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ALK-positive anaplastic large cell lymphoma presenting multiple lymphomatous polyposis: A case report and literature review

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World Journal of Clinical Cases 2019年第15期7卷 2049-2057页

作者： Makoto Saito Koh Izumiyama Reiki Ogasawara Akio Mori Takeshi Kondo Masanori Tanaka Masanobu Morioka kencho miyashita Mishie Tanino Department of Internal Medicine and Hematology Aiiku HospitalSapporo 0640804Japan Department of Gastroenterology Aiiku HospitalSapporo 0640804Japan Department of Surgical Pathology Asahikawa Medical University Hospital(formerly Department of Cancer PathologyHokkaido UniversityFaculty of Medicine)Asahikawa 0788510Japan

BACKGROUND Anaplastic large cell lymphoma(ALCL)is a type of T-cell lymphoma that can be divided into two categories:anaplastic lymphoma kinase-positive(ALK+)and *** ALK+ALCL is *** lymphomatous polyposis(MLP)is thought to be a representative form of gastrointestinal lesion in mantle cell lymphoma,and T-cell lymphomas seldom show this ***,we report the first known case of ALK+ALCL with gastroduodenal involvement to present with *** SUMMARY The patient was a 43-year-old man who was complained of a mass in the left inguinal area and was performed open ***+ALCL was diagnosed *** tomography scan demonstrated multiple lymph node lesions in the abdomen-pelvis/inguinal region,and scattered nodular lesions in both lung *** did not complain of gastrointestinal ***,esophagogastroduodenoscopy identified MLP lesions from the antrum of the stomach to the descending portion of the duodenum and mild thickened folds on the corpus of the stomach,and biopsy showed invasion of ALK+*** treated this patient with six cycles of CHOEP(Cyclophosphamide,Doxorubicin,Vincristine,Etoposide,and Prednisone)*** the conclusion of treatment,there was complete *** white scars were found on the stomach,endoscopically consistent with a remission image of *** endoscopic features of this case were thought to be similar to those of *** The macroscopic/endoscopic features of gastrointestinal ALK+ALCL may be more similar to those of B-cell lymphomas rather than T-cell lymphomas.

关键词： Anaplastic large-cell lymphoma Anaplastic lymphoma kinase Multiple lymphomatous polyposis T-cell lymphoma Gastrointestinal involvement

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^(18)F-FDG PET/CT imaging for a gastrointestinal mantle cell lymphoma with multiple lymphomatous polyposis

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World Journal of Gastroenterology 2014年第17期20卷 5141-5146页

作者： Makoto Saito Masaya Miyazaki Mishie Tanino Shinya Tanaka kencho miyashita Koh Izumiyama Akio Mori Tatsuro Irie Masanori Tanaka Masanobu Morioka Eriko Tsukamoto Department of Internal Medicine and Hematology Aiiku HospitalSapporo 064-0804Japan Department of Cancer Pathology Hokkaido University Graduate School of MedicineSapporo 060-8638Japan Department of Gastroenterology Aiiku HospitalSapporo 064-0804Japan Department of Nuclear Medicine Central CI ClinicSapporo 060-0042Japan

Multiple lymphomatous polyposis(MLP)is an uncommon type of gastrointestinal lymphoma characterized by the presence of multiple polyps along the gastrointestinal *** of this entity is in fact considered the counterpart of gastrointestinal tract involvement for mantle cell lymphoma(MCL).To our knowledge,there have been no reports on[fluorine-18]-fluorodeoxy-glucose(18F-FDG)-positron emission tomography(PET)/computed tomography(CT)imaging for gastrointestinal MCL with *** present the results of 18F-FDG PET/CT imaging in a patient with gastrointestinal tract involvement of MCL showing continuous MLP from the stomach to the rectum and intestinal ***-PET/CT findings were false negative in typical MLP spreading widely over the gastrointestinal tract,but uptake was noted in large lesions with deep infiltration considered atypical as *** FDG-PET/CT imaging,the Ki-67proliferative index,which is a cell proliferation marker,showed neither correlation with the presence of uptake nor the maximum standardized uptake value.

关键词： 18F-fluorodeoxy-glucose-positron emission tomography/computed tomography imaging Mantle cell lymphoma Multiple lymphomatous polyposis Gastrointestinal tract Ki-67 proliferative index

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Correspondence Principle for Empirical Equations in Terms of the Cosmic Microwave Background Temperature with Solid-State Ionics

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Journal of Modern Physics 2024年第1期15卷 51-63页

作者： Tomofumi miyashita miyashita Clinic Osaka Japan

Previously, we presented several empirical equations using the cosmic microwave background (CMB) temperature that were mathematically connected. Next, we proposed an empirical equation for the fine-structure constant. Considering the compatibility among these empirical equations, the CMB temperature (Tc) and gravitational constant (G) were calculated to be 2.726312 K and 6.673778 × 10-11 m3·kg-1·s-2, respectively. Every equation can be explained in terms of the Compton length of an electron (λe), the Compton length of a proton (λp) and α. However, these equations are difficult to follow. Using the correspondence principle with the thermodynamic principles in solid-state ionics, we propose a canonical ensemble to explain these equations in this report. For this purpose, we show that every equation can be explained in terms of Avogadro’s number and the number of electrons in 1 C.

