检索结果-南通市图书馆

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

极端天气增多露天音乐会应加强应急预案

商业周刊（中文版） 2024年第10期 28-31页

作者： kendra pierre-Louis 逸思(译) 不详

户外活动面临的极端天气威胁逐年增加,高温、暴风雨、野火烟雾、龙卷风都有可能导致人员伤亡。安娜·克拉拉·贝内维德斯(Ana Clara Benevides)在失去意识前,很可能是感到了呼吸困难。2023年11月17日,泰勒·斯威夫特(Taylor Swift)在里... 详细信息

户外活动面临的极端天气威胁逐年增加,高温、暴风雨、野火烟雾、龙卷风都有可能导致人员伤亡。安娜·克拉拉·贝内维德斯(Ana Clara Benevides)在失去意识前,很可能是感到了呼吸困难。2023年11月17日,泰勒·斯威夫特(Taylor Swift)在里约热内卢尼尔顿桑托斯体育场举行演唱会,现场观众人数达到6万名,热浪袭人,“体感温度”高达59摄氏度。

关键词：斯威夫特极端天气体感温度克拉拉呼吸困难桑托斯龙卷风暴风雨

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

奥运选手借助科技手段迎战极端高温

商业周刊（中文版） 2024年第12期 30-34页

作者： Ira Boudway kendra pierre-Louis Hayley Warren Jin Wu 程玺(译) 孟洁冰(译) 不详

从穿戴式热传感器到充气式冰块池,奥运选手们各显神通,调整训练和比赛方式,以迎战极端高温对于代表美国队参加巴黎奥运会的精英山地自行车运动员克里斯托弗·布莱文斯(Christopher Blevins)来说,不适是比赛的常态。“当你在一个半小时... 详细信息

从穿戴式热传感器到充气式冰块池,奥运选手们各显神通,调整训练和比赛方式,以迎战极端高温对于代表美国队参加巴黎奥运会的精英山地自行车运动员克里斯托弗·布莱文斯(Christopher Blevins)来说,不适是比赛的常态。“当你在一个半小时内拼尽了全力,感觉良好是不可能的,”布莱文斯说,他也参加了上届东京夏季奥运会。

关键词：奥运选手夏季奥运会美国队极端高温克里斯托弗充气式训练和比赛山地自行车运动

Race, the microbiome and colorectal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2019年第10期11卷 773-787页

作者： kendra J Royston Babatunde Adedokun Olufunmilayo I Olopade Division of Hematology Oncology University of ChicagoChicagoIL 60637United States Center for Clinical Cancer Genetics and Global Health Department of Medicine University of ChicagoChicagoIL 60637United States

In the past decade,more cancer researchers have begun to understand the significance of cancer prevention,which has prompted a shift in the increasing body of scientific *** area of fascination and great potential is the human *** studies suggest that the gut microbiota has significant roles in an individual’s ability to avoid cancer,with considerable focus on the gut microbiome and colorectal *** in mind,racial disparities with regard to colorectal cancer treatment and prevention are generally understudied despite higher incidence and mortality rates among Non-Hispanic Blacks compared to other racial and ethnic groups in the United States.A comprehension of ethnic differences with relation to colorectal cancer,dietary habits and the microbiome is a meritorious area of *** review highlights literature that identifies and bridges the gap in understanding the role of the human microbiome in racial disparities across colorectal ***,we explore the differences in the gut microbiota,common short chain fatty acids produced in abundance by microbes,and their association with racial differences in cancer acquisition.

关键词： Diet Epigenetics Microbiome Disparities Colorectal Colon Cancer

Envita’s precision Cancer Care: 35-Fold Improvement in Response Rates

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2024年第4期15卷 99-120页

作者： Sheba Goklany John C. Oertle III Ronald Matthias Jr. Daniel Warren David Medina Rory Sears Robert Zieve kendra Quart Christopher Aussems Jon Moma Shannon Miller Zach poteet Conner Coffin Courtney Middleton Erika Ware phylicia Zarnosky Julie Nowak Winlove Suasin Daniel Conway Chad Burk Ruth Tan-Lim Dino prato Envita Medical Centers Scottsdale AZ USA

