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Serum type Ⅳ collagen level is predictive for esophageal varices in patients with severe alcoholic disease

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World Journal of Gastroenterology 2008年第13期14卷 2044-2048页

作者： Satoshi Mamori Yasuyuki Searashi Masato Matsushima kenichi Hashimoto Shinichiro Uetake Hiroshi Matsudaira Shuji Ito Hisato Nakajima Hisao Tajiri Division of Gastroenterology and Hepatology Department ofInternal Medicine the Jikei University School of Medicine Tokyo105-8461 Japan Division of Clinical Research anddevelopment the Jikei University School of Medicine Tokyo105-8461 Japan Tokyo Medical Center of Alcohol RelatedDisabilities Tokyo 175-0091 Japan

AIM： To determine factors predictive for esophagea varices in severe alcoholic disease （SAD）. METHODS： Abdominal ultrasonography （US） was performed on 444 patients suffering from alcoholism. Forty-four patients found to have splenomegaly and/ or withering of the right liver lobe were defined as those with SAD. SAD patients were examined by upper gastrointestinal （UGI） endoscopy for the presence of esophageal varices. The existence of esophageal varices was then related to clinical variables. RESULTS： Twenty-five patients （56.8%） had esophageal varices. A univariate analysis revealed a significant difference in age and type Ⅳ collagen levels between patients with and without esophageal varices. A logistic regression analysis identified type Ⅳ collagen as the only independent variable predictive for esophageal varices （P = 0.017）. The area under the curve （AUC） for type Ⅳ collagen as determined by the receiver operating characteristic （ROC） for predicting esophageal varices was 0.78. CONCLUSION： This study suggests that the level of type Ⅳ collagen has a high diagnostic accuracy for the detection of esophageal varices in SAD.

关键词： Type Ⅳ collagen Esophageal varice Alcoholic disease Abdominal ultrasonography Alcoholism

Attosecond Optical and Ramsey-Type Interferometry by Postgeneration Splitting of Harmonic Pulse

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Ultrafast Science 2022年第3期2卷 9-17页

作者： Takuya Matsubara Yasuo Nabekawa kenichi L.Ishikawa Kaoru Yamanouchi Katsumi Midorikawa Attosecond Science Research Team RIKEN Center for Advanced Photonics2-1 HirosawaWako-shiSaitama 351-0198Japan Department of Chemistry School of ScienceThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Nuclear Engineering and Management Graduate School of EngineeringThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan Photon Science Center Graduate School of EngineeringThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan Research Institute for Photon Science and Laser Technology The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan

Attosecondattosecond science;extreme ultraviolet;high-order harmonic generation;Ramsey-type spectroscopy Optical and Ramsey-Type Interferometry by Postgeneration Splitting of Harmonic PulseTime domain Ramsey-type interferometry is useful for investigating spectroscopic information of quantum states in atoms and *** energy range of the quantum states to be observed with this scheme has now reached more than 20 eV by resolving the interference fringes with a period of a few hundred *** attosecond Ramsey-type interferometry requires the irradiation of a coherent pair of extreme ultraviolet(XUV)light pulses,while all the methods used to deliver the coherent XUV pulse pair until now have relied on the division of the source of an XUV pulse in two before the *** this paper,we report on a novel technique to perform attosecond Ramsey-type interferometry by splitting an XUV high-order harmonic(HH)pulse of a sub-20 fs laser pulse after its *** virtue of the postgeneration splitting of the HH pulse,we demonstrated that the optical interference emerging at the complete temporal overlap of the HH pulse pair seamlessly continued to the Ramsey-type electronic interference in a helium *** technique is applicable for studying the femtosecond dephasing dynamics of electronic wavepackets and exploring the ultrafast evolution of a cationic system entangled with an ionized electron with sub-20 fs resolution.

