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New aspects of a small GTPase RAB35 in brain development and function

Neural Regeneration Research 2025年第7期20卷 1971-1980页

作者： Ikuko Maejima ken Sato Laboratory of Molecular Traffic Institute for Molecular and Cellular RegulationGunma UniversityMaebashiJapan

In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or *** processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS *** of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative ***,it is important to understand the physiological and pathological roles of RAB proteins in brain ***35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell ***35 is also involved in neurite outgrowth and turnover of synaptic *** generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and *** mice exhibited defects in anxiety-related behaviors and spatial ***,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal *** contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex *** studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's *** this review,we provide an overview of the current understanding of subcellular functions of *** also provide insights into the phys

关键词： endocytosis endosomes hippocampal development neurodegenerative diseases RAB35

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Exploring the novel role of oligodendrocyte precursor cells in phagocytosis:beyond myelinogenesis

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Neural Regeneration Research 2025年第2期20卷 473-474页

作者： Gen Hamanaka ken Arai Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General Hospital and Harvard Medical SchoolCharlestownMAUSA

Roles of oligodendrocyte precursor cells in the central nervous system:Oligodendrocyte precursor cells(OPCs)have long been recognized for their critical role as precursors to oligodendrocytes,the primary myelin-producing *** precursors,OPCs mature and differentiate into oligodendrocytes,which contribute significantly to the formation of myelin sheaths around *** myelination,which is critical for the conduction of salutatory nerve impulses in the cerebral white matter,underscores the classical role of oligodendrocytes in central nervous system(CNS)***,because oligodendrocytes are differentiated cells that cannot proliferate.

关键词： critical system conduction

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OPTIMAL INVESTMENT WITH NOISE TRADING RISK

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Journal of Systems Science & Complexity 2008年第4期21卷 519-526页

作者： Yunhui XU Zhongfei LI ken Seng tan Lingnan College Sun Yat-Sen University Guangzhou 510275 China Department of Statistics and Actuarial Science University of Waterloo Waterloo Ontario N2L 3G1 Canada. Lingnan College Sun Yat-Sen University Guangzhou 510275 China Department of Statistics and Actuarial Science University of Waterloo Waterloo Ontario N2L 3G1 Canada China Institute for Actuarial Science Central University of Finance and Economics Beijing 100081 China.

This paper investigates the optimal dynamic investment for an investor who maximizes constant absolute risk aversion （CARA） utility in a discrete-time market with a riskfree bond and a risky stock. The risky stock is assumed to present both the dividend risk and the price risk. With our assumptions, the dividend risk is equivalent to fundamental risk, and the price risk is equivalent to the noise trading risk. The analytical expression for the optimal investment strategy is obtained by dynamic programming. The main result in this paper highlights the importance of differentiating between noise trading risk and fundamental risk for the optimal dynamic investment.

关键词： Dynamic investment noise trade overlapping generation serial correlation.

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Carbon nanosheets derived from reconstructed lignin for potassium and sodium storage with low voltage hysteresis

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Nano Research 2021年第12期14卷 4664-4673页

作者： Keren Jiang Xuehai tan Shengli Zhai ken Cadien Zhi Li Department of Chemical and Materials Engineering University of AlbertaEdmontonAlbertaT6G 1H9Canada

Lignin is the second most abundant and the only nature polymer rich in aromatic *** aromatic-unit-rich precursors often yield soft carbon after carbonization,the side chains in lignin crosslink with the aromatic units and form a rigid three-dimensional(3D)structure which eventually leads to hard *** a graphene oxide-catalyzed decomposition and repolymerization process,we successfully reconstructed lignin by partially tailoring the side *** to directly carbonized lignin,the carbonized reconstructed lignin possesses significantly fewer defects,86%fewer oxygen-functionalities,82%fewer micropores,and narrower interlayer *** parameters can be tuned by the amount of catalysts(graphene oxide).When tested as anode for K-ion and Na-ion batteries,the carbonized reconstructed lignin delivers notably higher capacity at low-potential range(especially for Na-storage),shows much-improved performance at high current density,and most importantly,reduces voltage hysteresis between discharge and charge process by more than 50%,which is critical to the energy efficiency of the energy storage *** study reveals that the voltage hysteresis in K-storage is much severer than that in Na-storage for all *** practical K-ion battery applications,the voltage hysteresis deserves more attention in future electrode materials design and the reconstruct ion strategy introduced in this work provides potential low-cost solution.

