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Characterization of a microsecond pulsed non-equilibrium atmospheric pressure Ar plasma using laser scattering and optical emission spectroscopy

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Plasma Science and Technology 2020年第6期22卷 120-127页

作者： Fengdong JIA Yong WU Qi MIN Maogen SU Keigo TAKEDA kenji ishikawa Hiroki KONDO Makoto SEKINE Masaru HORI Zhiping ZHONG School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049People's Republic of China Institute of Applied Physics and Computational Mathematics Beijing 100088People's Republic of China Key Laboratory of Atomic and Molecular Physics&Functional Material of Gansu Province College of Physics and Electronic EngineeringNorthwest Normal UniversityLanzhou 730070People's Republic of China Department of Electrical and Electronic Engineering Faculty of Science and TechnologyMeijo UniversityNagoya 468-8502Japan Graduate School of Engineering Nagoya UniversityNagoya 464-8603Japan CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190People's Republic of China

A non-equilibrium atmospheric pressure argon(Ar)plasma excited by microsecond pulse is studied experimentally by laser scattering and optical emission spectroscopy(OES),and theoretically by collisional-radiative(CR)*** specifically,the electron temperature and electron density of plasma are obtained directly by the laser Thomson scattering,the gas temperature is measured by laser Raman scattering,the optical emissions of excited Ar states of plasma are measured by *** laser scattering results show that the electron temperature is about 1 eV which is similar to that excited by 60 Hz AC power,but the gas temperature is as low as 300 K compared to about 700 K excited by 60 Hz AC *** is shown that the microsecond pulsed power supply,rather than nanosecond ones,is short enough to reduce the gas temperature of atmospheric pressure plasma to near room *** electron temperature and electron density are also obtained by CR model based on OES,and find that the intensities of the optical emission intensity lines of 727.41,811.73,841.08,842.83,852.44 and 912.86 nm of Ar can be used to characterize the behavior of electron density and electron temperature,it is very useful to quickly estimate the activity of the atmospheric pressure Ar plasma in many applications.

关键词： plasma diagnosis laser Thomson scattering atmospheric pressure plasma

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Impact of microsecond-pulsed plasma-activated water on papaya seed germination and seedling growth

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Chinese Physics B 2022年第12期31卷 630-641页

作者： Deng-Ke Xi Xian-Hui Zhang Si-Ze Yang Seong Shan Yap kenji ishikawa Masura Hori Seong Ling Yap Plasma Technology Research Center Department of PhysicsFaculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Fujian Engineering Research Center for EDAFujian Provincial Key Laboratory of Electromagnetic Wave Science and Detection TechnologyXiamen Key Laboratory of Multiphysics Electronic InformationInstitute of Electromagnetics and AcousticsXiamen UniversityXiamen 361005China Department of Physics Xiamen University MalaysiaSelangor Darul Ehsan 43900Malaysia Center for Low-temperature Plasma Sciences Nagoya UniversityNagoya 464-8603 AichiJapan

The seed of Carica papaya consists of a hard shell-like testa with inhibitors in vivo causing slow,erratic and asynchronous *** this work,plasma-activated water prepared by microsecond-pulsed plasma jets(μPAW)was applied to treat papaya ***μPAW after plasma activation of 30 min was about 40℃.The reactive species such as NO_(2),NO_(3),and H_(2)O_(2)in theμPAW activated from deionized water were measured and correlated to the seed germination rate and the seedling growth ***μPAW-treated papaya seed achieved a higher germination rate of 90%,which is 26%higher than the control group using deionized *** the results with a hot water(40℃)reference group showed that the reactive species inμPAW played primary roles in germination improvement,with little effect caused by the heat ***μPAW also sterilized the treated seeds,reducing the germination *** morphological change in the seeds was observed by SEM,showing an effect of physical etching after treatment promoting seed *** biochemical mechanism of the seed germination was deduced with reference to the evolution of surface chemistry,functional groups,and ABA *** accelerated seed metabolism observed was corresponded to the chemical modification ***,early seedlings developed from treated seeds were observed to be healthy,grow more leaves,and have better root *** content of MDA in the treated papaya seedlings decreased along with increased SOD and higher ion ***μPAW that can be prepared at atmospheric pressure for bulk production offers a low-risk and cost-effective seed priming technology that may significantly increase the production of agricultural crops.

