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Pyroptosis:A promising target for lung cancer therapy

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2023年第2期1卷 94-101页

作者： Wensheng Zhou Lishu Zhao Hao Wang Xinyue Liu Yujin Liu Kandi Xu Hui Yu kenichi Suda Yayi He Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of Medical Oncology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China School of Medicine Tongji UniversityShanghai 200092China Department of Medicine Division of Medical Oncology and Department of PathologyUniversity of Colorado Cancer CenterAuroraCO 80045USA Department of Surgery Division of Thoracic SurgeryKindai University Faculty of MedicineOsaka-Sayama 589-8511Japan

Pyroptosis is a type of programed cell death that differs from apoptosis,ferroptosis,or *** studies have reported that it plays a critical role in tumorigenesis and modification of the tumor microenvironment in multiple *** this review,we briefly describe the canonical,non-canonical,and alternative mechanisms of pyroptotic cell *** also summarize the potential roles of pyroptosis in oncogenesis,tumor development,and lung cancer treatment,including chemotherapy,radiotherapy,targeted therapy,and ***-tosis has double-edged effects on the modulation of the tumor environment and lung cancer *** exploration of pyroptosis-based drugs could provide novel therapeutic strategies for lung cancer.

关键词： Lung cancer Pyroptosis Gasdermin Treatment Immunotherapy

Application of microbially induced carbonate precipitation to form biocemented artificial sandstone

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第3期13卷 579-592页

作者： Charalampos Konstantinou Giovanna Biscontin Ning-Jun Jiang kenichi Soga Department of Engineering University of CambridgeCambridgeCB21PZUK Department of Civil and Environmental Engineering University of Hawaii at ManoaHonoluluHI96822USA Department of Civil and Environmental Engineering University of CaliforniaBerkeleyCA94720USA

It is difficult to collect and characterise well-preserved samples of weakly-cemented granular rocks as conventional sampling techniques often result in destruction of the *** alternative approach is to prepare synthetic geomaterials to match required *** paper introduces microbially induced carbonate precipitation(MICP)as a method to reliably deliver artificiallycemented specimens with customised properties,closely resembling those of soft carbonate *** specimens are generated from materials with two highly different particle size distributions(PSDs)to access a range of achievable combinations of strengths and *** MICP parameters are kept constant across all samples to obtain similar calcium carbonate characteristics(size of individual crystals,type,etc.),while injected volume is varied to achieve different cementation *** uniform cementation of very coarse sands has been considered very difficult to achieve,the results show that both the fine and coarse sand specimens present high degrees of uniformity and a good degree of *** unconfined compressive strengths(UCSs)(less than 3000 kPa)and porosities(0.25e0.4)of the artificial specimens fall in the same range of values reported for natural *** strength gainwas greater in the fine sand than that in the coarse sand,as the void size in the latter was significantly larger compared to the calcium carbonate crystals’size,resulting in precipitation on less effective locations,away from contacts between *** strengths and porosities obtained for the two sands in this work fall within ranges reported in the literature for natural soft rocks,demonstrating theMICP technique is able to achieve realistic properties and may be used to produce a full range of properties by varying the grain sizes,and possibly the width of PSD.

关键词： Granular rocks Biocementation Microbially induced carbonate precipitation (MICP) Grain size Uniformity Efficiency Artificial rock

TEMPO-substituted polyacrylamide for an aqueous electrolyte-typed and organic-based rechargeable device

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Science China Chemistry 2012年第5期55卷 822-829页

作者： CHIKUSHI Natsuru YAMADA Hiroshi OYAIZU kenichi NISHIDE Hiroyuki Department of Applied Chemistry Waseda University Tokyo 169-8555 Japan

