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Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses

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Cellular & Molecular Immunology 2018年第11期15卷 953-962页

作者： Tomonori Yaguchi Asuka Kobayashi Takashi Inozume kenji Morii Haruna Nagumo Hiroshi Nishio Takashi Iwata Yuyo ka Ikumi katano Ryoji Ito Mamoru Ito Yutaka kawakami Division of Cellular Signaling Institute for Advanced Medical ResearchKeio University School of MedicineTokyo 160-8582Japan Department of Dermatology Yamanashi University School of MedicineYamanashi 409-3898Japan Department of Obstetrics and Gynecology Keio University School of MedicineTokyo 160-8582Japan Central Institute for Experimental Animals Kanagawa 210-0821Japan

Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune ***,when human peripheral blood mononuclear cells(PBMCs)are transferred into NOG(NOD/Shi-scid,IL-2rg null)mice,severe graft versus host disease(GVHD)hinders long term detailed *** of human PBMCs into newly developed murine MHC class I-and class II-deficient NOG(NOG-dKO;NOG-Iab,B2m-double-knockout)mice showed sufficient engraftment of human immune cells with little sign of *** with influenza vaccine resulted in an increase in influenza-specific human IgG Ab,indicating induction of antigen-specific B cells in the NOG-dKO *** with human dendritic cells pulsed with HLA-A2 restricted cytomegalovirus peptide induced specific cytotoxic T cells,indicating the induction of antigen-specific T cells in the NOG-dKO *** cell therapies(ACTs)using melanoma antigen recognized by T cells(MART-1)-specific TCR-transduced activated T cells showed strong tumor growth inhibition in NOG-dKO mice without any sign of GVHD accompanied by preferential expansion of the transferred MART-1-specific T *** using cultured human melanoma infiltrating T cells also showed anti-tumor effects against autologous melanoma cells in NOG-dKO mice,in which changes in human cancer phenotypes by immune intervention,such as increased CD271 expression,could be ***,NOG-dKO mice are useful tools for more detailed analysis of both the induction and effector phases of T-cell and B-cell responses for a longer period than regular NOG mice.

关键词： adoptive cell therapy humanized mouse vaccine

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Overdoped High Current Density Bi2-xPbxSr2CaCu2O8＋δ Intrinsic Josephson Junction Mesas and Their Switching Current Distributions

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Chinese Physics Letters 2010年第8期27卷 207-210页

作者： Minoru SUZUKI kenji HAMADA Ryota TAKEMURA Masayuki OHMAKI Itsuhiro kaKEYA Department of Electronic Science and Engineering Kyoto University Kyotodaigaku-Katsura Nishikyo-ku Kyoto 615-8510 Japan

Small and thin mesa structures of intrinsic Josephson junctions 1- 2μm on a side and 1.5-7.5 nm in thickness are fabricated from single crystals of Bi2-xPbxSr2CaCu2O8＋δ with a nominal Pb content x from 0.2 to 0.5. The Josephson critical current density jc is found to be pronouncedly large, ranging from 10 to 50 ka/cm^2. Switching current probability measurements for these mesa samples show an indication of a crossover to the macroscopic quantum tunneling region.

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贝加尔地区(西伯利亚和蒙古)湖水集水系统和沉积物信息（英文）

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地球环境学报 2011年第3期2卷 417-425页

作者： kaSHIWAYA kenji Institute of Nature and Environmental Technology Kanazawa University

Sediment information is closely related to a lake-catchment *** Baikal and Lake Khuvsgul in the Baikal depression have shown different sedimentary trends during the past 800 ka;the sediment discharge(sedimentation rate) in Baikal basically followed the global climatic change,whereas that in Khuvsgul did not always do *** elementary mathematical model is used to explain the difference,considering changes in the catchment area and water *** calculations based on the model suggest that sedimentary conditions are closely related to changes in the water level and erosion area,which probably had a significant influence on Lake Khuvsgul and little influence on Lake Baikal.

关键词： Lake Baikal Lake Khuvsgul lake-catchment system model

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贝加尔湖沉积物记录的第四纪大陆气候对轨道驱动的响应（英文）

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地球环境学报 2011年第3期2卷 442-449页

作者： OCHIAI Shinya kaSHIWAYA kenji Low Level Radioactivity Laboratory Institute of Nature and Environmental TechnologyKanazawa University Institute of Nature and Environmental Technology Kanazawa University

The long sediment core BDP98 obtained from Lake Baikal was analyzed in order to discuss the periodicity of glacial cycles in the terrestrial climatic record of the past 2.6 *** analysis shows that the Baikal grain size record has been dominated by orbit-related cycles with periods of about100 ka,41 ka,and 23 ka,similar to those in the marine isotope ***,there are some notable differences between the Baikal and oceanic *** the marine isotope record,the 41 ka cycle was dominant before 1 Ma and the 100 ka cycle became significant only ***,in the Baikal record,the 100 ka period has appeared continuously throughout the past 2.6 Ma,and no appreciable shift in period is *** results suggest that the terrestrial climatic response to orbital forcing,as imprinted in the Baikal sediment,is different from the oceanic *** 100 ka cycle detected in the Baikal record from before 1 Ma may be attributable to relatively long interglacials with skipping of two or three 41 ka obliquity *** result may support the hypothesis that the 100 ka cycle is paced by the obliquity cycle.

关键词： Lake Baikal lake sediment grain size orbital-scale climatic changes

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