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Recent trends in bone metastasis treatments:A historical comparison using the new Katagiri score system

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World Journal of Clinical Cases 2024年第15期12卷 2499-2505页

作者： kenji matsuda Kazuhiro Shimazu Hanae Shinozaki Koji Fukuda Taichi Yoshida Daiki Taguchi Kyoko Nomura Hiroyuki Shibata Department of Clinical Oncology Akita University Graduate School of MedicineAkita 010-8543Japan Department of Environmental Health Science and Public Health Akita University Graduate School of MedicineAkita 010-8543Japan Department of Comprehensive Cancer Control Akita University Graduate School of MedicineAkita 010-8543Japan

BACKGROUND Bone metastasis has various negative *** of daily living(ADL)and quality of life(QOL)can be significantly decreased,survival may be impacted,and medical expenses may *** is estimated that at least 5%cancer patients might be suffering from bone *** 2016,we published the Comprehensive Guidelines for the Diagnosis and Treatment of Bone *** then,the therapeutic outcomes for patients have gradually *** life expectancy is a major determinant of surgical intervention,the strategy should be modified if the prolongation of survival is to be *** To monitor how bone metastasis treatment has changed before and after launch of our guidelines for bone *** For advanced cancer patients with bone metastasis who visited the Department of Clinical Oncology at Akita University hospital between 2012 and 2023,parameters including the site and number of bone metastases,laboratory data,and survival time,were extracted from electronic medical records and the Katagiri score was *** association with survival was determined for each *** Data from 136 patients were *** 1-year survival rate for the poor prognosis group with a higher Katagiri score was 20.0%in this study,which was 6%and an apparent improvement from 2014 when the scoring system was *** factors significantly affecting survival included five or more bone metastases than less(P=0.0080),and treatment with chemotherapy(P<0.001),bone modifying agents(P=0.0175)and immune checkpoint inhibitors(P=0.0128).In recent years,advances in various treatment methods have extended the survival period for patients with advanced *** is necessary not only to simply extend survival time,but also to maintain ADL and improve *** Various therapeutic interventions including surgical approach for bone metastasis,which is a disorder of locomotor organs,are increasingly *** and scoring system for p

关键词： Bone metastasis New Katagiri scoring system Prognosis Immune check point inhibitors Survival

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日本热泵市场的发展

暖通空调 2014年第E8期44卷 3-5页

作者： kenji matsuda 三石日本制冷空调工业协会(JRAIA) 不详

热泵市场的扩张已经掀起了节能的热潮．很多国家都将目光投向节能技带和机制的利用。日市制造商们正成为制造中心．他们在热泵市场上的份额达到了近30％。日市制造商们在努力为减少全球能耗贡献着自己的力量。日市也已经开始转向低GWP... 详细信息

热泵市场的扩张已经掀起了节能的热潮．很多国家都将目光投向节能技带和机制的利用。日市制造商们正成为制造中心．他们在热泵市场上的份额达到了近30％。日市制造商们在努力为减少全球能耗贡献着自己的力量。日市也已经开始转向低GWP值制冷剂的使用．以防止全球继续变暖。

关键词：市场热泵日本制造商 GWP值制冷剂节能能耗

In vivo direct neuronal conversion as a therapeutic strategy for ischemic stroke

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Neural Regeneration Research 2025年第8期20卷 2309-2310页

作者： Takashi Irie Taito matsuda Department of Stem Cell Biology and Medicine Graduate School of Medical SciencesKyushu UniversityFukuokaJapan Department of Neurology Neurological InstituteGraduate School of Medical SciencesKyushu UniversityFukuokaJapan

Stroke causes neuronal loss,which ultimately results in persistent neurological ***,stroke was the third-leading cause of death and disability combined in all ages in 2019,after neonatal disorders and ischemic heart *** that year,there were 12.2 million incident strokes,101 million prevalent strokes,and 143 million disability-adjusted life-years due to stroke.

关键词： neonatal death therapeutic

Literature review of the energy sources for performing laparoscopic colorectal surgery

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World Journal of Gastrointestinal Surgery 2012年第1期4卷 1-8页

作者： Tsukasa Hotta Katsunari Takifuji Shozo Yokoyama kenji matsuda Takashi Higashiguchi Toshiji Tominaga Yoshimasa Oku Takashi Watanabe Toru Nasu Tadamichi Hashimoto Koichi Tamura Junji Ieda Naoyuki Yamamoto Hiromitsu Iwamoto Hiroki Yamaue Second Department of Surgery Wakayama Medical UniversitySchool of Medicine