A hydrophilic radical polymer, poly(2,2,6,6-teteramethylpiperidinyloxyl-4-yl acrylamide) (PTAm), was synthesized via oxidation of the corresponding precursor polymer, poly(2,2,6,6-teteramethylpiperidine-4-yl acrylamide). Electrochemical properties of the PTAm layer were characterized in three aqueous electrolytes of sodium chloride (NaCl), sodium tetrafluoroborate (NaBF4), and sodium hexafluorophosphate (NaPF6) to optimize its activity as an organic cathode. The counter anion species significantly affected the capacity and the cycle performance of the PTAm layer. The PTAm layer in the presence of BF4? displayed quantitative redox capacity beyond 1 μm layer thickness and maintained the discharging capacity of 110 mAh g-1 (97% vs. the calculated capacity) even after 1000 cycle charging/discharging, which could be ascribed to its appropriate affinity to the aqueous electrolyte without any dissolution into the electrolyte. A totally organic-based rechargeable cell was fabricated using PTAm and poly(N-4,4'-bipyridinium-N-decamethylene dibromide) as the cathode and the anode, respectively, and the aqueous electrolyte of NaBF4. The cell gave a plateau voltage at 1.2 V both on charging and discharging and an excellent charging/discharging cyclability of >2000 with high coulombic efficiency of >95%.

关键词：聚丙烯酰胺水溶液充电设备电解质氧化还原能力放电容量电化学性能类型四氟硼酸钠

Curative resection with endoscopic submucosal dissection of early gastric cancer in Helicobacter pylori-negative Ménétrier’s disease:A case report

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World Journal of Gastroenterology 2022年第5期28卷 594-601页

作者： Koh Fukushi kenichi Goda Hitoshi Kino Masayuki Kondo Mimari Kanazawa Ken Kashima Akira Kanamori Keiichiro Abe Tsunehiro Suzuki Keiichi Tominaga Hidetsugu Yamagishi Atsushi Irisawa Department of Gastroenterology Dokkyo Medical UniversityMibu 321-0293TochigiJapan Department of Diagnostic Pathology Dokkyo Medical UniversityMibu 321-0293TochigiJapan

BACKGROUND Adult-onset Ménétrier’s disease is strongly associated with Helicobacter pylori(***)infection and an elevated risk of *** of early-stage gastric cancer developed in ***-negative Ménétrier’s disease are extremely *** report a case of early gastric cancer in ***-negative Ménétrier’s disease that was curatively resected with endoscopic submucosal dissection(ESD).CASE SUMMARY A 60-year-old woman was referred to our hospital after her medical examination detected ***-enhanced upper gastrointestinal(UGI)radiography revealed translucency of the nodule-aggregating surface with giant *** tests showed hypoproteinemia and were negative for serum *** immunoglobulin G *** 99mTc-DTPA-human serum albumin scintigraphy showed protein loss from the *** endoscopy showed a 40-mm protruding erythematous lesion on giant rugae of the greater curvature of lower gastric body,suggesting early-stage gastric cancer due to Ménétrier’s *** bloc resection with ESD was performed for diagnosis and *** of ESD showed well-differentiated tubular *** cancer was confined to the mucosa,and complete curative resection was *** hyperplasia and atrophy of the gastric glands were observed in non-tumor areas,histologically corresponding to Ménétrier’s *** years after ESD,gastric cancer had not recurred,and Ménétrier’s disease remained in remission with spontaneous regression of giant gastric *** Complete curative resection was achieved through ESD in a patient with earlystage gastric cancer and ***-negative Ménétrier’s disease.

关键词： Ménétrier’s disease Helicobacter pylori Gastric cancer Endoscopic resection Endoscopic submucosal dissection Case report

Certification Criteria in Type I Ecolabelling Related to Metals for Sustainable Materials Management

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Journal of Shanghai Jiaotong university(Science) 2012年第3期17卷 377-379页

作者： ICHIRO Daigo kenichi Nakajima TAKASHI Fujisaki Graduate School of Engineering The University of TokyoTokyo 113-8656Japan National Institute for Environmental Studies Tsukuba 305-8506Japan Japan Environment Association Tokyo 103-0002Japan

A sustainable materials management for metals should be achieved to conserve resources of metal *** the sustainable materials management,material flows through the whole life cycle of materials have been recognized by material flow analysis(MFA) *** MFA studies pointed out that cyclic use of metals could be enhanced not only by increasing quantity of recovered scrap but also by upgrading quality of the *** general,the quality is degraded by contaminants which commingle at disassembling *** mixture of contaminants depends on usage of materials in ***,Type I ecolabelling has a potential to convey messages for avoiding mixture of contaminants to the producers of finished *** this study,on the basis of a survey on existing certification criteria related to metals in the world,a general concept of certification criteria on sustainable materials management for metals in Type I ecolabelling system is ***,we propose six criteria in the form of certification criteria in Type I ecolabelling system.

