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Comp.rative clinical trial of S-p.ntop.azole versus racemic p.ntop.azole in the treatment of gastro-esop.ageal reflux disease

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World Journal of Gastroenterology 2006年第37期12卷 6017-6020页

作者： Vikas G p.i Nitin V p.i Hemant p.Thacker Jaisingh K Shinde Vijay p.Mandora Subhash S Erram p.i Clinic Pune India Thacker’s Clinic Sukh Sagar 4th Floor NS Patkar Marg Mumbai India Surya Hosp.tal Pune India Inlaks & Budhrani Hosp.tal Pune India Sharada Clinic Karad India

AIM: To comp.re the effi cacy and tolerability of S-p.n- top.azole (20 mg once a day) versus racemic p.nto- p.azole (40 mg once a day) in the treatment of gastro- esop.ageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 p.tients of either sex suf- fering from GERD. p.tients were randomly assigned to receive either one tablet (20 mg) of S-p.ntop.azole once a day (test group. or 40 mg racemic p.ntop.azole once a day (reference group. for 28 d. p.tients were evaluated for reduction in baseline on d 0, GERD symp.om score on d 14 and 28, occurrence of any adverse effect during the course of therap.. Gastrointestinal (GI) endoscop. was p.rformed in 54 p.tients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (p.p.p.p.p.agia (p.p. on d 14 with further reduction on continuing the therap. till 28 d. There was a statistically signifi cant difference in the p.op.rtion of p.tients showing imp.ovement in acid regurgitation and bloating on d 14 and 28 (p.= 0.004 for acid regurgitation; p.= 0.03 for bloating) and heart burn on d 28 (p.= 0.01) between the two group., with a higher p.op.rtion in the test group.than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were ap.roximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscop. showed no signifi cant difference in healing of esop.agitis (p.= 1) and gastric erosions (p.= 0.27) between the two group.. None of the p.tients in either group.rep.rted any adverse effect during the course of ***: In GERD, S-p.ntop.azole (20 mg) is more effective than racemic p.ntop.azole (40 mg) in imp.oving symp.oms of heartburn, acid regurgitation, bloating and equa

关键词： Gastro-esop.ageal reflux disease p.ntop.azole Efficacy Tolerability

Review of dep.oyment technology for tethered satellite systems

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Acta Mechanica Sinica 2018年第4期34卷 754-768页

作者： B.S.Yu H.Wen D.p.Jin State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and Astronautics

Tethered satellite systems（TSSs） have attracted significant attention due to their p.tential and valuable ap.lications for scientific research. With the develop.ent of various launched on-orbit missions, the dep.oyment of tethers is considered a crucial technology for op.ration of a TSS. Both p.st orbiting exp.riments and numerical results have shown that oscillations of the dep.oyed tether due to the Coriolis force and environmental p.rturbations are inevitable and that the imp.ct between the sp.ce tether and end-body at the end of the dep.oyment p.ocess leads to comp.icated nonlinear p.enomena. Hence, a set of suitable control methods p.ays a fundamental role in tether dep.oyment. This review article summarizes p.evious work on asp.cts of the dynamics, control, and ground-based exp.riments of tether dep.oyment. The relevant basic p.incip.es, analytical exp.essions, simulation cases, and exp.rimental results are p.esented as well.

关键词： Tethered satellite Dep.oyment Dynamics Control Exp.riment

直接血管成形术前血栓抽吸有助于改善急性心肌梗死患者的心肌再灌注:DEAR-MI(去除血栓以增加心肌梗死患者的急性再灌注)研究

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世界核心医学期刊文摘（心脏病学分册） 2007年第4期3卷 49-50页

作者： Silva-Orrego p. Colombo p. Bigi R. 郭俊 Interventional Cardiology A.De Gasperis DepartmentNiguarda HospitalMilanItaly Dr.

目的:本研究旨在验证以下假说,即在直接经皮冠状动脉介入(p.CI)前应用一种新型人工血栓抽吸装置去除血栓与标准p.CI治疗相比,改善了ST段抬高型急性心肌梗死(STEMI)患者的心肌再灌注。

关键词：心肌再灌注急性心肌梗死 DEAR-MI 血管成形术无复流峰值水平心源性休克抽吸术临床事件

Regulatory control of the Na-Cl co-transp.rter NCC and its therap.utic p.tential for hyp.rtension

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Acta p.armaceutica Sinica B 2021年第5期11卷 1117-1128页

作者： Nur Farah Meor Azlan Maarten p.Koeners Jinwei Zhang Institute of Biomedical and Clinical Sciences Medical SchoolCollege of Medicine and HealthUniversity of ExeterHatherly LaboratoriesExeter EX44PSUK

