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Technical Possibilities of Cloud-Based Virtual Reality Implementing Software as a Service for Online Collaboration in Urban Planning

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International Journal of Communications, Network and System Sciences 2014年第11期7卷 463-473页

作者： Zhenjiang Shen Yan Ma kenichi sugihara Zhenhan Lei Evan Shi School of Environmental Design Kanazawa University Kanazawa Japan Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing China Gifu Keizai University Ogaki Japan Forum 8 Inc. Tokyo Japan Department of Computer Science University of California Los Angeles USA

In this paper we discuss the technical possibilities of cloud-based virtual reality (cloud-based VR) computing tools for online collaboration in urban planning and design. We first create a digital asset representing our design proposal of a pedestrian bridge in Shibuya, Tokyo. A platform for cloud-based VR technology, i.e., a VR-Cloud server, is used to open the VR dataset to public collaboration over the Internet. The digital asset representing the design scheme of our pedestrian bridge includes buildings, roads, trees and street furniture for the entire urban area. The vehicles and people are designed and inputted into the virtual world of the urban area, in which they run and walk with predefined behaviour scenarios. Users share the VR world by accessing the VR-Cloud servers from remote clients, using cloud communication software to review vehicle and pedestrian crowd simulations and discuss the design concepts. Meanwhile, we compare the advantages and disadvantages of three cloud-based VR tools on their technical support for net collaboration: 1) VR-Cloud;2) Google Earth;and 3) 3DVIA.

关键词： VR-Cloud Design Coordination and Communication Server Digital Asset and Pedestrian Bridge

Clinical Significance of Platelet-Derived Growth Factor-C Expression in Colorectal Cancer

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Journal of Cancer Therapy 2014年第1期5卷 11-20页

作者： Shinichi Yamauchi Satoru Iida Megumi Ishiguro Toshiaki Ishikawa Hiroyuki Uetake kenichi sugihara Department of Surgical Oncology Graduate School Tokyo Medical and Dental University Tokyo Japan Department of Translational Oncology Graduate School Tokyo Medical and Dental University Tokyo Japan

Platelet-derived growth factors (PDGFs) are known to be associated with tumor growth and angiogenesis through their activation of the receptor tyrosine kinases, PDGF receptors alpha and beta. Several studies revealed the participation of the PDGF family in colorectal cancer (CRC). However, the role of platelet derived growth factor-C (PDGFC) in CRC is less well studied. This study aimed to determine the correlation between PDGFC expression and the prognosis of patients with CRCs. Tumor samples were obtained from patients with CRC who underwent surgical resection between 2002 and 2006. The mRNA expression of PDGFC was investigated by quantitative reverse transcription-polymerase chain reaction in 85 patients with stage I-IV CRC. PDGFC protein expression was analyzed by immunohistochemistry, and the relationship between PDGFC protein expression and clinicopathologic features was investigated in 245 patients with stage I-III CRC. PDGFC mRNA expression in cancer tissues was significantly higher in patients with distant metastases than in those without metastases (P = 0.016). PDGFC protein overexpression was associated with significantly worse overall and relapse-free survival (P P < 0.0001, respectively). Moreover, PDGFC protein overexpression was an independent risk factor for CRC recurrence (relative risk = 3.395, 95% confidence interval = 1.895 - 6.081, P < 0.001). In the present study, PDGFC overexpression appeared to be predictive of recurrence and poor prognosis in patients with CRC.

关键词： Platelet-Derived Growth Factor-C Colorectal Cancer Prognosis mRNA Expression Immunohistochemistry

Expression of 5-Lipoxygenase in human colorectal cancer

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World Journal of Gastroenterology 2006年第39期12卷 6355-6360页

作者： Labile Togba Soumaoro Satoru Iida Hiroyuki Uetake Megumi Ishiguro Yoko Takagi Tetsuro Higuchi Masamichi Yasuno Masayuki Enomoto kenichi sugihara Department of Surgical Oncology Graduate School Tokyo Medical and Dental University Tokyo 113-8519 Japan Department of Translational Oncology Graduate School Tokyo Medical and Dental University Tokyo 113-8519 Japan

AIM: To evaluate the 5-lipoxygenases (Loxs) expression level in human colorectal cancer specimens in order to determine its clinicopathologic significance in human tumorigenesis. METHODS: The relative quantity of 5-Lox mRNA in paired 91 colorectal tumor and adjacent normal mucosa samples was determined by real time quantitative PCR. Additionally, the expression of 5-Lox and cyclooxygenase (Cox)-2 proteins was also examined using immunohistochemical staining methods. RESULTS: There was a marked increase in 5-Lox mRNA levels in the tumor compared with paired normal mucosa samples (P < 0.0001). Sixty six (72.5%) tumors showed high 5-Lox mRNA levels. The positivity rate of 5-Lox and Cox-2 protein expression was 68.7% and 79.1% respectively. There was a significant association between tumoral 5-Lox mRNA level and tumor size (Rho = 0.392, P = 0.0002), depth or vessel invasion. CONCLUSION: These results suggest that 5-Lox is up-regulated in colorectal cancer and that inhibition of its expression might be valuable in the prevention and treatment of colorectal cancer.

关键词： 5-脂肪氧合酶结肠癌直肠癌环氧合酶-2

Over-the-scope-clipping system for anastomotic leak after colorectal surgery:Report of two cases

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World Journal of Gastroenterology 2014年第24期20卷 7984-7987页

作者： Hirotoshi Kobayashi Akifumi Kikuchi Satoshi Okazaki Megumi Ishiguro Toshiaki Ishikawa Satoru Iida Hiroyuki Uetake kenichi sugihara Center for Minimally Invasive Surgery Tokyo Medical and Dental UniversityTokyo 113-8519Japan Department of Surgical Oncology Graduate SchoolTokyo Medical and Dental UniversityTokyo 113-8519Japan Department of Translational Oncology Graduate SchoolTokyo Medical and Dental UniversityTokyo 113-8519Japan

An anastomotic leak is one of the major complications following colorectal *** treatments for anastomotic leak are total parenteral nutrition or temporary *** over-the-scope-clipping(OTSC)system was originally developed to treat intestinal perforation or to close the tissue after natural orifice transluminal endoscopic *** cases of successful management of an anastomotic leak after colorectal surgery using the OTSC system are *** patient avoided a temporary *** the other,hospitalization was shortened by the use of the OTSC *** OTSC system can be a potential option in the management of anastomotic leaks after colorectal surgery.

关键词： Over-the-scope-clipping Colorectal cancerAnastomot