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Helicobacter pylori infection and liver diseases: Epidemiology and insights into pathogenesis

World Journal of Gastroenterology 2018年第32期24卷 3617-3625页

作者： Kazuya Okushin Takeya Tsutsumi Kazuhiko Ikeuchi Akira Kado kenichiro enooku Hidetaka Fujinaga Kyoji Moriya Hiroshi Yotsuyanagi Kazuhiko Koike Department of Gastroenterology Graduate School of Medicine The University of Tokyo Department of Infection Control and Prevention Graduate School of Medicine The University of Tokyo Division of Infectious Diseases Advanced Clinical Research Center Institute of Medical Science The University of Tokyo Department of Infectious Diseases The University of Tokyo

Both Helicobacter pylori(H. pylori) infection and liver diseases, including nonalcoholic fatty liver disease(NAFLD), viral hepatitis, and hepatocellular carcinoma(HCC), have high prevalences worldwide, and the relationship between H. pylori infection and liver disease has been discussed for many years. Although positive correlations between H. pylori and NAFLD have been identified in some clinical and experimental studies, nega-tive correlations have also been obtained in high-quality clinical studies. Associations between H. pylori and the pathogenesis of chronic viral hepatitis, mainly disease progression with fibrosis, have also been suggested in some clinical studies. Concerning HCC, a possible role for H. pylori in hepatocarcinogenesis has been identified since H. pylori genes have frequently been detected in resected HCC specimens. However, no study hasrevealed the direct involvement of H. pylori in promoting the development of HCC. Although findings regarding the correlations between H. pylori and liver disease pathogenesis have been accumulating, the existing data do not completely lead to an unequivocal conclusion. Further high-quality clinical and experimental analyses are necessary to evaluate the efficacy of H. pylori eradication in ameliorating the histopathological changes observed in each liver disease.

关键词： Helicobacter pylori Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Hepatitis C virus Hepatitis B virus Viral hepatitis Hepatocellular carcinoma

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Assessment of disease progression in patients with transfusion-associated chronic hepatitis C using transient elastography

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World Journal of Gastroenterology 2012年第12期18卷 1385-1390页

作者： Ryota Masuzaki Ryosuke Tateishi Haruhiko Yoshida Toru Arano Koji Uchino kenichiro enooku Eriko Goto Hayato Nakagawa Yoshinari Asaoka Yuji Kondo Tadashi Goto Hitoshi Ikeda Shuichiro Shiina Masao Omata Kazuhiko Koike Department of Gastroenterology Graduate School of MedicineThe University of Tokyo Department of Clinical Laboratory The University of Tokyo Hospital Yamanashi Prefectural Hospital Organization

METHODS： Between December 2006 and June 2008, a total of 524 transfusion-associated HCV-RNA positive patients with or without HCC were enrolled, Liver stiffness was obtained noninvasively by using Fibroscan （Echosens, Paris, France）, The date of blood transfusion was obtained by interview, Duration of infection was derived from the interval between the date of bloodtransfusion and the date of liver stiffness measurement （LSM）. Patients were stratified into four groups based on the duration of infection （17-29 years; 30-39 years; 40-49 years; and 50-70 years）. The difference in liver stiffness between patients with and without HCC was assessed in each group. Multiple linear regression analysis was used to determine the factors associated with liver stiffness.RESULTS： A total of 524 patients underwent LSM. Eight patients were excluded because of unsuccessful measurements. Thus 516 patients were included in the current analysis （225 with HCC and 291 without）. The patients were 244 men and 272 women, with a mean age of 67.8 ±9.5 years. The median liver stiffness was 14.3 kPa （25.8 in HCC group and 7.6 in non HCC group）. The patients who developed HCC in short duration of infection were male dominant, having lower platelet count, with a history of heavier alcohol consumption, showing higher liver stiffness, and receiving blood transfusion at an old age. Liver stiffness was positively correlated with duration of infection in patients without HCC （r = 0.132, P = 0.024） but not in patients with HCC （r = -0.103, P = 0.123）. Liver stiffness was significantly higher in patients with HCC than in those without in each duration group （P 〈 0.0001）. The factors significantly associated with high liver stiffness in multiple regression were age at blood transfusion （P 〈 0.0001）, duration of infection （P = 0.0015）, and heavy alcohol consumption （P = 0.043）CONCLUSION： Although liver stiffness gradually increases over time, HCC develops in patients with high stiffness value regardle

关键词： Transfusion-associated hepatitis C Transientelastography Hepatocellular carcinoma Liver stiffness Ultrasonography Liver fibrosis

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Minimally invasive surgeries for insertional Achilles tendinopathy:A commentary review

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World Journal of Orthopedics 2023年第6期14卷 369-378页

作者： kenichiro Nakajima Center for Foot and Ankle Surgery Department of Orthopedic SurgeryYashioCentral General HospitalYashio-shi 340-0814SaitamaJapan

