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Precise Synthesis of Organometallic Dendrimers

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复旦学报（自然科学版） 2005年第5期44卷 823-824页

作者： K. Onitsuka S. takahashi The Institute of Scientific and Industrial Research Osaka University8-1 Mihogaoka Ibaraki Osaka 567-0047 JapanThe Institute of Scientific and Industrial Research Osaka University8-1 Mihogaoka Ibaraki Osaka 567-0047 Japan

Dendrimers possessing a regularly branched architecture and large spherical dimensions have attracted significant attention because of their unique and tunable properties as well as their potential applications. The incorporation of organometallic species into dendritic molecules has been attracting much attention, because the addition of properties characteristic of organometallic complexes, such as magnetic, electronic, and photo-optical properties, as well as reactivity may lead to the realization of new functionalized dendrimers. Although there are many examples of organometallic dendrimers that contain metallic species at the core or at the periphery, dendrimers composed of organometallic complexes in each generation are still limited. We present here convergent and divergent approaches to novel organometallic dendrimers, of which the skeletons were built up with platinum-acetylide units.

关键词：有机金属树型化合物乙炔化物合成方法光学性质

Evaluation method of dam behavior during construction and reservoir filling and application to real dams

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Frontiers of Structural and Civil Engineering 2010年第1期4卷 92-101页

作者： Yuji KOHGO Akira takahashi Tomokazu SUZUKI Tokyo University of Agriculture and Technology TokyoJapan Tokyo Electric Power Company Limited TokyoJapan Tokyo Electric Power Services Company Limited TokyoJapan

In this paper we analyzed a real fill-type dam,named the Minami-Aiki Dam,to verify a numerical consolidation method with an elastoplastic model for unsaturated *** validities were conducted by comparing the analyzed and measured values during construction and *** settlements calculated showed good agreement to those *** the changing patterns of the measured and calculated pore water pressures were similar,the amounts of pore water pressures induced by the self-weights of embankment and the dissipation speeds were *** earth pressures measured at the bottom of the core zone showed good agreement with those *** method is valid for estimating behavior of fill-type dams during construction and impounding.

关键词： fill dam consolidation analysis unsaturated geo-materials impounding construction

Thrombocytopenia after liver transplantation:should we care?

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World Journal of Gastroenterology 2018年第13期24卷 1386-1397页

作者： Kazuhiro takahashi Shunji Nagai Mohamed Safwan Chen Liang Nobuhiro Ohkohchi Department of Surgery Division of Gastroenterological and Hepatobiliary Surgery and Organ Transplantation University of TsukubaTsukubaIbaraki 3058575Japan Transplant and Hepatobiliary Surgery Henry Ford HospitalDetroitMl 48202United States

Transient thrombocytopenia is a common phenomenon after liver transplantation. After liver transplantation(LT), platelet count decreases and reaches a nadir on postoperative days 3-5, with an average reduction in platelet counts of 60%; platelet count recovers to preoperative levels approximately two weeks after LT. The putative mechanisms include haemodilution, decreased platelet production, increased sequestration, medications, infections, thrombosis, or combination of these processes. However, the precise mechanisms remain unclear. The role of platelets in liver transplantation has been highlighted in recent years, and particular attention has been given to their effects beyond hemostasis and thrombosis. Previous studies have demonstrated that perioperative thrombocytopenia causes poor graft regeneration, increases the incidence of postoperative morbidity, and deteriorates the graft and decreases patient survival in both the short and long term after liver transplantation. Platelet therapies to increase perioperative platelet counts, such as thrombopoietin, thrombopoietin receptor agonist, platelet transfusion, splenectomy, and intravenous immunoglobulin treatment might have a potential for improving graft survival, however clinical trials are lacking. Further studies are warranted to detect direct evidence on whether thrombocytopenia is the cause or result of poor-graft function and postoperative complications, and to determine who needs platelet therapies in order to prevent postoperative complications and thus improve post-transplant outcomes.

关键词： Thrombocytopenia Liver regeneration Platelet therapy Platelet Thrombopoietin receptor agonist Intravenous immunoglobulin treatment Liver transplantation

Optical spectroscopy and photometry of main-belt asteroids with a high orbital inclination

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Research in Astronomy and Astrophysics 2017年第2期17卷 43-50页

作者： Aya Iwai Yoichi Itoh Tsuyoshi Terai Ranjan Gupta Asoke Sen Jun takahashi National Institute of Advanced Industrial Science and Technology Ibaraki 305-8563Japan Nishi-Harima Astronomical Observatory Center for AstronomyUniversity of HyogoISIyogo 679-5313Japan National Astronomical Observatory of Japan HiloHawaii 96720USA Inter-University Centre for Astronomy and Astrophysics GaneshkhindPune 411 007India Department of Physics Assam UniversitySilchar 788 001India

We carried out low-resolution optical spectroscopy of 51 main-belt asteroids, most of which have highly-inclined orbits. They are selected from D-type candidates in the SDSS-MOC 4 catalog. Using the University of Hawaii 2.2 m telescope and the Inter-University Centre for Astronomy and Astrophysics 2 m telescope in India, we determined the spectral types of 38 asteroids. Among them, eight asteroids were classified as D-type asteroids. Fractions of D-type asteroids are 3.0 ± 1.1% for low orbital inclination main-belt asteroids and 7.3 ± 2.0% for high orbital inclination main-belt asteroids. The results of our study indicate that some D-type asteroids were formed within the ecliptic region between the main belt and Jupiter, and were then perturbed by Jupiter.