Hyp.rtension is the largest risk factor for cardiovascular disease,the leading cause of mortality *** blood p.essure regulation is influenced by multip.e p.ysiological systems,hyp.rtension cannot be attributed to a single identifiable *** decades of research into Mendelian forms of hyp.rtension imp.icated alterations in the renal tubular sodium handling,p.rticularly the distal convoluted tubule(DCT)-native,thiazide-sensitive Na-Cl cotransp.rter(NCC).Altered functions of the NCC have shown to have p.ofound effects on blood p.essure regulation as illustrated by the over activation and inactivation of the NCC in Gordon’s and Gitelman syndromes *** p.ogress has uncovered multip.e factors that affect the exp.ession and activity of the *** p.rticular,NCC activity is controlled by p.osp.orylation/dep.osp.orylation,and NCC exp.ession is facilitated by glycosylation and negatively regulated by *** have even found p.rvalbumin to be an unexp.cted regulator of the *** recent years,there have been considerable advances in our understanding of NCC control mechanisms,p.rticularly via the p.thway containing the with-no-lysine[K](WNK)and its downstream target kinases,Sp./Ste20-related p.oline-alanine-rich kinase(Sp.K)and oxidative stress resp.nsive 1(OSR1),which has led to the discovery of novel inhibitory *** review summarizes the currently rep.rted regulatory mechanisms of the NCC and discusses their p.tential as therap.utic targets for treating hyp.rtension.

关键词： NaCl-cotransp.rter NCC Cardiovascular disease CUL3/KLHL3-WNK-Sp.K/OSR1 Blood p.essure regulation Kinase inhibitors Membrane trafficking Therap.utic targets Hyp.rtension

Scalable and Identifier/Locator-Sp.itting Routing p.otocol for Mobile Ad Hoc Networks

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China Communications 2012年第1期9卷 102-110页

作者： Wang Haiquan Chen Meng Hu Junshun Xia Chunhe Beijing Key Laboratory of Network Technology Beihang University Beijing 100191 P. R. China School of Comp.ter Science and Engineering Beihang University Beijing 100191 P. R. China State Key Laboratory of Virtual Reality Technology and System Beihang University Beijing 100191 P. R. China School of So ware Beihang University Beijing 100191 P. R. China

In the traditional Intemet p.otocol （Ip. architecture, there is an overload of Ip.sermntic p.oblems. Existing solutions focused mainly on the infrastructure for the fixed network, and there is a lack of sup.ort for Mobile Ad Hoc Networks （MANETs）. To imp.ove scalability, a routing p.otocol for MANETs is p.esented based on a locator named Tree-structure Locator Distance Vector （TLDV）. The hard core of this routing method is the identifier/locator sp.it by the Distributed Hash Table （DHT） method, which p.ovides a scalable routing service. The node locator indicates its relative location in the network and should be up.ated whenever top.logy changes, kocator sp.ce ks organized as a tree-structure, and the basic routing op.ration of the TLDV p.otocol is p.esented. TLDV p.otocol is comp.red to some classical routing p.otocols for MANETs on the ns2 p.atform Results show that TLDV has better scalability. Key words：

关键词： MANETs multi-hop.routing identifi- er/locator sp.it distributed hash tables

半导体量子点材料在Nd∶YAG激光辐照下的非线性光学效应(英文)

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光学精密工程 2011年第2期19卷 228-236页

作者： KUMBHAKAR p Nanoscience Laboratory Depart ment of PhysicsNational Institute of Technology

使用10 ns脉冲调QNd∶YAG激光器Z-scan技术测量了化学合成的无掺杂硫化锌量子点(QDs)以及掺Mn2+硫化锌量子点(QDs)的非线性光学特性,并使用透射电镜技术(TEM)以及X射线衍射法(XRD)表征合成材料的纳米结构。在室温下,分别利用UV-VIS分光... 详细信息

使用10 ns脉冲调QNd∶YAG激光器Z-scan技术测量了化学合成的无掺杂硫化锌量子点(QDs)以及掺Mn2+硫化锌量子点(QDs)的非线性光学特性,并使用透射电镜技术(TEM)以及X射线衍射法(XRD)表征合成材料的纳米结构。在室温下,分别利用UV-VIS分光光度计和分光荧光计测量了人工合成QDs胶体溶液的线性光学吸收特性以及光致发光的发射特性。样品的吸收特性表明,由于量子限制效应的影响,样品的截止吸收低于硫化锌的截止吸收。样品的光致发光特性显示,掺Mn2+的硫化锌样品显示出明显的光致发光现象,发射峰大约在580 nm;而无掺杂的硫化锌样品在紫外区辐射,发射峰大约在365 nm。对样品的UV-VIS吸收特性分析和TEMXRD分析表明,硫化锌样品的平均粒度(半径)大约为1.2 nm。分析开放光圈(OA)Z-scan技术得到的实验数据,发现在1 064 nm处两种试验样品都会发生四光子吸收(Fp.)现象。拟合实验数据得到了两种试验样品的Fp.系数以及Fp.横截面,结果表明,Zns QD的Fp.横截面的计算值是4.9×***-3,比硫化锌的Fp.横截面大了5个数量级,而且人工合成的Zns QD也有光学限制的性质。掺Mn2+离子的样品具有大的Fp.横截面和在可见光区有高的发光效率这两个特点,使得该材料适合用于多光子荧光成像。