关键词： lignin batteries polarization voltage hysteresis ring-forming defects

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Wear Behavior of Cold Pressed and Sintered Al_2O_3/TiC/CaF_2-Al_2O_3/TiC Laminated Ceramic Composite

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Acta Metallurgica Sinica(English Letters) 2013年第2期26卷 157-166页

作者： Xuefeng yang Jian CHENG Peilong SONG Shouren WANG Liying yang Yanjun WANG ken MAO School of Mechanical Engineering University of Jinan Key Laboratory for Anisotropy and Texture of Materials of the Ministry of Education Northeastern University School of Engineering Warwick University

A novel laminated Al2O3/TiC/CaF2-Al2O3/TiC sandwich ceramic composite was fabricated through cold pressing and sintering to achieve better anti-wear performance, such as low friction coefficient and low wear rate. Al2O3/TiC/CaF2 and Al2O3/TiC composites were alternatively built layer-by-layer to obtain a sandwich structure. Solid lubricant CaF2 was added evenly into the Al2O3/TiC/CaF2 layer to reduce the friction and wear. Al2O3/TiC ceramic was also cold pressed and sintered for comparison. Friction analysis of the two ceramics was then conducted via a wear-and-tear machine. Worn surface and surface compositions were examined by scanning electron microscopy and energy dispersion spectrum, respectively. Results showed that the laminated Al2O3/TiC/CaF2-Al2O3/TiC sandwich ceramic composite has lower friction coefficient and lower wear rate than those of Al2O3/TiC ceramic alone because of the addition of CaF2 into the laminated Al2O3/TiC/CaF2-Al2O3/TiC sandwich ceramic composite. Under the friction load, the tiny CaF2 particles were scraped from the Al2O3/TiC/CaF2 layer and spread on friction pairs before falling off into micropits. This process formed a smooth, self-lubricating film, which led to better anti-wear properties. Adhesive wear is the main wear mechanism of Al2O3/TiC/CaF2 layer and abrasive wear is the main wear mechanism of Al2O3/TiC layer.

关键词： Friction and wear characteristics Wear property Ceramic-matrix compos-ites Layer manufacture Surface appearance Sliding

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深圳证券交易所

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城市环境设计 2014年第6期 38-51页

作者： Kunle Adeyemi Ryann Aoukar Sebastian Appl Laura Baird Waichuen Chan Jan Dechow Lukas Drasnar Matthew Engele Leo Ferretto Clarisa Garcia Fresco Alasdair Graham Jaitian Gu Matthew Haseltine Joo Ferreira Marques Jesus Matthew Jull Alexde Jong Santiago Hierro kennedy Klaas Kresse Miranda Lee Anna Little Luxiang Liu David Eugin Moon Cristina Murphy Se Yoon Park Ferdjan Vander Pijl Franscesca Portesine Idrees Rasouli Korbinian Schneider Wolfgang Schwarzwalder Felix Schwimmer Richard Sharam Lukasz Skalec Christine Svensson Lukasz Szlachcic ken yang tan Michela Tonus Miroslav Vavrina Na Wei Xinyuan Wang Leonie Wenz Su Xia Yunchao Xu yang yang Yun Zhang

股票市场的本质是投机买卖:基于资本,而非物质。深圳证券交易所可被设想为虚拟股票市场的具体实践:这一栋拥有悬浮基座的建筑物不但能发挥物理功能,为股票市场提供场地,更重要的是它象征了股票市场。一般来说,基座用以锚固结构,并将其... 详细信息

股票市场的本质是投机买卖:基于资本,而非物质。深圳证券交易所可被设想为虚拟股票市场的具体实践:这一栋拥有悬浮基座的建筑物不但能发挥物理功能,为股票市场提供场地,更重要的是它象征了股票市场。一般来说,基座用以锚固结构,并将其牢牢地与地面连接;然而,深圳证券交易所的基座却沿着塔楼从地面往高处攀升,投机买卖的热烈气氛在驱动交易市

关键词：深圳证券交易所深交所半钢化玻璃

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Multiple Impact Phenomenon in Impact Hammer Testing:Theoretical Analysis and Numerical Simulation

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Acta Mechanica Solida Sinica 2021年第6期34卷 830-843页

作者： Junyin Li ken Lin Yanchao Hu Yuliang yang Yong Wang Zhilong Huang Department of Engineering Mechanics Zhejiang UniversityHangzhou310027China Hangzhou Zhongpu Technology Co. Ltd.Hangzhou310012China Pengcheng Lab Shenzhen518055China