关键词： minor planets, asteroids general -- techniques spectroscopic

Numerical Investigation of Flow Fields in Inductively Coupled Plasma Wind Tunnels

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Plasma Science and Technology 2014年第10期16卷 930-940页

作者：喻明浩 Yusuke takahashi Hisashi KIHARA Ken-ichi ABE Kazuhiko YAMADA Takashi ABE Department of Aeronautics and Astronautics Kyushu UniversityFukuoka 819-0395Japan Division of Mechanical and Space Engineering Hokkaido UniversitySapporo 060-8628Japan Institute of Space and Astronautical Science Japan Aerospace Exploration AgencySagamihara 252-5210Japan

Numerical simulations of 10 kW and 110 kW inductively coupled plasma （ICP） wind tunnels were carried out to study physical properties of the flow inside the ICP torch and vacuum chamber with air as tile working gas. Two-dimensional compressible axisymmetric Navier- Stokes （N-S） equations that took into account 11 species and 49 chemical reactions of air, were solved. A heat source model was used to describe the heating phenomenon instead of solving the electromagnetic equations. In the vacuum chamber, a four-temperature model was coupled with N-S equations. Numerical results for tile 10 kW ICP wind tunnel are presented and discussed in detail as a representative case. It was found that the plasma flow in the vacuum chamber tended to be in local thermoehemical equilibrium. To study the influence of operation conditions on the flow field, simulations were carried out for different chamber pressures and/or input powers. The computational results for the above two ICP wind tunnels were compared with corresponding experimental data. The computational and experimental results agree well, therefore the flow fields of ICP wind tunnels can be clearly understood.

关键词： inductively coupled plasma Joule heating vacuum chamber chemical reactions

Efficacy of the revised Vienna Classification for diagnosing colorectal epithelial neoplasias

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World Journal of Gastroenterology 2009年第19期15卷 2351-2356页

作者： Kenji Tominaga Sumio Fujinuma Takuro Endo Yoshihisa Saida Kei takahashi Iruru Maetani Division of Gastroenterology Department of Internal MedicineToho University Ohashi Medical Center2-17-6 OhashiMeguro-kuTokyo 153-8515Japan Third Department of Surgery Toho University Ohashi Medical Center2-17-6 OhashiMeguro-kuTokyo 153-8515Japan Department of Surgical Pathology Toho University Ohashi Medical Center2-17-6 OhashiMeguro-kuTokyo 153-8515Japan

AIM： To prospectively investigate the efficacy of the revised Vienna Classification for diagnosing colorectal epithelial neoplastic lesions in cold biopsy ***： Patients were selected for inclusion if they had colorectal epithelial lesions that were not considered suitable for direct endoscopic resection,These included colorectal polyps ≥ 10 mm and lesions suspected of being carcinomas capable of invading the colorectal submucosa or beyond, including strictures, based on the cold biopsies obtained from each lesion prior to resection. We investigated the relationship between diagnoses based on cold biopsy samples using the revised Vienna Classification and resected specimens of the same lesions, and the therapeutic implications of diagnoses made using the revised Vienna Classification. The same cold biopsy specimens were also examined using the Japanese Group Classification guidelines, and compared with the resected specimens of the same lesions for ***： A total of 179 lesions were identified. The sensitivity, specificity, positive and negativepredictive values of the revised Vienna Classification for distinguishing between intramucosal lesions and submucosal invasive carcinomas in cold biopsy specimens was 22.2%, 100%, 100%, and 71.4%,respectively, and for distinguishing between intramucosal lesions and those invading the submucosa or beyond was 59.7%, 100%, 100%, and 37.6%,respectively. The sensitivity, specificity, positive and negative predictive values of the Japanese Group Classification for distinguishing between intramucosal lesions and submucosal invasive carcinomas in cold biopsy specimens was 83.3%, 91.4%, 83.3%. and 91.4%, respectively, and for distinguishing between intramucosal lesions and those invading the submucosa or beyond was 95.1%, 91.4%, 97.9%, and 82.1%, respectively. A total of 137 of 144 carcinomas that had invaded the submucosa or beyond and three high-grade intraepithelial neoplasias were diagnosed as ＂carcinoma＂

关键词： Biopsy Cancer Colonoscopy Colorectalepithelial neoplasia Revised Vienna Classification

Complete response to multidisciplinary therapy in a patient with primary gastric choriocarcinoma

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World Journal of Gastroenterology 2013年第31期19卷 5187-5194页

作者： Kazuhiro takahashi Shigeki Tsukamoto Ken Saito Nobuhiro Ohkohchi Katsu Hirayama Division of Gastro-enterological and Hepatobiliary Surgery and Organ Transplantation Department of Surgery University of Tsukuba Tsukuba 3058575 Japan Department of Surgery Hiraka General Hospital Yokote 0138610 Japan