关键词： plasma-activated water non-thermal plasma microbial inactivation seed metabolism

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Growth processes and crystallographic properties of nanographenes synthesized employing in-liquid plasma

Growth processes and crystallographic properties of nanograp...

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第三届微电子及等离子体技术国际会议

作者： Hiroki Kondo Tatsuya Hagino kenji ishikawa Keigo Takeda Hiroyuki Kano Makoto Sekine Masaru Hori Department of electrical engineering and computer science graduate school of engineeringNagoya University Plasma nanotechnology research center graduate school of engineeringNagoya University

Nanographene materials have attracted much attention as their unique structures,interesting properties,and promising device ***,we established a high-speed synthesis technique of nanographene employing alcohols and in-liquid plasma,and confirm high crystallinity of synthesized *** this study,growth processes and mechanisms of nanographenes are *** this method,one Ni electrode was immersed into an ethanol,and the other was fixed above the ethanol level at gaseous Ar *** a 9 kV and 60 Hz ac-power to these electrodes,the in-liquid plasma was *** the plasma discharge for 20 minutes,it was found that black-colored nanographenes with a size of microns were dispersed in the *** black substances and yellow-colored extraction liquid were separated by *** sharp G-band peaks at 1581 cm-1 in Raman spectra and the interlayer spacing（3.33 A） between graphite basal planes observed in the transmission electron microscopy（TEM） images revealed the high-crystallinity of synthesized *** the crystallographic properties were not significantly changed owing to the kinds of alcohols and electrode *** the other hand,according to the liquid chromatography analysis,various types of aromatic hydrocarbons were generated in the *** results indicate that the in-liquid plasma discharge induce the dissolution of alcoholic molecules and generation of aromatic hydrocarbons as elementary steps of nanographene ***,the polymerization of the aromatic hydrocarbons results in the nanographene *** results will open the way to further development of high-speed synthesis and precise control of crystallographic properties.

关键词： Nanographene In-liquid plasma transmission electron microscopy Raman spectroscopy liquid chromatography

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Particle selectivity of filtering by C. elegans

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Theoretical & Applied Mechanics Letters 2019年第2期9卷 61-65页

作者： Yuki Suzuki kenji Kikuchi Keiko Tsuruta-Numayama Takuji ishikawa Graduate School of Engineering Tohoku University

A nematode Caenorhabditis elegans(C. elegans) is a filter feeder, which draws a suspension of bacteria and separates bacteria from the solvent by using pharyngeal pumping motions and specific mouth parts. This mechanism has not been fully understood. We investigated the mechanism of filtering of bacteria in the pharynx of C. elegans by visualization by fluorescent particles and dyed E. coli. We succeeded in quantifying the selectivity of bacteria-sized particles by C. elegans. The most accumulated particles were those of 0.5 μm in diameter. The quantity of accumulated particles of 0.2 μm or 1.0 μm in diameter was about one third of that of particles of 0.5μm in diameter. The least accumulated particles were those of 0.05 μm in diameter. These results suggest that the pharyngeal structures of C. elegans would be suitable for eating bacteria because the size of bacteria ingested by C. elegans worms is about 0.5 μm in diameter. We also succeeded in visualizing pharyngeal structures and pumping motions and flow in the pharynx. We found that there were phase differences in the motions among procorpus, metacorpus and isthmus. This result suggests filtering would occur at the two tips of procorpus and isthmus by the phase differences. We found that bacteria-sized particles and bacteria were flowed and trapped in the channels, which existed along the central lumen from tip of procorpus to isthmus. From our results, we proposed the novel mechanism of filtering of bacteria through the channels for flowing and trapping. In future, this selective filtering mechanism of C. elegans would be applied to development of microfluidic filtration devices for medical and biological equipment.

