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Kinetic study of all-or-none hemolysis induced by cationic amphiphilic polymethacrylates with antimicrobial activity

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Chinese Chemical Letters 2015年第4期26卷 479-484页

作者： Kazuma Yasuhara kenichi kuroda Graduate School of Materials Science Nara Institute of Science and Technology Department of Biologic and Materials Sciences University of Michigan School of Dentistry

To gain an understanding of the toxicity of antimicrobial polymers to human cells, their hemolytic action was investigated using human red blood cells （RBCs）. We examined the hemolysis induced by cationic amphiphilic methacrylate random copolymers, which have amino ethyl sidechains as cationic units and either butyl or methyl methacpjlate as hydrophobic units. The polymer with 30 tool% butyl sidechains （B3o） displayed higher hemolytic toxicity than the polymer with 59 tool% methyl sidechains （Ms9）. B3o also induced faster release of hemoglobin from RBCs than lVlsg. A new theoretical model is proposed based on two consecutive steps to form active polymer species on the RBC membranes, which are associated to RBC lysis. This model takes the all-or-none release of hemoglobin by the rupture of RBCs into account, providing new insight into the polymer-induced hemolysis regarding how individual or collective ceils respond to the polymers.

关键词： HemolysisAntimicrobial polymerAmphiphilic polymethacrylateKinetic analysisMembrane disruption

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Correlations between the Profile of Mood States (POMS) and the WHOQOL-26 among Japanese University Students

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Health 2016年第5期8卷 416-420页

作者： Kayo Shichiri Masako Shibuya Mayumi Watanabe Mikie Tahashi Kyoko Kaminushi Tomoko Uenoyama Ichiro Mashima kenichi Murayama Takeshi kuroda Yoshiki Suzuki Health Administration Center Niigata University Niigata Japan Comprehensive Medical Education Center Niigata University Niigata Japan Medical Informatics Niigata University Medical and Dental Hospital Niigata University Niigata Japan

In this study, we investigated six types of mood state (tension-anxiety, depression-dejection, anger-hostility, vigor, fatigue, and confusion) using the Profile of Mood States (POMS) with 40 Japanese university students. We examined five main quality of life (QOL) domains (physical health, psychological health, social relationships, and environmental health) using the World Health Organization Quality of Life Scale (WHOQOL-26). We also examined the total scale score. We examined Spearman’s rank correlations between POMS mood state and QOL scores and compared male and female students’ scores. The results indicated statistically significant correlations between all six mood states and three broad WHOQOL-26 domains (physical health, psychological health, and social relationships). Moreover, the relationship between mood state and QOL showed a gender difference. There were correlations between mood states and the QOL domains of social relationships and environmental health for males. In contrast, mood state correlated with the QOL domains of physical health and psychological health in females. The findings suggest that gender-specific health provision is needed to care for young university students in Japan. However, our study has several limitations;therefore, larger-scale studies with older subjects are needed in the future.

关键词： Quality of Life (QOL) Profile of Mood States (POMS) WHOQOL-26 Correlation Analyses Japanese University Students

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