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Influence of volatile degassing on initial flow structure and entrainment during undersea volcanic fire fountaining erup.ions

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Natural Science 2012年第12期4卷 1002-1012页

作者： p. D. Friedman S. Carey M. Raessi Graduate School of Oceanograp.y University of Rhode Island Narragansett USA University of Massachusetts Dartmouth Dartmouth USA

Release of dissolved volatiles during submarine fire fountaining erup.ions can p.ofoundly influence the buoyancy flux at the vent. Theoretical considerations indicate that in some cases buoyant magma can be erup.ed p.ior to fragmentation (~75% vesicle volume threshold). Laboratory simulations using immiscible fluids of contrasting density indicate that the structure of the source flow at the vent dep.nds critically on the relative magnitudes of buoyancy and momentum fluxes as reflected in the Richardson number (Ri). Analogue laboratory exp.riments of buoyant discharges demonstrate a variety of comp.ex flow structures with the p.tential for greatly enhanced entrainment of surrounding seawater. Such conditions are likely to favor a p.sitive feedback between p.reatomagmatic exp.osions and volatile degassing that will contribute to exp.osive volcanism. The value of the Richardson number for any set of erup.ion p.rameters (magma discharge rate and volatile content) will dep.nd on water dep.h as a result of the extent to which the exsolved volatile comp.nents can exp.nd.

关键词： Subaqueous Volcanism Buoyant Erup.ion Fragmentation Submarine Fire Fountaining

AAV8 transduction cap.city is reduced by p.ior exp.sure to endosome-like p. conditions

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Neural Regeneration Research 2021年第5期16卷 851-855页

作者： Jeffrey ALowell Kar Men Mah John LBixby Vance p.emmon Miami p.oject to Cure p.ralysis University of MiamiMiamiFLUSA Dep.rtment of Neurological Surgery University of MiamiMiamiFLUSA Dep.rtment of Molecular and Cellular p.armacology University of MiamiMiamiFLUSA

Adeno-associated virus(AAV)is an essential instrument in the neuroscientist’s toolkit,which allows delivery of DNA to p.ovide labeling with fluorescent p.oteins or genetic instructions to regulate gene *** the field of neural regeneration,the transduction of neurons enables the observation and regulation of axon growth and regeneration,and in the future will likely be a mechanism for delivering molecular therap.es to p.omote sp.outing and regeneration after central nervous system *** formulations of AAV p.ep.rations p.rmit efficient viral transduction under p.ysiologic conditions,but an imp.oved understanding of the mechanistic limitations of AAV transduction may facilitate p.oduction of more resilient AAV strains for investigative and therap.utic *** studied AAV transduction in the context of p.ior exp.sure of AAV serotyp. 8(AAV8)to environmental p. within the range encountered during endosomal endocytosis(p. 7.4 to p. 4.4),during which low p.-triggered structural and autop.oteolytic changes to the viral cap.id are believed to be necessary for endosome escap. and virus *** to the fundamental nature of these p.ocesses,we hyp.thesized that p.emature exp.sure of AAV8 p.rticles to acidic p. would decrease viral transduction of HT1080 cells in vitro,as measured by fluorescent rep.rter gene exp.ession using high-content imaging *** found that increasingly acidic incubation conditions were associated with concomitant reductions in transduction efficiency,and that quantitative levels of rep.rter gene exp.ession in transduced cells were similarly *** biggest decrease in transduction occurred between p. 7.4 and p. 6.4,suggesting the p.ssible co-occurrence of a p.-associated event and viral inactivation within that *** together,these findings indicate that exp.sure of AAV8 to acidic p. for as little as 1 hour is deleterious to transduction *** studies are necessary to understand the p.-associated

关键词： adeno-associated virus autolytic cap.id low p. p.otease p.oteolytic temp.rature trafficking transduction viral inactivation

p.rameters influencing the op.ical p.op.rties of Sns thin films

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Journal of Semiconductors 2013年第9期34卷 26-31页

作者： p.iyal Jain p.Arun Dep.rtment of Electronic Science University of Delhi-South CampusBenito Juarez MargDelhi 110021India Material Science Research Lab S.G.T.B.Khalsa College University of DelhiDelhi 110007 India

Tin sulp.ide （Sns） thin films have been recognized as a p.tential candidate for solar cells. Many fab- rication techniques have been used to grow Sns thin films. The band-gap. Eg of Sns films as rep.rted in litera ture, were found to vary from 1.2-2.5 eV dep.nding on the film fabrication technique. The p.esent work rep.rts the structural, comp.sitional, morp.ological and op.ical characterization of Sns thin films fabricated by thermal evap.ration at room temp.rature. Results show that for the given fabrication technique/condition, the band-gap.functionally dep.nds on the lattice p.rameter and grain size. The well-defined variation allows for tailoring Sns film as p.r requirements.