Primary gastric choriocarcinoma is a rapidly growing neoplasm with an average survival of several months in untreated *** with lymph node dissection followed by chemotherapy is the treatment of *** used for gastric adenocarcinoma are usually ***,median survival remains less than six *** this case report,we describe a case of primary gastric choriocarcinoma with a clinical complete response to multidisciplinary treatment including surgery,chemotherapy,and radiofrequency ablation(RFA).The patient was originally referred for general *** demonstrated a large tumor occupying the fornix,and total gastrectomy with lymph node dissection was *** days later,multiple liver metastatic recurrences with high serum levels of beta-human chorionic gonadotropin(β-hCG) were *** with a gonadal choriocarcinoma regimen consisting of etoposide,methotrexate,actinomycin D,cyclophosphamide,and vincristine(EMA/CO),was *** three cycles,serum β-hCG decreased markedly and the tumors *** months later,multiple lung metastatic recurrences were *** one cycle of EMA/CO,only one nodule *** tomography-guided RFA was performed for this oligometastatic *** patient has been alive with no evidence of disease for 10 years after the initial *** the best of our knowledge,this patient with recurrent primary gastric choriocarcinoma has achieved the longest *** present case is the first report of choriocarcinoma metastatic to the lung successfully treated with *** our retrospective analysis of recurrent or unresectable primary gastric choriocarcinoma,we propose that gonadal choriocarcinoma regimens can be considered as first-line for primary gastric choriocarcinoma.

关键词： Primary gastric choriocarcinoma Betahuman chorionic gonadotropin Etoposide,methotrexate,actinomycin D,cyclophosphamide,and vincristine Oligometastatic Radiofrequency ablation

Immunological effect of local ablation combined with immunotherapy on solid malignancies

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Chinese Journal of Cancer 2017年第6期36卷 252-257页

作者： Yusuke takahashi Noriyuki Matsutani Takashi Nakayama Hitoshi Dejima Hirofumi Uehara Masafumi Kawamura Department of General Thoracic Surgery Teikyo University School of Medicine

Recent comprehensive investigations clarified that immune microenvironment surrounding tumor cells are deeply involved in tumor progression,metastasis,and response to ***,several immunotherapeutic trials have achieved successful results,and the immunotherapeutic agents are available in clinical *** enhance their demonstrated efficacy,combination of immunotherapy and ablation has begun to *** ablations have considerable advantages as an alternative therapeutic option,especially its minimal *** addition,local ablations have shown immune-regulatory effect in preclinical and clinical *** the corresponding mechanisms are still unclear,the local ablations combined with immunotherapy have been suggested in the treatment of several solid *** article aims to review the published data on the immune-regulatory effects of local ablations including stereotactic body radiotherapy,cryoablation,radiofrequency ablation,and high-intensityfocused *** also discuss the value of local ablations combined with *** ablations have the potential to improve future patient outcomes;however,the effectiveness and safety of local ablations combined with immunotherapy should be further investigated.

关键词：免疫治疗剂免疫效应实体瘤免疫调节作用高强度聚焦超声肿瘤细胞临床实践综合调查

CAMSAP3-dependent microtubule dynamics regulates Golgi assembly in epithelial cells

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Journal of Genetics and Genomics 2017年第1期44卷 39-49页

作者： Jing Wang Honglin Xu Yuqiang Jiang Mikiko takahashi Masatoshi Takeichi Wenxiang Meng State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences No.19A Yuquan RoadBeijing 100049China Faculty of Pharmaceutical Sciences Teikyo Heisei University4-21-2 NakanoNakano-kuTokyo 164-8530Japan RIKEN Center for Developmental Biology 2-2-3 Chuo-kuKobe 650-0047Japan

The Golgi assembly pattern varies among cell types. In fibroblast cells, the Golgi apparatus concentrates around the centrosome that radiates microtubules; whereas in epithelial cells, whose microtubules are mainly noncentrosomal, the Golgi apparatus accumulates around the nucleus independently of centrosome. Little is known about the mechanisms behind such cell wpe-specific Golgi and microtubule organization. Here, we show that the microtubule minus-end binding protein Nezha/CAMSAP3 （calmodulin-regulated spectrin-associated protein 3） plays a role in translocation of Golgi vesicles in epithelial cells. This function of CAMSAP3 is supported by CG-NAP （centrosome and Golgi localized PKN- associated protein） through their binding. Depletion of either one of these proteins similarly induces fragmentation of Golgi membranes. Furthermore, we find that stathmin-dependent microtubule dynamics is graded along the radial axis of ceils with highest activity at the perinuclear region, and inhibition of this gradient disrupts perinuclear distribution of the Golgi apparatus. We propose that the assembly of the Golgi apparatus in epithelial cells is induced by a multi-step process, which includes CAMSAP3-dependent Golgi vesicle clustering and graded microtubule dynamics.

关键词： CG-NAP Nezha/CAMSAP3 Golgi Noncentrosomal micfotubules Stathmin