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Effects of elafibranor on liver fibrosis and gut barrier function in a mouse model of alcohol-associated liver disease

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World Journal of Gastroenterology 2024年第28期30卷 3428-3446页

作者： Aritoshi Koizumi Kosuke Kaji Norihisa nishimura Shohei Asada Takuya Matsuda Misako Tanaka Nobuyuki Yorioka Yuki Tsuji Koh Kitagawa Shinya Sato Tadashi Namisaki Takemi Akahane Hitoshi Yoshiji Department of Gastroenterology Nara Medical UniversityKashihara 634-8521Japan

BACKGROUND Alcohol-associated liver disease(ALD)is a leading cause of liver-related morbidity and mortality,but there are no therapeutic targets and modalities to prevent ALD-related liver *** proliferator activated receptor(PPAR)α and δ play a key role in lipid metabolism and intestinal barrier homeostasis,which are major contributors to the pathological progression of ***,elafibranor(EFN),which is a dual PPARαand PPARδagonist,has reached a phase III clinical trial for the treatment of metabolic dysfunctionassociated steatotic liver disease and primary biliary ***,the benefits of EFN for ALD treatment is *** To evaluate the inhibitory effects of EFN on liver fibrosis and gut-intestinal barrier dysfunction in an ALD mouse *** ALD-related liver fibrosis was induced in female C57BL/6J mice by feeding a 2.5% ethanol(EtOH)-containing Lieber-DeCarli liquid diet and intraperitoneally injecting carbon tetrachloride thrice weekly(1 mL/kg)for 8 ***(3 and 10 mg/kg/day)was orally administered during the experimental *** and molecular analyses were performed to assess the effect of EFN on steatohepatitis,fibrosis,and intestinal barrier *** EFN effects on HepG2 lipotoxicity and Caco-2 barrier function were evaluated by cell-based *** The hepatic steatosis,apoptosis,and fibrosis in the ALD mice model were significantly attenuated by EFN *** promoted lipolysis and β-oxidation and enhanced autophagic and antioxidant capacities in EtOH-stimulated HepG2 cells,primarily through PPARα***,EFN inhibited the Kupffer cell-mediated inflammatory response,with blunted hepatic exposure to lipopolysaccharide(LPS)and toll like receptor 4(TLR4)/nuclear factor kappa B(NF-κB)*** improved intestinal hyperpermeability by restoring tight junction proteins and autophagy and by inhibiting apoptosis and proinflammatory *** protective effect on intestinal bar

关键词： Liver fibrosis Ethanol Gut barrier function Apoptosis Autophagy Peroxisome proliferator activated receptor

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小拜登离席

财新周刊 2024年第3期 12-13页

作者： Kent nishimura(图) 无不详视觉中国

当地时间2024年1月10日,美国首部华盛顿,美国总统拜登的儿子亨特·拜登(中)在国会听证会上露面,当时众议院共和党人正准备提出决议定其藐视国会,亨特一行人突然离场。当日,经过6小时的听证会后,委员会23名成员投票支持该决议、14名成员... 详细信息

当地时间2024年1月10日,美国首部华盛顿,美国总统拜登的儿子亨特·拜登(中)在国会听证会上露面,当时众议院共和党人正准备提出决议定其藐视国会,亨特一行人突然离场。当日,经过6小时的听证会后,委员会23名成员投票支持该决议、14名成员反对。众议院将就此事进行全体投票,并可能对亨特·拜登提出进一步的刑事诉讼。

关键词：众议院共和党人听证会刑事诉讼国会亨特投票决议

A study on control method of new type UAV

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材料与冶金学报 2015年第2期14卷 149-151,158页

作者： kenji Nishigaki Kohei Kawakami Shin- Ichiro Nishida Masaharu nishimura Kazunori Sakurama Department of Mechanical and Aerospace Engineering Tottori University 4 -101 Koyama- M inami Tottori 680 -8552 Japan

In late years the use of UAV which is suitable for the observation activities in a dangerous area is pushed forw ard.R otary wing type UAV which can perform vertical takeoff and landing and hovering is used. We propose a compact U AV called SW U M which is without tail rotor. We adopt " stator wing" as an anti- torque compensation mechanism instead of a tail ***,the attitude control test around yaw axis was performed using the SW UM prototype on a free rotational table. It was confirmed that the attitude of the vehicle around yaw axis by stator wings was controlled well. We studied a control method for translational motion of this vehicle. The horizontal translational motion will be achieved by tilting the body fone of stator *** created the mathematical model of the kinetics of this vehicle,and are performed analysis by the computer simulation.

