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Effects of a Single Bolus Intravenous Dose of Tramadol on Minimum Alveolar Concentration( MAC) of Sevoflurane in Dogs

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畜牧与兽医 2012年第S2期44卷 36-36页

作者： Takaharu Itami Tomoohito Ishizuka Jun Tamura Sho Fukui kenjirou miyoshi Kazuto Yamashita Department of Small Animal Clinical Sciences School of Veterinary Medicineand Rakuno gakuen University

Tramadol is an atypical opioid analgesic widely used in small animal *** study was designed to determine the effect of a single intravenous (IV) dose of tramadol on the minimum alveolar concentration (MAC) of sevoflurane in *** beagle dogs were anesthetized twice to determine the sevoflurane MAC with or without an administration of tramadol (4 mg/kg,IV) at 7-days *** sevoflurane MAC was determined using a tail clamp method in each dog ventilated with positive pressure *** tramadol administration produced a significant reduction in the sevoflurane MAC by 22.3 ± 12.2% (1.44 ± 0.28% with tramadol versus 1.86 ± 0.29% without tramadol,P =0.010).This MAC reduction had been determined from 122 ± 19 to 180 ± 41 min following the tramadol *** this period,the plasma concentrations of tramadol and its metabolite,O-desmethyltramadol (M1),decreased from 429 ± 64 to 332 ± 55 ng/mL and from 136 ± 24 to 114 ± 68 ng/mL,respectively,but these changes were not statistically significant (P = 0.070 for tramadol and P = 0.716 for M1).There was no significant difference in heart rate,mean arterial blood pressure and SpO2between the control and tramadol *** dogs that received tramadol treatment sometimes breathed ***,their respiratory rates significantly increased and PETCO2decreased during the MAC *** conclusion,the single IV dose of tramadol produced a significant reduction in the sevoflurane MAC in dog.

关键词： dog MAC,O-desmethyltramadol(M1) sevoflurane tramadol

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