关键词： ecolabelling metal recycling certification criteria life cycle thinking design for environment

SYNTHESIS OF NOVEL BI-FUNCTIONAL COPOLYMER BEARING STERICALLY HINDERED PHENOL AND HINDERED AMINE GROUPS VIA RING-OPENING METATHESIS POLYMERIZATION

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Chinese Journal of Polymer Science 2008年第5期26卷 525-531页

作者： Bo-yong Xue kenichi Ogata Akinori Toyota Graduate School of Engineering Tokyo University of Agriculture and Technology2-24-16 Naka-choKoganei-shiTokyo 184-8588Japan

Norbornene derivatives exo,endo-2-[2-(3,5-di-tert-butyl-4-hydroxyphenoxy)-acetoxy]methyl-5-norbornene(M1) and 3,3,5,5-tetramethyl-4-piperidinyl 5-norbornene-exo,endo-2-carboxylate(M2)were synthesized and polymerized by RuCl_2(=CHPh)(PCy_3)_2 to prepare a novel kind of bi-functional polymer bearing sterically hindered phenol(SHP)and hindered amine(HLAS)groups via ring-opening metathesis polymerization(ROMP).The resulting copolymers were characterized by gel permeation chromatography(GPC),~1H-NMR and differen...

关键词： Sterically hindered phenol Hindered amine Ring-opening metathesis polymerization(ROMP)

Instantaneous Creep in Face-centered Cubic Metals at Ultra- low Strain Rates by a High-resolution Strain Measurement

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Journal of Wuhan University of Technology(Materials Science) 2013年第6期28卷 1096-1100页

作者： SHEN Junjie Ikeda kenichi Hata Satoshi Nakashima Hideharu School of Mechanical Engineering Tianjin University of Technology Department of Electrical and Materials Science Faculty of Engineering SciencesKyushu University

Instantaneous creep in face-centered cubic metals, 5N Al（99.999%）, 2N Al （99%） and 4N Cu （99.99%） with different grain sizes, was firstly investigated by sudden stress-change experiments at ultra- low strain rates ε ≤10-10 s-1 and temperature T 〈 0.32 Tn. The experimental results indicate that the observed instantaneous creep is strongly dependent on grain size, the concentration of impurity, and stacking fault energy. Creep in high-purity aluminum, 5N Al, with a very large grain size, d 〉 1600μm, shows non-viscous behavior, and is controlled by the recovery of dislocations in the boundary of dislocation cells. On the other hand, for 5N A1 with a small grain size, d=30μm, and low-purity aluminum, 2N A1, with d8= 25μm, creep shows viscous behavior and may be related to ＇low temperature grain boundary sliding＇. For high-purity copper, 4N Cu, with d= 40 grn and lower stacking fault energy, creep shows a non-viscous behavior, and is controlled by the recovery process of dislocations. For all of the samples, creep shows anelastic behavior.

关键词： face-centered cubic metals instantaneous creep ultra-low strain rate high strain resolution measurement

Bovine sperm selection procedure prior to cryopreservation for improvement of post-thawed semen quality and fertility

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Journal of Animal Science and Biotechnology 2020年第1期11卷 44-57页

作者： MariaPortia B.Nagata Junki Egashira Naoto Katafuchi Kenji Endo Kazuko Ogata kenichi Yamanaka Tadayuki Yamanouchi Hideo Matsuda Yutaka Hashiyada kenichi Yamashita Advanced Manufacturing Research Institute National Institute of Advanced Industrial Science and Technology(AIST)807-1 Shuku-machiTosuSaga 841-0052Japan Saga Prefectural Livestock Experiment Station 23242-2 Yamauchi-machiMiyanoTakeoSaga 849-2305Japan Morinaga Dairy Service Co.Ltd. 1-159 ToyoharaotsuNasu-gun Nasu-machiTochigi 329-3224Japan National Livestock Breeding Center(NLBC) 1 OdakuraharaOdakuraNishigo-muraNishishirakawa-gunFukushima 961-8511Japan Institute of Livestock and Grassland Science National Agriculture and Food Research Organization(NARO)Ikenodai 2TsukubaIbaraki 305-0901Japan Faculty of Agriculture Saga University1 Honjo-machiSaga 840-8502Japan.7Ishikawa Prefectural University1-308 SuematsuNonoichi-shiIshikawa 921-8836Japan.