Laparoscopic surgery for colorectal disease has become widespread as a minimally invasive *** is important because the increasing availability of new devices allows us to perform procedures with a reduced length of surgery and decreased blood *** herein report the results of a literature review of energy sources for laparoscopic colorectal surgery,focused especially on 6 studies comparing ultrasonic coagulating shears(UCS) and other *** also describe our laparoscopic dissection techniques using UCS for colorectal *** short-term outcomes of surgeries using UCS and Ligasure for laparoscopiccolorectal surgery were superior to conventional *** authors have reported that the length of surgery or blood loss when Ligasure was used for laparoscopic colorectal surgery is less than when UCS was *** the other hand,a recent study demonstrated that there were no significant differences between the short-term outcomes of UCS and Ligasure for laparoscopic colorectal *** is therefore suggested that the choice of technique used should be made according to the surgeon’s *** also describe our laparoscopic dissection techniques using UCS(Harmonic ACE) for colorectal cancer with regard to the retroperitoneum dissection,dissection technique,dissection technique around the feeding artery,and various other dissection *** therefore review the outcomes of using various energy sources for laparoscopic colorectal surgery and describe our laparoscopic dissection techniques with UCS(Harmonic ACE) for colorectal cancer.

关键词： Laparoscopic surgery Ultrasonic coagulating shears Harmonic Scalpel Ligasure Colon and rectum Dissection technique

Rise in deaths from drug overdose and firearm injury during coronavirus disease 2019 pandemic and its impact on organ transplantation

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World Journal of Transplantation 2025年第2期15卷 265-275页

作者： Roshan Dhand kenji Okumura Seigo Nishida Abhay Dhand Horace Greeley High School ChappaquaNY 10514United States Department of Surgery Westchester Medical Center and New York Medical CollegeValhallaNY 10595United States Department of Surgery and Medicine Westchester Medical Center and New York Medical CollegeValhallaNY 10595United States

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic had a profound societal impact in the United States which was associated with a decrease in overall life expectancy and an increase in substance abuse and firearm *** under-standing of changes in mortality trends during the pandemic and its effect on organ availability for transplantation is *** To examine the trends of substance abuse and firearm injury fatalities during COVID-19 and a potential correlation with organ *** Crude rates of population-based deaths among adults(18-75 years)from firearm injury and substance abuse from the period of 2014-2021 were obtained from centers of disease control wide-ranging online data for epidemiologic research *** rates of causes of donor(18-75 years)deaths from 2014-2021 were obtained from the united network for organ sharing *** Average annual percentage change(AAPC)deaths among the United States population were 16.4%from substance abuse and 3.4%from firearm *** in cause of death among organ donors was 10.9%from drug intoxication and 2.1%from firearm *** was a significant(P<0.001)and progressive increase in mortality from both causes during the pandemic(2020-2021)and significant correlation(P<0.001)between population and donor causes of ***-19 exacerbated trends in substance abuse and firearm mortality with a consequent increase in organ donation from donors who died from these two *** Identifying the socioeconomic and regional disparities associated with increase in deaths from substance abuse and firearms can help guide post-pandemic healthcare policies and mitigate their impact on organ transplantation.

关键词： COVID-19 Transplantation Disparities Substance abuse Opioid overdose Firearm injury Mortality Pandemic Coronavirus Determinants of health

Relationship between gastric mucosal atrophy by endoscopy and non-ampullary duodenal epithelial tumors

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 84-92页

作者： Kazuya Ohno Eiji Nakatani Takafumi Kurokami Asami Kawai Ryosuke Itai Masanori matsuda YuichiMasui Tatsunori Satoh Shinya Ikeda Taiyo Hirata Shodai Takeda Makoto Suzuki Ken Haruma Department of Gastroenterology Shizuoka General HospitalShizuoka 420-8527Japan Research Support Center Graduate School of Public HealthShizuoka Graduate University of Public HealthShizuoka 420-0881Japan Department of Pathology Shizuoka General HospitalShizuoka 420-8527Japan Department of General Internal Medicine 2 Kawasaki Medical SchoolOkayama 700-8505Japan

