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Diffuse large B-cell lymphoma successfully treated with amplified natural killer therapy alone: A case report

World Journal of Clinical Cases 2023年第30期11卷 7432-7439页

作者： kenjiro nagai Syo nagai Yuji Okubo Keisuke Teshigawara Department of Internal Medicine Medical Corporation Ebino Centro ClinicEbino 889-4304Japan Department of Internal Medicine Higashinotoin ClinicKyoto 604-8175Japan

BACKGROUND The prognosis of patients with advanced diffuse large B-cell lymphoma(DLBCL)is poor,with a 5-year survival rate of approximately 50%.The mainstay of treatment is multidrug combination chemotherapy,which has been associated with serious side *** natural killer(ANK)cell therapy amplifies and activates natural killer(NK)cells to attack only malignant *** ANK cells attack programmed death ligand 1(PD-L1)-positive tumor cells,ANK therapy is considered effective against adult T-cell lymphoma and malignant *** SUMMARY Herein,we report a case of an older patient with advanced DLBCL who was successfully treated with ANK immunotherapy.A 91-year-old female visited our hospital with sudden swelling of the right axillary lymph node in April *** patient was diagnosed with stage II disease,given the absence of splenic involvement or contralateral *** therapy was *** rounds of lymphocyte sampling were performed on July 28,*** reduce the occurrence of side effects,the six samples were diluted by half to obtain 12 *** NK cells were administered twice *** treatment efficacy was evaluated by performing computed tomography and serological tests every 1 or 2 *** treatment suppressed lesion growth,and the antitumor effect persisted for several *** patient experienced mild side ***-L1 immunostaining was positive,indicating that the treatment was highly *** ANK therapy can be used as a first-line treatment for malignant lymphoma;the PD-L1 positivity rate can predict treatment efficacy.

关键词： Diffuse large B-cell lymphoma Natural killer cells Immunostaining Hodgkin's lymphoma Older adult Case report

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