关键词： attosecond science extreme ultraviolet high-order harmonic generation Ramsey-type spectroscopy Optical and Ramsey-Type Interferometry by Postgeneration Splitting of Harmonic Pulse

Corticospinal excitability during motor imagery is diminished by continuous repetition-induced fatigue

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Neural Regeneration Research 2021年第6期16卷 1031-1036页

作者： Akira Nakashima Takefumi Moriuchi Daiki Matsuda Takashi Hasegawa Jirou Nakamura Kimika Anan Katsuya Satoh Tomotaka Suzuki Toshio Higashi kenichi Sugawara Department of Rehabilitation Juzenkai HospitalNagasakiJapan Graduate School of Biomedical Sciences Nagasaki UniversityNagasakiJapan School of Rehabilitation Kanagawa University of Human ServicesYokosukaJapan

Application of continuous repetition of motor imagery can improve the performance of exercise ***,there is a lack of more detailed neurophysiological evidence to support the formulation of clear standards for interventions using motor ***,identification of motor imagery intervention time is necessary because it exhibits possible central ***,the purpose of this study was to elucidate the development of fatigue during continuous repetition of motor imagery through objective and subjective *** study involved two *** experiment 1,14 healthy young volunteers were required to imagine grasping and lifting a 1.5-L plastic bottle using the whole *** participant performed the motor imagery task 100 times under each condition with 48 hours interval between two conditions:500 mL or 1500 mL of water in the bottle during the demonstration *** fatigue and a decrease in pinch power appeared under the 1500-mL *** were changes in concentration ability or corticospinal excitability,as assessed by motor evoked potentials,between each set with continuous repetition of motor imagery also under the 1500-mL ***,in experiment 2,12 healthy volunteers were required to perform the motor imagery task 200 times under the 1500-mL *** concentration ability and corticospinal excitability *** is the first study to show that continuous repetition of motor imagery can decrease corticospinal excitability in addition to producing mental *** study was approved by the Institutional Ethics Committee at the Nagasaki University Graduate School of Biomedical and Health Sciences(approval No.18121302)on January 30,2019.

关键词： central nervous system concentration continuous repetition of motor imagery corticospinal excitability mental fatigue motor evoked potential motor imagery muscle fatigue neurophysiology transcranial magnetic stimulation

Bile duct hamartomas(von Mayenburg complexes) mimicking liver metastases from bile duct cancer:MRC findings

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World Journal of Gastroenterology 2006年第8期12卷 1321-1323页

作者： Yasuhiko Nagano kenichi Matsuo Katsuya Gorai Kazuya Sugimori Chikara Kunisaki Hideyuki Ike Katsuaki Tanaka Toshio Imada Hiroshi Shimada Yokohama City University Medical Center Gastroenterological CenterYokohamaJapan Department of Gastroenterological Surgery Yokohama City UniversityGraduate School of MedicineYokohamaJapan

We present a case of a 72-year-old man with a common bile duct cancer, who was initially believed to have multiple liver metastases based on computed tomography findings, and in whom magnetic resonance cholangiography （MRC） revealed a diagnosis of bile duct hamartomas. At exploration for pancreaticoduodenectomy, liver palpation revealed disseminated nodules at the surface of the liver. These nodules showed gray-white nodular lesions of about 0.5 cm in diameter scattered on the surface of both liver lobes, which were looked like multiple liver metastases from bile duct cancer. Frozen section of the liver biopsy disclosed multiple bile ducts with slightly dilated lumens embedded in the collagenous stroma characteristics of multiple bile duct hamartomas （BDHs）. Only two reports have described the MRC features of bile duct hamartomas. Of all imaging procedures, MRC provides the most relevant features for the imaging diagnosis of bile duct hamartomas.

关键词： Bile duct hamartoma Magnetic resonance cholangiography Multiple liver metastases

Small serotonin-positive pancreatic endocrine tumors caused obstruction of the main pancreatic duct

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World Journal of Gastroenterology 2012年第45期18卷 6669-6673页

作者： Masami Ogawa Yoshiaki Kawaguchi Atsuko Maruno Hiroyuki Ito Toshio Nakagohri kenichi Hirabayashi Hiroshi Yamamuro Tomohiro Yamashita Tetsuya Mine Department of Gastroenterology Tokai University School of Medicine143 ShimokasuyaIsehara 259-1193Japan Department of Gastroenterological Surgery Tokai University School of Medicine143 ShimokasuyaIsehara 259-1193Japan Department of Pathology Tokai University School of Medicine143 ShimokasuyaIsehara 259-1193Japan Department of Radiology Tokai University School of Medicine143 ShimokasuyaIsehara 259-1193Japan

