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Audio-Visual Biofeedback for Respiratory Motion Management: Comparison of the Reproducibility of Breath-Holding between Visual and Audio Guidance

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Journal of Modern Physics 2018年第13期9卷 2286-2294页

作者： Naoki Sano Masahide Saito Hiroshi Onishi kengo kuriyama Takafumi Komiyama Kan Marino Shinichi Aoki Masayuki Araya Department of Radiology University of Yamanashi Yamanashi Japan

Purpose: To compare the reproducibility of breath-holding and comfort between two biofeedback guidance methods (audio and visual) in a respiratory monitoring system. Method and Materials: An audio-feedback respiratory monitoring device, which was modified from a visual-feedback self-respiration monitoring system (Abches, APEX Medical Inc., Tokyo, Japan) previously developed by the authors’ group, was constructed. Twenty patients (13 men, 7 women;mean age, 68.5 years;range, 54 - 85 years) with tumors in the thorax or abdominal region were enrolled in the present study. Computed tomography images were acquired from all patients three times using the two (i.e., audio and visual) respiration monitoring devices. To evaluate the reproducibility of breath-holding, the distance between an anatomical landmark and the tumor position was measured. Furthermore, patients were asked which guidance method they preferred (visual or audio) for comfortable breath-holding. Results: The two guidance methods improved the reproducibility of breath-holding compared with free-breathing, and no significant overall differences between two methods were observed (the mean displacements of the landmark-tumor distance were 2.60 ±1.38 mm and 2.35 ±1.63 mm, for visual and audio guidance, respectively). In five patients, the magnitude of position displacement in the series of three computed tomography images under audio guidance was twice as large as the other under visual guidance. Audio guidance was preferred to visual guidance by 65% (13 of 20) of the patients. However, the reproducibility of breath-holding did not always correspond with patient preference. Conclusion: There were some individual differences in the reproducibility of the visual and audio guidance methods. More appropriate, individualized guidance methods for each patient would improve the reproducibility of breath-holding in respiratory motion management.

关键词： Respiratory Motion Management

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Evaluation of Deformable Image Registration and Dose Accumulation Using Histogram Matching Algorithm between kVCT and MVCT with Helical Tomotherapy

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Journal of Modern Physics 2018年第13期9卷 2274-2285页

作者： Masahide Saito Yuki Shibata Naoki Sano kengo kuriyama Takafumi Komiyama Kan Marino Shinichi Aoki Hiroshi Onishi Department of Radiology University of Yamanashi Yamanashi Japan

Purpose: To evaluate the accuracy of deformable image registration (DIR) between the planning kVCT (pCT) and the daily MVCT combined with the histogram matching (HM) algorithm, and evaluate the deformable dose accumulation using a suggested method for adaptive radiotherapy with Helical Tomotharapy (HT). Methods: For five prostate cancer patients (76 Gy/38 Fr) treated with HT in our institution, seven MVCT series (a total of 35 series) acquired weekly were investigated. First, to minimize the effect of different HU values between pCT and MVCT, this image-processing method adjusts HU values between pCT and MVCT images by using image cumulative histograms of HU values, generating an HM-MVCT. Then, the DIR of the pCT to the HM-MVCT was performed, generating a deformed pCT. Finally, deformable dose accumulation was performed toward the pCT image. Results: The accuracy of DIR was significantly improved by using the HM algorithm, compared with non-HM method for several structures (p ±0.05, 0.83 ±0.06, and 0.90 ± 0.04 for the CTV, rectum, and bladder, respectively, while that of the HM method was 0.81 ±0.06, 0.81 ±0.04, and 0.92 ±0.06, respectively. For the deformable dose accumulation, some difference was observed between the two methods, particularly for the small calculated regions, such as rectum V60 and V70. Conclusion: Adapting the HM method can improve the accuracy of DIR. Furthermore, dose calculation using the deformed pCT using HM methods can be an effective tool for adaptive radiotherapy.