关键词： Temperature of the Cosmic Microwave Background

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Ratio of Gravitational Force to Electric Force from Empirical Equations in Terms of the Cosmic Microwave Background Temperature

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Journal of Modern Physics 2024年第5期15卷 674-689页

作者： Tomofumi miyashita miyashita Clinic Osaka Japan

Previously, we presented several empirical equations using the cosmic microwave background (CMB) temperature. Next, we propose an empirical equation for the fine-structure constant. Considering the compatibility among these empirical equations, the CMB temperature (Tc) and gravitational constant (G) were calculated to be 2.726312 K and 6.673778 × 10−11 m3∙kg−1∙s−2, respectively. Every equation could be explained in terms of the Compton length of an electron (λe), the Compton length of a proton (λp) and a. Furthermore, every equation could also be explained in terms of Avogadro’s number and the number of electrons in 1 C. However, the ratio of the gravitational force to the electric force cannot be uniquely determined when the unit of the Planck constant (Js) is changed. In this study, we showed that every equation can be described in terms of Planck constant. From the assumption of minimum mass, the ratio of gravitational force to electric force could be elucidated.

关键词： Ratio of Gravitational Force to Electric Force Minimum Mass Temperature of the Cosmic Microwave Background

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Algorithms for Empirical Equations in Terms of the Cosmic Microwave Background Temperature

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Journal of Modern Physics 2024年第10期15卷 1567-1585页

作者： Tomofumi miyashita miyashita Clinic Osaka Japan

Previously, we presented several empirical equations using the cosmic microwave background (CMB) temperature. Next, we propose an empirical equation for the fine-structure constant. Considering the compatibility among these empirical equations, the CMB temperature (Tc) and gravitational constant (G) were calculated to be 2.726312 K and 6.673778 × 10−11 m3∙kg−1∙s−2, respectively. Every equation can be explained numerically in terms of the Compton length of an electron (λe), the Compton length of a proton (λp) and α. Furthermore, every equation can also be explained in terms of the Avogadro number and the number of electrons at 1 C. We show that every equation can be described in terms of the Planck constant. Then, the ratio of the gravitational force to the electric force can be uniquely determined with the assumption of minimum mass. In this report, we describe the algorithms used to explain these equations in detail. Thus, there are no dimension mismatch problems.

关键词： Temperature of the Cosmic Microwave Background Minimum Mass The Ratio of Gravitational Force to Electric Force Dimension Analysis Redefinition Method Fine Structure Constant

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4-1BB transcriptomic expression patterns across malignancies:Implications for clinical trials of 4-1BB agonists

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Cancer Communications 2024年第10期44卷 1168-1172页

作者： Yuji Uehara Shumei Kato Daisuke Nishizaki Hirotaka miyashita Suzanna Lee Mary K.Nesline Sarabjot Pabla Jeffrey M.Conroy Paul DePietro Heidi Ko Jason K.Sicklick Razelle Kurzrock Department of Thoracic Oncology and Respiratory Medicine Tokyo Metropolitan Cancer and Infectious Diseases CenterKomagome HospitalTokyoJapan Department of Precision Cancer Medicine Center for Innovative Cancer TreatmentTokyo Medical and Dental UniversityTokyoJapan Center for Personalized Cancer Therapy and Division of Hematology and Oncology Department of MedicineUniversity of California San DiegoMoores Cancer CenterLa JollaCaliforniaUnited States Dartmouth Cancer Center Hematology and Medical OncologyLebanonNew HampshireUnited States Labcorp Oncology DurhamNorth CarolinaUnited States OmniSeq Incorporation BuffaloNew YorkUnited States Division of Surgical Oncology Department of SurgeryCenter for Personalized Cancer TherapyUniversity of California San DiegoLa JollaCaliforniaUnited States Medical College of Wisconsin Cancer Center and Genomic Sciences and Precision Medicine Center Medical College of WisconsinMilwaukeeWisconsinUnited States Department of Oncology Medical College of Wisconsin Cancer CenterMilwaukeeWisconsinUnited States Department of Oncology University of NebraskaOmahaNebraskaUnited States

4-1BB,a member of the tumor necrosis factor receptor superfamily,is an important co-stimulatory molecule regulating the activity of immune cells across a range of physiological and pathological processes,which culminates in a potent immune response(Figure 1A and B)[1,2].Numerous clinical trials have been conducted utilizing 4–1BB agonists(Supplemental Table S1);however,previous and ongoing 4-1BB agonist trials are being conducted without biomarker selection,which potentially explains their modest ***,several studies suggest the potential value of utilizing transcriptomics in addition to genomics to identify the unique immunologic signature of individual tumors[3–7].

