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Alteration of Taste Acuity in Pediatric Cancer Patients after Treatment Completion: A Cross-Sectional Study Using a Filter-Paper Disc Method

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Food and Nutrition Sciences 2014年第14期5卷 1440-1446页

作者： Ayako Nagai Masaru Kubota Souichi Adachi ken-ichiro watanabe Yasufumi Takeshita Department of Human Life and Environment Nara Women’s University Nara Japan Department of Pediatrics Kyoto University Hospital Kyoto Japan Department of Pediatrics Nara Medical University Hospital Nara Japan

Taste acuity of adult patients undergoing cancer treatment has been well investigated;however, studies of taste acuity after completion of cancer treatment are limited, particularly in children. This study aimed to assess taste acuity in pediatric cancer patients after treatment completion. Seventy-three patients who had completed cancer treatment (median age, 13 years;range, 7 - 18 years) and had not received any further treatment for at least 6 months were enrolled. Eighty-one healthy children (median age, 10 years;range, 8 - 19 years) served as controls. We determined the thresholds for four tastes (sweet, salty, sour, and bitter) using the filter-paper disc method. There was no significant difference in the thresholds of taste acuity for the four test solutions between the patient and control groups. The duration since treatment completion (<5 years vs. ≥5 years) had no significant impact on taste acuity for the four test solutions. The threshold for tasting salt was significantly higher in the group that had received chemotherapy + radiation and/or hematopoietic stem cell transplantation than that in the group that had received chemotherapy-only. Our results indicated that taste acuity after treatment completion in pediatric cancer patients was the same as that in healthy children. However, some treatment modalities were correlated with an impaired ability to taste salt. Gustatory test results should be considered while deciding nutritional support modalities after treatment completion in pediatric cancer patients.

关键词： Pediatric Cancer Cancer Treatment Filter-Paper Disc Method Taste Acuity

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Recent advances in treatment of follicular lymphoma: efficacy of PI3Kα/δ inhibitor (TQ-B3525)

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2341-2343页

作者： Takuya watanabe Department of Internal Medicine and Gastroenterology Watanabe Internal Medicine Aoyama ClinicNiigata-city 9502002Japan

The commented study reports the results of monotherapy using TQ-B3525,a novel phosphatidylinositol-3 kinase(PI3K)inhibitor developed in China,in patients with refractory/relapsed follicular lymphoma(r/r FL).

关键词： PI3K lymphoma treatment

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Electroluminescence from pure resonant states in hBN-based vertical tunneling junctions

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Light(Science & Applications) 2024年第8期13卷 1557-1564页

作者： Magdalena Grzeszczyk Kristina Vaklinova kenji watanabe Takashi Taniguchi Konstantin SNovoselov Maciej Koperski Institute for Functional Intelligent Materials National University of SingaporeSingapore 117544Singapore Research Center for Functional Materials National Institute for Materials ScienceTsukuba 305-0044Japan International Center for Materials Nanoarchitectonics National Institute for Materials ScienceTsukuba 305-0044Japan Department of Materials Science and Engineering National University of SingaporeSingapore 117575Singapore

Defect centers in wide-band-gap crystals have garnered interest for their potential in applications among optoelectronic and sensor ***,defects embedded in highly insulating crystals,like diamond,silicon carbide,or aluminum oxide,have been notoriously difficult to excite electrically due to their large internal *** address this challenge,we realized a new paradigm of exciting defects in vertical tunneling junctions based on carbon centers in hexagonal boron nitride(hBN).The rational design of the devices via van der Waals technology enabled us to raise and control optical processes related to defect-to-band and intradefect *** fundamental understanding of the tunneling events was based on the transfer of the electronic wave function amplitude between resonant defect states in hBN to the metallic state in graphene,which leads to dramatic changes in the characteristics of electrons due to different band structures of constituent *** our devices,the decay of electrons via tunneling pathways competed with radiative recombination,resulting in an unprecedented degree of tuneability of carrier dynamics due to the significant sensitivity of the characteristic tunneling times on the thickness and structure of the *** enabled us to achieve a high-efficiency electrical excitation of intradefect transitions,exceeding by several orders of magnitude the efficiency of optical excitation in the sub-band-gap *** work represents a significant advancement towards a universal and scalable platform for electrically driven devices utilizing defect centers in wide-band-gap crystals with properties modulated via activation of different tunneling mechanisms at a level of device engineering.

