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Assessment of disease progression in patients with transfusion-associated chronic hepatitis C using transient elastography

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World Journal of Gastroenterology 2012年第12期18卷 1385-1390页

作者： Ryota Masuzaki Ryosuke Tateishi Haruhiko Yoshida Toru Arano Koji Uchino kenichiro Enooku Eriko goto Hayato Nakagawa Yoshinari Asaoka Yuji Kondo Tadashi goto Hitoshi Ikeda Shuichiro Shiina Masao Omata Kazuhiko Koike Department of Gastroenterology Graduate School of MedicineThe University of Tokyo Department of Clinical Laboratory The University of Tokyo Hospital Yamanashi Prefectural Hospital Organization

METHODS： Between December 2006 and June 2008, a total of 524 transfusion-associated HCV-RNA positive patients with or without HCC were enrolled, Liver stiffness was obtained noninvasively by using Fibroscan （Echosens, Paris, France）, The date of blood transfusion was obtained by interview, Duration of infection was derived from the interval between the date of bloodtransfusion and the date of liver stiffness measurement （LSM）. Patients were stratified into four groups based on the duration of infection （17-29 years; 30-39 years; 40-49 years; and 50-70 years）. The difference in liver stiffness between patients with and without HCC was assessed in each group. Multiple linear regression analysis was used to determine the factors associated with liver stiffness.RESULTS： A total of 524 patients underwent LSM. Eight patients were excluded because of unsuccessful measurements. Thus 516 patients were included in the current analysis （225 with HCC and 291 without）. The patients were 244 men and 272 women, with a mean age of 67.8 ±9.5 years. The median liver stiffness was 14.3 kPa （25.8 in HCC group and 7.6 in non HCC group）. The patients who developed HCC in short duration of infection were male dominant, having lower platelet count, with a history of heavier alcohol consumption, showing higher liver stiffness, and receiving blood transfusion at an old age. Liver stiffness was positively correlated with duration of infection in patients without HCC （r = 0.132, P = 0.024） but not in patients with HCC （r = -0.103, P = 0.123）. Liver stiffness was significantly higher in patients with HCC than in those without in each duration group （P 〈 0.0001）. The factors significantly associated with high liver stiffness in multiple regression were age at blood transfusion （P 〈 0.0001）, duration of infection （P = 0.0015）, and heavy alcohol consumption （P = 0.043）CONCLUSION： Although liver stiffness gradually increases over time, HCC develops in patients with high stiffness value regardle

关键词： Transfusion-associated hepatitis C Transientelastography Hepatocellular carcinoma Liver stiffness Ultrasonography Liver fibrosis

Effect of annealing temperature on multiferroic properties of Bi_(0.85)Nd_(0.15)FeO_3 thin films prepared by sol-gel method

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Science China(Technological Sciences) 2010年第6期53卷 1572-1575页

作者： goto Takashi Institute for Materials Research Tohoku UniversitySendai 980-8577Japan

Bi0.85Nd0.15FeO3 films were prepared on Pt/Ti/SiO2/Si substrate by a sol-gel method,and annealed at different *** effect of annealing temperature on the crystal structure,dielectric,ferroelectric,and ferromagnetic properties was *** the Bi0.85Nd0.15FeO3 films were annealed at 490-600°C,the single phase was ***0.85Nd0.15FeO3 film annealed at 600°C showed good multiferroic properties with εr of 145 (at 1 MHz),Ms of 44.8 emu/cm3,and 2Pr of 16.6 μC/cm2.

关键词： Bi0.85Nd0.15FeO3 thin films sol-gel method annealing temperature ferroelectric properties ferromagnetic properties

A Review:Structural Oxide Coatings by Laser Chemical Vapor Deposition

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Journal of Wuhan University of Technology(Materials Science) 2016年第1期31卷 1-5页

作者： Takashi goto Institute for Materials Research Tohoku University

Yttria-stabilized zirconia and-alumina films were prepared by laser chemical vapor deposition at deposition rates of several hundred micrometers per ***,the structural oxide coatings by laser chemical vapor deposition are *** laser can significantly accelerate the chemical reaction and grain growth in CVD,yielding high deposition *** films contain large amounts of nanopores that act as thermal insulation and are thus promising as coating materials for gas turbine blades of Ni-based superalloys and WC-Co cutting tools.

