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畜牧与兽医 2012年第S2期44卷 3-4页

作者： Kenji Tani Department of Veterinary Surgery Joint Faculty of Veterinary MedicineYamaguchi University

1 Identification of the affected interspace:What site is disk material across the vertebral canal?Either myelography or advanced imaging should be performed for definitive diagnosis.CT is more accurate and usually much faster than myelography,especially in chondrodystrophoid breed.CT is non-invasive as mineralized disk material shows clearly without need for contrast in most cases such as MiniaturedDucksfund which is very common breed in Japan.CTmyelography may be necessary if the extrude material is not mineralized.MR images are superior to CT in a viewpoint to evaluate spinal cord.

关键词： vertebral viewpoint breed canal faster clearly articular removed exact facilitate

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Aldehyde dehydrogenase activity helps identify a subpopulation of murine adipose-derived stem cells with enhanced adipogenic and osteogenic differentiation potential

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World Journal of Stem Cells 2017年第10期9卷 179-186页

作者： Harumichi Itoh Shimpei Nishikawa Tomoya Haraguchi Yu Arikawa Shotaro Eto Masato Hiyama Toshie Iseri Yoshiki Itoh Munekazu Nakaichi Yusuke Sakai Kenji Tani Yasuho Taura Kazuhito Itamoto Department of Small Animal Clinical Science Joint Faculty of Veterinary Medicine Yamaguchi University Department of Veterinary Surgery Joint Faculty of Veterinary Medicine Yamaguchi University Department of Veterinary Radiology Joint Faculty of Veterinary Medicine Yamaguchi University Department of Veterinary Pathology Joint Faculty of Veterinary Medicine Yamaguchi University

AIM To identify and characterize functionally distinct subpopulation of adipose-derived stem cells(ADSCs).METHODS ADSCs cultured from mouse subcutaneous adipose tissue were sorted fluorescence-activated cell sorter based on aldehyde dehydrogenase(ALDH) activity, a widely used stem cell marker. Differentiation potentials were analyzed by utilizing immunocytofluorescece and its quantitative analysis.RESULTS Approximately 15% of bulk ADSCs showed high ALDH activity in flow cytometric analysis. Although significant difference was not seen in proliferation capacity, the adipogenic and osteogenic differentiation capacity was higher in ALDHHi subpopulations than in ALDHLo. Gene set enrichment analysis revealed that ribosome-related gene sets were enriched in the ALDHHi subpopulation. CONCLUSION High ALDH activity is a useful marker for identifying functionally different subpopulations in murine ADSCs. Additionally, we suggested the importance of ribosome for differentiation of ADSCs by gene set enrichment analysis.

关键词：脂肪质导出 stem/stromal 房间醛脱氢酶活动流动 cytometry Subpopulation 核糖体

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Effects of an oral iron chelator, deferasirox, on advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第40期22卷 8967-8977页

作者： Issei Saeki Naoki Yamamoto Takahiro Yamasaki Taro Takami Masaki Maeda Koichi Fujisawa Takuya Iwamoto Toshihiko Matsumoto Isao Hidaka Tsuyoshi Ishikawa Koichi Uchida Kenji Tani Isao Sakaida Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine Yamaguchi 755-8505 Japan Yamaguchi University Health Administration Center Yamaguchi 755-8511 Japan Department of Oncology and Laboratory Medicine Yamaguchi University Graduate School of Medicine Yamaguchi 755-8505 Japan Department of Human Nutrition Faculty of Nursing and Human Nutrition Yamaguchi 755-8502 Japan Center of Research and Education for Regenerative Medicine Yamaguchi University Graduate School of Medicine Yamaguchi Prefectural University Yamaguchi 755-8505 Japan Department of Veterinary Surgery Joint Faculty of Veterinary Medicine Yamaguchi University Yamaguchi 755-8511 Japan