New clinical approaches are imperative beyond the widely adopted National Comprehensive Cancer Network (NCCN) guidelines, utilized by prominent cancer institutions. Cancer is the leading cause of death among individuals younger than 85 years within the United States. Despite significant technological advances, including the expenditure of hundreds of billions, treatment outcomes and overall survival have not notably improved for most types of advanced cancer over the last several decades. Over the past 24 years, Envita Medical Centers has pioneered a unique form of personalized treatment approach for late-stage and refractory cancer patients, introducing groundbreaking innovations in the field. Our integrated algorithm utilizes advanced genomics, transcriptomics, and highly tailored immunotherapy, resulting in remarkable outcome improvements. This study presents Envita’s innovative personalized treatment algorithms and examines the response outcomes of 199 late-stage cancer patients treated at Envita Medical Centers over a two-year period. Compared to standard of care and palliative chemotherapy, Envita’s treatment demonstrated a remarkable 35-fold improvement in overall response rates (Figure 1). Moreover, 88% of the patients, the majority presenting with Stage 3 or 4 cancer, experienced a 43-fold improvement in quality of life with minimal side effects, as compared to standard of care chemotherapy and palliative care. This revolutionary success is attributed to Envita’s personalized therapeutic algorithms, which incorporate customized immunotherapy. Envita’s precision care approach has also achieved a 100% better response rate compared to over 65 global chemotherapy clinical trials with more than 2700 patients. The results from this study suggest that a wider utilization of Envita’s personalized approach can significantly benefit patients with late-stage and refractory cancer.

关键词： Envita Medical Centers Late-stage Cancer Overall Response Rate Quality of Life Circulating Tumor Cells (CTCs) Mutant Allele Frequency (MAF) precision Care

Effect of non-steroidal anti-inflammatory drugs on post-surgical complications against the backdrop of the opioid crisis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Burns & Trauma 2018年第3期6卷 190-198页

作者： Hannah Zhao-Fleming Audrey Hand Kelly Zhang Robert polak Armand Northcut Daron Jacob Sharmila Dissanaike kendra p.Rumbaugh Department of Surgery Texas Tech University Health Sciences Center3601 4th StreetSTOP 8312LubbockTX 79430USA Burn Center of Excellence Texas Tech University Health Sciences CenterLubbockTXUSA School of Medicine Texas Tech University Health Sciences CenterLubbockTXUSA

The USA is currently going through an opioid crisis, associated with tremendous economic and societal impacts. In response to this crisis, healthcare professionals are looking for alternative pain management methods, and non-steroidal anti-inflammatory drugs (NSAIDs) are a sensible choice because of their effectiveness after surgical procedures. However, before surgeons start prescribing NSAIDs in place of opioids, it is crucial to first understand their potential post-surgical complications. The goal of this review is to summarize the data obtained through both animal and human studies, which suggest how a dramatic increase in NSAID use may affect these post-surgical complications. We first provide a short review outlining the mechanisms of action of NSAIDs, followed by a summary of animal studies, which show a trend towards the negative effects of NSAIDs on wound healing and an association between NSAID use and wound infections. Lastly, we present evidence from human studies on the association of NSAIDs with the following complications:anastomotic leaks, necrotizing soft tissue infections, bleeding complications, orthopedic injuries, wound healing, and cancer care. The human studies are much more variable in their conclusions as to whether NSAIDs are beneficial or not, with the only strong evidence showing that NSAIDs inhibit bone healing. This may partially be explained by male and female differences in response to NSAIDs as many animal studies showing the inhibitory effects of NSAIDs were performed on females, while al the human studies were performed with both sexes. We conclude that strong caution should be used in the prescription of NSAIDs, especially in female patients, but larger scale studies are warranted before solid recommendations can be made.

关键词： NSAIDs Opioids Anastomotic leaks Necrotizing soft tissue infections Bleeding Orthopedic injuries Wound healing Cancer care non-steroidal anti-inflammatory

Inhibition of translation and immune responses by the virulence factor Nsp1 of SARS-CoV-2

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2020年第1期5卷 487-489页

作者： kendra R.Vann Adam H.Tencer Tatiana G.Kutateladze Department of pharmacology University of Colorado School of MedicineAuroraCO 80045USA

Structural analysis of SARS-CoV-2 virulence factors is crucial for the development of vaccines and anti-viral *** cryo-EM structures of the viral protein Nsp1 bound to the human ribosomal machinery shed light onto the... 详细信息

关键词： immune shutdown vaccines

Integrated primary care-behavioral health program development and implementation in a rural context

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Family Medicine and Community Health 2018年第3期6卷 131-141页

作者： kendra Campbell Loren McKnight Angel R.Vasquez Department of psychology University of Alaska FairbanksFairbanksAKUSA