Background:The application of cryopreservation and artificial insemination technology have contributed to the advancement of animal ***,a substantial proportion of spermatozoa undergoes alterations and loses their fertility during cryopreservation,rendering the frozen-thawed semen impractical for routine *** is known to reduce sperm lifespan and *** in cryosurvival of spermatozoa from different sires and even with the individual sire is common in artificial insemination(AI)*** goal is to improve post-thawed semen quality by optimization of cryopreservation technique through sperm selection prior to cryopreservation ***:Our strategy of sperm selection based on rheotaxis and thermotaxis(SSRT)on macrosale in a rotating fluid flow demonstrated the ability to maintain the original pre-freezing structural integrity,viability and biological function related to fertilization *** strategy has a positive effect on the cryosurvival and fertilizing abilities of spermatozoa as supported by the improvement on pregnancy rate of Japanese Black heifers and Holstein repeat *** technique protected further sublethal damage to bovine spermatozoa(higher%cryosurvival than the control)and resulted in the improvement of DNA *** selected spermatozoa demonstrated slower and controlled capacitation than unprocessed control which is thought to be related to sperm longevity and consequently to appropriate timing during in vivo ***:These results provide solid evidence that improvement of post-thawed semen quality by SSRT method is beneficial in terms of cryosurvival,longevity of post-thawed sperm,and optimization of in vivo fertilization,embryo development and calving as supported by the favorable results of field fertility study.

关键词： Cryopreservation Fertility Livestock Rheotaxis Spermatozoa Thermotaxis

Comparison of fecal calprotectin levels and endoscopic scores for predicting relapse in patients with ulcerative colitis in remission

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World Journal of Gastroenterology 2023年第47期29卷 6111-6121页

作者： Natsuki Ishida Tatsuhiro Ito kenichi Takahashi Yusuke Asai Takahiro Miyazu Tomohiro Higuchi Satoshi Tamura Shinya Tani Mihoko Yamade Moriya Iwaizumi Yasushi Hamaya Satoshi Osawa Ken Sugimoto Department of Endoscopic and Photodynamic Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan First Department of Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan Department of Laboratory Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan

BACKGROUND Although the usefulness of endoscopic scores,such as the Mayo Endoscopic Subscore(MES),Ulcerative Colitis Endoscopic Index of Severity(UCEIS),and Ulcerative Colitis Colonoscopic Index of Severity(UCCIS),and biomarkers such as fecal calprotectin(FC)for predicting relapse in ulcerative colitis(UC)has been reported,few studies have included endoscopic scores for evaluating the entire *** To compare the usefulness of FC value and MES,UCEIS,and UCCIS for predicting relapse in patients with UC in clinical *** In total,75 patients with UC in clinical and endoscopic remission who visited our institution between February 2019 and March 2022 were *** diagnosis of UC was confirmed based on the clinical presentation,endoscopic findings,and histology,according to the current established criteria for *** samples were collected the day before or after the colonoscopy for measurement of *** evaluations were performed using MES,UCEIS,and *** primary outcome measure of this study was the assessment of the association between relapse within 12 mo and MES,UCEIS,UCCIS,and *** secondary outcome was the comparison between endoscopic scores and biomarkers in en-rolled patients with UC with mucosal *** and UCCIS showed a significant correlation with UCEIS (r = 0.537, P < 0.001 and r = 0.957, P < 0.001, respectively).Receiver-operating characteristic analysis for predicting MES 0 showed that the area under the curve ofUCCIS was significantly higher than that of FC (P < 0.01). During the 1-year observation period, 18 (24%) patientsexperienced a relapse, and both the FC and UCCIS of the relapse group were significantly higher than that of theremission group. The cut-off values for predicting relapse were set at FC = 323 mg/kg and UCCIS = 10.2. The areaunder the curve of the receiver-operating characteristic analysis for predicting relapse did not show a significantdifference between FC and UCCIS. The accuracy of the

关键词： Ulcerative colitis Mayo Endoscopic Subscore Ulcerative Colitis Endoscopic Index of Severity Ulcerative Colitis Colonoscopic Index of Severity Fecal calprotectin Relapse