BACKGROUND The pathogenesis of non-ampullary duodenal epithelial tumors(NADETs)is not fully *** that express gastric-type mucin phenotypes(GNADETs)are noteworthy because of their high *** foveolar metaplasia,from which G-NADETs originate,protects the duodenal mucosa from gastric *** gastric acid secretion is affected by endoscopic gastric mucosal atrophy(EGMA),we hypothesized that EGMA would be associated with *** To evaluate the association between EGMA and the occurrence of *** This cross-sectional retrospective study investigated the relationship between EGMA and NADETs in 134 *** duodenum was divided into parts 1(bulb),2(superior duodenal angle to the papilla),and 3(anal side of the papilla to the horizontal part).The effects of gastric acidity and presence of Brunner’s glands were *** was divided into types C(no or mild atrophy)and O(severe atrophy).Mucin phenotype expressions in NADETs were divided into gastric,intestinal,gastrointestinal,and *** When NADETs were classified according to EGMA,105 were classified as type C and 29 as type O.G-NADETs were present in 11.9%(16 cases)of all cases,and all 16 cases were of type *** G-NADETs,93.8%(15 cases)were present in part 1 or *** was an association between G-NADETs and type C in part 1,and 50.0%(eight of 16 cases)of G-NADETs were associated with a current or previous Helicobacter pylori infection ***,all eight cases occurred in part *** G-NADETs were significantly associated with type *** acidity and Brunner's gland growth may be associated with G-NADETs.

关键词： Gastric acidity Gastric foveolar metaplasia Gastric mucosal atrophy Helicobacter pylori Mucin phenotype Nonampullary duodenal epithelial tumor

Valley-selective manipulation of moiréexcitons through optical Stark effect

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Chinese Physics B 2025年第1期34卷 14-18页

作者： Chenran Xu Jichen Zhou Zhexu Shan Wenjian Su kenji Watanabe Takashi Taniguchi Dawei Wang Yanhao Tang School of Physics Zhejiang UniversityHangzhou 310027China Zhejiang Key Laboratory of Micro-Nano Quantum Chips and Quantum Control Zhejiang UniversityHangzhou 310027China Research Center for Electronic and Optical Materials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Research Center for Materials Nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan

Semiconductor moirésuperlattices provide great platforms for exploring exotic collective *** Stark effect,a shift of the electronic transition in the presence of a light field,provides an ultrafast and coherent method of manipulating matter states,which,however,has not been demonstrated in moiré***,we report the valleyselective optical Stark effect of moiréexcitons in the WSe_(2)/WS_(2)superlattice by using transient reflection *** valley-selective energy shifts up to 7.8 meV have been observed for moiréexcitons,corresponding to pseudomagnetic fields as large as 34 *** results provide a route to coherently manipulate exotic states in moirésuperlattices.

关键词： optical Stark effect moir´e exciton transient reflection spectroscopy

Liver transplant practices in the era of normothermic machine perfusion in the United States

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World Journal of Transplantation 2025年第2期15卷 257-264页

作者： kenji Okumura Abhay Dhand Bima J Hasjim Ryosuke Misawa Hiroshi Sogawa Gregory Veillette Seigo Nishida Department of Surgery Westchester Medical CenterValhallaNY 10595United States Department of Surgery University of CaliforniaIrvine Medical CenterOrangeCA 92697United States

BACKGROUND Normothermic liver machine perfusion(NMP)is a novel technology used to preserve and evaluate the function of liver *** To assess NMP utilization in liver transplant(LT)*** All adult deceased-donor LT recipients between January 2021 and September 2023 in the United States were *** including discard rates,survival,preservation time and timing of surgery were compared between two groups:NMP vs *** Between 2021 and 2023,NMP was utilized in 1493(6.3%)of all LTs in the United *** to non-NMP group,NMP group had lower allograft discard rate(6.5%vs 10%,P<0.001),older recipients’age(median:47 vs 42 years,P<0.001),and higher utilization of donors from donation after circulatory death(DCD)(55%vs 11%,P<0.001).NMP group also had longer distances between recipient and donor hospitals(median:156 vs 138 miles,P<0.001),longer preser-vation time(median:12.2 vs 5.8 hours,P<0.001),and more daytime reperfusion(74%vs 55%,P<0.001).Post-transplant survival outcomes were comparable between the two *** a subgroup analysis of NMP,recipients in the long preservation time(≥8 hours)group had higher daytime reperfusion(78%vs 55%,P<0.001)and similar post-transplant survival when compared to the short preservation time(<8 hours)*** The utilization of NMP is associated with lower discard rates and increased DCD organs for *** allows for prolonging the preservation time and increased occurrence of daytime LT,without any impact on the survival outcomes.

关键词： Liver transplant Machine perfusion Daytime Distance

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分布式空调系统适用性评价研究

暖通空调 2008年第5期38卷 29-32页

作者：王宝龙燕达韩林俊邵双全严玢曲凯阳石文星李先庭江亿松田宪儿清华大学三菱重工业株式会社

介绍了分布式空调系统适用性评价的基本原理,调研获取了适用性评价的基本一级指标,给出了各个评价指标的获取方法并建立了计算模型,举例说明了该方法的可用性。

关键词：分布式空调系统适用性评价满意率全年运行能耗