关键词： Radiotherapy Tomotherapy MVCT Histogram-Matching Deformable Image Registration

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Microbial characteristics in anaerobic membrane bioreactor treating domestic sewage:Effects of HRT and process performance

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Journal of Environmental Sciences 2022年第1期34卷 392-399页

作者： Jialing Ni Jiayuan Ji Yu-You Li kengo Kubota Department of Civil and Environmental Engineering Graduate School of EngineeringTohoku University6-6-06 AobaAramakiAoba-ku 980-8579SendaiJapan Department of Frontier Science for Advanced Environment Graduate School of Environmental StudiesTohoku University6-6-06 AobaAramakiAoba-ku 980-8579SendaiJapan

Two anaerobic membrane bioreactors(AnMBRs)equipped with different membrane pore size(0.4 or 0.05μm)were operated at 25℃and fed with domestic *** hydraulic retention time(HRT)of the reactors was *** microbial communities of the two AnMBRs were investigated by 16S rRNA gene amplicon sequencing to see the effects of *** predominant Archaea was an aceticlastic methanogen *** composition of hydrogenotrophic methanogens changed with the HRTs:the population of Methanobacterium was higher for longer HRTs,whereas the population of unclassified Methanoregulaceae was higher for shorter *** Anaerolineae,Bacteroidia and Clostridia bacteria were dominant in both of the reactors,with a combined relative abundance of over 55%.The relative abundance of Anaerolineae was proportional to the biogas production *** change in the population of hydrogenotrophic methanogens or Anaerolineae can be used as an indicator for process *** sum of the relative abundance of Anaerolineae and Clostridia fluctuated slightly with changes in the HRT in both AnMBRs when the reactor was stably *** co-occurrence analysis revealed the relative abundance of the operational taxonomic units belonging to Anaerolineae and Clostridia was functionally equivalent during the treatment of real domestic sewage.A principal coordination analysis revealed that the changes in the microbial community in each reactor were consistent with the change of *** addition,both the HRT and the stability of the process are important factors for maintaining microbial community structures.

关键词： Anaerobic membrane bioreactor Co-occurrence analysis Hydrogenotrophic methanogen HRT Microbial community structure Principal coordinate analysis

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SINGLE AND DOUBLE EDGE INTERFACE CRACK SOLUTIONS FOR ARBITRARY FORMS OF MATERIAL COMBINATION

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Acta Mechanica Solida Sinica 2012年第4期25卷 404-416页

作者： Xin Lan Nao-Aki Noda kengo Michinaka Department of Mechanical Engineering Kyushu Institute of Technology

In this paper interfacial edge crack problems are considered by the application of the finite element method. The stress intensity factors are accurately determined from the ratio of crack-tip-stress value between the target given unknown and reference problems. The reference problem is chosen to produce the singular stress fields proportional to those of the given unknown problem. Here the original proportional method is improved through utilizing very refined meshes and post-processing technique of linear extrapolation. The results for a double-edge interface crack in a bonded strip are newly obtained and compared with those of a single-edge interface crack for different forms of combination of material. It is found that the stress intensity factors should be compared in the three different zones of relative crack lengths. Different from the case of a cracked homogeneous strip, the results for the double edge interface cracks are found to possibly be bigger than those for a single edge interface crack under the same relative crack length.

关键词： stress intensity factor single edge interface crack double edge interface crack combination of material bonded strip

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Generation of spectrally stable 6.5-fs visible pulses via filamentation in krypton

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High Power Laser Science and Engineering 2016年第2期4卷 75-79页

作者： Keisuke Kaneshima kengo Takeuchi Nobuhisa Ishii Jiro Itatani The Institute for Solid State Physics The University of Tokyo

We produced 5-μJ, 6.5-fs visible pulses at a repetition rate of 1 kHz using filamentation in a gas cell filled with krypton followed by spectral selection and phase compensation by a combination of dielectric mirrors. The visible pulses have a smooth spectrum from 520 to 650 nm with a shot-to-shot stability in each spectral component of better than 2%(standard deviation). This pulse compression scheme is simple and robust, and can be easily integrated into intense ultrashort-pulse laser systems.