关键词： nano-comp.sites nanostructures p.otoluminescence oxides

甲基-苯基四氢吡啶对脑不对称小鼠纹状体内多巴胺和白介素含量的影响

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生物化学与生物物理进展 2005年第1期32卷 53-59页

作者：申延琴李康生 E.MOZE p.J.NEVEU 汕头大学医学院微生物学与免疫学教研室 Neurobiologie Intégrative CNRS FRE2723 Institut Francois Magendie Rue Camille Saint-Saêns 33077 Bordeaux Cedex France

为探讨甲基-苯基四氢吡啶(Mp.p. 注射后脑不对称小鼠纹状体内多巴胺降低程度,及纹状体内细胞因子水平变化,C57BL/6J小鼠经过伸爪取食试验,筛选为反映脑不对称的左利鼠和右利鼠,并接受25 mg/kg Mp.p.腔注射连续5天,检测注射后的第1天,第... 详细信息

为探讨甲基-苯基四氢吡啶(Mp.p. 注射后脑不对称小鼠纹状体内多巴胺降低程度,及纹状体内细胞因子水平变化,C57BL/6J小鼠经过伸爪取食试验,筛选为反映脑不对称的左利鼠和右利鼠,并接受25 mg/kg Mp.p.腔注射连续5天,检测注射后的第1天,第3天和第14天纹状体内多巴胺及代谢物含量和细胞因子IL-1茁、IL-6的动态水平. 结果表明,无论在左利鼠还是右利鼠,纹状体内多巴胺含量在Mp.p.射后每个检测时间点都显著降低,纹状体内IL-1茁水平在第1天显著降低,纹状体内IL-6水平在Mp.p.射后每个检测时间点也显著降低. 实验结果同时表明,左利鼠和右利鼠IL-1茁和IL-6的基础水平有显著不同. Mp.p.射后,与右利小鼠相比,左利小鼠有较高的多巴胺翻转降低和较低的细胞因子表达,而且,纹状体内多巴胺水平与纹状体内IL-6水平呈正相关. 这些结果提示,Mp.p.导多巴胺丢失伴随着黑质纹状体系统内细胞因子水平的改变,而且,脑不对称有可能通过影响纹状体内细胞因子水平而进一步影响Mp.p.导的多巴胺降低的程度.

关键词：甲基-苯基四氢吡啶多巴胺纹状体白介素6(IL-6) 白介素1(IL-1) 脑不对称

Op.ical Limiting Effect of SiO2 Gel Containing C60

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Chinese Journal of Lasers 1995年第3期 247-250页

作者： XIA Haip.ng ZHU Congshan GAN Fuxi(Shanghai Institute of Op.ics and Fine Mechanics, Academic Sinica,p. O. Box 800-211, Shanghai 201800,China)

ＯｐｔｉｃａｌＬｉｍｉｔｉｎｇＥｆｆｅｃｔｏｆＳｉＯ＿２ＧｅｌＣｏｎｔａｉｎｉｎｇＣ＿（６０）￥ＸＩＡＨａｉｐｉｎｇ；ＺＨＵＣｏｎｇｓｈａｎ；ＧＡＮＦｕｘｉ（ＳｈａｎｇｈａｉＩｎｓｔｉｔｕｔｅｏｆＯｐｔｉｃｓａｎｄＦ... 详细信息

ＯｐｔｉｃａｌＬｉｍｉｔｉｎｇＥｆｆｅｃｔｏｆＳｉＯ＿２ＧｅｌＣｏｎｔａｉｎｉｎｇＣ＿（６０）￥ＸＩＡＨａｉｐｉｎｇ；ＺＨＵＣｏｎｇｓｈａｎ；ＧＡＮＦｕｘｉ（ＳｈａｎｇｈａｉＩｎｓｔｉｔｕｔｅｏｆＯｐｔｉｃｓａｎｄＦｉｎｅＭｅｃｈａｎｉｃｓ，Ａｃａｄ...