We report 2 cases of pancreatic endocrine tumors that caused obstruction of the main pancreatic duct(MPD).A 49-year-old asymptomatic man was referred to our institution because dilation of the MPD was revealed by abdominal ultrasonography(US).No tumor was detected by endoscopic ultrasonography,computed tomography(CT),and magnetic resonance imaging(MRI).The diameter of the MPD was > 20 mm at the body,and no dilation was noted at the *** malignancy was not confirmed through cytology or imaging,pancreatic cancer was strongly ***-denectomy was *** and immunohistochemical examination revealed a 5 mm × 3 mm serotonin-positive endocrine *** was present around the MPD and seemed to cause stricture.A 32-year-old asymptomatic man had elevated serum amylase,and US demonstrated dilation of the *** tumor was detected by CT and *** cancer was suspected due to stricture and dilation of the *** of middle part of pancreas was *** and immunohistochemical examination revealed a serotonin-positive endocrine tumor sized 5 mm × 4 *** report 2 cases of serotonin-positive pancreatic endocrine tumors that caused stricture of the MPD in spite of the small size of the tumor.

关键词： Serotonin Pancreatic endocrine tumor Main pancreatic duct Obstruction Dilatation

Non-contact real-time detection of trace nitro-explosives by MOF composites visible-light chemiresistor

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National Science Review 2022年第10期9卷 188-195页

作者： Wei-Hua Deng Ming-Shui Yao Min-Yi Zhang Masahiko Tsujimoto kenichi Otake Bo Wang Chun-Sen Li Gang Xu Susumu Kitagawa State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of Sciences Chinese Academy of Sciences Institute for Integrated Cell-Material Sciences (WPI-i Ce MS) Kyoto University Institute for Advanced Study Kyoto University Institute for Integrated Cell-Material Sciences (WPI-iCeMS) Kyoto University Institute for Advanced Study Kyoto University Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Key Laboratory of Cluster Science Ministry of Education School of Chemistry and Chemical Engineering Beijing Institute of Technology Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China

To create an artificial structure to remarkably surpass the sensitivity,selectivity and speed of the olfaction system of animals is still a daunting ***,we propose a core-sheath pillar(CSP) architecture with a perfect synergistic interface that effectively integrates the advantages of metal-organic frameworks and metal oxides to tackle the above-mentioned *** sheath material,NH2-MIL-125,can concentrate target analyte,nitro-explosives,by 1012 times from its *** perfect band-matched synergistic interface enables the TiO2core to effectively harvest and utilize visible *** room temperature and under visible light,CSP(TiO2,NH2-MIL-125) shows an unexpected self-promoting analyte-sensing *** experimentally reached limit of detection(～0.8 ppq,hexogeon) is 103 times lower than the lowest one achieved by a sniffer dog or all sensing techniques without analyte ***,the sensor exhibits excellent selectivity against commonly existing interferences,with a short response time of 0.14 min.

关键词： MOFs metal oxides electrical devices thin films gas sensors

Over-the-scope-clipping system for anastomotic leak after colorectal surgery:Report of two cases

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World Journal of Gastroenterology 2014年第24期20卷 7984-7987页

作者： Hirotoshi Kobayashi Akifumi Kikuchi Satoshi Okazaki Megumi Ishiguro Toshiaki Ishikawa Satoru Iida Hiroyuki Uetake kenichi Sugihara Center for Minimally Invasive Surgery Tokyo Medical and Dental UniversityTokyo 113-8519Japan Department of Surgical Oncology Graduate SchoolTokyo Medical and Dental UniversityTokyo 113-8519Japan Department of Translational Oncology Graduate SchoolTokyo Medical and Dental UniversityTokyo 113-8519Japan

An anastomotic leak is one of the major complications following colorectal *** treatments for anastomotic leak are total parenteral nutrition or temporary *** over-the-scope-clipping(OTSC)system was originally developed to treat intestinal perforation or to close the tissue after natural orifice transluminal endoscopic *** cases of successful management of an anastomotic leak after colorectal surgery using the OTSC system are *** patient avoided a temporary *** the other,hospitalization was shortened by the use of the OTSC *** OTSC system can be a potential option in the management of anastomotic leaks after colorectal surgery.

