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International Journal of Clinical Medicine 2015年第2期6卷 85-95页

作者： Mizuki Komatsu Masayuki Okazaki ken tsuchiya Hiroshi Kawaguchi Kosaku Nitta Department of Nephrology Jyoban Hospital Fukushima Japan Department of Medicine Kidney Center Tokyo Women’s Medical University Tokyo Japan

Background: Cardiovascular (CV) diseases are the most frequent cause of death in hemodialysis (HD) patients. The aim of this study was to identify risk factors for CV events in HD patients with preserved left ventricular ejection fraction (PEF). Objectives: A total of 213 HD patients (69 years, 64.1% males) were enrolled. Demographic, laboratory test, and echocardiographic data were recorded, and CV events during the 32-month follow-up period were documented. Results: During the follow-up period, 31 patients (14.6%) died and 50 patients (23.5%) suffered a fatal or nonfatal CV event. Age and serum albumin, C-reactive protein, total cholesterol, non-HDL cholesterol, and NT-proBNP levels were associated with CV events according to a univariate analyses. A multivariate analysis identified a low serum albumin value

关键词： Cardiovascular Events Albumin Echocardiography Hemodialysis Mortality

An Invitation of the Combination of the Geriatric Nutritional Risk Index and the Triglyceride to High-Density Lipoprotein Cholesterol Ratio as a Mortality Predictor in Maintenance Hemodialysis Patients

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International Journal of Clinical Medicine 2017年第2期8卷 86-97页

作者： Ayako Hasegawa Norio Hanafusa Masayuki Okazaki Mizuki Komatsu Hiroshi Kawaguchi ken tsuchiya Kosaku Nitta Department of Medicine Kidney Center Tokyo Women’s Medical University Tokyo Japan Department of Blood Purification Kidney Center Tokyo Women’s Medical University Tokyo Japan Department of Nephrology Jyoban Hospital Fukushima Japan

Background: The geriatric nutritional risk index (GNRI) has been developed as a tool to assess the nutritional risk. The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio has been shown to be a predictor of cardiovascular (CV) outcomes in the general population. Objectives: The aim of this study was to determine whether the combination of GNRI and TG/HDL-C ratio is a predictor of all-cause mortality and CV deaths in maintenance hemodialysis (MHD) patients. Methods: We performed a retrospective, observational cohort study in which we enrolled 341 MHD patients from a single center in Japan who had been followed up for a mean of 48.0 ± 12.7 months. The outcomes were defined as the occurrence of all-cause mortality and CV deaths during the follow-up period. Baseline GNRI and TG/HDL-C ratios were investigated for associations with outcomes by using Cox proportion hazards models adjusted for demographic parameters. Results: Overall, 101 of the subjects had died, of whom 52 died due to CV events during the mean follow-up period of 48.0 ± 12.7 months. The patients were grouped into four categories according to a median GNRI Conclusion: The combination of GNRI and TG/HDL-C ratio is an easily accessible marker for predicting all-cause mortality and CV deaths in MHD patients.

关键词： GNRI Triglyceride HDL-Cholesterol Mortality Hemodialysis

Transcriptional factors, Mafs and their biological roles

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世界糖尿病杂志：英文版（电子版） 2015年第1期6卷 175-183页

作者： Mariko tsuchiya Ryoichi Misaka Kosaku Nitta ken tsuchiya Institute of Geriatrics Tokyo Women’s Medical University Department of Medicine IV Tokyo Women’s Medical University

The Maf family of transcription factors is characterized by a typical b Zip structure; these transcription factors act as important regulators of the development and differentiation of many organs and tissues, including the kidney. The Maf family consists of two subgroups that are characterized according to their structure: large Maf transcription factors and small Maf transcriptionfactors. The large Maf subgroup consists of four proteins, designated as MAFA, MAFB, c-MAF and neural retina-specific leucine zipper. In particular, MAFA is a distinct molecule that has been attracting the attention of researchers because it acts as a strong transactivator of insulin, suggesting that Maf transcription factors are likely to be involved in systemic energy homeostasis. In this review, we focused on the regulation of glucose/energy balance by Maf transcription factors in various organs.

关键词： Cell Insulin MAFA Microarray siRNA

Spontaneous regression of hepatic inflammatory pseudotumor with primary biliary cirrhosis:Case report and literature review

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World Journal of Gastroenterology 2006年第10期12卷 1645-1648页

作者： Hiroshi Koide ken Sato Toshio Fukusato kenji Kashiwabara Noriaki Sunaga Takafumi tsuchiya Saeko Morino Naondo Sohara Satoru Kakizaki Hitoshi Takagi Masatomo Mori Department of Medicine and Molecular Science Gunma University Graduate School of Medicine MaebashiGunma 371-8511Japan Department of Pathology Teikyo University School of Medicine Itabashi-kuTokyo 173-8605Japan Clinical Pathology Gunma University Graduate School of Medicine MaebashiGunma 371-8511Japan

Hepatic inflammatory pseudotumor （IPT） is a rare benign non-neoplastic lesion characterized by proliferating fibrous tissue infiltrated by inflammatory cells. The exact etiology of IPT remains unclear. Although the association of IPT with systemic inflammatory disorders has been well established, a specific relationship with cholangitis is distinctly rare. We report a case of spontaneous regression of hepatic IPT with primary biliary cirrhosis （PBC）. To date, only two cases of IPT with PBC have been reported. In our case, however, IPT developed during the course of improvement of cholangitis of PBC induced by effective treatment, differing from two previously reported cases. Our case indicates that the development of IPT does not also relate to the activity of cholangitis and/or hyper gamma-globulinemia, since our case was confirmed radiologically to be free of IPT when biliary enzymes and immunoglobulins were much higher than the corresponding values on admission. Comparison of our case with the two previously reported cases suggests that IPT occurring with PBC does not represent the same disease entity or be a bystander for PBC.