关键词： Nematode C.elegans Pharynx Pumping Filtering Selectivity

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BRIEF ARTICLE New reduced volume preparation regimen in colon capsule endoscopy

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World Journal of Gastroenterology 2012年第17期18卷 2092-2098页

作者： Yasuo Kakugawa Yutaka Saito Shoichi Saito kenji Watanabe Naoki Ohmiya Mitsuyuki Murano Shiro Oka Tetsuo Arakawa Hidemi Goto Kazuhide Higuchi Shinji Tanaka Hideki ishikawa Hisao Tajiri Division of Screening Technology and Development Research Center for Cancer Prevention and ScreeningNational Cancer CenterTokyo 104-0045Japan Endoscopy Division National Cancer Center HospitalTokyo 104-0045Japan Department of Endoscopy Jikei University School of MedicineTokyo 105-8461Japan Department of Gastroenterology Osaka City University Graduate School of MedicineOsaka 545-8685Japan Department of Therapeutic Medicine Nagoya University Graduate School of MedicineNagoya 466-8560Japan Second Department of Internal Medicine Osaka Medical CollegeOsaka 569-8686Japan Department of Endoscopy Hiroshima University HospitalHiroshima 734-8551Japan Department of Molecular-Targeting Cancer Prevention Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyoto 602-0841Japan

AIM:To evaluate the effectiveness of our proposed bowel preparation method for colon capsule ***:A pilot,multicenter,randomized controlled trial compared our proposed "reduced volume method"(group A) with the "conventional volume method"(group B) preparation *** A did not drink polyethylene glycol electrolyte lavage solution(PEGELS) the day before the capsule procedure,while group B drank 2 *** the procedure day,groups A and B drank 2 L and 1 L of PEG-ELS,respectively,and swallowed the colon capsule(PillCam COLON capsule).Two hours later the first booster of 100 g magnesium citrate mixed with 900 mL water was administered to both groups,and the second booster was administered six hours post capsule ingestion as long as the capsule had not been excreted by that *** videos were reviewed for grading of cleansing level,RESULTS:Sixty-four subjects were enrolled,with results from 60 *** A and B included 31 and 29 subjects,***-nine(94%) subjects in group A and 25(86%) subjects in group B had adequate bowel preparation(ns).Twenty-two(71%) of the 31 subjects in group A excreted the capsule within its battery life compared to 16(55%) of the 29 subjects in group B(ns).Of the remaining 22 subjects whose capsules were not excreted within the battery life,all of the capsules reached the left side colon before they stopped functioning.A single adverse event was reported in one subject who had mild symptoms of nausea and vomiting one hour after starting to drink PEG-ELS,due to ingesting the PEG-ELS faster than ***:Our proposed reduced volume bowel preparation method for colon capsule without PEG-ELS during the days before the procedure was as effective as the conventional volume method.

关键词： Colon capsule endoscopy Polyethylene glycol electrolyte lavage solution Colon cleanliness Reduced volume preparation method Isotonic magnesium citrate

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Effects of an oral iron chelator, deferasirox, on advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第40期22卷 8967-8977页

作者： Issei Saeki Naoki Yamamoto Takahiro Yamasaki Taro Takami Masaki Maeda Koichi Fujisawa Takuya Iwamoto Toshihiko Matsumoto Isao Hidaka Tsuyoshi ishikawa Koichi Uchida kenji Tani Isao Sakaida Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine Yamaguchi 755-8505 Japan Yamaguchi University Health Administration Center Yamaguchi 755-8511 Japan Department of Oncology and Laboratory Medicine Yamaguchi University Graduate School of Medicine Yamaguchi 755-8505 Japan Department of Human Nutrition Faculty of Nursing and Human Nutrition Yamaguchi 755-8502 Japan Center of Research and Education for Regenerative Medicine Yamaguchi University Graduate School of Medicine Yamaguchi Prefectural University Yamaguchi 755-8505 Japan Department of Veterinary Surgery Joint Faculty of Veterinary Medicine Yamaguchi University Yamaguchi 755-8511 Japan

AIM To evaluate the inhibitory effects of deferasirox(DFX) against hepatocellular carcinoma(HCC) through basic and clinical *** In the basic study, the effect of DFX was investigated in three hepatoma cell lines(Hep G2, Hep3 B, and Huh7), as well as in an N-nitrosodiethylamine-induced murine HCC model. In the clinical study, six advanced HCC patients refractory to chemotherapy were enrolled. The initial dose of DFX was 10 mg/kg per day and was increased by 10 mg/kg per day every week, until the maximum dose of 30 mg/kg per day. The duration of a single course of DFX therapy was 28 consecutive days. In the event of dose-limiting toxicity(according to the Common Terminology Criteria for Adverse Events v.4.0), DFX dose was *** Administration of DFX inhibited the proliferation of hepatoma cell lines and induced the activation of caspase-3 in a dose-dependent manner in vitro. In the murine model, DFX treatment significantly suppressed the development of liver tumors(P < 0.01), and significantly upregulated the mR NA expression levels of hepcidin(P < 0.05), transferrin receptor 1(P < 0.05), and hypoxia inducible factor-1α(P < 0.05) in both tumor and non-tumor tissues, compared with control mice. In the clinical study, anorexia and elevated serum creatinine were observed in four and all six patients, respectively. However, reduction in DFX dose led to decrease in serum creatinine levels in all patients. After the first course of DFX, one patient discontinued the therapy. We assessed the tumor response in the remaining five patients; one patient exhibited stable disease, while four patients exhibited progressive disease. The one-year survival rate of the six patients was 17%.CONCLUSION We demonstrated that DFX inhibited HCC in the basic study, but not in the clinical study due to dose-limiting toxicities.