关键词： Over-the-scope-clipping Colorectal cancer Anastomotic leak Colorectal surgery Double stapling technique

Intraoperative ultrasound as an educational guide for laparoscopic biliary surgery

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World Journal of Gastroenterology 2008年第15期14卷 2370-2376页

作者： kenichi Hakamada Shunji Narumi Yoshikazu Toyoki Masaki Nara Motonari Oohashi Takuya Miura Hiroyuki Jin Syuichi Yoshihara Michihiro Sugai Mutsuo Sasaki Department of Gastroenterological Surgery Hirosaki University Graduate School of Medicine5 Zaifu-choHirosaki 036-8562Japan

AIM: To analyze the efficacy of routine intraoperative ultrasound (IOUS) as a guide for understanding biliary tract anatomy, to avoid bile duct injury (BDI) after laparoscopic cholecystectomy (LC), as well as any burden during the learning period. METHODS: A retrospective analysis was performed using 644 consecutive patients who underwent LC from 1991 to 2006. An educational program with the use of IOUS as an operative guide has been used in 276 cases since 1998. RESULTS: IOUS was highly feasible even in patients with high-grade cholecystitis. No BDI was observed after the introduction of the educational program, despite 72% of operations being performed by inexperienced surgeons. Incidences of other morbidity, mortality, and late complications were comparable before and after the introduction of routine IOUS. However, the operation time was significantly extended after the educational program began (P < 0.001), and the grade of laparoscopic cholecystitis (P = 0.002), use of IOUS (P = 0.01), and the experience of the surgeons (P = 0.05) were significant factors for extending the length of operation. CONCLUSION: IOUS during LC was found to be a highly feasible modality, which provided accurate, real- time information about the biliary structures. Theeducational program using IOUS is expected to minimize the incidence of BDI following LC, especially when performed by less-skilled surgeons.

关键词： Intraoperative ultrasound Cholecystolithiasis Laparoscopic cholecystectomy Bile duct injury Education program

Confirming Stereochemical Structures of Strigolactones Produced by Rice and Tobacco

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Molecular Plant 2013年第1期6卷 153-163页

作者： Xiaonan Xie Kaori Yoneyama Takaya Kisugi kenichi Uchida Seisuke Ito Kohki Akiyama Hideo Hayashi Takao Yokota Takahito Nomura Koichi Yoneyama Weed Science Center Utsunomiya University 350 Mine-machi Utsunomiya 321-8505 Japan Department of Biosciences Faculty of Science and Technology Teikyo University 1-1 Toyosatodai Utsunomiya 320-8851 Japan Graduate School of Life and Environmental Sciences Osaka Prefecture University 1-1 Gakuen-cho Nakaku Sakai Osaka 599-8531 Japan

Major strigolactones （SLs） produced by rice （Oryza sativa L. cv. Nipponbare） and tobacco （Nicotiana tabacum L. cv. Michinoku No. 1） were purified and their stereochemical structures were determined by comparing with optically pure synthetic standards for their NMR and CD data and retention times and mass fragmentations in ESI-LC/MS and GC-MS. SLs purified from root exudates of rice plants were orobanchol, orobanchyl acetate, and ent-2＂-epi-5-deoxystr- igol. In addition to these SLs, 7-oxoorobanchyl acetate and the putative three methoxy-5~deoxystrigol isomers were detected by LC-MS/MS. The production of 7-oxoorobanchyl acetate seemed to occur in the early growth stage, as it was detected only in the root exudates collected during the first week of incubation. The root exudates of tobacco contained at least 11 SLs, including solanacol, solanacyl acetate, orobanchol, ent-2＂-epi-orobanchol, orobanchyl acetate, ent-2＇- epi-orobanchyl acetate, 5-deoxystrigol, ent-2＂-epi-5-deoxystrigol, and three isomers of putative didehydro-orobanchol whose structures remain to be clarified. Furthermore, two sorgolactone isomers but not sorgolactone were detected as minor SLs by LC-MS/MS analysis. It is intriguing to note that rice plants produced only orobanchol-type SLs, derived from ent-2＂-epi-5-deoxystrigol, but both orobanchol-type and strigol-type SLs, derived from 5-deoxystrigol were detected in tobacco plants.

关键词： germination stimulant Orobanche rice root parasitic plant Striga strigolactone tobacco.