关键词： clinical utilizing Figure

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PREPARATION OF PHOTOFUNCTIONAL POLYMER THIN FILMS BY LANGMUIR-BLODGETT TECHNIQUE

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Chinese Journal of Polymer Science 1999年第1期17卷 75-79页

作者： Tokuji miyashita Tatsuo Taniguchi Yoshihito Fukasawa Institute for Chemical Reaction Science Tohoku University Sendai 980-8577 JapanInstitute for Chemical Reaction Science Tohoku University Sendai 980-8577 JapanInstitute for Chemical Reaction Science Tohoku University Sendai 980-8577 Japan

Polymer LB films containing photofuntional groups were prepared by the copolymerization of N-dodecylacrylamide (DDA), which has an excellent property to form a stable monolayer and LB multilayerswith photofunctional monomers. Tris(2, 2'-bipyridine) ruthenium complex, Ru(bpy)_3^(2+), one of the most well-known redox-active sensitizer, was incorporated into the DDA copolymer. The photogalvanic effect based onthe photoinduced electron transfer using the ruthenium complex in the polymer LB monolayer was discussed.

关键词： Photofunctional polymer Polymer LB film, N-Dodecylacrylamide Ruthenium complex

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Observations of Magnetic Reconnection in the Magnetotail Associated With Substorms

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空间科学学报 2010年第4期30卷 312-320页

作者： Y.miyashita Solar-Terrestrial Environment Laboratory Nagoya UniversityFuro-choChikusa-kuNagoyaAichi 464-8601Japan

Magnetic reconnection is one of the most important,dynamic phenomena in the magnetotail in terms of magnetic field line configuration change and energy *** is believed to occur in the distant magnetotail mainly during southward interplanetary magnetic field periods and in the near-Earth magnetotail in association with *** the present paper,we discuss several important issues concerning magnetic reconnection in the magnetotail associated with substorms,such as reconnection signatures,location,timing,spatial scale,and behavior,from the macroscopic,observational point of view.

关键词：地球磁尾磁重联亚暴测相行星际磁场能量释放配置条件空间尺度

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Role of atomic-scale thermal fluctuations in the coercivity

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npj Computational Materials 2020年第1期6卷 1084-1090页

作者： Yuta Toga Seiji miyashita Akimasa Sakuma Takashi Miyake National Institute for Materials Science(NIMS) Tsukuba 305-0047Japan Elements Strategy Initiative Center for Magnetic Materials(ESICMM) TsukubaJapan Institute for Solid State Physics University of TokyoKashiwa 277-8581Japan The Physical Society of Japan Tokyo 113-0033Japan Department of Applied Physics Tohoku UniversitySendai 980-8579Japan National Institute of Advanced Industrial Science and Technology(AIST) Tsukuba 305-8568Japan

The microscopic mechanism of coercivity at finite temperature is a crucial issue for permanent *** we present the temperature dependence of the coercivity of an atomistic spin model for the highest-performance magnet Nd_(2)Fe_(14)*** quantitative analysis of the magnetization reversal with thermal fluctuations,we focus on the free energy landscape as a function of the *** free energy is calculated by the replica-exchange Wang–Landau *** approach allows us to address a slow nucleation problem,i.e.,thermal activation effects,in the magnetization *** concretely observed that the thermal fluctuations lead to a downward convexity in the coercivity concerning the ***,through analyzing the microscopic process of the thermal activation(nucleation),we discover the activation volume is insensitive to a magnetic field around the *** insensitivity explains the linear reduction of the free energy barrier by the magnetic field in the nucleation process.

关键词： thermal activation magnetization

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Total Synthesis of the Zoanthamine Alkaloid

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复旦学报（自然科学版） 2005年第5期44卷 781-782页

作者： M.miyashita Graduate of Science Hokkaido UniversitySapporo 060-0810Japan

The zoanthamine alkaloids, a type of heptacyclic marine alkaloid isolated from colonial zoanthids of the genus Zoanthus sp., have attracted much attention from a wide area of science, because of their distinctive biological and pharmacological properties as well as their chemical structures with stereochemical ***, norzoanthamine (1)[1] can suppress the loss of bone weight and strength in ovariectomized mice and has been considered a promising candidate for an antiosteoporotic drug[1], whereas zoanthamine (2)[2] has exhibited potent inhibitory activity toward phorbol myristate-induced inflammation in addition to powerful analgesic effects[2]. See Fig. 1.

关键词：生物碱合成方法藕合反应生物药理学化学结构

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