关键词： laser CVD yttria-stabilized zirconia alumina plasma nano-pores

Rebamipide enema therapy for left-sided ischemic colitis patients accompanied by ulcers:Open label study

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World Journal of Gastroenterology 2008年第25期14卷 4059-4064页

作者： Satohiro Matsumoto kenichiro Tsuji Satoshi Shirahama Department of Internal Medicine Kamigoto Hospital

AIM: To attempt rectal administration of rebamipide in the treatment of ischemic colitis patients with ulcers, and evaluate its effects. METHODS: We compared 9 ischemic colitis patients (2 men, 7 women) with ulcers treated by bowel rest only from 2000 to 2005 (conventional therapy group), with 6 patients (2 men, 4 women) treated by rebamipide enema therapy in 2006 (rebamipide enema therapy group) and analyzed the mean duration of fasting and hospitalization, degree of ulcer healing, and decrease in WBC count for the two groups. RESULTS: The mean duration of fasting and hos- pitalization were 2.7 ± 1.8 d and 9.2 ± 1.5 d in the rebamipide group and 7.9 ± 4.1 d and 17.9 ± 6.8 d in the control group, respectively, and signifi cantly re- duced in the rebamipide group (t = -2.915; P = 0.0121 and t = -3.054; P = 0.0092). As for the degree of ul- cer healing at 7 d after admission, the ulcer score was reduced by 3.5 ± 0.5 (points) in the rebamipide group and 2.8 ± 0.5 (points) in the control group (t = 1.975; P = 0.0797), while the decrease in WBC count was 120.0 ± 55.8 (× 102/μL) in the rebamipide group and 85.9 ± 56.8 (× 102/μL) in the control group (t = 1.006; P = 0.3360). CONCLUSION: In left-sided ischemic colitis patients with ulcers, rebamipide enema therapy significantly reduced the duration of fasting and hospitalization, recommending its use as a new and effective thera- peutic alternative.

关键词： Ischemic colitis Rebamipide-enema Fast-ing Hospitalization Ulcer healing White blood cells

Clinical investigation of 41 patients with ischemic colitis accompanied by ulcer

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World Journal of Gastroenterology 2007年第8期13卷 1236-1239页

作者： Satohiro Matsumoto kenichiro Tsuji Satoshi Shirahama Department of Internal Medicine Kamigoto Hospital Nagasaki Japan

AIM: To investigate the relationship among the presence of ulcer lesions, underlying disease, and clinical course in patients with ischemic colitis. METHODS: The subjects were 41 patients (10 male and 31 female; mean age 70 years) with ischemic colitis who were admitted to and received treatment in our hospital from 2000 to 2006. We compared their characteristics and analyzed the mean lengths of admission and fast- ing for 9 patients with ulcer lesions (ulcer group) and 32 without (non-ulcer group). RESULTS: The groups with presence and absence of ulcer differed significantly only in white blood cell (WBC) count. Lengths of fasting and admission were 7.9 d and 17.9 d for the ulcer group and 4.4 d and 10.7 d for the non-ulcer group, respectively, and significantly longer in the ulcer group (P = 0.0057 and 0.0001). There was no correlation between presence of ulcer and presence of underlying diseases. CONCLUSION: Lengths of fasting and admission were significantly longer in patients with ischemic colitis with ulcer than for those without ulcer.

关键词： Ischemic colitis Ulcer Fasting Admission White blood cell

Recent Advances in Protein Extraction and Chiral Separation of Biomolecules

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Tsinghua Science and Technology 2006年第2期11卷 194-201页

作者： Masahiro goto Department of Applied Chemistry Graduate School of Engineering Kyushu University Fukuoka Japan

Reverse micelles create unique environment in organic media. They are capable of solubilizing hydrophilic biomolecules （e.g., proteins, peptides, amino acids, and DNAs） in their aqueous interior. This feature brings about the practical use of biomaterials in organic media because reverse micelles solubilize them with the intrinsic activity. In this paper, we focus on recent two topics concerning protein extraction and chiral separation of biomolecules using liquid membranes. In the first topic, we present recent attempts to extract proteins from an aqueous solution into isooctane using reverse micelles, and some important operational parameters to achieve an efficient protein transfer are discussed. Furthermore, novel function of reverse micelles as a protein activation medium is introduced. In the reverse micellar phase, denatured proteins were completely reactivated in the reverse micellar solution. The reverse micellar technique is found to be a useful tool not only for protein separation but also for protein refolding. Furthermore, we found that a cyclic ligand carixarene has an extraction ability to set up optimum conditions for protein transfer. In the second topic, we have found that a supported liquid membrane （SLM） encapsulating enzymes shows high enantioselectivity （enantioselective excess value is over 96%） in the transport of racemic pharmaceutical compound ibuprofen. A different experiment also suggests that the α-chymotrypsin-catalyzed reactions droved the enantioselective transport of L-phenylalanine based on the enantioselectivity of the enzyme. The SLM encapsulating the surfactant-enzyme complex enabled the highly enantioselective separation of racemic mixtures. It can be envisioned that arrangement of appropriate enzymes in the SLM system will allow enantioselective separation of various useful organic compounds.