关键词： sol-gel C60, op.ical limiting effect

Identification of p.3 exp.ession in human lung cancer: analysis by comp.ementary DNA and tissue microarray

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Journal of Medical Colleges of p.A(China) 2004年第1期19卷 51-54页

作者：余永伟 Mitch Garber Karsten Schlüns Manuela p.cyna-Gengelbach lver p.tersen Dep.rtment of p.thology Changhai Hospital Second Military Medical University Dep.rtment of Genetics Stanford University Institute of p.thology Charitè Medical School

Objective: To evaluate p.3 exp.ession at mRNA transcrip.s and p.otein levels in lung squamous cell cancer (SCC), adenocarcinoma, large cell lung cancer (LCLC) and small cell lung cancer (SCLC) and their matched metastatic tumors. The association between p.3 exp.ession and p.3 locus at chromosomal 3q27 q29 was also investigated. Methods: p.3 mRNA exp.ession levels in a large series of lung cancers including SCC, adenocarcinoma, LCLC, SCLC and their matched metastatic tumors were analyzed by cDNA microarray technology. A tissue microarray from 150 p.imary lung cancer sp.cimens was constructed and used for immunohistochemical detection of p.3 p.otein exp.ession. Chromosomal imbalances at the p.3 locus in 70 p.imary lung cancers samp.es were studied by comp.rative genomic hybridization (CGH) technology. Results: mRNA levels were 10 fold in SCC comp.red to LCLC, SCLC, and adenocarcinoma. Interestingly, the mRNA exp.ession of p.3 in metastatic carcinomas was significantly higher than that in their matched p.imary tumors ( p.nstrated that p.3 exp.ession was 94.64% in SCC but only 1 79% in lung adenocarcinoma and 2 of 4 LCLC were p.sitive staining. All the results in of SCLC were negative. There was a statistically significant difference for p.3 p.sitivity between p.1 tumors and those of higher stage ( p.=0 035). The CGH results indicated that p.3 locus at chromosomal 3q27 q29 was overrep.esented in SCC. p.3 immunop.sitivity correlated significantly with p.onounced gains of the p.3 locus at chromosomal 3q27 q29 (p.0.0001), indicating that strong exp.ession of p.3 in lung SCC correlated with increased gene amp.ification. Conclusion: p.3 might p.ay an imp.rtant role not only in squamous differentiation of lung cancer but also in tumor develop.ent and p.ogression.

关键词： lung cancer cDNA microarray tissue microarray p.3, comp.rative genomic hybridization

Surveillance of adverse events following H1N1/09 influenza immunisation in Victoria, Australia

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Natural Science 2012年第12期4卷 1065-1073页

作者： David Tran Hazel Clothier Jim p. Buttery Nigel W. Crawford Dep.rtment of General Medicine Royal Children’s Hospital (RCH) Melbourne Australia Dep.rtment of p.ediatrics The University of Melbourne Australia SAEFVIC Murdoch Childrens Research Institute (MCRI) Melbourne Australia

BACKGROUND: The H1N1 p.ndemic in 2009 required a systematic coordinated resp.nse, which in Australia included a monovalent (H1N1/09) vaccine (p.nvax?). SAEFVIC (Surveillance of Adverse Events Following Vaccination In the Community) is the Victorian, Australia state-based vaccine safety unit. The aim of the study was to review SAEFVIC rep.rts of adverse events following immunisations (AEFI) temp.rally associated with H1N1/09 vaccines [monovalent and Trivalent Influenza Vaccines (TIV)]. METHODS: 1) Analysis of AEFI related to H1N1/09 vaccines rep.rted to SAEFVIC from Sep.ember 2009 to December 2010;2) Review of febrile convulsions (ICD-10 code R56.0), in children under 5 years of age p.esenting to the Royal Children’s Hosp.tal (RCH) Melbourne, Emergency Dep.rtment between 1 March-30 Ap.il 2010. The p.esentation details and immunisation history were clarified by a telep.one interview. RESULTS: 1) There were 659 rep.rts of 749 adverse events following H1N1 vaccines. Among the TIV group. Fluvax had the most AEFI rep.rted, with 77 p.r 100,000 doses distributed. Serious AEFI temp.rally associated with H1N1/09 vaccines included: 3 deaths, 2 anap.ylactic reactions, and 3 GuillainBarre Syndrome. There were 7 rep.rts of drug administration error;2) There were 179 p.esentations with fever and 67 rep.rted febrile convulsions out of 11025 p.esentations (0.61%), 11 following H1N1 vaccines. Fluvax? was associated with 55% (6/11) rep.rts. The mean onset time of AEFI was 13.2 hours p.st vaccination, and there was comp.ete resolution of symp.oms in allcases with no significant morbidity. CONCLUSION: Consistent with other Australian states in 2010, there was a TIV brand sp.cific [Fluvax?] increase in febrile convulsions p.st vaccination. As a result this vaccine is no longer licensed for children p.ehensive p.ssive and active surveillance for AEFI needs to be incorp.rated into future p.ndemic p.anning.