关键词： Hepatic inflammatory pseudotumor Primary biliary cirrhosis Spontaneous regression Ursodeoxycholic acid Bezafibrate

Characteristics of Anomalous Radio Propagation before and after the 2011 Tohoku-Oki Earthquake as Seen by Oblique Ionograms

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Open Journal of Earthquake Research 2020年第2期9卷 100-112页

作者： Kiyoshi Igarashi Toshio tsuchiya ken Umeno Department of Applied Mathematics and Physics Graduate School of Informatics Kyoto University Kyoto Japan

The characteristics of anomalous radio propagation in the frequency 1 - 30 MHz before and after the 2011 Tohoku-Oki earthquake are firstly revealed by using oblique ionograms for the pass from Wakkanai to Kokubunji which is closest to the epicenter. An oblique ionogram with a wavy-shape-trace was observed at 06:30 UTC on 11 March 2011 after the 2011 Tohoku-Oki earthquake. The velocity of northward-propagating disturbance caused this wavy-shape-trace is estimated to be 130 m/s. This wave-shape-trace shows very clear signature appearing in the oblique ionograms as the characteristic of strong ionospheric disturbances triggered by the earthquake. An oblique ionogram with a steep slopy-shape-trace was observed at 04:45 UTC on 11 March 2011 one hour before the 2011 Tohoku-Oki earthquake. This slopy-shape-trace is investigated as the signatures of preseismic ionospheric anomaly. This anomalous oblique ionogram with a slopy-shape-trace is examined with the slope ratio of virtual height to sweep-frequency, and the difference between monthly median foF2 and hourly value foF2 at Wakkanai and Kokubunji. These features appearing in oblique ionograms suggest that it is useful for studying the signatures of preseismic ionospheric anomaly.

关键词： Ionospheric Disturbances Oblique Ionogram Anomalous Radio Propagation Atmospheric Gravity Waves

Hyperglycemia is a significant prognostic factor of hepatocellular carcinoma after curative therapy

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World Journal of Gastroenterology 2013年第2期19卷 249-257页

作者： Takanori Hosokawa Masayuki Kurosaki Kaoru tsuchiya Shuya Matsuda Masaru Muraoka Yuichiro Suzuki Nobuharu Tamaki Yutaka Yasui Toru Nakata Takashi Nishimura Shoko Suzuki ken Ueda Hiroyuki Nakanishi Jun Itakura Yuka Takahashi Namiki Izumi Division of Gastroenterology and Hepatology Musashino Red Cross HospitalTokyo 180-8610Japan

AIM:To evaluate whether metabolic factors are related to distant recurrence of hepatocellular carcinoma(HCC) and survival after curative ***:This retrospective study included 344 patients whose HCC was treated curatively by radiofrequency ablation(RFA) *** mean age was 67.6 years and the mean observation period was 4.04 *** etiological background of liver disease was hepatitis B virus infection in 30,hepatitis C virus infection in 278,excessive alcohol drinking in 9,and other in 27 *** Child-Pugh classification grade was A(n = 307) or B(n = 37).The number of HCC nodules was one in 260,two in 61,and three in 23 *** surveillance of HCC recurrence after curative therapy with RFA,patients were radiologically evaluated every 3 *** associated with distant recurrence of HCC or survival were ***:Inadequate maintenance of blood glucose in diabetic patients was associated with higher incidence of distant *** 1-,2-,and 3-year recurrence rates were significantly higher in diabetic patients with inadequate maintenance of blood glucose compared with the others:50.6% vs 26.8%,83.5% vs 54.4%,and 93.8% vs 73.0%,respectively(P = 0.0001).Inadequate maintenance of blood glucose was an independent predictor of distant recurrence [adjusted relative risk 1.97(95%CI,1.33-2.91),(P = 0.0007)] after adjustment for other risk factors,such as number of HCC nodules [2.03(95%CI,1.51-2.73),P < 0.0001] and initial level of serum alpha fetoprotein(AFP) [1.43(95%CI,1.04-1.97),P = 0.028].Obesity was not an independent predictor of *** incidence of distant recurrence did not differ between diabetic patients with adequate maintenance of blood glucose and non-diabetic *** 232 patients who had HCC recurrence,138 had a second *** 1-,2-,and 3-year rates of second recurrence were significantly higher in diabetic patients with inadequate maintenance of blood glucose than in the others:9.0% vs 5.9%,53.1

关键词： Hyperglycemia Hepatocellular carcinoma Recurrence Radio frequency ablation Survival