关键词： filamentation ultrafast spectroscopy ultrashort visible pulses

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Characterization of Three Homoeologous cDNAs Encoding Chloroplast-targeted Aminolevulinic Acid Dehydratase in Common Wheat

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Journal of Integrative Plant Biology 2011年第12期53卷 942-950页

作者： Yu Takenouchi Haruka Nakajima kengo Kanamaru Shigeo Takumi Laboratory of Plant Genetics Graduate School of Agricultural Science Kobe University Kobe 657-8501 Japan Laboratory of Biological Chemistry Graduate School of Agricultural Science Kobe University Kobe 657-8501 Japan

In the tetrapyrrole biosynthetic pathway of higher plants, 5-aminolevulinic acid （ALA） is metabolized by ALA dehydratase （ALAD）. Here, we isolated ALAD1 cDNA from common wheat （Triticum aestivum L.） and its diploid progenitors, and produced transgenic tobacco plants expressing the wheat ALAD1 gene. The ALAD1 genes were highly conserved among wheat relatives, and three homoeologous loci of wheat ALAD1 （TaALAD1） were equally transcribed in common wheat. A transient expression assay of a TaALAD1-GFP （green fluorescent protein） fusion protein suggested that TaALAD1 is localized in chloroplasts. Overexpression of TaALAD1 in transgenic tobacco resulted in a significant increase in ALAD activity in leaves. Moreover, the transgenic tobacco showed vigorous growth and increased survival rate on medium containing ALA at herbicidal concentrations. These results indicate that wheat ALAD1 has catalytic activity in metabolizing ALA in plastids, and that ectopic expression of TaALAD1 in transgenic plants increases their tolerance to ALA application at high concentrations.

关键词： 5-aminolevulinic acid chloroplast targeting herbicide resistance transgenic tobacco Triticum aestivum 5-aminolevulinic acid dehydratase transcriptional control

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Disseminated carcinomatosis of the bone marrow caused by granulocyte colony-stimulating factor:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2022年第10期14卷 2077-2084页

作者： kengo Fujita Ayaka Okubo Toshitsugu Nakamura Nobumichi Takeuchi Department of Medical Oncology Ina Central HospitalNagano 396-8555Japan Department of Diagnostic Pathology Ina Central HospitalNagano 396-8555Japan

BACKGROUND Disseminated carcinomatosis of the bone marrow(DCBM)is a widespread metastasis with a hematologic disorder that is mainly caused by gastric *** it commonly occurs as a manifestation of recurrence long after curative treatment,the precise mechanism of relapse from dormant status remains *** colony-stimulating factor(G-CSF)can promote cancer progression and invasion in various ***,the potential of G-CSF to trigger recurrence from a cured malignancy has not been *** SUMMARY A 55-year-old Japanese woman was diagnosed with Ewing sarcoma localized on the fifth lumbar vertebrae 6 years after curative gastrectomy for T1 gastric *** palliative surgery to release nerve compression,pathological diagnosis of the resected specimen was followed by curative radiation and *** treatment,G-CSF was administered 32 times for severe neutropenia *** months after completing definitive treatment,she complained of severe back pain and was diagnosed as multiple bone metastases with DCBM from gastric *** palliative chemotherapy,she died of disseminated intravascular coagulation 13 d after the *** examination of the autopsied bone marrow confirmed a diffuse positive staining for the G-CSF receptor(G-CSFR)in the relapsed gastric cancer cell cytoplasm,whereas the primary lesion cancer cells showed negative staining for *** this case,G-CSF administration may have been the key trigger for the disseminated relapse of a dormant gastric *** administering G-CSF to cancer survivors,recurrence of a preceding cancer should be monitored even after curative treatment.

关键词： Disseminated bone marrow carcinomatosis Gastric cancer Granulocyte colony-stimulating factor Cancer survivor Immunostaining Case report

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One-Step Synthesis of Magnetically Recyclable Au/Co/Fe Triple- Layered Core-Shell Nanoparticles as Highly Efficient Catalysts for the Hydrolytic Dehydrogenation of Ammonia Borane

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Nano Research 2011年第12期4卷 1233-1241页

作者： kengo Aranishi Hai-Long Jiang Tomoki Akita Masatake Haruta Qiang Xu National Institute of Advanced Industrial Science and Technology （AIST） Ikeda Osaka 563-8577 Japan Graduate School of Engineering Kobe University Nada Ku Kobe Hyogo 657-8501 Japan Graduate School of Urban Environmental Sciences Tokyo Metropolitan University Minami-Osawa Hachioji Tokyo 192-0397 Japan Core Research for Evolutional Science and Technology （CREST） Japan Science and Technology Agency （JST） Kawaguchi Saitama 332-0012 Japan