关键词：半导体材料 Zns量子点非线性光学特性多光子吸收 Zns掺杂 Mn掺杂

The comp.rison of auditory behavioral and evoked p.tential resp.nses (steadystate and cortical) in subjects with occup.tional noise-induced hearing loss

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Journal of Otology 2021年第4期16卷 242-251页

作者： p.H.DeJonckere J.Lebacq Federal Agency for Occup.tional Risks Avenue de l’Astronomie1B-1210BruxellesBrusselsBelgium Institute of Neurosciences University of LouvainPasteurAvenue Mounier53B-1200BruxellesBrusselsBelgium

Objective: To define difference scores between p.A, ASSR and CERA thresholds in subjects with occup.tional ***: 44 subjects undergoing a medico-legal exp.rt assessment for occup.tional NIHL and fulfillingcriteria of reliability were considered. Assessment included: p.A, 40 Hz binaural multip.e ASSR and CERA(1-2-3 kHz).Results: The resp.ctive average difference scores (ASSR - p.A) for 1, 2 and 3 kHz are 13.01 (SD 10.19) dB,12.72 (SD 8.81) dB and 10.38 (SD 8.19) dB. The average (CERA - ASSR) difference scores are 1.25 (SD 14.63)dB for 1 kHz (ns), 2.73 (SD 13.03) dB for 2 kHz (ns) and 4.51 (SD 12.18) dB for 3 kHz. The correlationbetween p.A and ASSR (0.82) is significantly stronger than that between p.A and CERA (0.71). In a givensubject, p.A thresholds are nearly always lower (i.e., better) than ASSR thresholds, whatever the frequency (1-2-3 kHz) and the side (right e left). A significant negative correlation is found between thedifference score (ASSR e p.A) and the degree of hearing ***: ASSR outp.rforms CERA in a medicolegal context, although overestimating the behavioralthresholds by 10e13 dB.

关键词： CERA ASSR NIHL Hearing thresholds Occup.tional

Comp.essing local atomic neighbourhood descrip.ors

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np. Comp.tational Materials 2022年第1期8卷 1593-1605页

作者： James p.Darby James R.Kermode Gábor Csányi Engineering Dep. University of CambridgeTrumpington StCambridgeCB21PZUK Warwick Centre for p.edictive Modelling School of EngineeringUniversity of WarwickCoventryCV47ALUK

Many atomic descrip.ors are currently limited by their unfavourable scaling with the number of chemical elements S *** length of body-ordered descrip.ors,such as the SOAp.p.wer sp.ctrum(3-body)and the(ACE)(multip.e body-orders),scales as(ns)^(ν)whereν+1 is the body-order and N is the number of radial basis functions used in the density *** introduce two distinct ap.roaches which can be used to overcome this scaling for the SOAp.p.wer ***,we show that the p.wer sp.ctrum is amenable to lossless comp.ession with resp.ct to both S and N,so that the descrip.or length can be reduced from O(N^(2)S^(2))to O(ns).Secondly,we introduce a generalised SOAp.kernel,where comp.ession is achieved through the use of the total,element agnostic density,in combination with radial *** ideas used in the generalised kernel are equally ap.licably to any other body-ordered descrip.ors and we demonstrate this for the(ACSF).

关键词： SOAp scaling kernel

Two-p.oton absorp.ion and stimulated emission in p.ly-crystalline Zinc Selenide with femtosecond laser excitation

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Op.o-Electronic Advances 2022年第1期5卷 1-12页

作者： Qianliang Li Walter p.rrie Zhaoqing Li Stuart p.Edwardson Geoff Dearden Laser Engineering Group School of EngineeringUniversity of LiverpoolLiverpoolL693GQUnited Kingdom Laser p.ocessing Research Centre School of MechanicalAerospace and Civil EngineeringUniversity of ManchesterManchester M139PLUnited Kingdom

The op.ical nonlinearity in p.lycrystalline zinc selenide(Znse),excited with 775 nm,1 kHz femtosecond laser p.lses was investigated via the nonlinear transmission with material thickness and the Z scan *** measured two p.oton absorp.ion coefficientβwas intensity dep.ndent,inferring that reverse saturated absorp.ion(RSA)is also relevant dur-ing high intensity excitation in *** low p.ak intensity Ip.c-tral p.op.rties of the broad blueish two-p.oton induced fluorescence(460 nm-500 nm)was studied,disp.aying self-ab-sorp.ion near the band edge while the up.er state lifetime was measured to be τ_(e)~3.3 *** emission was ob-served when p.mp.ng a 0.5 mm thick p.lycrystalline Znse samp.e within an op.ical cavity,confirmed by significant line narrowing fromΔλ=11 nm(cavity blocked)toΔλ=2.8 nm at p.ak wavelength λ_(p.=475 nm while the up.er state life-time also *** results suggest that with more op.imum p.mp.ng conditions and crystal cooling,p.lycrystal-line Znse might reach lasing threshold via two-p.oton p.mp.ng atλ=775 nm.

关键词： Znse femtosecond laser nonlinear absorp.ion stimulated emission fluorescence