Studies of minimally invasive surgery for insertional Achilles tendinopathy are *** establish this surgery,the following techniques must be minimally invasive:Exostosis resection at the Achilles tendon insertion,debridement of degenerated Achilles tendon,reattachment using anchors or augmentation using flexor hallucis longus(FHL)tendon transfer,and excision of the posterosuperior calcaneal *** on these four perspectives were reviewed to establish minimally invasive surgery for insertional Achilles *** for exostosis resection were demonstrated in one case study,where blunt dissection around the exostosis was performed,and the exostosis was resected using an abrasion burr under fluoroscopic *** for debridement of degenerated Achilles tendon were demonstrated in the same case study,where the space left after resection of the exostosis was used as an endoscopic working space,and the degenerated Achilles tendon and intra-tendinous calcification were debrided *** tendon reattachment techniques using suture anchors have been demonstrated in several ***,there are no studies on FHL tendon transfer techniques for Achilles tendon *** contrast,endoscopic posterosuperior calcaneal prominence resection is already ***,studies on ultrasound-guided surgeries and percutaneous dorsal wedge calcaneal osteotomy as minimally invasive surgery were reviewed.

关键词： Achilles tendon Endoscopy Fluoroscopy Osteotomy Ultrasonography Tendinopathy Surgery

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Practical BRDF reconstruction using reliable geometric regions from multi-view stereo

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Computational Visual Media 2019年第4期5卷 325-336页

作者： Taishi Ono Hiroyuki Kubo kenichiro Tanaka Takuya Funatomi Yasuhiro Mukaigawa Nara Institute of Science and Technology IkomaNara 630-0192Japan

In this paper,we present a practical method for reconstructing the bidirectional reflectance distribution function(BRDF)from multiple images of a real object composed of a homogeneous *** key idea is that the BRDF can be sampled after geometry estimation using multi-view stereo(MVS)*** contribution is selection of reliable samples of lighting,surface normal,and viewing directions for robustness against estimation errors of *** method is quantitatively evaluated using synthesized images and its effectiveness is shown via real-world experiments.

关键词： BRDF reconstruction multi-view stereo(MVS) photogrammetry rendering

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Cancer-associated fibroblasts in hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第30期22卷 6841-6850页

作者： Norio Kubo kenichiro Araki Hiroyuki Kuwano Ken Shirabe Department of Hepatobiliary and Pancreatic Surgery Gunma University Graduate School of Medicine Department of General Surgical Science Gunma University Graduate School of Medicine

The hepatic stellate cells in the liver are stimulated sustainably by chronic injury of the hepatocytes, activating myofibroblasts, which produce abundant collagen. Myofibroblasts are the major source of extracellular proteins during fibrogenesis, and may directly, or secreted products, contribute to carcinogenesis and tumor progression. Cancer-associated fibroblasts(CAFs) are one of the components of the tumor microenvironment that promote the proliferation and invasion of cancer cells by secreting various growth factors and cytokines. CAFs crosstalk with cancer cells stimulates tumor progression by creating a favorable microenvironment for progression, invasion, and metastasis through the epithelial-mesenchymal transition. Basic studies on CAFs have advanced, and the role of CAFs in tumors has been elucidated. In particular, for hepatocellular carcinoma, carcinogenesis from cirrhosis is a known fact, and participation of CAFs in carcinogenesis is supported. In this review, we discuss the current literature on the role of CAFs and CAF-related signaling in carcinogenesis, crosstalk with cancer cells, immunosuppressive effects, angiogenesis, therapeutic targets, and resistance to chemotherapy. The role of CAFs is important in cancer initiation and progression. CAF-targeted therapy may be effective for suppression not only of fibrosis but also cancer progression.

关键词： Cancer associated fibroblast Hepatic stellate cell Hepatocellular carcinoma Immunosuppression Therapeutic target

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Visualization of flashback in a premixed burner with swirling flow

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Science China(Technological Sciences) 2010年第1期53卷 40-45页

作者： Satoshi TANIMURA Masaharu KOMIYAMA kenichiro TAKEISHI Yuji IWASAKI Kiyonobu NAKAYAMA Mitsubishi Heavy Industries Ltd.2-1-1ShinhamaArai-choTakasagoHyogo676-0871Japan Department of Mechanical Engineering Osaka University2-1YamadaokaSuitaOsaka565-0871Japan

In this study,the measurement object is a flame propagating in a premixed burner with swirling flow in order to investigate unsteady flame behavior in a gas turbine *** flashback,the flame propagating upstream was visualized with a high-speed ***,we established the technique to measure the instantaneous flow fields of unburned fuel-air mixture in a swirling premixed burner using particle image velocimetry(PIV).As a result,the characteristics of flame behavior propagating upstream were *** it was found that a low velocity region existed in the vicinity of the flame *** relationship between low velocity region and flame behavior was discussed in detail.