Magnetically recyclable Au/Co/Fe core-shell nanoparticles （NPs） have been successfully synthesized via a one-step in situ procedure. Transmission electron microscope （TEM）, energy dispersive X-ray spectroscopic （EDS）, and electron energy-loss spectroscopic （EELS） measurements revealed that the trimetallic Au/Co/Fe NPs have a triple-layered core-shell structure composed of a Au core, a Co-rich inter-layer, and a Fe-rich shell. The Au/Co/Fe core-shell NPs exhibit much higher catalytic activities for hydrolytic dehydrogenation of ammonia borane （NHBBH3, AB） than the monometallic （Au, Co, Fe） or bimetallic （AuCo, AuFe, CoFe） counterparts.

关键词： Triple-layered core-shell nanoparticles heterogeneous catalysis ammonia borane hydrogen generation

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Fabrication and characterization of TiO2-based dye-sensitized solar cells

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Progress in Natural Science:Materials International 2011年第2期21卷 122-126页

作者： Takeo OKU Nariaki KAKUTA kengo KOBAYASHI Atsushi SUZUKI Kenji KIKUCHI Department of Materials Science The University of Shiga PrefectureShiga 522-8533Japan

Dye-sensitized solar cells TiO2with were *** phase composition and microstructures of the solar cells were examined by X-ray diffractometry and transmission electron microscopy,and the energy levels of the present solar cells were also *** results show that a solar cell mixed with xylenol orange and rose Bengal shows a higher conversion efficiency compared to solar cells with a single *** introduction of amorphous TiO2layers results in an improvement of the conversion efficiency.

关键词： solar cell TiO2 dye porphyrin microstructure

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Niche Differentiation of Phenol-Degrading Microorganisms in UASB Granular Sludge as Revealed by Fluorescence in situ Hybridization

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Engineering 2022年第2期8卷 61-66页

作者： kengo Kubota Kei Igarashi Masayoshi Yamada Yasuyuki Takemura Yu-You Li Hideki Harada Department of Civil and Environmental Engineering Tohoku UniversitySendai 980-8579Japan Department of Urban Environmental Design and Engineering National Institute of TechnologyKagoshima CollegeKirishima 899-5193Japan New Industry Creation Hatchery Center Tohoku UniversitySendai 980-8579Japan

A microbial community structure of granules harvested from an anaerobic sludge blanket reactor treating phenolic wastewater was investigated using fluorescence in situ hybridization(FISH)and clone library *** of Syntrophorhabdaceae and Cryptanaerobacter were observed to be responsible for phenol *** accurate taxonomic assignment of Cryptanaerobacter clones,phylogenetic analysis using nearly full-length 16S ribosomal RNA(rRNA)gene sequences was *** oligonucleotide probes were designed to detect the following three taxonomic groups:Syntrophorhabdaceae,Cryptanaerobacter,and *** analysis of thin sections of anaerobic granules showed a random distribution of bacteria and ***,a well-defined distribution of Syntrophorhabdaceae,Cryptanaerobacter,and Syntrophus was *** and Syntrophus were found on the outer layer of the granules and were closely associated with each other,while Syntrophorhabdaceae was located in the deeper part of the *** specific distribution of the bacteria is most likely due to their metabolic association and affinity for the *** degradation in the granular sludge was observed to be carried out in the following ***,Cryptanaerobacter converts phenol to benzoate,which is then degraded by Syntrophus into *** syntrophic degradation of phenol occurs near the surface of the granule,where the phenol concen-tration is *** the deeper part of the granule,where the phenol concentration is lower,Syntrophorhabdaceae degrades phenol into *** observed that Syntrophorhabdaceae is less likely to produce benzoate as an intermediate to feed the neighboring organisms,which contradicts the theo-ries presented by previous studies.

关键词： Cryptanaerobacter Fluorescence in situ hybridization Anaerobic phenol degradation Syntrophorhabdaceae Syntrophus UASB granular sludge

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