和增强腹部检查,随后作无专用体模的QCT定量骨密度测定,QCT测量部位为L1-L3椎体。结... 详细信息

目的作者对临床上常用的CT检查部位,腹部和盆腔作了临床应用性实验,以期能获得测量骨矿密度的简便方法。方法 26例患者(男13例,女13例),分别作了CT平扫和增强腹部检查,随后作无专用体模的QCT定量骨密度测定,QCT测量部位为L1-L3椎体。结果平扫CT和QCT的平均骨矿密度分别是96.54和87.70(平均差为8.85,p=0.0005;95％自信区间4.32～13.38)。平扫和增强CT扫描之间QCT测量平均差无统计学意义(P=0.17)。结论根据本文作出的换算公式,可在常规CT平扫和增强扫描的方法中作QCT骨矿密度测量,无需作专门的QCT扫描测量。换算公式为d_(平均值)=C-8.45×0.995,式中“d”和“C”分别表示QCT骨矿密度测量和常规CT扫描检查。

关键词：骨质疏松症骨密度 X线计算机体层摄影定量CT 骨矿含量测定方法

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金属有机框架材料在电化学/电化学发光免疫分析中的应用

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电化学 2023年第6期29卷 4-18页

作者：覃晓丽詹子颖 Sara Jahanghiri kenneth Chu 张丛洋丁志峰湖南农业大学化学与材料科学学院湖南长沙410128 department of Chemistry Western UniversityLondonONN6A 5B7Canada

设计和研制具有超灵敏、高精度、选择性好的免疫传感器对于疾病的早期诊断和筛查以及疾病治疗过程的监测具有十分重要的意义。其中,电化学免疫分析法和电化学发光(ECL)免疫分析法,由于具有稳定性好、灵敏度高、线性范围宽、可控性好等... 详细信息

设计和研制具有超灵敏、高精度、选择性好的免疫传感器对于疾病的早期诊断和筛查以及疾病治疗过程的监测具有十分重要的意义。其中,电化学免疫分析法和电化学发光(ECL)免疫分析法,由于具有稳定性好、灵敏度高、线性范围宽、可控性好等优点而备受关注,已成为当前的研究热点之一。金属有机框架(MOFs)作为一类新型的多孔晶体材料,由于其具有比表面积大、化学稳定性好、孔径和纳米级骨架结构可调节等优点,在电化学和ECL免疫传感器的制备中得到了广泛的应用。MOFs不仅可以作为固定生物识别分子的敏感平台,还可以用于富集痕量分析物和信号分子来放大分析信号,提高电化学或ECL免疫分析的灵敏度。目前,科研人员已合成各种各样具有不同性能和形貌的MOFs纳米材料,并用于开发高性能的电化学免疫传感器和ECL免疫传感器。本文综述了不同类型的基于MOFs纳米材料的电化学/ECL免疫传感器的制备及其在免疫分析中的检测应用。研究表明,MOFs不仅可以作为电极表面修饰的基底、信号探针(包括电活性标记分子和电化学发光发光标记探针)、催化活性标记物,还可以作为负载各种生物分子、纳米材料的载体,最终可用于灵敏的电化学和ECL检测。此外,本综述还讨论了未来发展功能化MOFs纳米材料的挑战和机遇,并为未来设计和制造基于MOFs的高性能免疫传感器提出了一些指导性意见。

关键词：金属有机框架电化学免疫传感器电化学发光法免疫传感器免疫分析