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Successful treatment with laparoscopic surgery and sequential multikinase inhibitor therapy for hepatocellular carcinoma:A case report

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World Journal of Gastrointestinal Surgery 2022年第3期14卷 260-267页

作者： Yutaka Endo Motohide Shimazu Tadayuki Sakuragawa Yusuke Uchi Motonori Edanami ken sunamura Soji Ozawa Naokazu Chiba Shigeyuki Kawachi Department of Surgery Tama Kyuryo HospitalTokyo 1940297Japan Department of Digestive and Transplantation Surgery Tokyo Medical University Hachioji Medical CenterTokyo 1930998Japan

BACKGROUND Hepatocellular carcinoma(HCC)with massive portal vein tumor thrombosis(PVTT)and distant metastasis is considered ***,due to recent developments in systemic chemotherapy,successful cases of conversion therapy for unresectable diseases have been ***,we report a successful multidisciplinary approach for treatment of multi-visceral recurrence with sequential multikinase inhibitor and laparoscopic *** SUMMARY A 63-year-old woman with chronic hepatitis B virus infection was diagnosed with ***,she underwent two rounds of laparoscopic partial hepatectomy,laparoscopic left adrenalectomy,and transcatheter arterial chemoembolization plus sorafenib for *** years after initial hepatectomy,she presented with a 43-mm mass in the spleen and tumor thrombus involving the main portal vein trunk with *** liver function was Child-Pugh B(8),and protein induced by vitamin K absence or antagonist II(PIVKA II)levels were elevated up to 46.291 mAU/*** initial treatment with regorafenib for three months was unsuccessful,the patient was administered *** months post-treatment,there was no contrast enhancement of PVTT or splenic *** was discontinued due to severe ***,splenic metastasis became viable,and PIVKA II ***,hand-assisted laparoscopic splenectomy was *** experienced no clinical recurrence 14 mo after *** Conversion surgery after successful multikinase inhibitor treatment might be considered an effective treatment option for advanced HCC.

关键词： Hepatocellular carcinoma Lenvatinib Portal vein Venous thrombosis Splenic neoplasms Case report

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