关键词： Liver tumor Hepatocellular carcinoma Advanced stage Iron-chelator Deferasirox

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Transient Stability Analysis of Power System with Photovoltaic Systems Installed

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Journal of Energy and Power Engineering 2015年第10期9卷 896-904页

作者： Masaki Yagami Seiichiro ishikawa Yoshihiro Ichinohe kenji Misawa Junji Tamura Department of Electrical and Electronic Engineering Hokkaido University of Science Sapporo 006-8585 Japan Department of Electrical and Electronic Engineering Kitami Institute of Technology Kitami 090-8507 Japan

The impact of large-scale grid-connected PV （photovoltaics） on power system transient stability is discussed in this paper. In response to an increase of PV capacity, the capacity of conventional synchronous generator needs to be reduced relatively. This leads to the lower system inertia and the higher generator reactance, and hence, the power system transient stability may negatively be affected. In particular, the impact on the transient stability may become more serious when the considerable amounts of PV systems are disconnected simultaneously during voltage sag. In this work, the potential impact of significant PV penetration on the transient stability is assessed by a numerical simulation using PSCAD/EMTDC.

关键词： Photovoltaic LVRT (low-voltage ride-through) synchronous generator infinite bus transient stability.

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Clinical characteristics of gastrointestinal immune-related adverse events of immune checkpoint inhibitors and their association with survival

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World Journal of Gastroenterology 2021年第41期27卷 7190-7206页

作者： Kentaro Yamada Tsunaki Sawada Masanao Nakamura Takeshi Yamamura Keiko Maeda Eri ishikawa Tadashi Iida Yasuyuki Mizutani Naomi Kakushima Takuya ishikawa Kazuhiro Furukawa Eizaburo Ohno Takashi Honda Hiroki Kawashima Masatoshi Ishigami Satoshi Furune Tetsunari Hase kenji Yokota Osamu Maeda Naozumi Hashimoto Masashi Akiyama Yuichi Ando Mitsuhiro Fujishiro Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoya City 4668560AichiJapan Department of Endoscopy Nagoya University HospitalNagoya City 4668560AichiJapan Department of Clinical Oncology and Chemotherapy Nagoya University HospitalNagoya City 4668560AichiJapan Department of Respiratory Medicine Nagoya University Graduate School of MedicineNagoya City 4668560AichiJapan Department of Dermatology Nagoya University Graduate School of MedicineNagoya City 4668560AichiJapan Department of Gastroenterology and Hepatology Graduate School of MedicineThe University of TokyoTokyo 1138655Japan

BACKGROUND Despite the popularity of immune checkpoint inhibitors(ICIs)in the treatment of advanced cancer,patients often develop gastrointestinal(GI)and non-GI immune-related adverse events(irAEs).The clinical characteristics and survival outcomes of GI-irAEs have not been fully elucidated in previous *** necessitates the evaluation of the impact of GI-irAEs on patients receiving ICI *** To evaluate the clinical characteristics of GI-irAEs and their impact on survival in patients treated with *** In this single-center,retrospective,observational study,we reviewed the records of 661 patients who received ICIs for various cancers at Nagoya University Hospital from September 2014 to August *** analyzed the clinical characteristics of patients who received ICI *** also evaluated the correlation between GI-irAE development and prognosis in non-small cell lung cancer(LC)and malignant melanoma(MM).Kaplan-Meier analysis was used to compare the median overall survival(OS).Multivariate Cox proportional hazards models were used to identify prognostic factors.A P value<0.05 was considered statistically *** GI-irAEs occurred in 34 of 605 patients(5.6%)treated with an anti-programmed cell death-1/programmed death-ligand 1(anti-PD-1/PD-L1)antibody alone and in nine of 56 patients(16.1%)treated with an anti-cytotoxic T-lymphocyte antigen 4(CTLA-4)antibody alone or a combination of anti-PD-1 and anti-CTLA-4 *** cumulative incidence and median daily diarrhea frequency were significantly higher in patients receiving anti-CTLA-4 antibodies(P<0.05).In 130 patients with MM,OS was significantly prolonged in the group that continued ICI treatment despite the development of GI-irAEs compared to the group that did not experience GI-irAEs(P=0.035).In contrast,in 209 patients with non-small cell LC,there was no significant difference in OS between the *** multivariate analyses showed that a performance status of 2-3(ha