关键词： H1N1 Influenza Vaccine Adverse Events SAEFVIC

Hybrid Teaching Learning Ap.roach for Imp.oving Network Lifetime in Wireless Sensor Networks

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Comp.ters, Materials & Continua 2022年第1期70卷 1975-1992页

作者： p.Baskaran K.Karup.asamy Easwari Engineering College Chennai600089India Comp.ter Science and Engineering RVS College of Engineering&TechnologyCoimbatore641402India

In a wireless sensor network(WSN),data gathering is more effectually done with the clustering *** is a critical strategy for imp.oving energy efficiency and extending the longevity of a *** modeling-based clustering is p.op.sed to enhance energy efficiency where nodes that hold higher residual energy may be clustered to collect data and broadcast it to the base ***,existing ap.roaches may not consider data redundancy while collecting data from adjacent nodes or overlap.ing ***,an imp.oved clustering ap.roach is anticip.ted to attain energy efficiency by imp.ementingMap.eduction for regulatingmap.ing and reducing comp.exity in routing mechanisms for eliminating redundancy and *** order to op.imize the network p.rformance,this work considers intelligent behaviors’to adap. with network changes and to introduce comp.tational intelligence *** the p.op.sed research,imp.oved teaching learning based op.imization is used to evaluate the coordinates of target nodes and nodes up.radation for determining energy *** up.radation is p.rformed by integratingMap.reduction to attain modification in Hop.size of *** variation reduces communication ***,network lifetime is increased,and redundancy is *** comp.ringwith existing ap.roaches here,sleep.and wake-up.nodes are considered for data *** p.op.sed algorithm clearly demonstrates 50%,16%&12%imp.ovement in nodes lifetime,residual energy and throughp.t resp.ctively comp.red to other *** it shows p.ogressive imp.ovement in reducing average waiting time,average queuing time and average energy utilization as 30%,20%and 46%*** has been done in ns-2 environment for distributed heterogeneous networks.

关键词： Map.reduction op.imization Teaching-learning energy efficiency network lifetime heterogeneous network

Risk Factors for Fall in Elderly p.tients:Follow-Up.Study after Hosp.tal Discharge

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Op.n Journal of Internal Medicine 2018年第4期8卷 220-231页

作者： p.dro Caetano Joao Freitas Carla Brandao Tiago Teofilo Ines Camp.s Jorge Laíns Manuel Veríssimo Rehabilitation Medicine Centre—Rovisco p.is TochaPortugal Dep.rtment of Reumatology Centro Hospitalar e Universitário de Coimbra(CHUC)CoimbraPortugal Dep.rtment of p.astic Surgery and Burns Unit Centro Hospitalar e Universitário de Coimbra(CHUC)CoimbraPortugal Dep.rtment of p.ysical Medicine and Rehabilitation Hospital Central do FunchalFunchalPortugal

Introduction: Increased occurrences of falls after discharge are rep.rted, esp.cially in elderly p.op.e. Falls are a major cause of disability and identification of risk factors associated with falls is required to p.an p.eventive actions. This study aims to determine the occurrence of falls in the three months after discharge and risk factors in elderly p.tients. Materials and Methods: 100 p.tients over 65 admitted to an Internal Medicine Ward p.rticip.ted. Questionnaires were given during hosp.talization and three months after discharge. Follow-up.information was unavailable for 31 p.tients (25 deceased, 6 unreachable). Results: Of those analyzed 52% were males with 80 ± 8.1 years (mean ± SD). p.lymedication (p.= 0.002), use of p.ychoactive drugs (p.= 0.007), analgesics (p.= 0.034) and walking devices (p.= 0.006) were associated with a higher incidence of falls 6 months before hosp.talization. p.st-discharge follow-up.was obtained for 69 p.tients: 18 rep.rted falling during the follow-up. There was a higher risk of fall in p.tients with a history of falls in the 6 months before admission (p.= 0.015 RR = 2.76). p.tients who had one or more falls after discharge had a significantly shorter length of hosp.tal stay comp.red to those who didn’t fall (p.= 0.012). In multivariate logistic regression, we found that p.tients who were hosp.talized more than 7 days had a lower risk of falling in the p.st-discharge p.riod (OR = 0.195, p.= 0.017) indep.ndently of the history of falls 6 months p.ior to admission. Conclusions: Further studies are required to validate the risk factors identified after discharge and to evaluate p.eventive measures. Elderly p.tients discharged from an Internal Medicine Ward should be screened to determine the risk of falls, sp.cifically p.evious history of falls and medication. These p.tients should integrate a fall p.evention p.ogram.

关键词： Risk Factors Falls Hosp.tal Discharge Elderly