AIM To evaluate the inhibitory effects of deferasirox(DFX) against hepatocellular carcinoma(HCC) through basic and clinical studies.METHODS In the basic study, the effect of DFX was investigated in three hepatoma cell lines(Hep G2, Hep3 B, and Huh7), as well as in an N-nitrosodiethylamine-induced murine HCC model. In the clinical study, six advanced HCC patients refractory to chemotherapy were enrolled. The initial dose of DFX was 10 mg/kg per day and was increased by 10 mg/kg per day every week, until the maximum dose of 30 mg/kg per day. The duration of a single course of DFX therapy was 28 consecutive days. In the event of dose-limiting toxicity(according to the Common Terminology Criteria for Adverse Events v.4.0), DFX dose was reduced.RESULTS Administration of DFX inhibited the proliferation of hepatoma cell lines and induced the activation of caspase-3 in a dose-dependent manner in vitro. In the murine model, DFX treatment significantly suppressed the development of liver tumors(P < 0.01), and significantly upregulated the mR NA expression levels of hepcidin(P < 0.05), transferrin receptor 1(P < 0.05), and hypoxia inducible factor-1α(P < 0.05) in both tumor and non-tumor tissues, compared with control mice. In the clinical study, anorexia and elevated serum creatinine were observed in four and all six patients, respectively. However, reduction in DFX dose led to decrease in serum creatinine levels in all patients. After the first course of DFX, one patient discontinued the therapy. We assessed the tumor response in the remaining five patients; one patient exhibited stable disease, while four patients exhibited progressive disease. The one-year survival rate of the six patients was 17%.CONCLUSION We demonstrated that DFX inhibited HCC in the basic study, but not in the clinical study due to dose-limiting toxicities.

关键词：肝肿瘤 Hepatocellular 癌先进舞台 Iron-chelator Deferasirox

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Effect of Fuselage Cross Section on Aerodynamic Characteristics of Reusable Launch Vehicles

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Open Journal of Fluid Dynamics 2016年第3期6卷 222-233页

作者： kenji Tadakuma Yasuhiro tani Shigeru Aso Innovative R & D Engineering Company Toyota Motor Corporation Toyota Japan Department of Aeronautics and Astronautics Kyushu University Fukuoka Japan

An experimental study on examining aerodynamic characteristics of fuselage cross sections for RLVs (Reusable Launch Vehicles) was conducted at Mach number 0.3, 0.9 and 4.0 in the wind tunnel of ISAS (Institute of Space and Astronautical Science), JAXA (Japan Aerospace Exploration Agency). Three bodies, having the same projected area and length, with and without a set of fins, were tested. Their cross sections are a circle, a square and a triangle with rounded corners. The results showed that the fuselage cross sections had large effects on aerodynamic characteristics in subsonic and transonic flow. The lift coefficient of the model having the triangular cross section with a set of the fins was larger than that of the others in high angles of attack region due to contributions of the separation vortices generated from the fuselage expanding to the wing surface.

关键词： Reusable Launch Vehicle Aerodynamic Characteristics Fuselage Cross Section Separation Vortex

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NTT DoCoMo 3G网络的发展和运维

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世界电信 2005年第6期18卷 36-38页

作者：大西健治谷直树 NTT DoCoMo网络计划部国际事业推进部门 NTT DoCoMo国际网络开发部计划部门

NTT DoCoMo是全球首家提供商用3G服务的运营商,但其发展之路并非一帆风顺,而是经历了曲折和探索。介绍了NTT DoCoMo移动通信的发展,特别是3G建设和运维过程中的经验教训,主要集中在网络覆盖范围的扩大、服务质量的提高、网络的安全防灾... 详细信息

NTT DoCoMo是全球首家提供商用3G服务的运营商,但其发展之路并非一帆风顺,而是经历了曲折和探索。介绍了NTT DoCoMo移动通信的发展,特别是3G建设和运维过程中的经验教训,主要集中在网络覆盖范围的扩大、服务质量的提高、网络的安全防灾,以及全球化策略中对标准的关注和多方面的合作。

关键词：移动通信 3G WCDMA 运营标准化覆盖 DoCoMo 3G网络 NTT 服务质量一帆风顺

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