As conducting an impact hammer testing during experimental modal analysis,the multiple impact phenomenon must be *** is generally recognized that the multiple impact phenomenon is induced by the tester’s improper operation and can be avoided through more careful *** study theoretically and numerically investigates the whole process of the dynamical interaction between the hammer tip and the impacted structure and discovers the intrinsically physical mechanism of the multiple impact *** determination of the interacting process comes down to solve two sets of governing differential equations alternately,and the effectiveness of the theoretical analysis is validated by numerical *** dimensionless parameters governing the interacting process are recognized in the theoretical *** critical stiffness ratio for a given impacted location and the critical impacted location for a given stiffness ratio are analytically *** results can guide impact hammer testing to avoid the occurrence of multiple impact by suggesting the hammer tip and impacted locations.

关键词： Impact hammer testing Modal analysis Multiple impact Theoretical analysis Numerical simulation

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HESSIAN MATRIX BASED SADDLE POINT DETECTION FOR GRANULES SEGMENTATION IN 2D IMAGE

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Journal of Electronics(China) 2008年第6期25卷 728-736页

作者： Chen ken Wang Yicong yang Rener College of Information Science and Engineering Ningbo University Zhejiang 315211 China

Segmenting the touching objects in an image has been remaining as a hot subject due to the problematic complexities, and a vast number of algorithms designed to tackle this issue have come into being since a decade ago. In this paper, a new granule segmentation algorithm is developed using saddle point as the cutting point. The image is binarized and then sequentially eroded to form a gray-scale topographic counterpart, followed by using Hessian matrix computation to search for the saddle point. The segmentation is performed by cutting through the saddle point and along the maximal gradient path on the topographic surface. The results of the algorithm test on the given real images indicate certain superiorities in both the segmenting robustness and execution time to the referenced methods.

关键词： Hessian matrix Image segment Saddle point Touching objects

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PROBE:NOISE-AND-ROTATION RESIStanCE OF HOPFIELD NEURAL NETWORK IN IMAGED TRAFFIC SIGN RECALL

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Journal of Electronics(China) 2013年第2期30卷 183-189页

作者： Chen ken yang Shoujian Celal Batur College of Information Science and Engineering Ningbo University College of Engineering The University of Akron

This paper examines the noise and rotation resistance capacity of Hopfield Neural Network （HNN） given four corrupted traffic sign images. In the study, Signal-to-Noise Ratio （SNR）, recall rate and pattern complexity are defined and employed to evaluate the recall performance. The experimental results indicate that the HNN possesses significant recall capacity against the strong noise corruption, and certain restoring competence to the rotation. It is also found that combining noise with rotation does not further challenge the HNN corruption resistance capability as the noise or rotation alone does.

关键词： Hopfield Neural Network (HNN) Traffic sign identification Pattern complexity Recall rate

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Method for Visual Localization of Oil and Gas Wellhead Based on Distance Function of Projected Features

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International Journal of Automation and computing 2017年第2期14卷 147-158页

作者： Ying Xie Xiang-Dong yang Zhi Liu Shu-Nan Ren ken Chen Department of Mechanical Engineering Tsinghua University Beijing 100084 China Beijing Key Lab of Precision/Ultra-precision Manufacturing Equipments and Control Beijing 100084 China State Key Laboratory of Tribology Beijing 100084 China

A localization method based on distance function of projected features is presented to solve the accuracy reduction or failure problem due to occlusion and blurring caused by smog, when dealing with vision based localization for target oil and gas wellhead （OGWH）. Firstly, the target OGWH is modeled as a cylinder with marker, and a vector with redundant parameter is used to describe its pose. Secondly, the explicit mapping relationship between the pose vector with redundant parameter and projected features is derived. Then, a 2D-point-to-feature distance function is proposed, as well as its derivative. Finally, based on this distance function and its derivative, an algorithm is proposed to estimate the pose of target OGWH directly according to the 2D image information, and the validity of the method is verified by both synthetic data and real image experiments. The results show that this method is able to accomplish the localization in the case of occlusion and blurring, and its anti-noise ability is good especially with noise ratio of less than 70%.

关键词： Robot vision visual localization 3D object localization model based pose estimation distance function of projectedfeatures nonlinear least squares random sample consensus (RANSAC).

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