关键词： stator wing UAV anti-torque control simulator

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太赫兹行波管用金刚石输能窗研究进展

材料导报 2024年第16期38卷 20-28页

作者：张鹏伟宋惠白慧萍易剑江南西村一仁云南大学材料与能源学院昆明650091 中国科学院宁波材料技术与工程研究所浙江宁波315201

太赫兹波处于电磁波谱中电子学与光子学之间的空隙区域,具有不同于低频微波和高频光学的独特属性,在无线通信、生物医学、公共安全等军事和民用领域具有广阔的应用前景。太赫兹技术重点是对太赫兹波的产生和传输进行研究,当前所面临问... 详细信息

太赫兹波处于电磁波谱中电子学与光子学之间的空隙区域,具有不同于低频微波和高频光学的独特属性,在无线通信、生物医学、公共安全等军事和民用领域具有广阔的应用前景。太赫兹技术重点是对太赫兹波的产生和传输进行研究,当前所面临问题是在不产生额外传输损耗下保证高效率传输太赫兹信号。太赫兹行波管输能窗是典型的结构与功能一体化器件,主要起着行波管内外信号传递的作用,同时要保证器件内部的真空度以及对太赫兹波表现出高度“透明”。本文通过对近年来的文献进行总结整理,综述了国内外太赫兹行波管的应用和研究进展,揭示了未来发展大功率、高效率和宽频带传输是实现太赫兹真空器件实际应用的重点,这将对输能窗材料本身以及超精密加工提出了巨大挑战。纵观近几年国内外输能窗材料的发展历程,笔者们认为,与传统输能窗材料相比,单晶金刚石强度高,导热好,微波损耗小,没有晶界,气密性好,是最理想的太赫兹行波管输能窗口材料,也是目前研究发展的主流趋势。

关键词：太赫兹输能窗金刚石介电性能

Aggregation-induced emission and thermally activated delayed fluorescence of 2,6-diaminobenzophenones

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Science China Chemistry 2018年第8期61卷 925-931页

作者： Masaki Shimizu Masaki Nakatani Kenta nishimura Faculty of Molecular Chemistry and Engineering Kyoto Institute of Technology

Exploration of novel organic luminophores that exhibit thermally activated delayed fluorescence(TADF) in the aggregated state is very crucial for advance of delayed luminescence-based applications such as time-gated bio-sensing and temperature *** report herein that synthesis, photophysical properties, molecular and crystal structures, and theoretical calculations of 2,6-bis(diarylamino)benzophenones. Absorption spectra in solution and calculations using density functional theory(DFT) method revealed that the optical excitation took place through intramolecular charge-transfer from one diarylamino moiety to an aroyl group. While the benzophenones did not luminesce in solution, the solids of the benzophenones emitted green light with moderate-to-good quantum yields. Thus, the benzophenones exhibit aggregation-induced emission. Based on the lifetime measurement, the green emission of the solids was found to include TADF. The emergence of the TADF is supported by the small energy gap between the excited singlet and triplet states, which was estimated by time-dependent DFT calculations. Thin films of poly(methyl methacrylate) doped by the benzophenones also showed green prompt and delayed fluorescence whose lifetimes were in the order of microseconds. Linear correlation between logarithm value of TADF lifetime and temperature was observed with the benzophenone in powder, suggesting that the benzophenones can serve as molecular thermometers workable under aqueous conditions.