关键词： carbide tunneling defect

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Field induced Chern insulating states in twisted monolayer–bilayer graphene

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Chinese Physics B 2024年第6期33卷 69-73页

作者：王政文韩英卓 kenji watanabe Takashi Taniguchi 姜宇航毛金海 School of Physical Science and CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100049China College of Materials Science and Optoelectronic Technology Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China Advanced Materials Laboratory National Institute for Materials ScienceTsukuba 305-0044Japan

Unraveling the mechanism underlying topological phases, notably the Chern insulators(Ch Is) in strong correlated systems at the microscopy scale, has captivated significant research interest. Nonetheless, Ch Is harboring topological information have not always manifested themselves, owing to the constraints imposed by displacement fields in certain experimental configurations. In this study, we employ density-tuned scanning tunneling microscopy(DT-STM) to investigate the Ch Is in twisted monolayer–bilayer graphene(t MBG). At zero magnetic field, we observe correlated metallic *** under a magnetic field, a metal–insulator transition happens and an integer Ch I is formed emanating from the filling index s = 3 with a Chern number C = 1. Our results underscore the pivotal role of magnetic fields as a powerful probe for elucidating topological phases in twisted Van der Waals heterostructures.

关键词： Chern insulators strong correlation effects two-dimensional van der Waals heterostructure density-tuned scanning tunneling microscopy(DT-STM)

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Dynamic Hand Gesture-Based Person Identification Using Leap Motion and Machine Learning Approaches

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Computers, Materials & Continua 2024年第4期79卷 1205-1222页

作者： Jungpil Shin Md.AlMehedi Hasan Md.Maniruzzaman Taiki watanabe Issei Jozume School of Computer Science and Engineering The University of AizuAizuwakamatsuFukushima965-8580Japan Department of Computer Science&Engineering Rajshahi University of Engineering&TechnologyRajshahi6204Bangladesh

Person identification is one of the most vital tasks for network security. People are more concerned about theirsecurity due to traditional passwords becoming weaker or leaking in various attacks. In recent decades, fingerprintsand faces have been widely used for person identification, which has the risk of information leakage as a resultof reproducing fingers or faces by taking a snapshot. Recently, people have focused on creating an identifiablepattern, which will not be reproducible falsely by capturing psychological and behavioral information of a personusing vision and sensor-based techniques. In existing studies, most of the researchers used very complex patternsin this direction, which need special training and attention to remember the patterns and failed to capturethe psychological and behavioral information of a person properly. To overcome these problems, this researchdevised a novel dynamic hand gesture-based person identification system using a Leap Motion sensor. Thisstudy developed two hand gesture-based pattern datasets for performing the experiments, which contained morethan 500 samples, collected from 25 subjects. Various static and dynamic features were extracted from the handgeometry. Randomforest was used to measure feature importance using the Gini Index. Finally, the support vectormachinewas implemented for person identification and evaluate its performance using identification accuracy. Theexperimental results showed that the proposed system produced an identification accuracy of 99.8% for arbitraryhand gesture-based patterns and 99.6% for the same dynamic hand gesture-based patterns. This result indicatedthat the proposed system can be used for person identification in the field of security.