关键词： gas turbine lean premixed combustion flashback particle image velocimetry

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Global standardization of laparoscopic liver resection and challenges for the future

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Hepatobiliary Surgery and Nutrition 2019年第4期8卷 386-388页

作者： kenichiro Araki Norifumi Harimoto Ken Shirabe Division of Hepatobiliary and Pancreatic Surgery Department of General Surgical Science Gunma University Graduate School of Medicine Gunma Japan

Hepatobiliary Surgery and Nutrition recently published a review by X Cai that describes the current status and future of laparoscopic liver resection (LLR) in China. The advent of LLR has led to significant changes in the field of liver surgery, with numerous reports outlining how this procedure offers a better, less invasive approach for the treatment of liver disease. Two international consensus conferences regarding LLR—held in 2008 (Louisville, USA) and 2014 (Morioka, Japan)—highlighted the efficacy and safety of LLR, and discussed the surgical indications, technique, standardizations, and precautions that should be considered when performing LLR (1,2). Delegates deliberated whether open liver resection (OLR) should remain the current standard procedure for liver disease, and the importance of LLR within this arena. There was agreement that minor LLR offers sufficient safety and benefit to be considered standard practice, but major resection requires further investigation. The most recent guidelines from the European meeting on LLR, held in 2017 in Southampton, UK (3), integrate the available evidence and expert knowledge on LLR, taking into consideration relevant stakeholders' opinions and complying with international methodology standards across five domains (indications, patients and complex diseases, procedures, techniques, and implementation). The guidelines emphasize the importance of a team-oriented approach and the need to recruit experts in OLR and laparoscopic surgery within a specialist center.

关键词： resection Surgery standardization

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To develop a quantitative method for predicting shrinkage porosity in squeeze casting

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China Foundry 2009年第1期6卷 53-56页

作者： Shaomin Li kenichiro Mine Shinji Sanakanishi Koichi Anzai Ahresty Corporation Toyohashi Japan Tohoku University Sendai Japan

In order to secure high strength and high elongation of suspension parts,it is critical to predict shrinkage porosity quantitatively.A new simulation method for quantitative prediction of shrinkage porosity when replenishing molten metal has been proposed for squeeze casting *** examine the accuracy of the calculation model,the proposed method was applied to a plate model.

关键词： quantitative prediction shrinkage porosity simulation squeeze casting

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Stochastic model predictive braking control for heavy-duty commercial vehicles during uncertain brake pressure and road profile conditions

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Control Theory and Technology 2022年第2期20卷 248-262页

作者： Ryota Nakahara Kazuma Sekiguchi kenichiro Nonaka Masahiro Takasugi Hiroki Hasebe Kenichi Matsubara Graduate School of Integrative Science and Engineering Tokyo City UniversityTamazutsumiSetagaya-kuTokyo 1588557Japan Nabtesco Automotive Co. Ltd.HirakawachoChiyoda-kuTokyo 1020093Japan

When heavy-duty commercial vehicles(HDCVs)must engage in emergency braking,uncertain conditions such as the brake pressure and road profile variations will inevitably affect braking *** minimize these uncertainties,we propose a combined longitudinal and lateral controller method based on stochastic model predictive control(SMPC)that is achieved via Chebyshev–Cantelli *** our method,SMPC calculates braking control inputs based on a finite time prediction that is achieved by solving stochastic programming elements,including chance *** accomplish this,SMPC explicitly describes the probabilistic uncertainties to be used when designing a robust control *** main contribution of this paper is the proposal of a braking control formulation that is robust against probabilistic friction circle uncertainty *** specifically,the use of Chebyshev–Cantelli inequality suppresses road profile influences,which have characteristics that are different from the Gaussian distribution,thereby improving both braking robustness and control performance against statistical ***,since the Kalman filtering(KF)algorithm is used to obtain the expectation and covariance used for calculating deterministic transformed chance constraints,the SMPC is reformulated as a KF embedded deterministic ***,the effectiveness of our proposed method is verified via a MATLAB/Simulink and TruckSim co-simulation.

关键词： Heavy-duty commercial vehicle Brake system Stochastic model predictive control Road profile

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Carbon Nanobelts:Brief History and Perspective

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Precision Chemistry 2023年第9期1卷 516-523页

作者： Daiki Imoto Akiko Yagi kenichiro Itami Department of Chemistry Graduate School of ScienceNagoya UniversityNagoya 464-8602Japan Institute of Transformative Bio-Molecules(WPI-ITbM) Nagoya UniversityNagoya 464-8602Japan

Carbon nanotubes(CNTs)are an emerging nanomaterial because of their outstanding performance in various *** recent years,the segment molecules of CNTs,referred to as carbon nanorings(CNRs)or carbon nanobelts(CNBs),have gained attention for their unique structures and properties,as well as their potential as seed molecules for the precise synthesis of *** are rigid and thick segments of CNTs whose synthesis has been addressed by scientists fascinated by the uniqueness of CNBs long before the discovery of *** 60 years of efforts by synthetic chemists all over the world,the synthesis of the first CNB,(6,6)CNB,was achieved by our group in *** this milestone,diverse types of nanobelts have been synthesized through various synthetic routes,thereby demonstrating their photophysical,magnetic,and redox properties derived from rigid belt *** applications of CNBs have also been introduced *** formation of the host−guest complex,transformation to three-dimensional molecules,and measurement of conductivity have been reported for *** paper summarizes the brief history and perspective of *** synthetic campaigns and aggressive application of CNBs would create novel and groundbreaking scenes in materials science.

关键词： carbon nanobelt carbon nanoring carbon nanotube cycloparaphenylene aromatic compounds organic synthesis

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