关键词： protein extraction chiral separation reverse micellar technique

Minimally invasive surgeries for insertional Achilles tendinopathy:A commentary review

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World Journal of Orthopedics 2023年第6期14卷 369-378页

作者： kenichiro Nakajima Center for Foot and Ankle Surgery Department of Orthopedic SurgeryYashioCentral General HospitalYashio-shi 340-0814SaitamaJapan

Studies of minimally invasive surgery for insertional Achilles tendinopathy are *** establish this surgery,the following techniques must be minimally invasive:Exostosis resection at the Achilles tendon insertion,debridement of degenerated Achilles tendon,reattachment using anchors or augmentation using flexor hallucis longus(FHL)tendon transfer,and excision of the posterosuperior calcaneal *** on these four perspectives were reviewed to establish minimally invasive surgery for insertional Achilles *** for exostosis resection were demonstrated in one case study,where blunt dissection around the exostosis was performed,and the exostosis was resected using an abrasion burr under fluoroscopic *** for debridement of degenerated Achilles tendon were demonstrated in the same case study,where the space left after resection of the exostosis was used as an endoscopic working space,and the degenerated Achilles tendon and intra-tendinous calcification were debrided *** tendon reattachment techniques using suture anchors have been demonstrated in several ***,there are no studies on FHL tendon transfer techniques for Achilles tendon *** contrast,endoscopic posterosuperior calcaneal prominence resection is already ***,studies on ultrasound-guided surgeries and percutaneous dorsal wedge calcaneal osteotomy as minimally invasive surgery were reviewed.

关键词： Achilles tendon Endoscopy Fluoroscopy Osteotomy Ultrasonography Tendinopathy Surgery

Blood Stasis Syndrome in Japan and Its Molecular Biological Analysis

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Chinese Journal of Integrative Medicine 2014年第7期20卷 490-495页

作者： Hirozo goto Department of Kampo Medicine Hokusei Hospital

Blood stasis syndrome is one of the pathological concepts of Oriental traditional medicine. In Oriental traditional medicine, blood is thought of as not only blood but also as a living component of the body. In fact, blood stasis syndrome is related to not just circulation disorders but dermatological and gynecological and other diseases. In Japan, the concept of blood stasis syndrome is based on the past literature, for instance, Synopsis of Golden Chamber （Jin Kui Yao Lue）, etc. There are many signs of this syndrome, such as a dry mouth, fullness of the abdomen and rough skin. However, the levels of importance of these signs had been unclear. Therefore, in order to determine the levels of seriousness, a scoring system of blood stasis syndrome was made based on multivariate analysis by Dr. Terasawa （Terasawa＇s Blood Stasis Score）. Using the scoring system, we have studied blood stasis syndrome mainly related to blood circulation using modem techniques of analysis. From the results, we found that patients with blood stasis syndrome showed hemorheological abnormalities, and an improvement in these abnormalities was shown after administration of removing-blood stasis formulae. Furthermore, we have studied blood stasis syndrome from the point of view of molecular biology. We searched for the specific protein expression in blood stasis syndrome by proteomic analysis, and found no specific protein expression. However, there may be a possibility of developing a diagnostic algorithm for blood stasis by construction of a decision tree. During the past few years, as one of the molecular biological factors affecting blood stasis syndrome, we have been studying hypoxia inducible factor, which is located in the upstream of many genes. Above all, blood stasis syndrome is more than just circulatory deficit but encompasses the pathological concept of constant multilateral change in the living body.

关键词： blood stasis syndrome Terasawa's Blood Stasis Score hemorheological abnormalities proteomic analysis decision tree hypoxia inducible factor

Prefrontal cortical dopamine from an evolutionary perspective

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Neuroscience Bulletin 2015年第2期31卷 164-174页

作者： Young-A Lee Yukiori goto Department of Food Science and Nutrition Catholic University of Daegu Kyoto University Primate Research Institute

In this article, we propose the hypothesis that the prefrontal cortex （PFC） acquired neotenic development as a consequence of mesocortical dopamine （DA） innervation, which in turn drove evolution of the PFC into becoming a complex functional system. Accordingly, from the evolutionary perspective, decreased DA signaling in the PFC associated with such adverse conditions as chronic stress may be considered as an environmental adaptation strategy. Psychiatric disorders such as schizophrenia and attention deficit/hyperactivity disorder may also be understood as environmental adaptation or a by-product of such a process that has emerged through evolution in humans. To investigate the evolutionary perspective of DA signaling in the PFC, domestic animals such as dogs may be a useful model.

关键词： neurodevelopment neoteny psychiatric disorder stress animal model synaptic plasticity environmental adaptation