关键词： Person identification leap motion hand gesture random forest support vector machine

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Moving doubly heavy baryon in a strongly coupled plasma via holography

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Chinese Physics C 2024年第8期48卷 42-55页

作者： Xuan Liu Jia-Jie Jiang Xun Chen Mitsutoshi Fujita Akira watanabe School of Nuclear Science and Technology University of South ChinaHengyang 421001China School of Mathematics and Physics University of South ChinaHengyang 421001China

Gauge/gravity duality is used to study the properties of the doubly heavy baryon(QQq)at finite rapidity and temperature in heavy-ion *** investigate the impact of rapidity on string breaking and screening of QQq and compare these effects with the results for QQ¯in *** reveal that the string-breaking distances of QQq and QQ¯are close in the confined state,and the effects of rapidity and temperature on the string breaking are not *** interesting result shows that QQq cannot be determined at sufficiently high temperatures and ***,QQ¯can exist under any conditions as long as the separation distance is sufficiently ***,the screening distances of QQq and QQ¯are compared at finite rapidity and *** on the above analysis,we infer that QQ¯is more stable than QQq at finite rapidity and temperature.

关键词： holographic QCD QGP heavy quark

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Aging-induced memory loss due to decreased N1-acetyl-5-methoxykynuramine,a melatonin metabolite,in the hippocampus:a potential prophylactic agent for dementia

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Neural Regeneration Research 2025年第6期20卷 1705-1706页

作者： Kazuki watanabe Atsuhiko Hattori Department of Immunobiology Institute of Development Aging and CancerTohoku UniversitySendaiMiyagiJapan Department of Sport and Wellness College of Sport and WellnessRikkyo UniversityNiizaSaitamaJapan

Melatonin(N-acetyl-5-methoxytryptamine)is known as the hormone of darkness because it is synthesized at night and involved in regulating the circadian *** hormone is primarily synthesized by the vertebrate pineal gland,but is ubiquitous among invertebrates,unicellular organisms,plants,and even cyanobacteria(Hattori and Suzuki,2024).Melatonin is well-conserved evolutionarily and possesses several physiological functions,such as immune response,bone and glucose metabolism,and memory formation besides regulating the circadian rhythm.

关键词： metabolism primarily agent

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Ultrasound-guided peripheral nerve blocks for anterior cutaneous nerve entrapment syndrome after robot-assisted gastrectomy: A case report

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2719-2723页

作者： Yukiko Saito Hirohisa Takeuchi Joho Tokumine Ryuji Sawada Kunitaro watanabe Tomoko Yorozu Department of Anesthesiology Kyorin University School of MedicineTokyo 181-8611Japan Department of Surgery Kyorin University School of MedicineTokyo 181-8611Japan

BACKGROUND Anterior cutaneous nerve entrapment syndrome(ACNES)is a condition mani-festing with pain caused by strangulation of the anterior cutaneous branch of the lower intercostal *** case report aims to provide new insight into the selection of peripheral nerve blocks for the ACNES *** SUMMARY A 66-year-old woman manifested ACNES after a robot-assisted distal *** ultrasound-guided rectal sheath block was effective for pain triggered by the port ***,the sudden severe pain,which radiated laterally from the previous site,remained.A transversus abdominis plane block was performed for the remaining pain and effectively relieved *** In this case,the trocar port was inserted between the rectus and transverse abdominis *** intercostal nerves might have been entrapped on both sides of the rectus and transversus abdominis ***,rectus sheath and transverse abdominis plane blocks were required to achieve complete pain *** the best of our knowledge,this is the first report on use of a combination of rectus sheath and transverse abdominis plane blocks for pain relief in ACNES.

关键词： Anterior cutaneous nerve entrapment syndrome Rectus sheath block Trans-verse abdominal plane block Hydrodissection Robot-assisted gastrectomy Case report

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Examining the Hypothesis of Common Factors Shared by Different Addictive Behaviors and Gender Effects on Propensity to Addiction Type

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Open Journal of Medical Psychology 2024年第3期13卷 58-70页

作者： Masayo Uji Junko watanabe Toshinori Kitamura Department of Clinical Psychology Human Development Education Graduate School of Education Hyogo University of Teacher Education Kat Japan Academic Skill Support Center Kumamoto Health Science University Kumamoto Japan Kitamura Institute Mental Health Tokyo Tokyo Japan