Objective:Despite the known benefits of integrated primary care and behavioral health services,integrated behavioral health services have not been readily used in medical clinics in interior *** minimal resources,we recently developed an integrated primary care-behavioral health program in a medical clinic in interior Alaska to meet clinic and community *** objective of this study was to explore initial program outcomes and determine the feasibility of program development and ***:We initially conducted a needs assessment for integrating behavioral health services into primary *** development was informed by specific clinic *** program implementation,initial program outcomes were tracked with use of data from the electronic health record and patient and provider use and satisfaction *** level of integration of primary care and behavioral health services was evaluated with the practice Integration ***:A total of 188 patients were seen by behavioral health consultants during the initial pilot phase,including 44.0%referred for mental health symptoms,33.1%referred for physical health issues,and 22.3%referred for both mental and physical health *** initial program outcomes indicate modest clinical improvement(measured by the nine-item patient Health Questionnaire)as well as patient and provider satisfaction with the model,and a moderate level of practice ***:On the basis of the initial findings,it appears that our integrated primary care-behavioral health program has the potential to serve an important role in addressing the behavioral health needs of the local *** implementation procedure and initial program outcomes suggest that such models are feasible in rural and small-scale settings with minimal overhead costs.

关键词： Integrated healthcare primary care behavioral health program development rural healthcare

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asthma in pregnancy

World Journal of pharmacology 2014年第4期3卷 56-71页

作者： Hayley K Blackburn Douglas R Allington kendra A procacci Michael p Rivey Department of pharmacy practice University of Montana Skaggs School of Pharmacy Missoula MT 59812 United States Department of pharmacy Community Medical Center Missoula MT 59804 United States Department of pharmacy Grant Creek Family Practice Missoula MT 59804 United States

Asthma affects approximately 8% of women during pregnancy. pregnancy results in a variable course for asthma control, likely contributed to by physiological changes affecting the respiratory, immune, and hor-monal systems. While asthma during pregnancy has been associated with an increased risk of maternal and fetal complications including malformations, available data also suggest that active asthma management and monitoring can decrease the risk of adverse outcomes. The diagnosis, disease classifcation, and goals for asthma management in the pregnant woman are the same as for nonpregnant patients. However, evidence shows that pregnant asthmatics are more likely to be under-treated, resulting in asthma exacerbations occurring in approximately one third and hospitalization in one tenth of patients. pharmacotherapeutic management of asthma exacerbations in pregnant patients follows stan-dard treatment guidelines. In contrast, the principles of asthma maintenance therapy are slightly modified in the pregnant patient. patients and practitioners may avoid use of asthma medications due to concern for a risk of fetal complications and malformations. A variable amount of information is available regarding the risk of a given asthma medication to cause adverse fetal out-comes, and it is preferable to use an inhaled product. Nevertheless, based on available data, the majority of asthma medications are regarded as safe for use during pregnancy. And, any increased risk to either the mother or fetus from medication use appears to be small compared to that associated with poor asthma control.

关键词： Asthma pregnancy Fetal outcomes Maternal outcomes Management of asthma pharmacotherapy

Clinical and epidemiologic variations of esophageal cancer in Tanzania

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2016年第3期8卷 314-320页

作者： Jaime V Gabel Robert M Chamberlain Twalib Ngoma Julius Mwaiselage kendra K Schmid Crispin Kahesa Amr S Soliman Department of Epidemiology College of Public Health University of Nebraska Medical Center M. D. Anderson Cancer Center University of Texas Ocean Road Cancer Institute Department of Biostatistics College of Public Health University of Nebraska Medical Center

AIM: To estimate the incidence of esophageal cancer(EC) in Kilimanjaro in comparison to other regions in Tanzania. METHODS: We also examined the clinical, epidemiologic, and geographic distribution of the 1332 EC patients diagnosed and/or treated at Ocean Road Cancer Institute(ORCI) during the period 2006-2013. Medical records were used to abstract patient information on age, sex, residence, smoking status, alcohol consumption, tumor site, histopathologic type of tumor, date and place of diagnosis, and type and date of treatment at ORCI. Regional variation of EC patients was investigated at the level of the 26 administrative regions of Tanzania. Total, age- and sex-specific incidence rates were calculated. RESULTS: Male patients 55 years and older had higher incidence of EC than female and younger patients. Of histopathologically-confirmed cases, squamous-cell carcinoma represented 90.9% of histopathologic types of tumors. The administrative regions in the central andeastern parts of Tanzania had higher incidence rates than western regions, specifically administrative regions of Kilimanjaro, Dar es Salaam, and Tanga had the highest rates. CONCLUSION: Further research should focus on investigating possible etiologic factors for EC in regions with high incidence in Tanzania.

关键词： Esophagus Cancer Tanzania Epidemiology Distribution