关键词： donor-acceptor system delayed fluorescence temperature sensor

Bacteremia or pseudobacteremia?Review of pseudomonas fluorescens infections

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World Journal of Emergency Medicine 2017年第2期8卷 151-154页

作者： Takeshi nishimura kenji Hattori Akihiko Inoue Taiji Ishii Tctsuya Yumoto Kohei Tsukahara Astunori Nakao Satoshi Ishihara Shinichi Nakayama Hyogo Emergency Medical Center 1-3-1 Wakinohamakaigando-riChuo-kuKobeHyogo 651-0073Japan Department of Emergency and Critical Care Medicine Okayama University Graduate School of MedicineDentistry and Pharmaceutical Sciences2-5-1 ShikatachoKitakuOkayama CityOkayama700-8558Japan

INTRODUCTION *** is an aerobic,Gram-negative bacillus related to Pseudomonas *** other species of Pseudomonas,the organism is widespread in nature and is found in water,moist soil,and *** to its low virulence,*** is an infrequent cause of infections except for catheter-related bloodstream infections in cancer *** August 1,2003 to May 31,2016,Hyogo Emergency Medical Center and the Kobe Red Cross Hospital treated three cases of bloodstream infection

关键词： Bacteremia pseudobacteremia pseudomonas fluorescens infections

Base flow separation for soil erosion simulation in a granitic forested headwater catchment using a process-based model, GeoWEPP

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International Journal of Sediment Research 2023年第4期38卷 494-502页

作者： Takuhei Yamasaki Shoichiro Hamamoto Taku nishimura The Graduate School of Agricultural and Life Sciences The University of Tokyo

Distributed erosion models, which simulate the physical processes of water flow and soil erosion, are effective for predicting soil erosion in forested catchments. Although subsurface flow through multiple pathways is dominant for runoff generation in forested headwater catchments, the process-based erosion model, Geo-spatial interface for Water Erosion Prediction Project(Geo WEPP), does not have an adequate subsurface component for the simulation of hillslope water flow. In the current study, the quick flow related to soil erosion during rainfall events is separated from the total hydrograph using base flow separation for Geo WEPP to use direct runoff to predict sediment discharge from a granitic-forested catchment in Japan. Water runoff and sediment discharge also are simulated using the conventional method that reproduces the total hydrograph, and the accuracy of the calculation and estimated erodibility parameters are evaluated. The proposed procedure reproduced the quick-flow runoff during rainfall and the cumulative sediment discharge from the catchment. Simultaneously, the proposed procedure overestimates water runoff during extreme weather events, such as typhoons. The estimated erodibility parameters for the hillslope soil were comparable to those of the surface soil in Japan using both the proposed procedure and the conventional one. Conversely, the channel erodibility obtained from the proposed procedure matched the observed sediment characteristics in the granitic forested catchment. The proposed procedure is a promising method to predict sediment discharge from forested catchments based on the geological features of the catchment.

关键词： Soil erosion Base flow separation GeoWEPP Headwater catchment Forest

Quality assessment of volunteered geographic information for outdoor activities:an analysis of OpenStreetMap data for names of peaks in Japan

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Geo-Spatial Information Science 2023年第3期26卷 333-345页

作者： Jun Yamashita Toshikazu Seto Nobusuke Iwasaki Yuichiro nishimura Faculty of Social and Cultural Studies Kyushu UniversityFukuokaJapan Faculty of Letters Komazawa UniversityTokyoJapan Sciences NAROInstitute for Agro-EnvironmentalTsukubaJapan Faculty of Letters Nara Women’s UniversityNaraJapan

Geographical studies of outdoor activities have increased in recent years with the rise in popularity of these activities worldwide,including in *** geographic information(VGI)is a key tool for organizing outdoor activities as it offers a means to determine the locational information and names of *** evaluate the quality of VGI,geospatial data generated by land survey agencies and other VGI are often utilized as reference ***,since these reference data may not be available,other methods are necessary to assure the quality of *** this study,we examined five trust indicators based on the inherent characteristics of VGI through an empirical case *** used mountain names extracted from OpenStreetMap in Japan as data because there were almost no other VGI in the *** a result,we isolated three trust indicators,namely versions,users,and tag corrections,to examine the thematic accuracy of VGI because these were the only statistically significant ***,we found that the prediction rate of thematic accuracy was very *** improve thematic accuracy,this study recommends using the most accurate versions,applying correctly given tags,and considering the motivations and characteristics of the VGI contributors.

关键词： Outdoor activities volunteered geographic information(VGI) OpenStreetMap(OSM) data quality assessment trust integrated usage

The Effect of Umami Stimulation on Salivary Secretion Rate and Duration

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