Background: From the two facts reported by previous research: 1) frequent co-occurrence of more than one addictive behavior, 2) childhood adversities identified as origins of different types of addictive behaviors, it is assumed that all types of addictive behaviors, regardless of substance, behavioral, or relationship, share common factors which have not yet been proven by epidemiological research. The Shorter PROMIS Questionnaire (SPQ) was previously developed to assess 16 types of addictive behaviors. Its factor structure, however, has not been fully investigated. Confirming the factor structure will enable us to hypothesize the common factor(s) shared by all, or if not all, most types of addictive behaviors. Aims: This study aimed at 1) examining the factor structure of the SPQ, 2) confirming the reliability of the questionnaire, and 3) examining the impacts of gender and age on each addictive behavior. Methods: Data obtained from 232 Japanese adults who completed all items of the SPQ were used for the analyses. After confirming the one-factor structure model for each of the 16 subscales, the validity of the one-factor structure of the SPQ was evaluated using Confirmatory Factor Analysis (CFA), by adapting 16 subscale scores as observed variables. If its validity was not confirmed, another model which showed better compatibility to the data was explored. The reliability of the SPQ as well as that of all 16 subscales was evaluated. Also, the impacts of gender and age on each subscale score were examined. Results: The one-factor structure for each of the 16 subscales was confirmed. The compatibility of the SPQ one-factor model was not acceptable. The best fit model was a bi-factor model in which one main factor was shared by all 16 subscales, and three factors were shared by some specific addictive behaviors. Male respondents were more likely than female respondents to show high scores in Alcohol, Tobacco, Gambling, Sex, and Recreational Drugs, and low scores only

关键词： Addictive Behaviors Shorter PROMIS Questionnaire Confirmatory Factor Analysis

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Performance Comparison of Vision Transformer- and CNN-Based Image Classification Using Cross Entropy: A Preliminary Application to Lung Cancer Discrimination from CT Images

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Journal of Biomedical Science and Engineering 2024年第9期17卷 157-170页

作者： Eri Matsuyama Haruyuki watanabe Noriyuki Takahashi Faculty of Informatics The University of Fukuchiyama Kyoto Japan School of Radiological Technology Gunma Prefectural College of Health Sciences Gunma Japan School of Health Sciences Fukushima Medical University Fukushima Japan

This study evaluates the performance and reliability of a vision transformer (ViT) compared to convolutional neural networks (CNNs) using the ResNet50 model in classifying lung cancer from CT images into four categories: lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), large cell carcinoma (LULC), and normal. Although CNNs have made significant advancements in medical imaging, their limited capacity to capture long-range dependencies has led to the exploration of ViTs, which leverage self-attention mechanisms for a more comprehensive global understanding of images. The study utilized a dataset of 748 lung CT images to train both models with standardized input sizes, assessing their performance through conventional metrics—accuracy, precision, recall, F1 score, specificity, and AUC—as well as cross entropy, a novel metric for evaluating prediction uncertainty. Both models achieved similar accuracy rates (95%), with ViT demonstrating a slight edge over ResNet50 in precision and F1 scores for specific classes. However, ResNet50 exhibited higher recall for LULC, indicating fewer missed cases. Cross entropy analysis showed that the ViT model had lower average uncertainty, particularly in the LUAD, Normal, and LUSC classes, compared to ResNet50. This finding suggests that ViT predictions are generally more reliable, though ResNet50 performed better for LULC. The study underscores that accuracy alone is insufficient for model comparison, as cross entropy offers deeper insights into the reliability and confidence of model predictions. The results highlight the importance of incorporating cross entropy alongside traditional metrics for a more comprehensive evaluation of deep learning models in medical image classification, providing a nuanced understanding of their performance and reliability. While the ViT outperformed the CNN-based ResNet50 in lung cancer classification based on cross-entropy values, the performance differences were minor and may not hold c

关键词： Lung Cancer Classification Vision Transformers Convolutional Neural Networks Cross Entropy Deep Learning

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