关键词： Colitis Cytotoxic T-lymphocyte antigen 4 Diarrhea Drug-related side effects and adverse reactions Immune checkpoint inhibitors Prognosis

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Remain Aggressive Behavior in Children with Temporal Lobe Epilepsy after Surgery

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Journal of Behavioral and Brain Science 2015年第3期5卷 81-87页

作者： Sayuri Sukigara Eiji Nakagawa Masanori ishikawa kenji Sugai Masayuki Sasaki Takanobu Kaido Akio Takahashi Taisuke Otsuki Department of Child Neurology National Center Hospital National Center of Neurology and Psychiatry (NCNP) Tokyo Japan Department of Psychiatry NCNP Tokyo Japan Department of Neurosurgery NCNP Tokyo Japan

Behavioral problems have a high rate in patients with temporal lobe epilepsy but there have been few detailed reports about pediatric patients. We report two children with temporal lobe epilepsy who manifest behavior abnormality remaining after surgery. One child developed complex partial seizures at 10 years and 3 months of age caused by a left temporal ganglioglioma and manifested behavioral problems of lability, aggression, impulsivity and disinhibition. Seizures were relieved after temporal lobe resection at 10 years and 8 months of age but behavioral symptoms had been remained. The second child developed epilepsy at 3 years of age. He manifested similar behavioral problems at 7 years old. Seizures were relieved after temporal lobe resection at 13 years old but behavioral symptoms had been remained. Their courses suggested that aggressive behavior might be associated with not only temporal lesion but also other lesions such as frontal lobe or neural circuitry between both lobes. It is important to inform families of patients that behavioral disorders may not improve after epileptic surgery.

关键词： Temporal Lobe Epilepsy Behavioral Disorder Aggression Epileptic Surgery

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Syntheses of Soluble Biopolyimides Using 4-Aminophenylalanine

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Chinese Journal of Polymer Science 2020年第10期38卷 1117-1123,I0007页

作者： kenji Takad Hiromasa Shinagaw Yuki Morita Manjit SGrewal Kazuya Taya Amit Kumar Tatsuo Kaneko Graduate Schoo/of Advanced Science and Technology Energy and Environment AreaJapan Advanced Institute of Science and Technology(AISTI1-1 AsahidaiNomiIshikawa923-1292Japan Marialnrganomeallics Laboratony Department ofChemisty Atma Ram Sanatan Dharma CllegeUniversity of DelhiNew Delhi-10021India

4-Aminophenylalanine(4APhe),an exotic amino acid which is obtained as a microorganism metabolite of glucose,is polycondensed with various tetracarboxylic dianhydrides as a diamine monomer to obtain poly(amic acid)*** thermal imidization of poly(amic acid)s is made at 220°C with stepwise heating from 100°*** of the obtained polyimides(PIs)exhibited good solubility in organic solvents such as N,N-dimethylformamide,N.N dimethylacetamide,and *** progress of imidization was observed by proton nuclear magnetic resonance and infrared spectroscopy to confrm that the imidization ratio was up to 98%.Carboxylate group of the side-chains of PIs affected their solubilities despite the high imidization ratio,and the solubility was lost for any organic solvents by decarboxylation at 280。C,confirmed from mass-loss of thermogravimetric ***,a new series of PIs were obtained with abilities of solvent-molding in PI state and thermal resistivityt enhancement by further heating after molding.

关键词： Bio-based polymers Polyimides Amino acids 4-Aminophenylalanine Soluble polyimides

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